The role of human glutathione S-transferases (hGSTs) in the detoxification of the food-derived carcinogen metabolite N-acetoxy-PhIP, and the effect of a polymorphism in hGSTA1 on colorectal cancer risk

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 482, Issue 1-2, 2001, Pages 3-10

  Coles, B ^a   Nowell, S A ^b   MacLeod, S L ^b   Sweeney, C ^a,b   Lang, N P ^b,c   Kadlubar, F F ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

Author keywords

Colorectal cancer; Detoxification; hGSTA1 genetic polymorphism; Human glutathione S transferases; PhIP

Indexed keywords

CARCINOGEN; DNA; GLUTATHIONE; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE A1; GLUTATHIONE TRANSFERASE A2; GLUTATHIONE TRANSFERASE A2 2; GLUTATHIONE TRANSFERASE A4 4; GLUTATHIONE TRANSFERASE M1 1; GLUTATHIONE TRANSFERASE M2 2; GLUTATHIONE TRANSFERASE M4 4; GLUTATHIONE TRANSFERASE P1 1; GLUTATHIONE TRANSFERASE T1 1; GLUTATHIONE TRANSFERASE T2 2; GLUTATHIONE TRANSFERASE Z1 1; HETEROCYCLIC AMINE; ISOENZYME; N ACETOXY 2 AMINO 1 METHYL 6 PHENYLIMIDAZOL[4,5 B]PYRIDINE; RECOMBINANT ENZYME; UNCLASSIFIED DRUG;

ACETYLATION; ADULT; AGED; ANALYTIC METHOD; ARTICLE; CANCER RISK; CATALYSIS; CATALYST; CAUCASIAN; COLORECTAL CANCER; CONTROLLED STUDY; DETOXIFICATION; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; FEMALE; GENE FREQUENCY; GENE SEQUENCE; GENETIC POLYMORPHISM; GENOTYPE; HOMOZYGOSITY; HUMAN; LIVER; MAJOR CLINICAL STUDY; MALE; METABOLITE; OXIDATION; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN EXPRESSION; SULFATION;

EID: 0035479621     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(01)00187-7     Document Type: Article

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