Role of human CYP1A1 and NAT2 in 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine-induced mutagenicity and DNA adducts

Xenobiotica

Volumn 39, Issue 5, 2009, Pages 399-406

  Bendaly, J ^a   Metry, K J ^a   Doll, M A ^a   Jiang, G ^a   States, J C ^a   Smith, N B ^a   Neale, J R ^a   Holloman, J L ^a   Pierce Jr , W M ^a   Hein, D W ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

2 amino 1 methyl 6 Phenylimidazo 4,5 b pyridine; 2 Amino 1 methyl 6 phenylimidazo 4,5 b pyridine (PhIP); Cytochrome P450 (CYP) 1A1; N acetyltransferase 2 (NAT2); P4501A1

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; ARYLAMINE ACETYLTRANSFERASE; CARCINOGEN; CYTOCHROME P450 1A1; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE;

ACETYLATION; ACETYLATOR PHENOTYPE; ALLELE; ANIMAL CELL; ARTICLE; CANCER RISK; CATALYSIS; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA ADDUCT; DNA DAMAGE; ENZYME ACTIVITY; ENZYME POLYMORPHISM; EXCISION REPAIR; EXPOSURE; GENETIC POLYMORPHISM; GENETIC TRANSFECTION; GENOTOXICITY; HYDROXYLATION; MUTAGENESIS; MUTAGENICITY; NONHUMAN;

ANIMALS; ARYLAMINE N-ACETYLTRANSFERASE; CARCINOGENS; CHO CELLS; CRICETINAE; CRICETULUS; CYTOCHROME P-450 CYP1A1; DNA ADDUCTS; DNA DAMAGE; HUMANS; IMIDAZOLES; MUTAGENESIS; MUTAGENS; POLYMORPHISM, GENETIC; TRANSFECTION;

CRICETULUS GRISEUS;

EID: 70350336880     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.1080/00498250902748953     Document Type: Article

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