Short telomeres result in chromosomal instability in hematopoietic cells and precede malignant evolution in human aplastic anemia

Leukemia

Volumn 26, Issue 4, 2012, Pages 700-707

  Calado, R T ^a   Cooper, J N ^a,b   Padilla Nash, H M ^c   Sloand, E M ^a   Wu, C O ^a   Scheinberg, P ^a   Ried, T ^c   Young, N S ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

aplastic anemia; cancer; chromosome instability; myelodysplasia; telomere

Indexed keywords

CYCLOSPORIN A; THYMOCYTE ANTIBODY;

ADOLESCENT; ADULT; AGED; APLASTIC ANEMIA; ARTICLE; BONE MARROW CELL; CHILD; CHROMOSOMAL INSTABILITY; CONTROLLED STUDY; CYTOGENETICS; FEMALE; HEMATOPOIETIC CELL; HUMAN; IN VITRO STUDY; LOSS OF FUNCTION MUTATION; MAJOR CLINICAL STUDY; MALE; MONOSOMY 7; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; STRUCTURAL CHROMOSOME ABERRATION; TELOMERE SHORTENING;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANEMIA, APLASTIC; ANEUPLOIDY; CELL TRANSFORMATION, NEOPLASTIC; CHILD; CHILD, PRESCHOOL; CHROMOSOMAL INSTABILITY; FEMALE; HEMATOPOIETIC SYSTEM; HUMANS; MALE; MIDDLE AGED; TELOMERE SHORTENING;

EID: 84859638170     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2011.272     Document Type: Article

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