-
1
-
-
33744948987
-
Kinetic analysis of the Ku-DNA binding activity reveals a redox-dependent alteration in protein structure that stimulates dissociation of the Ku-DNA complex
-
Andrews BJ. 2006. Kinetic analysis of the Ku-DNA binding activity reveals a redox-dependent alteration in protein structure that stimulates dissociation of the Ku-DNA complex. J Biol Chem 281:13596-13603.
-
(2006)
J Biol Chem
, vol.281
, pp. 13596-13603
-
-
Andrews, B.J.1
-
2
-
-
0038454621
-
Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment
-
Bhatia R, Holtz M, Niu N, Gray R, Snyder DS, Sawyers CL. 2003. Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment. Blood 101:4701-4707.
-
(2003)
Blood
, vol.101
, pp. 4701-4707
-
-
Bhatia, R.1
Holtz, M.2
Niu, N.3
Gray, R.4
Snyder, D.S.5
Sawyers, C.L.6
-
3
-
-
0242299705
-
Reduced DNA double strand breaks in chlorambucil resistant cells are related to high DNA-PKcs activity and low oxidative stress
-
Boldogh I, Roy G, Lee MS, Bacsi A, Hazra TK, Bhakat KK, Das GC, Mitra S. 2003. Reduced DNA double strand breaks in chlorambucil resistant cells are related to high DNA-PKcs activity and low oxidative stress. Toxicology 193:137-152.
-
(2003)
Toxicology
, vol.193
, pp. 137-152
-
-
Boldogh, I.1
Roy, G.2
Lee, M.S.3
Bacsi, A.4
Hazra, T.K.5
Bhakat, K.K.6
Das, G.C.7
Mitra, S.8
-
4
-
-
0034235119
-
Telomere length shortening in chronic myelogenous leukemia is associated with reduced time to accelerated phase
-
Boultwood J, Peniket A, Watkins F. 2000. Telomere length shortening in chronic myelogenous leukemia is associated with reduced time to accelerated phase. Blood 96:358-361.
-
(2000)
Blood
, vol.96
, pp. 358-361
-
-
Boultwood, J.1
Peniket, A.2
Watkins, F.3
-
5
-
-
0346850823
-
Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog RAD51L3
-
Braybrooke JP, Li JL, Wu L, Caple F, Benson FE, Hickson ID. 2003. Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog RAD51L3. J Biol Chem 278: 48357-48366.
-
(2003)
J Biol Chem
, vol.278
, pp. 48357-48366
-
-
Braybrooke, J.P.1
Li, J.L.2
Wu, L.3
Caple, F.4
Benson, F.E.5
Hickson, I.D.6
-
6
-
-
30944455282
-
Severe combined immunodeficiency and microcephaly in siblings with hypomorphic mutations in DNA ligase IV
-
Buck D, Moshous D, de Chasseval R, Ma Y, le Deist F, Cavazzana-Calvo M, Fischer A, Casanova JL, Lieber MR, de Villartay JP. 2006. Severe combined immunodeficiency and microcephaly in siblings with hypomorphic mutations in DNA ligase IV. Eur J Immunol 36:224-235.
-
(2006)
Eur J Immunol
, vol.36
, pp. 224-235
-
-
Buck, D.1
Moshous, D.2
de Chasseval, R.3
Ma, Y.4
Le Deist, F.5
Cavazzana-Calvo, M.6
Fischer, A.7
Casanova, J.L.8
Lieber, M.R.9
de Villartay, J.P.10
-
7
-
-
0242418183
-
Drug treatment in the development of mismatch repair defective acute leukemia and myelodysplastic syndrome
-
Casorelli I, Offman J, Mele L, Pagano L, Sica S, D'Errico M, Giannini G, Leone G, Bignami M, Karran P. 2003. Drug treatment in the development of mismatch repair defective acute leukemia and myelodysplastic syndrome. DNA Repair 2:547- 559.
-
(2003)
DNA Repair
, vol.2
, pp. 547-559
-
-
Casorelli, I.1
Offman, J.2
Mele, L.3
Pagano, L.4
Sica, S.5
D'Errico, M.6
Giannini, G.7
Leone, G.8
Bignami, M.9
Karran, P.10
-
8
-
-
0033119701
-
Defending genome integrity during DNA replication: A proposed role for RecQ family helicases
-
Chakraverty RK, Hickson ID. 1999. Defending genome integrity during DNA replication: A proposed role for RecQ family helicases. BioEssays 21:286-294.
-
(1999)
BioEssays
, vol.21
, pp. 286-294
-
-
Chakraverty, R.K.1
Hickson, I.D.2
-
9
-
-
44849117230
-
Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair
-
Chen X, Zhong S, Zhu X, Dziegielewska B, Ellenberger T, Wilson GM, MacKerell AD, Tomkinson AE. 2008. Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res 68:3169-3177.
-
(2008)
Cancer Res
, vol.68
, pp. 3169-3177
-
-
Chen, X.1
Zhong, S.2
Zhu, X.3
Dziegielewska, B.4
Ellenberger, T.5
Wilson, G.M.6
MacKerell, A.D.7
Tomkinson, A.E.8
-
10
-
-
52049084111
-
BCR/ABL and other kinases from chronic myeloproliferative disorders stimulate single-strand annealing, an unfaithful DNA double-strand break repair
-
Cramer K, Nieborowska-Skorska M, Koptyra M, Slupianek A, Penserga ET, Eaves CJ, Aulitzky W, Skorski T. 2008. BCR/ABL and other kinases from chronic myeloproliferative disorders stimulate single-strand annealing, an unfaithful DNA double-strand break repair. Cancer Res 68:6884-6888.
-
(2008)
Cancer Res
, vol.68
, pp. 6884-6888
-
-
Cramer, K.1
Nieborowska-Skorska, M.2
Koptyra, M.3
Slupianek, A.4
Penserga, E.T.5
Eaves, C.J.6
Aulitzky, W.7
Skorski, T.8
-
11
-
-
0034891215
-
Microsatellite instability occurs in defined subsets of patients with acute myeloblastic leukaemia
-
Das-Gupta EP, Seedhouse CH, Russell NH. 2001. Microsatellite instability occurs in defined subsets of patients with acute myeloblastic leukaemia. Br J Haematol 114:307-312.
-
(2001)
Br J Haematol
, vol.114
, pp. 307-312
-
-
Das-Gupta, E.P.1
Seedhouse, C.H.2
Russell, N.H.3
-
12
-
-
34249015960
-
Activation induced cytidine deaminase acts as a mutator in BCR-ABL1-transformed acute lymphoblastic leukemia cells
-
Feldhahn N, Henke N, Melchior K, Duy C, Soh B, Klein F, von Levetzow G, Giebel B, Li A, Hofmann W, Jumaa H, Mu?schen M. 2007. Activation induced cytidine deaminase acts as a mutator in BCR-ABL1-transformed acute lymphoblastic leukemia cells. JEM 204:1157-1166.
-
(2007)
JEM
, vol.204
, pp. 1157-1166
-
-
Feldhahn, N.1
Henke, N.2
Melchior, K.3
Duy, C.4
Soh, B.5
Klein, F.6
von Levetzow, G.7
Giebel, B.8
Li, A.9
Hofmann, W.10
Jumaa, H.11
Muschen, M.12
-
13
-
-
0025373259
-
Oxidative damage to DNA during aging: 8-hydroxy-20-deoxyguanosine in rat organ DNA and urine
-
Fraga CG, Shigenaga MK, Park JW, Degan P, Ames BN. 1990. Oxidative damage to DNA during aging: 8-hydroxy-20-deoxyguanosine in rat organ DNA and urine. Proc Natl Acad Sci USA 87:4533-4537.
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 4533-4537
-
-
Fraga, C.G.1
Shigenaga, M.K.2
Park, J.W.3
Degan, P.4
Ames, B.N.5
-
14
-
-
85047695296
-
Increased error-prone non homologous DNA endjoining - a proposed mechanism of chromosomal instability in Bloom's syndrome
-
Gaymes TJ, North PS, Brady N, Hickson ID, Mufti GJ, Rassool FV. 2002. Increased error-prone non homologous DNA endjoining - a proposed mechanism of chromosomal instability in Bloom's syndrome. Oncogene 21:2525-2533.
-
(2002)
Oncogene
, vol.21
, pp. 2525-2533
-
-
Gaymes, T.J.1
North, P.S.2
Brady, N.3
Hickson, I.D.4
Mufti, G.J.5
Rassool, F.V.6
-
15
-
-
66049084743
-
Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: Potential for therapy of myeloid leukemia and myelodysplastic syndromes
-
Gaymes TJ, Shall S, MacPherson LJ, Twine NA, Lea NC, Farzaneh F, Mufti GJ. 2009. Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: Potential for therapy of myeloid leukemia and myelodysplastic syndromes. Haematologica 94:638-646.
-
(2009)
Haematologica
, vol.94
, pp. 638-646
-
-
Gaymes, T.J.1
Shall, S.2
MacPherson, L.J.3
Twine, N.A.4
Lea, N.C.5
Farzaneh, F.6
Mufti, G.J.7
-
16
-
-
49349140725
-
Mutations of the TP53 gene in acute myeloid leukemia are strongly associated with a complex aberrant karyotype
-
Haferlach C, Dicker F, Herholz H, Schnittger S, Kern W, Haferlach T. 2008. Mutations of the TP53 gene in acute myeloid leukemia are strongly associated with a complex aberrant karyotype. Leukemia 22:1539-1541.
-
(2008)
Leukemia
, vol.22
, pp. 1539-1541
-
-
Haferlach, C.1
Dicker, F.2
Herholz, H.3
Schnittger, S.4
Kern, W.5
Haferlach, T.6
-
17
-
-
0035902108
-
Genome maintenance mechanisms for preventing cancer
-
Hoeijmakers JH. 2001. Genome maintenance mechanisms for preventing cancer. Nature 411:366-374.
-
(2001)
Nature
, vol.411
, pp. 366-374
-
-
Hoeijmakers, J.H.1
-
18
-
-
33845242290
-
Polymorphisms in human homeobox HLX1 and DNA repair RAD51 genes increase the risk of therapy-related acute myeloid leukemia
-
Jawad M, Seedhouse C, Russell N. 2006. Polymorphisms in human homeobox HLX1 and DNA repair RAD51 genes increase the risk of therapy-related acute myeloid leukemia. Blood 108:3916-3918.
-
(2006)
Blood
, vol.108
, pp. 3916-3918
-
-
Jawad, M.1
Seedhouse, C.2
Russell, N.3
-
19
-
-
34248184445
-
Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated
-
Kennedy RD, Chen CC, Stuckert P, Archila EM, De la Vega MA, Moreau LA, Shimamura A, D'Andrea AD. 2007. Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated. J Clin Invest 117:1440- 1449.
-
(2007)
J Clin Invest
, vol.117
, pp. 1440-1449
-
-
Kennedy, R.D.1
Chen, C.C.2
Stuckert, P.3
Archila, E.M.4
De la Vega, M.A.5
Moreau, L.A.6
Shimamura, A.7
D'Andrea, A.D.8
-
22
-
-
33745608455
-
BCR/ABL kinase induces selfmutagenesis via reactive oxygen species to encode imatinib resistance
-
Koptyra M, Falinski R, Nowicki MO, Stoklosa T, Majsterek I, Nieborowska-Skorska M. 2006. BCR/ABL kinase induces selfmutagenesis via reactive oxygen species to encode imatinib resistance. Blood 108:319-327.
-
(2006)
Blood
, vol.108
, pp. 319-327
-
-
Koptyra, M.1
Falinski, R.2
Nowicki, M.O.3
Stoklosa, T.4
Majsterek, I.5
Nieborowska-Skorska, M.6
-
23
-
-
0037441757
-
A 20- year perspective on the International Fanconi Anemia Registry (IFAR)
-
Kutler DI, Singh B, Satagopan J, Batish SD, Berwick M, Giampietro PF, Hanenberg H, Auerbach AD. 2003. A 20-year perspective on the International Fanconi Anemia Registry (IFAR). Blood 101:1249-1256.
-
(2003)
Blood
, vol.101
, pp. 1249-1256
-
-
Kutler, D.I.1
Singh, B.2
Satagopan, J.3
Batish, S.D.4
Berwick, M.5
Giampietro, P.F.6
Hanenberg, H.7
Auerbach, A.D.8
-
24
-
-
34249693090
-
Instability of BCRABL gene in primary and cultured chronic myeloid leukemia stem cells
-
Jiang X, Saw KM, Eaves A, Eaves C. 2007. Instability of BCRABL gene in primary and cultured chronic myeloid leukemia stem cells. J Natl Cancer Inst 99:680-693.
-
(2007)
J Natl Cancer Inst
, vol.99
, pp. 680-693
-
-
Jiang, X.1
Saw, K.M.2
Eaves, A.3
Eaves, C.4
-
25
-
-
0037093096
-
The BLM helicase is necessary for normal DNA double-strand break repair
-
Langland G, Elliott J, Li Y, Creaney J, Dixon K, Groden J. 2002.The BLM helicase is necessary for normal DNA double-strand break repair. Cancer Res 62:2766-2770.
-
(2002)
Cancer Res
, vol.62
-
-
Langland, G.1
Elliott, J.2
Li, Y.3
Creaney, J.4
Dixon, K.5
Groden, J.6
-
27
-
-
70149123507
-
Global reduction of the epigenetic H3K79 methylation mark and increased chromosomal instability in CALM-AF10-positive leukemias
-
Lin Y, Kakadia PM, Chen Y, Li Y, Desphande A, Buske C, Zhang K, Zhang Y, Xu G, Bohlander SK. 2009. Global reduction of the epigenetic H3K79 methylation mark and increased chromosomal instability in CALM-AF10-positive leukemias. Blood 114:651-658.
-
(2009)
Blood
, vol.114
, pp. 651-658
-
-
Lin, Y.1
Kakadia, P.M.2
Chen, Y.3
Li, Y.4
Desphande, A.5
Buske, C.6
Zhang, K.7
Zhang, Y.8
Xu, G.9
Bohlander, S.K.10
-
28
-
-
0031724790
-
Analysis of mutations at the DNA repair genes in acute childhood leukaemia
-
Lin YW, Kubota M, Koishi S, Sawada M, Usami I, Watanabe K, Akiyama Y. 1998. Analysis of mutations at the DNA repair genes in acute childhood leukaemia. Br J Haematol 103:462-466.
-
(1998)
Br J Haematol
, vol.103
, pp. 462-466
-
-
Lin, Y.W.1
Kubota, M.2
Koishi, S.3
Sawada, M.4
Usami, I.5
Watanabe, K.6
Akiyama, Y.7
-
29
-
-
38849153665
-
Preferential loss of mismatch repair function in refractory and relapsed acute myeloid leukemia: Potential contribution to AML progression
-
Mao G, Yuan F, Absher K, Jennings CD, Howard DS, Jordan CT, Gu L. 2008. Preferential loss of mismatch repair function in refractory and relapsed acute myeloid leukemia: Potential contribution to AML progression. Cell Res 18:281-289.
-
(2008)
Cell Res
, vol.18
, pp. 281-289
-
-
Mao, G.1
Yuan, F.2
Absher, K.3
Jennings, C.D.4
Howard, D.S.5
Jordan, C.T.6
Gu, L.7
-
30
-
-
62849083222
-
The emerging role of nuclear architecture in DNA repair and genome maintenance
-
Misteli T, Soutoglou E. 2009. The emerging role of nuclear architecture in DNA repair and genome maintenance. Nat Rev Mol Cell Biol 10:243-254.
-
(2009)
Nat Rev Mol Cell Biol
, vol.10
, pp. 243-254
-
-
Misteli, T.1
Soutoglou, E.2
-
31
-
-
45749129047
-
The FLT3 inhibitor PKC412 in combination with cytostatic drugs in vitro in acute myeloid leukemia
-
Möllgaörd L, Deneberg S, Nahi H, Bengtzen S, Jonsson-Videsäter K, Fioretos T, Andersson A, Paul C, Lehmann S. 2008. The FLT3 inhibitor PKC412 in combination with cytostatic drugs in vitro in acute myeloid leukemia. Cancer Chemother Pharmacol 62:439-448.
-
(2008)
Cancer Chemother Pharmacol
, vol.62
, pp. 439-448
-
-
Möllgörd, L.1
Deneberg, S.2
Nahi, H.3
Bengtzen, S.4
Jonsson-Videsäter, K.5
Fioretos, T.6
Andersson, A.7
Paul, C.8
Lehmann, S.9
-
32
-
-
51349120502
-
Regulation of reactive oxygen species and genomic stability in hematopoietic stem cells
-
Naka K, Muraguchi T, Hoshii T, Hirao A. 2008. Regulation of reactive oxygen species and genomic stability in hematopoietic stem cells. Antioxid Redox Signal 10:1883-1894.
-
(2008)
Antioxid Redox Signal
, vol.10
, pp. 1883-1894
-
-
Naka, K.1
Muraguchi, T.2
Hoshii, T.3
Hirao, A.4
-
33
-
-
33646414521
-
ATR- Chk1 axis protects BCR/ABL leukemia cells from the lethal effect of DNA double-strand breaks
-
Nieborowska-Skorska M, Stoklosa T, Datta M, Czechowska A, Rink L, Slupianek A, Koptyra M, Seferynska I, Krszyna K, Blasiak J, Skorski T. 2006. ATR-Chk1 axis protects BCR/ABL leukemia cells from the lethal effect of DNA double-strand breaks. Cell Cycle 5:994-1000.
-
(2006)
Cell Cycle
, vol.5
, pp. 994-1000
-
-
Nieborowska-Skorska, M.1
Stoklosa, T.2
Datta, M.3
Czechowska, A.4
Rink, L.5
Slupianek, A.6
Koptyra, M.7
Seferynska, I.8
Krszyna, K.9
Blasiak, J.10
Skorski, T.11
-
34
-
-
9444264703
-
BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species-dependent DNA double-strand breaks
-
Nowicki MO, Falinski R, Koptyra M, Slupianek A, Stoklosa T, Gloc E, Nieborowska-Skorska M, Blasiak J, Skorski T. 2004. BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species-dependent DNA double-strand breaks. Blood 104:3746-3753.
-
(2004)
Blood
, vol.104
, pp. 3746-3753
-
-
Nowicki, M.O.1
Falinski, R.2
Koptyra, M.3
Slupianek, A.4
Stoklosa, T.5
Gloc, E.6
Nieborowska-Skorska, M.7
Blasiak, J.8
Skorski, T.9
-
35
-
-
35348821296
-
A backup DNA repair pathway moves to the forefront
-
Nussenzweig A, Nussenzweig MC. 2007. A backup DNA repair pathway moves to the forefront. Cell 131:223-225.
-
(2007)
Cell
, vol.131
, pp. 223-225
-
-
Nussenzweig, A.1
Nussenzweig, M.C.2
-
36
-
-
0037187198
-
Defending genome integrity during S-phase: Putative roles for RecQ helicases and topoisomerase III
-
Oakley T, Hickson ID. 2002. Defending genome integrity during S-phase: Putative roles for RecQ helicases and topoisomerase III. DNA Repair 1:175-207.
-
(2002)
DNA Repair
, vol.1
, pp. 175-207
-
-
Oakley, T.1
Hickson, I.D.2
-
37
-
-
10744233716
-
Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronicphase chronic myeloid leukemia
-
O'Brien SG, Guilhot F, Larson RA. 2003. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronicphase chronic myeloid leukemia. N Engl J Med 348:994-1004.
-
(2003)
N Engl J Med
, vol.348
, pp. 994-1004
-
-
O'Brien, S.G.1
Guilhot, F.2
Larson, R.A.3
-
38
-
-
36949012288
-
Targeted cancer therapies based on the inhibition of DNA strand break repair
-
O'Connor MJ, Martin NMB, Smith GCM. 2007. Targeted cancer therapies based on the inhibition of DNA strand break repair. Oncogene 26:7816-7824.
-
(2007)
Oncogene
, vol.26
, pp. 7816-7824
-
-
O'Connor, M.J.1
Martin, N.M.B.2
Smith, G.C.M.3
-
39
-
-
0343280013
-
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
-
Paull TT, Rogakou EP, Yamazaki V, Kirchgessner CU, Gellert M, Bonner WM. 2000. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr Biol 10:886-895.
-
(2000)
Curr Biol
, vol.10
, pp. 886-895
-
-
Paull, T.T.1
Rogakou, E.P.2
Yamazaki, V.3
Kirchgessner, C.U.4
Gellert, M.5
Bonner, W.M.6
-
40
-
-
2242443513
-
Insights into DNA recombination from the structure of a RAD51-BRCA2 complex
-
Pellegrini L, Yu DS, Lo T, Anand S, Lee M, Blundell TL, Venkitaraman AR. 2002. Insights into DNA recombination from the structure of a RAD51-BRCA2 complex. Nature 420:287-293.
-
(2002)
Nature
, vol.420
, pp. 287-293
-
-
Pellegrini, L.1
Yu, D.S.2
Lo, T.3
Anand, S.4
Lee, M.5
Blundell, T.L.6
Venkitaraman, A.R.7
-
41
-
-
0031974751
-
Molecular alterations in the TP53 gene of peripheral blood cells of patients with chronic myeloid leukemia
-
Peller S, Yona R, Kopilova Y. 1998. Molecular alterations in the TP53 gene of peripheral blood cells of patients with chronic myeloid leukemia. Genes Chromosomes Cancer 21:2-7.
-
(1998)
Genes Chromosomes Cancer
, vol.21
, pp. 2-7
-
-
Peller, S.1
Yona, R.2
Kopilova, Y.3
-
42
-
-
33846048570
-
Fusion tyrosine kinases: a result and cause of genomic instability
-
Penserga ET, Skorski T. 2007. Fusion tyrosine kinases: a result and cause of genomic instability. Oncogene 26:11-20.
-
(2007)
Oncogene
, vol.26
, pp. 11-20
-
-
Penserga, E.T.1
Skorski, T.2
-
43
-
-
0037430990
-
DNA double strand breaks (DSB) and non-homologous end joining (NHEJ) pathways in human leukemia
-
Rassool FV. 2003. DNA double strand breaks (DSB) and non-homologous end joining (NHEJ) pathways in human leukemia. Cancer Lett 193:1-9.
-
(2003)
Cancer Lett
, vol.193
, pp. 1-9
-
-
Rassool, F.V.1
-
44
-
-
0033166623
-
Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient
-
Riballo E, Critchlow SE, Teo SH, Doherty AJ, Priestley A, Broughton B, Kysela B, Beamish H, Plowman N, Arlett CF, Lehmann AR, Jackson SP, Jeggo PA. 1999. Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient. Curr Biol 9:699-702.
-
(1999)
Curr Biol
, vol.9
, pp. 699-702
-
-
Riballo, E.1
Critchlow, S.E.2
Teo, S.H.3
Doherty, A.J.4
Priestley, A.5
Broughton, B.6
Kysela, B.7
Beamish, H.8
Plowman, N.9
Arlett, C.F.10
Lehmann, A.R.11
Jackson, S.P.12
Jeggo, P.A.13
-
45
-
-
34547092709
-
Enhanced phosphorylation of Nbs1, a member of DNA repair/checkpoint complex Mre11-RAD50-Nbs1, can be targeted to increase the efficacy of imatinib mesylate against BCR/ABL-positive leukemia cells
-
Rink L, Slupianek A, Stoklosa T, Nieborowska-Skorska M, Urbanska K, Seferynska I, Reiss K, Skorski T. 2007. Enhanced phosphorylation of Nbs1, a member of DNA repair/checkpoint complex Mre11-RAD50-Nbs1, can be targeted to increase the efficacy of imatinib mesylate against BCR/ABL-positive leukemia cells. Blood 110:651-660.
-
(2007)
Blood
, vol.110
, pp. 651-660
-
-
Rink, L.1
Slupianek, A.2
Stoklosa, T.3
Nieborowska-Skorska, M.4
Urbanska, K.5
Seferynska, I.6
Reiss, K.7
Skorski, T.8
-
46
-
-
33845187185
-
RAD51 homologous recombination repair gene haplotypes and risk of acute myeloid leukaemia
-
Rollinson S, Smith AG, Allan JM, Adamson PJ, Scott K, Skibola CF, Smith M, Morgan GJ. 2007. RAD51 homologous recombination repair gene haplotypes and risk of acute myeloid leukaemia. Leuk Res 31:169-174.
-
(2007)
Leuk Res
, vol.31
, pp. 169-174
-
-
Rollinson, S.1
Smith, A.G.2
Allan, J.M.3
Adamson, P.J.4
Scott, K.5
Skibola, C.F.6
Smith, M.7
Morgan, G.J.8
-
47
-
-
0022976432
-
Non homologous recombination in mammalian cells: Role for the short sequence homologies in the joining reaction
-
Roth DB, Wilson JH. 1986. Non homologous recombination in mammalian cells: Role for the short sequence homologies in the joining reaction. Mol Cell Biol 6:4295-4304.
-
(1986)
Mol Cell Biol
, vol.6
, pp. 4295-4304
-
-
Roth, D.B.1
Wilson, J.H.2
-
48
-
-
42449145174
-
Internal tandem duplication of FLT3 (FLT3/ITD) induces increased ROS production, DNA damage, and misrepair: Implications for poor prognosis in AML
-
Sallmyr A, Fan J, Datta K, Kim KT, Grosu D, Shapiro P, Small D, Rassool F. 2008a. Internal tandem duplication of FLT3 (FLT3/ITD) induces increased ROS production, DNA damage, and misrepair: Implications for poor prognosis in AML. Blood 111:3173-3182.
-
(2008)
Blood
, vol.111
, pp. 3173-3182
-
-
Sallmyr, A.1
Fan, J.2
Datta, K.3
Kim, K.T.4
Grosu, D.5
Shapiro, P.6
Small, D.7
Rassool, F.8
-
49
-
-
50649087954
-
Genomic instability in myeloid malignancies: Increased reactive oxygen species (ROS), DNA double strand breaks (DSBs) and error-prone repair
-
Sallmyr A, Fan J, Rassool FV. 2008b. Genomic instability in myeloid malignancies: Increased reactive oxygen species (ROS), DNA double strand breaks (DSBs) and error-prone repair. Cancer Lett 270:1-9.
-
(2008)
Cancer Lett
, vol.270
, pp. 1-9
-
-
Sallmyr, A.1
Fan, J.2
Rassool, F.V.3
-
50
-
-
51649128895
-
Up- regulation of WRN and DNAligase IIIa in chronic myeloid leukemia: Consequences for the repair of DNA double-strand breaks
-
Sallmyr A, Tomkinson A, Rassool FV. 2008c. Up-regulation of WRN and DNAligase IIIa in chronic myeloid leukemia: Consequences for the repair of DNA double-strand breaks. Blood 112:1413-1423.
-
(2008)
Blood
, vol.112
, pp. 1413-1423
-
-
Sallmyr, A.1
Tomkinson, A.2
Rassool, F.V.3
-
51
-
-
65549123260
-
Mitochondrial uncoupling and the Warburg effect: Molecular basis for the reprogramming of cancer cell metabolism
-
Samudio I, Fiegl M, Andreeff M. 2009. Mitochondrial uncoupling and the Warburg effect: Molecular basis for the reprogramming of cancer cell metabolism. Cancer Res 69:2163-2166.
-
(2009)
Cancer Res
, vol.69
, pp. 2163-2166
-
-
Samudio, I.1
Fiegl, M.2
Andreeff, M.3
-
52
-
-
0034637599
-
The BCR/ABL tyrosine kinase induces production of reactive oxygen species in hematopoietic cells
-
Sattler M, Verma S, Shrikhande G. 2000. The BCR/ABL tyrosine kinase induces production of reactive oxygen species in hematopoietic cells. J Biol Chem 275:24273-24278.
-
(2000)
J Biol Chem
, vol.275
, pp. 24273-24278
-
-
Sattler, M.1
Verma, S.2
Shrikhande, G.3
-
53
-
-
0037111669
-
The genotype distribution of the XRCC1 gene indicates a role for base excision repair in the development of therapy-related acute myeloblastic leukemia
-
Seedhouse C, Bainton R, Lewis M. 2002. The genotype distribution of the XRCC1 gene indicates a role for base excision repair in the development of therapy-related acute myeloblastic leukemia. Blood 100:3761-3766.
-
(2002)
Blood
, vol.100
, pp. 3761-3766
-
-
Seedhouse, C.1
Bainton, R.2
Lewis, M.3
-
54
-
-
1942502414
-
Polymorphisms in genes involved in homologous recombination repair interact to increase the risk of developing acute myeloid leukemia
-
Seedhouse C, Faulkner R, Ashraf N. 2004. Polymorphisms in genes involved in homologous recombination repair interact to increase the risk of developing acute myeloid leukemia. Clin Cancer Res 10:2675-2680.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 2675-2680
-
-
Seedhouse, C.1
Faulkner, R.2
Ashraf, N.3
-
55
-
-
33751242335
-
DNA repair contributes to the drug-resistant phenotype of primary acute myeloid leukaemia cells with FLT3 internal tandem duplications and is reversed by the FLT3 inhibitor PKC412
-
Seedhouse CH, Hunter HM, Lloyd-Lewis B, Massip AM, Pallis M, Carter GI, Grundy M, Shang S, Russell NH. 2006. DNA repair contributes to the drug-resistant phenotype of primary acute myeloid leukaemia cells with FLT3 internal tandem duplications and is reversed by the FLT3 inhibitor PKC412. Leukemia 20:2130-2136.
-
(2006)
Leukemia
, vol.20
, pp. 2130-2136
-
-
Seedhouse, C.H.1
Hunter, H.M.2
Lloyd-Lewis, B.3
Massip, A.M.4
Pallis, M.5
Carter, G.I.6
Grundy, M.7
Shang, S.8
Russell, N.H.9
-
57
-
-
42049086836
-
BCR/ABL DNA damage and DNA repair: implications for new treatment concepts
-
Skorski T. 2008. BCR/ABL, DNA damage and DNA repair: implications for new treatment concepts. Leuk Lymphoma 49: 610-614.
-
(2008)
Leuk Lymphoma
, vol.49
, pp. 610-614
-
-
Skorski, T.1
-
58
-
-
0036261727
-
Fusion tyrosine kinases induce drug resistance by stimulation of homology-dependent recombination repair, prolongation of G(2)/M phase, and protection from apoptosis
-
Slupianek A, Hoser G, Majsterek I, Bronisz A, Malecki M, Blasiak J, Fishel R, Skorski T. 2002. Fusion tyrosine kinases induce drug resistance by stimulation of homology-dependent recombination repair, prolongation of G(2)/M phase, and protection from apoptosis. Mol Cell Biol 22:4189-4201.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 4189-4201
-
-
Slupianek, A.1
Hoser, G.2
Majsterek, I.3
Bronisz, A.4
Malecki, M.5
Blasiak, J.6
Fishel, R.7
Skorski, T.8
-
59
-
-
30344461008
-
BCR/ ABL modifies the kinetics and fidelity of DNA double-strand breaks repair in hematopoietic cells
-
Slupianek A, Nowicki MO, Koptyra M, Skorski T. 2006. BCR/ ABL modifies the kinetics and fidelity of DNA double-strand breaks repair in hematopoietic cells. DNA Repair 5:243-250.
-
(2006)
DNA Repair
, vol.5
, pp. 243-250
-
-
Slupianek, A.1
Nowicki, M.O.2
Koptyra, M.3
Skorski, T.4
-
60
-
-
77955984748
-
DNA repair XRCC1 Arg399Gln polymorphism alone and in combination with CYP2E1 polymorphisms significantly contribute to the risk of development of childhood acute lymphoblastic leukemia
-
doi:10.1016/j.leukres.2010.02.035
-
Tumer TB, Yilmaz D, Tanrikut C, Sahin G, Ulusoy G, ArincE. 2010. DNA repair XRCC1 Arg399Gln polymorphism alone and in combination with CYP2E1 polymorphisms significantly contribute to the risk of development of childhood acute lymphoblastic leukemia. Leuk Res doi:10.1016/j.leukres.2010.02.035.
-
(2010)
Leuk Res
-
-
Tumer, T.B.1
Yilmaz, D.2
Tanrikut, C.3
Sahin, G.4
Ulusoy, G.5
Arinc, E.6
-
61
-
-
18544372595
-
BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure
-
Yang H, Jeffrey PD, Miller J, Kinnucan E, Sun Y, Thoma NH, Zheng N, Chen PL, Lee WH, Pavletich NP. 2002. BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure. Science 297:1837-1848.
-
(2002)
Science
, vol.297
, pp. 1837-1848
-
-
Yang, H.1
Jeffrey, P.D.2
Miller, J.3
Kinnucan, E.4
Sun, Y.5
Thoma, N.H.6
Zheng, N.7
Chen, P.L.8
Lee, W.H.9
Pavletich, N.P.10
-
62
-
-
66249108601
-
Understanding the Warburg effect: The metabolic requirements of cell proliferation
-
Vander Heiden MG, Cantley LC, Thompson CB. 2009. Understanding the Warburg effect: The metabolic requirements of cell proliferation. Science 324:1029-1033.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
63
-
-
67549136242
-
Mitochondrial dysfunction leads to nuclear genome instability via an iron-sulfur cluster defect
-
Veatch JR, McMurray MA, Nelson ZW, Gottschling DE. 2009. Mitochondrial dysfunction leads to nuclear genome instability via an iron-sulfur cluster defect. Cell 137:1247-1258.
-
(2009)
Cell
, vol.137
, pp. 1247-1258
-
-
Veatch, J.R.1
McMurray, M.A.2
Nelson, Z.W.3
Gottschling, D.E.4
-
64
-
-
0242300088
-
Endogenous DNA doublestrand breaks: Production, fidelity of repair, and induction of cancer
-
Vilenchik MM, Knudson AG. 2003. Endogenous DNA doublestrand breaks: Production, fidelity of repair, and induction of cancer. Proc Natl Acad Sci 100:12871-12876.
-
(2003)
Proc Natl Acad Sci
, vol.100
, pp. 12871-12876
-
-
Vilenchik, M.M.1
Knudson, A.G.2
-
65
-
-
34548759123
-
Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins
-
Wang W. 2007. Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins. Nat Rev Genet 8:735-748.
-
(2007)
Nat Rev Genet
, vol.8
, pp. 735-748
-
-
Wang, W.1
-
66
-
-
67349142616
-
FLT3 inhibition and mechanisms of drug resistance in mutant FLT3-positive AML
-
Weisberg E, Barrett R, Liu Q, Stone R, Gray N, Griffin JD. 2009. FLT3 inhibition and mechanisms of drug resistance in mutant FLT3-positive AML. Drug Resist Updat 12:81-89.
-
(2009)
Drug Resist Updat
, vol.12
, pp. 81-89
-
-
Weisberg, E.1
Barrett, R.2
Liu, Q.3
Stone, R.4
Gray, N.5
Griffin, J.D.6
-
67
-
-
2942591949
-
A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia
-
Willmore E, de Caux S, Sunter NJ, Tilby MJ, Jackson GH, Austin CA, Durkacz BW. 2004. A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia. Blood 103:4659-4665.
-
(2004)
Blood
, vol.103
, pp. 4659-4665
-
-
Willmore, E.1
de Caux, S.2
Sunter, N.J.3
Tilby, M.J.4
Jackson, G.H.5
Austin, C.A.6
Durkacz, B.W.7
|