Structure and function of hainantoxin-III, a selective antagonist of neuronal tetrodotoxin-sensitive voltage-gated sodium channels isolated from the Chinese bird spider Ornithoctonus hainana

Journal of Biological Chemistry

Volumn 288, Issue 28, 2013, Pages 20392-20403

  Liu, Zhonghua ^a   Cai, Tianfu ^a   Zhu, Qi ^a,d   Deng, Meichun ^b   Li, Jiayan ^a   Zhou, Xi ^a   Zhang, Fan ^a   Li, Dan ^a   Li, Jing ^a   Liu, Yu ^c   Hu, Weijun ^a   Liang, Songping ^a  

^a HUNAN NORMAL UNIVERSITY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c HUNAN INSTITUTE OF SCIENCE AND TECHNOLOGY   (China)

^d LC Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC RESIDUES; BINDING SPECIFICITIES; CHANNEL INTERACTIONS; CURRENT AMPLITUDE; MECHANISM OF ACTION; REPOLARIZATION; SOLUTION STRUCTURES; TWO-DIMENSIONAL NMR;

DEPOLARIZATION; METABOLITES;

TOXIC MATERIALS;

ANALGESIC AGENT; HAINANTOXIN 3; KNOTTIN; POLYPEPTIDE; SCORPION VENOM; SODIUM CHANNEL NAV1.7; SPIDER VENOM; TETRODOTOXIN; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL BLOCKING AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CHANNEL GATING; COMPLEX FORMATION; CONTROLLED STUDY; DEPOLARIZATION; DRUG ISOLATION; ENZYME ACTIVATION; ENZYME INACTIVATION; HAPLOPELMA; MOUSE; NONHUMAN; ORNITHOCTONUS HAINANA; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN STRUCTURE; PROTEIN SYNTHESIS INHIBITION; RAT; REPOLARIZATION; SPINAL GANGLION; STRUCTURE ANALYSIS; TOXIN ANALYSIS; TOXIN STRUCTURE;

INHIBITOR CYSTINE KNOT MOTIF; NAV1.7; NMR; PATCH CLAMP ELECTROPHYSIOLOGY; PEPTIDES; SODIUM CHANNELS; SPIDER VENOM; TOXINS;

ANIMALS; CELLS, CULTURED; GANGLIA, SPINAL; HEK293 CELLS; HUMANS; ION CHANNEL GATING; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MEMBRANE POTENTIALS; MICE; NAV1.7 VOLTAGE-GATED SODIUM CHANNEL; NEURONS; PATCH-CLAMP TECHNIQUES; PROTEIN ISOFORMS; RATS; RATS, SPRAGUE-DAWLEY; SPIDER VENOMS; SPIDERS; TETRODOTOXIN; VOLTAGE-GATED SODIUM CHANNEL BLOCKERS; VOLTAGE-GATED SODIUM CHANNELS;

EID: 84880064536     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.426627     Document Type: Article

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