2-Amino-1-methyl-6-phenylimidazo [4,5-b] pyridine-induced DNA adducts and genotoxicity in Chinese Hamster Ovary (CHO) cells expressing human CYP1A2 and rapid or slow acetylator N-acetyltransferase 2

Molecular Carcinogenesis

Volumn 46, Issue 7, 2007, Pages 553-563

  Metry, Kristin J ^a   Zhao, Shuang ^a   Neale, Jason R ^a   Doll, Mark A ^a   States, J Christopher ^a   McGregor, W Glenn ^a   Pierce Jr , William M ^a   Hein, David W ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

2 amino 1 methyl 6 phenylimidazo 4,5 b pyridine; Acetylator phenotype; Cytochrome P4501a2; DNA adducts; Mutagenicity; N acetyltransferase 2; O acetylation

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; ACYLTRANSFERASE; ARYLAMINE ACETYLTRANSFERASE; COMPLEMENTARY DNA; CYTOCHROME P450 1A2; N HYDROXY 2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE O ACETYLTRANSFERASE; UNCLASSIFIED DRUG;

ACETYLATION; ALLELE; ANIMAL CELL; ARTICLE; BASE PAIRING; CATALYSIS; CATALYST; CELL CULTURE; CELL SURVIVAL; CHO CELL; CONTROLLED STUDY; CULTURE MEDIUM; CYP1A2 GENE; DNA ADDUCT; DNA SEQUENCE; ENZYME ACTIVITY; EXCISION REPAIR; GENE; GENE LOCUS; GENETIC POLYMORPHISM; GENETIC TRANSFECTION; GENOTOXICITY; HPRT GENE; HYDROXYLATION; MUTAGENESIS; NAT2 4 GENE; NAT2 5B GENE; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SEQUENCE ANALYSIS;

ACETYLATION; ANIMALS; ARYLAMINE N-ACETYLTRANSFERASE; CARCINOGENS; CHO CELLS; CRICETINAE; CRICETULUS; CYTOCHROME P-450 CYP1A2; DNA ADDUCTS; DNA DAMAGE; HUMANS; IMIDAZOLES;

CRICETULUS GRISEUS;

EID: 34447500199     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.20302     Document Type: Article

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