Common molecular determinants of tarantula huwentoxin-IV inhibition of Na + channel voltage sensors in domains II and IV

Journal of Biological Chemistry

Volumn 286, Issue 31, 2011, Pages 27301-27310

  Xiao, Yucheng ^a,b   Jackson II, James O ^b   Liang, Songping ^b   Cummins, Theodore R ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HUNAN NORMAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL TOXINS; BINDING MOTIF; MOLECULAR DETERMINANTS; SINGLE RESIDUE; SODIUM CHANNEL; TOXIN INTERACTIONS; VOLTAGE SENSOR;

BINDING SITES; ELECTROPHYSIOLOGY; SODIUM; TOXIC MATERIALS;

SENSORS;

ASPARTIC ACID; GLUTAMIC ACID; HUWENTOXIN IV; LEUCINE; SODIUM CHANNEL NAV1.7; SPIDER VENOM; UNCLASSIFIED DRUG;

ARTICLE; BIOSENSOR; CHANNEL GATING; CHEMICAL INTERACTION; CONTROLLED STUDY; ELECTROPHYSIOLOGY; HUMAN; HUMAN CELL; MOLECULAR BIOLOGY; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN MOTIF; RESIDUE ANALYSIS; SODIUM CURRENT; TOXIN ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PATCH-CLAMP TECHNIQUES; SEQUENCE HOMOLOGY, AMINO ACID; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; SPIDER VENOMS; SPIDERS;

ANIMALIA; TARANTULA;

EID: 79960987490     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.246876     Document Type: Article

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