메뉴 건너뛰기




Volumn 5, Issue 3, 2013, Pages 857-874

Induction of chromosomal instability via telomere dysfunction and epigenetic alterations in myeloid neoplasia

Author keywords

AML; Chromosomal instability; Epigenetics; Genetic instability; MDS; Myeloid leukemia; Telomeres

Indexed keywords

DNA METHYLTRANSFERASE 3A; TRANSCRIPTION FACTOR EZH2;

EID: 84880112197     PISSN: None     EISSN: 20726694     Source Type: Journal    
DOI: 10.3390/cancers5030857     Document Type: Review
Times cited : (13)

References (90)
  • 3
    • 0032542364 scopus 로고    scopus 로고
    • Genetic instabilities in human cancers
    • Lengauer, C.; Kinzler, K.W.; Vogelstein, B. Genetic instabilities in human cancers. Nature 1998, 396, 643-649.
    • (1998) Nature , vol.396 , pp. 643-649
    • Lengauer, C.1    Kinzler, K.W.2    Vogelstein, B.3
  • 5
    • 84884591984 scopus 로고    scopus 로고
    • Genetic instability: Tipping the balance
    • doi:10.1038/onc.2012.576
    • Janssen, A.; Medema, R.H. Genetic instability: Tipping the balance. Oncogene 2012, doi:10.1038/onc.2012.576.
    • (2012) Oncogene
    • Janssen, A.1    Medema, R.H.2
  • 9
    • 77953919322 scopus 로고    scopus 로고
    • Chromosomal instability correlates with poor outcome in patients with myelodysplastic syndromes irrespectively of the cytogenetic risk group
    • Heilig, C.E.; Loffler, H.; Mahlknecht, U.; Janssen, J.W.; Ho, A.D.; Jauch, A.; Kramer, A. Chromosomal instability correlates with poor outcome in patients with myelodysplastic syndromes irrespectively of the cytogenetic risk group. J. Cell Mol. Med. 2010, 14, 895-902.
    • (2010) J. Cell Mol. Med , vol.14 , pp. 895-902
    • Heilig, C.E.1    Loffler, H.2    Mahlknecht, U.3    Janssen, J.W.4    Ho, A.D.5    Jauch, A.6    Kramer, A.7
  • 11
    • 77952579886 scopus 로고    scopus 로고
    • New clues to the molecular pathogenesis of myelodysplastic syndromes
    • Jadersten, M.; Hellstrom-Lindberg, E. New clues to the molecular pathogenesis of myelodysplastic syndromes. Exp. Cell. Res. 2010, 316, 1390-1396.
    • (2010) Exp. Cell. Res , vol.316 , pp. 1390-1396
    • Jadersten, M.1    Hellstrom-Lindberg, E.2
  • 14
    • 35848961684 scopus 로고    scopus 로고
    • Clinical features and prognosis of patients with myelodysplastic syndromes
    • Germing, U.; Strupp, C.; Giagounidis, A. Clinical features and prognosis of patients with myelodysplastic syndromes. Cancer Treat. Rev. 2007, 33, S15-S18.
    • (2007) Cancer Treat. Rev , vol.33
    • Germing, U.1    Strupp, C.2    Giagounidis, A.3
  • 19
    • 84880120046 scopus 로고    scopus 로고
    • t(15;17)(q24;q21). Available online, accessed on 17 June
    • Huret, J.; Chomienne, C. t(15;17)(q24;q21). Available online: http://atlasgeneticsoncology.org/Anomalies/t1517ID1035.html/ (accessed on 17 June 2013).
    • (2013)
    • Huret, J.1    Chomienne, C.2
  • 20
    • 77449159028 scopus 로고    scopus 로고
    • Diagnosis and management of acute myeloid leukemia in adults: Recommendations from an international expert panel, on behalf of the European LeukemiaNet
    • Dohner, H.; Estey, E.H.; Amadori, S.; Appelbaum, F.R.; Buchner, T.; Burnett, A.K.; Dombret, H.; Fenaux, P.; Grimwade, D.; Larson, R.A., et al. Diagnosis and management of acute myeloid leukemia in adults: Recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood 2010, 115, 453-474.
    • (2010) Blood , vol.115 , pp. 453-474
    • Dohner, H.1    Estey, E.H.2    Amadori, S.3    Appelbaum, F.R.4    Buchner, T.5    Burnett, A.K.6    Dombret, H.7    Fenaux, P.8    Grimwade, D.9    Larson, R.A.10
  • 25
    • 3843080730 scopus 로고    scopus 로고
    • Dynamics of telomere erosion and its association with genome instability in myelodysplastic syndromes (MDS) and acute myelogenous leukemia arising from MDS: A marker of disease prognosis?
    • Sieglova, Z.; Zilovcova, S.; Cermak, J.; Rihova, H.; Brezinova, D.; Dvorakova, R.; Markova, M.; Maaloufova, J.; Sajdova, J.; Brezinova, J., et al. Dynamics of telomere erosion and its association with genome instability in myelodysplastic syndromes (MDS) and acute myelogenous leukemia arising from MDS: A marker of disease prognosis? Leuk. Res. 2004, 28, 1013-1021.
    • (2004) Leuk. Res , vol.28 , pp. 1013-1021
    • Sieglova, Z.1    Zilovcova, S.2    Cermak, J.3    Rihova, H.4    Brezinova, D.5    Dvorakova, R.6    Markova, M.7    Maaloufova, J.8    Sajdova, J.9    Brezinova, J.10
  • 29
    • 19844382620 scopus 로고    scopus 로고
    • Senescence and immortalization: Role of telomeres and telomerase
    • Shay, J.W.; Wright, W.E. Senescence and immortalization: Role of telomeres and telomerase. Carcinogenesis 2005, 26, 867-874.
    • (2005) Carcinogenesis , vol.26 , pp. 867-874
    • Shay, J.W.1    Wright, W.E.2
  • 33
    • 84883862595 scopus 로고    scopus 로고
    • Centrosome aberrations in bone marrow cells from patients with myelodysplastic syndromes correlate with chromosomal instability
    • doi:10.1007/s00277-013-1772-7
    • Nolte, F.; Giehl, M.; Haass, W.; Nowak, V.; Schumann, C.; Nowak, D.; Mossner, M.; Popp, H.D.; Schulze, T.J.; Klein, S., et al. Centrosome aberrations in bone marrow cells from patients with myelodysplastic syndromes correlate with chromosomal instability. Ann. Hematol. 2013, doi:10.1007/s00277-013-1772-7.
    • (2013) Ann. Hematol
    • Nolte, F.1    Giehl, M.2    Haass, W.3    Nowak, V.4    Schumann, C.5    Nowak, D.6    Mossner, M.7    Popp, H.D.8    Schulze, T.J.9    Klein, S.10
  • 35
    • 34548789121 scopus 로고    scopus 로고
    • Reactive oxygen species, DNA damage, and error-prone repair: A model for genomic instability with progression in myeloid leukemia?
    • Rassool, F.V.; Gaymes, T.J.; Omidvar, N.; Brady, N.; Beurlet, S.; Pla, M.; Reboul, M.; Lea, N.; Chomienne, C.; Thomas, N.S., et al. Reactive oxygen species, DNA damage, and error-prone repair: A model for genomic instability with progression in myeloid leukemia? Cancer. Res. 2007, 67, 8762-8771.
    • (2007) Cancer. Res , vol.67 , pp. 8762-8771
    • Rassool, F.V.1    Gaymes, T.J.2    Omidvar, N.3    Brady, N.4    Beurlet, S.5    Pla, M.6    Reboul, M.7    Lea, N.8    Chomienne, C.9    Thomas, N.S.10
  • 36
    • 51649128895 scopus 로고    scopus 로고
    • Up-regulation of WRN and DNA ligase IIIalpha in chronic myeloid leukemia: Consequences for the repair of DNA double-strand breaks
    • Sallmyr, A.; Tomkinson, A.E.; Rassool, F.V. Up-regulation of WRN and DNA ligase IIIalpha in chronic myeloid leukemia: Consequences for the repair of DNA double-strand breaks. Blood 2008, 112, 1413-1423.
    • (2008) Blood , vol.112 , pp. 1413-1423
    • Sallmyr, A.1    Tomkinson, A.E.2    Rassool, F.V.3
  • 37
    • 79952201572 scopus 로고    scopus 로고
    • Genetic instability in inherited and sporadic leukemias
    • Popp, H.D.; Bohlander, S.K. Genetic instability in inherited and sporadic leukemias. Genes Chromosomes Cancer 2010, 49, 1071-1081.
    • (2010) Genes Chromosomes Cancer , vol.49 , pp. 1071-1081
    • Popp, H.D.1    Bohlander, S.K.2
  • 38
    • 34547854351 scopus 로고    scopus 로고
    • Concise review: Telomere biology in normal and leukemic hematopoietic stem cells
    • Drummond, M.W.; Balabanov, S.; Holyoake, T.L.; Brummendorf, T.H. Concise review: Telomere biology in normal and leukemic hematopoietic stem cells. Stem Cells 2007, 25, 1853-1861.
    • (2007) Stem Cells , vol.25 , pp. 1853-1861
    • Drummond, M.W.1    Balabanov, S.2    Holyoake, T.L.3    Brummendorf, T.H.4
  • 39
    • 50549218525 scopus 로고
    • The limited in vitro lifetime of human diploid cell strains
    • Hayflick, L. The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 1965, 37, 614-636.
    • (1965) Exp. Cell Res , vol.37 , pp. 614-636
    • Hayflick, L.1
  • 40
    • 0035812845 scopus 로고    scopus 로고
    • The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability
    • Hemann, M.T.; Strong, M.A.; Hao, L.Y.; Greider, C.W. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell 2001, 107, 67-77.
    • (2001) Cell , vol.107 , pp. 67-77
    • Hemann, M.T.1    Strong, M.A.2    Hao, L.Y.3    Greider, C.W.4
  • 42
    • 77955845914 scopus 로고    scopus 로고
    • Telomeres and telomerase in normal and cancer stem cells
    • Shay, J.W.; Wright, W.E. Telomeres and telomerase in normal and cancer stem cells. FEBS Lett. 2010, 584, 3819-3825.
    • (2010) FEBS Lett , vol.584 , pp. 3819-3825
    • Shay, J.W.1    Wright, W.E.2
  • 43
    • 79952017845 scopus 로고    scopus 로고
    • Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins
    • Martinez, P.; Blasco, M.A. Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins. Nat. Rev. Cancer 2011, 11, 161-176.
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 161-176
    • Martinez, P.1    Blasco, M.A.2
  • 44
    • 84860261471 scopus 로고    scopus 로고
    • Telomerase: An RNP enzyme synthesizes DNA
    • doi:10.1101/chsperspect.a003558
    • Blackburn, E.H.; Collins, K. Telomerase: An RNP enzyme synthesizes DNA. Cold Spring Harb. Perspect. Biol. 2011, doi:10.1101/chsperspect.a003558.
    • (2011) Cold Spring Harb. Perspect. Biol
    • Blackburn, E.H.1    Collins, K.2
  • 45
    • 33748917567 scopus 로고    scopus 로고
    • Telomeres, telomerase, and human disease
    • Artandi, S.E. Telomeres, telomerase, and human disease. N. Engl. J. Med. 2006, 355, 1195-1197.
    • (2006) N. Engl. J. Med , vol.355 , pp. 1195-1197
    • Artandi, S.E.1
  • 47
    • 77953161582 scopus 로고    scopus 로고
    • Telomere loss as a mechanism for chromosome instability in human cancer
    • Murnane, J.P. Telomere loss as a mechanism for chromosome instability in human cancer. Cancer Res. 2010, 70, 4255-4259.
    • (2010) Cancer Res , vol.70 , pp. 4255-4259
    • Murnane, J.P.1
  • 48
    • 2642513907 scopus 로고    scopus 로고
    • DNA repair factors and telomere-chromosome integrity in mammalian cells
    • Hande, M.P. DNA repair factors and telomere-chromosome integrity in mammalian cells. Cytogenet. Genome Res. 2004, 104, 116-122.
    • (2004) Cytogenet. Genome Res , vol.104 , pp. 116-122
    • Hande, M.P.1
  • 49
    • 25444501224 scopus 로고    scopus 로고
    • Mitotic instability in cancer: Is there method in the madness?
    • Gisselsson, D. Mitotic instability in cancer: Is there method in the madness? Cell Cycle 2005, 4, 1007-1010.
    • (2005) Cell Cycle , vol.4 , pp. 1007-1010
    • Gisselsson, D.1
  • 51
    • 84861661655 scopus 로고    scopus 로고
    • Differential TERT promoter methylation and response to 5-aza-2'- deoxycytidine in acute myeloid leukemia cell lines: TERT expression, telomerase activity, telomere length, and cell death
    • Pettigrew, K.A.; Armstrong, R.N.; Colyer, H.A.; Zhang, S.D.; Rea, I.M.; Jones, R.E.; Baird, D.M.; Mills, K.I. Differential TERT promoter methylation and response to 5-aza-2'- deoxycytidine in acute myeloid leukemia cell lines: TERT expression, telomerase activity, telomere length, and cell death. Genes Chromosomes Cancer 2012, 51, 768-780.
    • (2012) Genes Chromosomes Cancer , vol.51 , pp. 768-780
    • Pettigrew, K.A.1    Armstrong, R.N.2    Colyer, H.A.3    Zhang, S.D.4    Rea, I.M.5    Jones, R.E.6    Baird, D.M.7    Mills, K.I.8
  • 55
    • 47149112001 scopus 로고    scopus 로고
    • Telomere maintenance and human bone marrow failure
    • Calado, R.T.; Young, N.S. Telomere maintenance and human bone marrow failure. Blood 2008, 111, 4446-4455.
    • (2008) Blood , vol.111 , pp. 4446-4455
    • Calado, R.T.1    Young, N.S.2
  • 56
    • 79954619814 scopus 로고    scopus 로고
    • Telomere biology and telomere diseases: Implications for practice and research
    • Young, N.S. Telomere biology and telomere diseases: Implications for practice and research. Hematology Am. Soc. Hematol. Educ. Program 2010, 2010, 30-35.
    • (2010) Hematology Am. Soc. Hematol. Educ. Program , vol.2010 , pp. 30-35
    • Young, N.S.1
  • 59
    • 84859638170 scopus 로고    scopus 로고
    • Short telomeres result in chromosomal instability in hematopoietic cells and precede malignant evolution in human aplastic anemia
    • Calado, R.T.; Cooper, J.N.; Padilla-Nash, H.M.; Sloand, E.M.; Wu, C.O.; Scheinberg, P.; Ried, T.; Young, N.S. Short telomeres result in chromosomal instability in hematopoietic cells and precede malignant evolution in human aplastic anemia. Leukemia 2012, 26, 700-707.
    • (2012) Leukemia , vol.26 , pp. 700-707
    • Calado, R.T.1    Cooper, J.N.2    Padilla-Nash, H.M.3    Sloand, E.M.4    Wu, C.O.5    Scheinberg, P.6    Ried, T.7    Young, N.S.8
  • 60
    • 0041592752 scopus 로고    scopus 로고
    • Mutations of the human telomerase RNA gene (TERC) in aplastic anemia and myelodysplastic syndrome
    • Yamaguchi, H.; Baerlocher, G.M.; Lansdorp, P.M.; Chanock, S.J.; Nunez, O.; Sloand, E.; Young, N.S. Mutations of the human telomerase RNA gene (TERC) in aplastic anemia and myelodysplastic syndrome. Blood 2003, 102, 916-918.
    • (2003) Blood , vol.102 , pp. 916-918
    • Yamaguchi, H.1    Baerlocher, G.M.2    Lansdorp, P.M.3    Chanock, S.J.4    Nunez, O.5    Sloand, E.6    Young, N.S.7
  • 62
    • 84856723118 scopus 로고    scopus 로고
    • Telomere shortening, clonal evolution and disease progression in myelodysplastic syndrome patients with 5q deletion treated with lenalidomide
    • Gohring, G.; Lange, K.; Hofmann, W.; Nielsen, K.V.; Hellstrom-Lindberg, E.; Roy, L.; Morgan, M.; Kreipe, H.; Busche, G.; Giagounidis, A., et al. Telomere shortening, clonal evolution and disease progression in myelodysplastic syndrome patients with 5q deletion treated with lenalidomide. Leukemia 2012, 26, 356-358.
    • (2012) Leukemia , vol.26 , pp. 356-358
    • Gohring, G.1    Lange, K.2    Hofmann, W.3    Nielsen, K.V.4    Hellstrom-Lindberg, E.5    Roy, L.6    Morgan, M.7    Kreipe, H.8    Busche, G.9    Giagounidis, A.10
  • 64
    • 49749104565 scopus 로고    scopus 로고
    • Roles of the histone acetyltransferase monocytic leukemia zinc finger protein in normal and malignant hematopoiesis
    • Katsumoto, T.; Yoshida, N.; Kitabayashi, I. Roles of the histone acetyltransferase monocytic leukemia zinc finger protein in normal and malignant hematopoiesis. Cancer Sci. 2008, 99, 1523-1527.
    • (2008) Cancer Sci , vol.99 , pp. 1523-1527
    • Katsumoto, T.1    Yoshida, N.2    Kitabayashi, I.3
  • 67
    • 0037099537 scopus 로고    scopus 로고
    • LCX, leukemia- associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23)
    • Ono, R.; Taki, T.; Taketani, T.; Taniwaki, M.; Kobayashi, H.; Hayashi, Y. LCX, leukemia- associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23). Cancer Res. 2002, 62, 4075-4080.
    • (2002) Cancer Res , vol.62 , pp. 4075-4080
    • Ono, R.1    Taki, T.2    Taketani, T.3    Taniwaki, M.4    Kobayashi, H.5    Hayashi, Y.6
  • 71
    • 84875223910 scopus 로고    scopus 로고
    • Genome-wide profiling of methylation identifies novel targets with aberrant hypermethylation and reduced expression in low-risk myelodysplastic syndromes
    • del Rey, M.; O'Hagan, K.; Dellett, M.; Aibar, S.; Colyer, H.A.; Alonso, M.E.; Diez-Campelo, M.; Armstrong, R.N.; Sharpe, D.J.; Gutierrez, N.C., et al. Genome-wide profiling of methylation identifies novel targets with aberrant hypermethylation and reduced expression in low-risk myelodysplastic syndromes. Leukemia 2013, 27, 610-618.
    • (2013) Leukemia , vol.27 , pp. 610-618
    • del Rey, M.1    O'Hagan, K.2    Dellett, M.3    Aibar, S.4    Colyer, H.A.5    Alonso, M.E.6    Diez-Campelo, M.7    Armstrong, R.N.8    Sharpe, D.J.9    Gutierrez, N.C.10
  • 72
    • 81555228423 scopus 로고    scopus 로고
    • Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia
    • Shen, Y.; Zhu, Y.M.; Fan, X.; Shi, J.Y.; Wang, Q.R.; Yan, X.J.; Gu, Z.H.; Wang, Y.Y.; Chen, B.; Jiang, C.L., et al. Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia. Blood 2011, 118, 5593-5603.
    • (2011) Blood , vol.118 , pp. 5593-5603
    • Shen, Y.1    Zhu, Y.M.2    Fan, X.3    Shi, J.Y.4    Wang, Q.R.5    Yan, X.J.6    Gu, Z.H.7    Wang, Y.Y.8    Chen, B.9    Jiang, C.L.10
  • 75
    • 42949122111 scopus 로고    scopus 로고
    • High EVI1 levels predict adverse outcome in acute myeloid leukemia: Prevalence of EVI1 overexpression and chromosome 3q26 abnormalities underestimated
    • Lugthart, S.; van Drunen, E.; van Norden, Y.; van Hoven, A.; Erpelinck, C.A.; Valk, P.J.; Beverloo, H.B.; Lowenberg, B.; Delwel, R. High EVI1 levels predict adverse outcome in acute myeloid leukemia: Prevalence of EVI1 overexpression and chromosome 3q26 abnormalities underestimated. Blood 2008, 111, 4329-4337.
    • (2008) Blood , vol.111 , pp. 4329-4337
    • Lugthart, S.1    van Drunen, E.2    van Norden, Y.3    van Hoven, A.4    Erpelinck, C.A.5    Valk, P.J.6    Beverloo, H.B.7    Lowenberg, B.8    Delwel, R.9
  • 78
    • 84866761541 scopus 로고    scopus 로고
    • Overexpression of EVI1 interferes with cytokinesis and leads to accumulation of cells with supernumerary centrosomes in G0/1 phase
    • Karakaya, K.; Herbst, F.; Ball, C.; Glimm, H.; Kramer, A.; Loffler, H. Overexpression of EVI1 interferes with cytokinesis and leads to accumulation of cells with supernumerary centrosomes in G0/1 phase. Cell Cycle 2012, 11, 3492-3503.
    • (2012) Cell Cycle , vol.11 , pp. 3492-3503
    • Karakaya, K.1    Herbst, F.2    Ball, C.3    Glimm, H.4    Kramer, A.5    Loffler, H.6
  • 80
    • 0347988045 scopus 로고    scopus 로고
    • Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases
    • Garcia-Cao, M.; O'Sullivan, R.; Peters, A.H.; Jenuwein, T.; Blasco, M.A. Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases. Nat. Genet. 2004, 36, 94-99.
    • (2004) Nat. Genet , vol.36 , pp. 94-99
    • Garcia-Cao, M.1    O'Sullivan, R.2    Peters, A.H.3    Jenuwein, T.4    Blasco, M.A.5
  • 82
    • 77949362793 scopus 로고    scopus 로고
    • Whole chromosome loss is promoted by telomere dysfunction in primary cells
    • Pampalona, J.; Soler, D.; Genesca, A.; Tusell, L. Whole chromosome loss is promoted by telomere dysfunction in primary cells. Genes Chromosomes Cancer 2010, 49, 368-378.
    • (2010) Genes Chromosomes Cancer , vol.49 , pp. 368-378
    • Pampalona, J.1    Soler, D.2    Genesca, A.3    Tusell, L.4
  • 83
    • 35748968799 scopus 로고    scopus 로고
    • Disruption of telomere maintenance by depletion of the MRE11/RAD50/NBS1 complex in cells that use alternative lengthening of telomeres
    • Zhong, Z.H.; Jiang, W.Q.; Cesare, A.J.; Neumann, A.A.; Wadhwa, R.; Reddel, R.R. Disruption of telomere maintenance by depletion of the MRE11/RAD50/NBS1 complex in cells that use alternative lengthening of telomeres. J. Biol. Chem. 2007, 282, 29314-29322.
    • (2007) J. Biol. Chem , vol.282 , pp. 29314-29322
    • Zhong, Z.H.1    Jiang, W.Q.2    Cesare, A.J.3    Neumann, A.A.4    Wadhwa, R.5    Reddel, R.R.6
  • 84
    • 64549109258 scopus 로고    scopus 로고
    • A role for monoubiquitinated FANCD2 at telomeres in ALT cells
    • Fan, Q.; Zhang, F.; Barrett, B.; Ren, K.; Andreassen, P.R. A role for monoubiquitinated FANCD2 at telomeres in ALT cells. Nucleic Acids Res. 2009, 37, 1740-1754.
    • (2009) Nucleic Acids Res , vol.37 , pp. 1740-1754
    • Fan, Q.1    Zhang, F.2    Barrett, B.3    Ren, K.4    Andreassen, P.R.5
  • 85
  • 87
  • 88
    • 0037144583 scopus 로고    scopus 로고
    • Cyclin F is degraded during G2-M by mechanisms fundamentally different from other cyclins
    • Fung, T.K.; Siu, W.Y.; Yam, C.H.; Lau, A.; Poon, R.Y. Cyclin F is degraded during G2-M by mechanisms fundamentally different from other cyclins. J. Biol. Chem. 2002, 277, 35140-35149.
    • (2002) J. Biol. Chem , vol.277 , pp. 35140-35149
    • Fung, T.K.1    Siu, W.Y.2    Yam, C.H.3    Lau, A.4    Poon, R.Y.5
  • 89
    • 0037378527 scopus 로고    scopus 로고
    • p53 binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice
    • Ward, I.M.; Minn, K.; van Deursen, J.; Chen, J. p53 binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice. Mol. Cell. Biol. 2003, 23, 2556-2563.
    • (2003) Mol. Cell. Biol , vol.23 , pp. 2556-2563
    • Ward, I.M.1    Minn, K.2    van Deursen, J.3    Chen, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.