Robust network topologies for generating switch-like cellular responses

PLoS Computational Biology

Volumn 7, Issue 6, 2011, Pages

  Shah, Najaf A ^a   Sarkar, Casim A ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NETWORK TOPOLOGY;

BI-STABILITY; CELL-CYCLE CONTROLS; CELLULAR RESPONSE; IN-PROCESS; NETWORK TOPOLOGY; PARAMETER SET; ROBUST NETWORK; SIGNALING NETWORKS; TRANSCRIPTIONAL NETWORKS; ULTRASENSITIVITY;

SIGNALING;

ENZYME; MITOGEN ACTIVATED PROTEIN KINASE; RECEPTOR; TRANSCRIPTION FACTOR;

ARTICLE; CATALYSIS; CELL ACTIVATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INACTIVATION; GENE REGULATORY NETWORK; HYBRID; MOLECULAR DYNAMICS; NONHUMAN; POSITIVE FEEDBACK; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION; STEADY STATE; STIMULUS RESPONSE; TRANSCRIPTION INITIATION; UPREGULATION; ARABIDOPSIS; BIOLOGICAL MODEL; BIOLOGY; FEEDBACK SYSTEM; METABOLISM; METHODOLOGY; SACCHAROMYCES CEREVISIAE;

ARABIDOPSIS; COMPUTATIONAL BIOLOGY; ENZYMES; FEEDBACK, PHYSIOLOGICAL; MODELS, BIOLOGICAL; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 79959859399     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1002085     Document Type: Article

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