Health bene fits of phytochemicals in whole foods

Nutritional Health: Strategies for Disease Prevention: Third Edition

Volumn , Issue , 2012, Pages 293-310

  Liu, Rui Hai ^a  

^a Cornell University ^*  (United States)

Author keywords

Antioxidants; Cancer; Cardiovascular disease; Dietary supplements; Fruit; Phytochemicals; Vegetables; Whole grains

Indexed keywords

EID: 84880153083     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-61779-894-8_13     Document Type: Chapter

References (62)

1. Temple NJ. Antioxidants and disease: more questions than answers. Nutr Res. 2000;20:449-59.
2. Willet WC. Diet and health: what should we eat. Science. 1994;254:532-7.
3. Willett WC. Balancing life-style and genomics research for disease prevention. Science. 2002;296:695-8.
4. Doll R, Peto R. Avoidable risks of cancer in the United States. J Natl Cancer Inst. 1981;66:1197-265.
5. Willet WC. Diet, nutrition, and avoidable cancer. Environ Health Perspect. 1995;103:165-70.
6. National Academy of Sciences. Committee on diet, nutrition, and cancer, assembly of life sciences, national research council. Diet, nutrition, and cancer. Washington: National Academy Press; 1982.
7. National Academy of Sciences. Committee on diet and health, national research council. Diet and health: implications for reducing chronic disease risk. Washington: National Academy Press; 1989.
8. USDA. Dietary Guidelines for Americans 2010. Available at http://www.cnpp.usda.gov/ dietaryguidelines.html (2011). Last Accessed 11 Feb 2011.
9. Liu RH. Health bene fits of fruits and vegetables are from additive and synergistic combination of phytochemicals. Am J Clin Nutr. 2003;78:517S-20.
10. Liu RH. Potential synergy of phytochemicals in cancer prevention: mechanism of action. J Nutr. 2004;134:3479S-85.
11. Ames BN, Gold LS. Endogenous mutagens and the causes of aging and cancer. Mutat Res. 1991;250:3-16.
12. Liu RH, Hotchkiss JH. Potential genotoxicity of chronically elevated nitric oxide: a review. Mutat Res. 1995;339:73-89.
13. Sun J, Chu Y-F, Wu X, Liu RH. Antioxidant and antiproliferative activities of fruits. J Agric Food Chem. 2002;50:7449-54.
14. Chu Y-F, Sun J, Wu X, Liu RH. Antioxidant and antiproliferative activities of vegetables. J Agric Food Chem. 2002;50:6910-6.
15. Hollman PCH, Arts ICW. Flavonols, flavones and flavanols-nature, occurrence and dietary burden. J Sci Food Agric. 2000;80:1081-93.
16. Hollman PCH, Katan MB. Dietary flavonoids: intake, health effects and bioavailability. Food Chem Toxicol. 1999;37:937-42.
17. Kuhnau J. The flavonoids. A class of semi-essential food components: their role in human nutrition. World Rev Nutr Diet. 1976;24:117-91.
18. Hertog MGL, Hollman PCH, Katan MB, Kromhout D. Intake of potentially anticarcinogenic flavonoids and their determinants in adults in The Netherlands. Nutr Cancer. 1993;20:21-9.
19. Adom KK, Liu RH. Antioxidant activity of grains. J Agric Food Chem. 2002;50:6182-7.
20. Dewanto V, Wu X, Liu RH. Processed sweet corn has higher antioxidant activity. J Agric Food Chem. 2002;50:4959-64.
21. Britton G. Structure and properties of carotenoids in relation to function. FASEB J. 1995;9:1551-8.
22. Ames BN, Shigenaga MK, Gold LS. DNA lesions, inducible DNA repair, and cell division: the three key factors in mutagenesis and carcinogenesis. Environ Health Perspect. 1993;101 Suppl 5:35-44.
23. Wang H, Cao GH, Prior RL. Total antioxidant capacity of fruits. J Agric Food Chem. 1996;44:701-5.
24. Vinson JA, Hao Y, Su X, Zubik L, Bose P. Phenol antioxidant quantity and quality in foods:fruits. J Agric Food Chem. 2001;49:5315-21.
25. Adom KK, Sorrells ME, Liu RH. Phytochemicals and antioxidant activity of wheat varieties. J Agric Food Chem. 2003;51:7825-34.
26. Block G, Patterson B, Subar A. Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence. Nutr Cancer. 1992;18:1-29.
27. Knekt P, Jarvinen R, Seppanen R, et al. Dietary flavonoids and the risk of lung cancer and other malignant neoplasms. Am J Epidemiol. 1997;146:223-30.
28. Le Marchand L, Murphy SP, Hankin JH, Wilkens LR, Kolonel LN. Intake of flavonoids and lung cancer. J Natl Cancer Inst. 2000;92:154-60.
29. Boyle SP, Dobson VL, Duthie SJ, Kyle JAM, Collins AR. Absorption and DNA protective effects of flavonoid glycosides from an onion meal. Eur J Nutr. 2000;39:213-23.
30. Dragsted LO, Strube M, Larsen JC. Cancer-protective factors in fruits and vegetables: biochemical and biological background. Pharmacol Toxicol. 1993;72:116-35.
31. Waladkhani AR, Clemens MR. Effect of dietary phytochemicals on cancer development. Int J Mol Med. 1998;1:747-53.
32. Hertog MGL, Feskens EJM, Hollman PCH, Katan MB, Kromhout D. Dietary antioxidant flavonoids and risk of coronary heart disease: The Zutphen Elderly Study. Lancet. 1993;342:1007-11.
33. Hertog MGL, Kromhout D, Aravanis C, et al. Flavonoid intake and long-term risk of coronary heart disease and cancer in the Seven Countries Study. Arch Intern Med. 1995;155:381-6.
34. Knekt P, Jarvinen R, Reunanen A, Maatela J. Flavonoid intake and coronary mortality in Finland: a cohort study. Br Med J. 1996;312:478-81.
35. Arai Y, Watanabe S, Kimira M, Shimoi K, Mochizuki R, Kinae N. Dietary intakes of flavonols, flavones and iso flavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration. J Nutr. 2000;131:2243-50.
36. Joshipura KJ, Hu FB, Manson JE, et al. The effect of fruit and vegetable intake on risk for coronary heart disease. Ann Intern Med. 2001;134:1106-14.
37. Liu S, Manson JE, Lee I-M, et al. Fruit and vegetable intake and risk of cardiovascular disease:the Women's Health Study. Am J Clin Nutr. 2000;72:922-8.
38. Bazzano LA, He J, Ogden LG, et al. Fruit and vegetable intake and risk of cardiovascular disease in US adults: the first National Health and Nutrition Examination Survey Epidemiologic Follow-up Study. Am J Clin Nutr. 2002;76:93-9.
39. Berliner J, Leitinger N, Watson A, Huber J, Fogelman A, Navab M. Oxidized lipids in atherogenesisi:formation, destruction and action. Thromb Haemost. 1997;78:195-9.
40. Witztum JL, Berliner JA. Oxidized phospholipids and isoprostanes in atherosclerosis. Curr Opin Lipidol. 1998;9:441-8.
41. Sanchez-Moreno C, Jimenez-Escrig A, Saura-Calixto F. Study of low-density lipoprotein oxidizability indexes to measure the antioxidant activity of dietary polyphenols. Nutr Res. 2000;20:941-53.
42. Ridker PM, Rifai N, Rose L, Buring JE, Cook NR. Comparison of C-reactive protein and lowdensity lipoprotein cholesterol levels in the prediction of first cardiovascular events. N Engl J Med. 2002;347:1557-65.
43. Libby P, Ridker PM, Maseri A. In flammation and atherosclerosis. Circulation. 2002;105:1135-43.
44. Brighenti F, Valtuena S, Pellegrini N, et al. Total antioxidant capacity of the diet is inversely and independently related to plasma concentration of high-sensitivity C-reactive protein in adult Italian subjects. Br J Nutr. 2005;93:619-25.
45. Esmaillzadeh A, Kimiagar M, Mehrabi Y, Azadbakht L, Hu FB, Willett WC. Fruit and vegetable intakes, C-reactive protein, and the metabolic syndrome. Am J Clin Nutr. 2006;84:1489-97.
46. Ommen GS, Goodman GE, Thomquist MD, Barnes J, Cullen MR. Effects of a combination of b -carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med. 1996;334:1150-5.
47. Stephens NG, Parsons A, Schofield PM, Kelly F, Cheeseman K, Mitchinson MJ. Randomized controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS). Lancet. 1996;347:154-60.
48. Yusuf S, Dagenais G, Pogue J, Bosch J, Sleight P. Vitamin E supplementation and cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med. 2000;342:154-60.
49. Hennekens CH, Buring JE, Manson JE, Stampfer M, Rosner B. Lack of effect of long- term supplementation with b -carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl J Med. 1996;334:1145-9.
50. Greenberg ER, Baron JA, Stuckel TA, Stevens MM, Mandel JS. A clinical trial of b -carotene to prevent basal cell and squamous cell cancers of the skin. N Engl J Med. 1990;323:789-95.
51. The a -Tocopherol, b -Carotene Cancer Prevention Study Group. The effect of vitamin E and b -carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med. 1994;330:1020-35.
52. The HOPE Investigators. Vitamin E supplementation and cardiovascular events in high-risk patients. N Engl J Med. 2000;342:154-60.
53. GISSI-Prevenzione Investigators. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione Trial. Lancet. 1999;354:447-55.
54. Blot WJ, Li JY, Taylor PR, et al. Nutrition intervention trials in Linxian, China: supplementation with speci fic vitamin/mineral combinations, cancer incidence, and disease-speci fic mortality in the general population. J Natl Cancer Inst. 1993;85:1483-92.
55. Salonen JT, Nyyssonen K, Salonen R, et al. Antioxidant supplementation in artherosclerosis prevention (ASAP) study: a randomized trial of the effect of vitamins E and C on 3-year progression of carotid atherosclerosis. J Intern Med. 2000;248:377-86.
56. Lippman SM, Klein EA, Goodman PJ, et al. Effects of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA. 2009;301:39-51.
57. Eberhardt MV, Lee CY, Liu RH. Antioxidant activity of fresh apples. Nature. 2000;405:903-4.
58. Liu RH, Liu J, Chen B. Apples prevent mammary tumors in rats. J Agric Food Chem. 2005;53:2341-3.
59. Yang J, Liu RH. Synergistic effect of apple extracts and quercetin 3- b -D-glucoside combination on antiproliferative activity in MCF-7 human breast cancer cells in vitro. J Agric Food Chem. 2009;57:8581-6.
60. He XJ, Liu RH. Triterpenoids isolated from apple peels have potent antiproliferative activity and may be partially responsible for apple's anticancer activity. J Agric Food Chem. 2007;55:4366-70.
61. He XJ, Liu RH. Phytochemicals of apple peels: isolation, structure elucidation, and their antiproliferative and antioxidant activities. J Agric Food Chem. 2008;56:9905-10.
62. Temple NJ, Gladwin KK. Fruits, vegetables, and the prevention of cancer: research challenges. Nutrition. 2003;19:467-70.