Telomere shortening and chromosomal instability in myelodysplastic syndromes

Genes Chromosomes and Cancer

Volumn 49, Issue 3, 2010, Pages 260-269

  Lange, Kathrin ^a   Holm, Lisa ^a   Nielsen, Kirsten Vang ^b   Hahn, Andreas ^a   Hofmann, Winfried ^a   Kreipe, Hans ^a   Schlegelberger, Brigitte ^a   Göhring, Gudrun ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b AGILENT TECHNOLOGIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TELOMERASE;

ADULT; AGED; ARTICLE; CENTROMERE; CHROMOSOMAL INSTABILITY; CHROMOSOME 7P; CHROMOSOME 7Q; CHROMOSOME ANALYSIS; CHROMOSOME SIZE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; HEMATOPOIETIC CELL; HUMAN; KARYOTYPE; MAJOR CLINICAL STUDY; MALE; METAPHASE; MONOSOMY 7; MYELODYSPLASTIC SYNDROME; PRIORITY JOURNAL; TELOMERE;

ANEMIA; CHROMOSOMAL INSTABILITY; CHROMOSOME BANDING; CHROMOSOMES, HUMAN, PAIR 7; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; KARYOTYPING; METAPHASE; MYELODYSPLASTIC SYNDROMES; REFERENCE VALUES; TELOMERASE; TELOMERE;

EID: 76649089645     PISSN: 10452257     EISSN: 10982264     Source Type: Journal    
DOI: 10.1002/gcc.20737     Document Type: Article

References (46)

1. Abrahamson G, Boultwood J, Madden J, Kelly S, Oscier DG, Rack K, Buckle VJ, Wainscoat JS. 1991. Clonality of cell populations in refractory anaemia using combined approach of gene loss and X-linked restriction fragment length polymorphism methylation analyses. Br J Haematol 79:550-555.
2. Alter BP, Giri N, Savage SA, Rosenberg PS. 2009. Cancer in dyskeratosis congenita. Blood 113:6549-6557.
3. Aul C, Gattermann N, Schneider W. 1992. Age-related incidence and other epidemiological aspects of myelodysplastic syndromes. Br J Haematol 82:358-367.
4. Blackburn EH. 2001. Switching and signaling at the telomere. Cell 106:661-673.
5. Blasco MA. 2007. Telomere length, stem cells and aging. Nat Chem Biol 3:640-649.
6. Blasco MA, Lee HW, Hande MP, Samper E, Lansdorp PM, DePinho RA, Greider CW. 1997. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91:25-34.
7. Boultwood J, Fidler C, Kusec R, Rack K, Elliott PJ, Atoyebi O, Chapman R, Oscier DG, Wainscoat JS. 1997. Telomere length in myelodysplastic syndromes. Am J Hematol 56:266-271.
8. Briatore F, Barrera G, Pizzimenti S, Toaldo C, Casa CD, Laurora S, Pettazzoni P, Dianzani MU, Ferrero D. 2009. Increase of telomerase activity and hTERT expression in myelodysplastic syndromes. Cancer Biol Ther 8:883-889.
9. Brummendorf TH, Balabanov S. 2006. Telomere length dynamics in normal hematopoiesis and in disease states characterized by increased stem cell turnover. Leukemia 20:1706-1716.
10. Brummendorf TH, Holyoake TL, Rufer N, Barnett MJ, Schulzer M, Eaves CJ, Eaves AC, Lansdorp PM. 2000. Prognostic implications of differences in telomere length between normal and malignant cells from patients with chronic myeloid leukemia measured by flow cytometry. Blood 95:1883-1890.
11. Brummendorf TH, Maciejewski JP, Mak J, Young NS, Lansdorp PM. 2001a. Telomere length in leukocyte subpopulations of patients with aplastic anemia. Blood 97:895-900.
12. Brummendorf TH, Rufer N, Holyoake TL, Maciejewski J, Barnett MJ, Eaves CJ, Eaves AC, Young N, Lansdorp PM. 2001b. Telomere length dynamics in normal individuals and in patients with hematopoietic stem cell-associated disorders. Ann N Y Acad Sci 938:293-303.
13. Chan SW, Blackburn EH. 2002. New ways not to make ends meet: Telomerase, DNA damage proteins and heterochromatin. Oncogene 21:553-563.
14. DakoCytomation. 2007. Telomere PNA FISH Kit/Cy3 Manual. Dako Denmark, A/S, Glostrup, Denmark.
15. Der-Sarkissian H, Bacchetti S, Cazes L, Londono-Vallejo JA. 2004. The shortest telomeres drive karyotype evolution in transformed cells. Oncogene 23:1221-1228.
16. Giagounidis AA, Germing U, Haase S, Hildebrandt B, Schlegel-berger B, Schoch C, Wilkens L, Heinsch M, Willems H, Aivado M, Aul C. 2004. Clinical, morphological, cytogenetic, and prognostic features of patients with myelodysplastic syndromes and del(5q) including band q31. Leukemia 18:113-119.
17. Giagounidis AA, Germing U, Strupp C, Hildebrandt B, Heinsch M, Aul C. 2005. Prognosis of patients with del(5q) MDS and complex karyotype and the possible role of lenalidomide in this patient subgroup. Ann. Hematol 84:569-571.
18. Gohring G, Karow A, Steinemann D, Wilkens L, Lichter P, Zeidler C, Niemeyer C, Welte K, Schlegelberger B. 2007. Chromosomal aberrations in congenital bone marrow failure disorders - An early indicator for leukemogenesis? Ann Hematol 86:733-739.
19. Greenberg P, Cox C, LeBeau MM, Fenaux P, Morel P, Sanz G, Sanz M, Vallespi T, Hamblin T, Oscier D, Ohyashiki K, Toyama K, Aul C, Mufti G, Bennett J. 1997. International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood 89:2079-2088.
20. Haase D, Germing U, Schanz J, Pfeilstocker M, Nosslinger T, Hildebrandt B, Kundgen A, Lubbert M, Kunzmann R, Giagounidis AA, Aul C, Trumper L, Krieger O, Stauder R, Muller TH, Wimazal F, Valent P, Fonatsch C, Steidl C. 2007. New insights into the prognostic impact of the karyotype in MDS and correlation with subtypes: Evidence from a core dataset of 2124 patients. Blood 110:4385-4395.
21. Hartmann U, Brummendorf TH, Balabanov S, Thiede C, Illme T, Schaich M. 2005. Telomere length and hTERT expression in patients with acute myeloid leukemia correlates with chromosomal abnormalities. Haematologica 90:307-316.
22. Hemann MT, Strong MA, Hao LY, Greider CW. 2001. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell 107:67-77.
23. ISCN;Shaffer L, Slovak M, Campbell L, editors. An International System for Human Cytogenetic Nomenclature. Basel, Switzerland: S.Karger.
24. Kirwan M, Vulliamy T, Marrone A, Walne AJ, Beswick R, Hillmen P, Kelly R, Stewart A, Bowen D, Schonland SO, Whittle AM, McVerry A, Gilleece M, Dokal I. 2009. Defining the pathogenic role of telomerase mutations in myelodysplastic syndrome and acute myeloid leukemia. Hum Mutat 30:1-7.
25. Lengauer C, Kinzler KW, Vogelstein B. 1998. Genetic instabilities in human cancers. Nature 396:643-649.
26. Martens UM, Zijlmans JM, Poon SS, Dragowska W, Yui J, Chavez EA, Ward RK, Lansdorp PM. 1998. Short telomeres on human chromosome 17p. Nat Genet 18:76-80.
27. Mathieu N, Pirzio L, Freulet-Marriere MA, Desmaze C, Sabatier L. 2004. Telomeres and chromosomal instability. Cell Mol Life Sci 61:641-656.
28. Mayer S, Bruderlein S, Perner S, Waibel I, Holdenried A, Ciloglu N, Hasel C, Mattfeldt T, Nielsen KV, Moller P. 2006. Sex-specific telomere length profiles and age-dependent erosion dynamics of individual chromosome arms in humans. Cytogenet Genome Res 112:194-201.
29. McClintock B. 1941. The stability of broken ends of chromosomes in Zea Mays. Genetics 26:234-282.
30. Millipore/Chemicon. 2007. TRAPEZEV® RT Telomerase Detection Kit, Manual, Millipore/Chemicon, Temecula, CA, USA.
31. Nimer SD. 2008. Myelodysplastic syndromes. Blood 111:4841-4851.
32. Ohyashiki JH, Iwama H, Yahata N, Ando K, Hayashi S, Shay JW, Ohyashiki K. 1999. Telomere stability is frequently impaired in high-risk groups of patients with myelodysplastic syndromes. Clin Cancer Res 5:1155-1160.
33. Olney HJ, Le Beau MM. 2007. Evaluation of recurring cytogenetic abnormalities in the treatment of myelodysplastic syndromes. Leuk Res 31:427-434.
34. Pedersen-Bjergaard J, Andersen MK, Andersen MT, Christiansen DH. 2008. Genetics of therapy-related myelodysplasia and acute myeloid leukemia. Leukemia 22:240-248.
35. Perner S, Bruderlein S, Hasel C, Waibel I, Holdenried A, Ciloglu N, Chopurian H, Nielsen KV, Plesch A, Hogel J, Moller P. 2003. Quantifying telomere lengths of human individual chromosome arms by centromere-calibrated fluorescence in situ hybridization and digital imaging. Am J Pathol 163:1751-1756.
36. RDevelopment Core Team. 2009. R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing. http://www.R-project.org.
37. Rigolin GM, Porta MD, Bugli AM, Castagnari B, Mauro E, Bragotti LZ, Ciccone M, Cuneo A, Castoldi G. 2004. Flow cytometric detection of accelerated telomere shortening in myelodysplastic syndromes: Correlations with aetiological and clinical-biological findings. Eur J Haematol 73:351-358.
38. Roos G, Krober A, Grabowski P, Kienle D, Buhler A, Dohner H, Rosenquist R, Stilgenbauer S. 2008. Short telomeres are associated with genetic complexity, high-risk genomic aberrations, and short survival in chronic lymphocytic leukemia. Blood 111:2246-2252.
39. Rowley JD, Olney HJ. 2002. International workshop on the relationship of prior therapy to balanced chromosome aberrations in therapy-related myelodysplastic syndromes and acute leukemia: Overview report. Genes Chromosomes Cancer 33:331-345.
40. Rufer N, Brummendorf TH, Kolvraa S, Bischoff C, Christensen K, Wadsworth L, Schulzer M, Lansdorp PM. 1999. Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood. J Exp Med 190:157-167.
41. Sashida G, Ohyashiki JH, Nakajima A, Sumi M, Kawakubo K, Tauchi T, Ohyashiki K. 2003. Telomere dynamics in myelodysplastic syndrome determined by telomere measurement of marrow metaphases. Clin Cancer Res 9:1489-1496.
42. Schlegelberger B, Metzke S, Harder S, Zühlke-Jenisch R, Zhang Y, Siebert R. 1999. Classical and molecular cytogenetics of tumor cells. In: Wegener R, editor. Diagnostic cytogenetics. Heidelberg; Springer Verlag. p. 151-185.
43. Shay JW, Wright WE. 2005. Senescence and immortalization: Role of telomeres and telomerase. Carcinogenesis 26:867-874.
44. Sieglova Z, Zilovcova S, Cermak J, Rihova H, Brezinova D, Dvorakova R, Markova M, Maaloufova J, Sajdova J, Brezinova J, Zemanova Z, Michalova K. 2004. Dynamics of telomere erosion and its association with genome instability in myelodysplastic syndromes (MDS) and acute myelogenous leukemia arising from MDS: A marker of disease prognosis? Leuk Res 28:1013-1021.
45. Stewart SA, Weinberg RA. 2006. Telomeres: Cancer to human aging. Annu Rev Cell Dev Biol 22:531-557.
46. Zijlmans JM, Martens UM, Poon SS, Raap AK, Tanke HJ, Ward RK, Lansdorp PM. 1997. Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats. Proc Natl Acad Sci USA 94:7423-7428.