Oxidized phospholipids and isoprostanes in atherosclerosis

Current Opinion in Lipidology

Volumn 9, Issue 5, 1998, Pages 441-448

  Witztum, Joseph L ^a   Berliner, Judith A ^b  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; ISOPROSTANE; PHOSPHOLIPID; RECEPTOR; UNCLASSIFIED DRUG;

ATHEROSCLEROSIS; CELL ACTIVATION; CELL TYPE; LIPID OXIDATION; PRIORITY JOURNAL; REVIEW;

ANIMALS; ARTERIOSCLEROSIS; DINOPROST; HUMANS; ISOMERISM; OXIDATION-REDUCTION; PHOSPHOLIPIDS;

ANIMALIA;

EID: 0031731850     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041433-199810000-00008     Document Type: Review

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45. •].
46. •], reviews a variety of aspects of the chemistry and biology of oxidized phospholipids.
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62. •] suggest that antiphospholipid antibodies should increase in situations of enhanced lipid peroxidation. In this study, in lupus patients who have increased titers of antiphospholipid antibodies, it was shown that there was a very strong correlation between the antibody titer and the urinary excretion of isoprostanes. This study supports the hypothesis that antiphospholipid antibodies may form in response to pro-oxidative conditions.