The regulating function of heterotrimeric G proteins in the immune system

Archivum Immunologiae et Therapiae Experimentalis

Volumn 61, Issue 4, 2013, Pages 309-319

  Wang, Yantang ^a   Li, Yan ^b   Shi, Guixiu ^b  

^a CHENGDU MEDICAL COLLEGE   (China)

^b THE FIRST AFFILIATED HOSPITAL OF XIAMEN UNIVERSITY   (China)

Author keywords

Autoimmune diseases; G proteins; Immune regulation; Lymphocyte development

Indexed keywords

CYTOKINE; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR G2A; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 2; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

AUTOIMMUNE DISEASE; AUTOIMMUNITY; CELL DEATH; CELL MATURATION; CELL SURVIVAL; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DISEASE ASSOCIATION; ENZYME ACTIVATION; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; LEUKOCYTE MIGRATION; LYMPHOCYTE; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE TRANSFER; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ANIMALS; AUTOIMMUNE DISEASES; CELL PROLIFERATION; CELL SURVIVAL; CHEMOTAXIS, LEUKOCYTE; CYTOKINES; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; IMMUNE SYSTEM; LYMPHOCYTES; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 84879841084     PISSN: 0004069X     EISSN: 16614917     Source Type: Journal    
DOI: 10.1007/s00005-013-0230-5     Document Type: Review

References (87)

1. Al-Aoukaty A, Rolstad B, Giaid A et al (1998) MIP-3alpha, MIP-3beta and fractalkine induce the locomotion and the mobilization of intracellular calcium, and activate the heterotrimeric G proteins in human natural killer cells. Immunology 95:618-624 (Pubitemid 28559156)
2. Arthur JC, Jobin C (2011) The struggle within: microbial influences on colorectal cancer. Inflamm Bowel Dis 17:396-409
3. Baumgart DC, Carding SR (2007) Inflammatory bowel disease: cause and immunobiology. Lancet 369:1627-1640 (Pubitemid 46722636)
4. Bennett LD, Fox JM, Signoret N (2011) Mechanisms regulating chemokine receptor activity. Immunology 134:246-256
5. Bjursten M, Hultgren OH, Hultgren Hornquist E (2004) Enhanced pro-inflammatory cytokine production in Galphai2-deficient mice on colitis prone and colitis resistant 129 Sv genetic backgrounds. Cell Immunol 228:77-80 (Pubitemid 38813330)
6. Bockaert J, Claeysen S, Becamel C et al (2002) G protein-coupled receptors: dominant players in cell-cell communication. Int Rev Cytol 212:63-132 (Pubitemid 34059823)
7. Browne CD, Del Nagro CJ, Cato MH et al (2009) Suppression of phosphatidylinositol 3,4,5-trisphosphate production is a key determinant of B cell anergy. Immunity 31:749-760
8. Bueno C, Lemke CD, Criado G et al (2006) Bacterial superantigens bypass Lck-dependent T cell receptor signaling by activating a Galpha11-dependent, PLC-beta-mediated pathway. Immunity 25:67-78 (Pubitemid 44066827)
9. Cantrell D (2002) Protein kinase B (Akt) regulation and function in T lymphocytes. Semin Immunol 14:19-26 (Pubitemid 34250705)
10. Chaffin KE, Perlmutter RM (1991) A pertussis toxin-sensitive process controls thymocyte emigration. Eur J Immunol 21:2565-2573
11. Coffield VM, Helms WS, Jiang Q et al (2004) Galpha13 mediates a signal that is essential for proliferation and survival of thymocyte progenitors. J Exp Med 200:1315-1324 (Pubitemid 39552572)
12. Cyster JG, Goodnow CC (1995) Pertussis toxin inhibits migration of B and T lymphocytes into splenic white pulp cords. J Exp Med 182:581-586
13. Dalwadi H, Wei B, Schrage M et al (2003) B cell developmental requirement for the G alpha i2 gene. J Immunol 170:1707-1715 (Pubitemid 36197385)
14. Davignon I, Catalina MD, Smith D et al (2000) Normal hematopoiesis and inflammatory responses despite discrete signaling defects in Galpha15 knockout mice. Mol Cell Biol 20:797-804 (Pubitemid 30044216)
15. Druey KM (2009) Regulation of G-protein-coupled signaling pathways in allergic inflammation. Immunol Res 43:62-76
16. Edwards RA, Smock AZ (2006) Defective arachidonate release and PGE2 production in Gi alpha2-deficient intestinal and colonic subepithelial myofibroblasts. Inflamm Bowel Dis 12:153-165
17. Edwards RA, Wang K, Davis JS et al (2008) Role for epithelial dysregulation in early-onset colitis-associated colon cancer in Gi2-alpha-/- mice. Inflamm Bowel Dis 14:898-907
18. Elgbratt K, Bjursten M, Willen R et al (2007) Aberrant T-cell ontogeny and defective thymocyte and colonic T-cell chemotactic migration in colitis-prone Galphai2-deficient mice. Immunology 122:199-209 (Pubitemid 47389948)
19. Elgbratt K, Jansson A, Hultgren-Hornquist E (2012) A quantitative study of the mechanisms behind thymic atrophy in Galphai2-deficient mice during colitis development. PLoS ONE 7:e36726
20. Entschladen F, Zanker KS, Powe DG (2011) Heterotrimeric G protein signaling in cancer cells with regard to metastasis formation. Cell Cycle 10:1086-1091
21. Fan H, Williams DL, Zingarelli B et al (2007) Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in macrophages by Galpha(i) proteins. Immunology 122:116-123 (Pubitemid 47222602)
22. Galandrini R, Henning SW, Cantrell DA (1997) Different functions of the GTPase Rho in prothymocytes and late pre-T cells. Immunity 7:163-174 (Pubitemid 27357274)
23. Garcia-Marcos M, Ghosh P et al (2009) GIV is a nonreceptor GEF for G alpha i with a unique motif that regulates Akt signaling. Proc Natl Acad Sci USA 106:3178-3183
24. Ghosh P, Garcia-Marcos M, Bornheimer SJ et al (2008) Activation of Galphai3 triggers cell migration via regulation of GIV. J Cell Biol 182:381-393
25. Girkontaite I, Missy K, Sakk V et al (2001) Lsc is required for marginal zone B cells, regulation of lymphocyte motility and immune responses. Nat Immunol 2:855-862
26. Goldsmith ZG, Dhanasekaran DN (2007) G protein regulation of MAPK networks. Oncogene 26:3122-3142 (Pubitemid 46763010)
27. Gotlind YY, Raghavan S, Bland PW et al (2011) CD4 + FoxP3 + regulatory T cells from Galphai2-/- mice are functionally active in vitro, but do not prevent colitis. PLoS ONE 6:e25073
28. Gu JL, Muller S, Mancino V et al (2002) Interaction of G alpha(12) with G alpha(13) and G alpha(q) signaling pathways. Proc Natl Acad Sci USA 99:9352-9357 (Pubitemid 34764617)
29. Hampe J, Lynch NJ, Daniels S et al (2001) Fine mapping of the chromosome 3p susceptibility locus in inflammatory bowel disease. Gut 48:191-197 (Pubitemid 32141842)
30. He J, Gurunathan S, Iwasaki A et al (2000) Primary role for Gi protein signaling in the regulation of interleukin 12 production and the induction of T helper cell type 1 responses. J Exp Med 191:1605-1610 (Pubitemid 30257356)
31. Herroeder S, Reichardt P, Sassmann A et al (2009) Guanine nucleotide-binding proteins of the G12 family shape immune functions by controlling CD4 + T cell adhesiveness and motility. Immunity 30:708-720
32. Hildeman D, Jorgensen T, Kappler J et al (2007) Apoptosis and the homeostatic control of immune responses. Curr Opin Immunol 19:516-521 (Pubitemid 47464912)
33. Holtzman MJ, Green JM, Jayaraman S et al (2000) Regulation of T cell apoptosis. Apoptosis 5:459-471 (Pubitemid 32162630)
34. Hornquist CE, Lu X, Rogers-Fani PM et al (1997) G(alpha)i2-deficient mice with colitis exhibit a local increase in memory CD4 + T cells and proinflammatory Th1-type cytokines. J Immunol 158:1068-1077 (Pubitemid 127469926)
35. Huang TT, Zong Y, Dalwadi H et al (2003) TCR-mediated hyper-responsiveness of autoimmune Galphai2(-/-) mice is an intrinsic naive CD4(+) T cell disorder selective for the Galphai2 subunit. Int Immunol 15:1359-1367 (Pubitemid 37369329)
36. Hwang JI, Fraser ID, Choi S et al (2004) Analysis of C5a-mediated chemotaxis by lentiviral delivery of small interfering RNA. Proc Natl Acad Sci USA 101:488-493 (Pubitemid 38084663)
37. Jiang M, Boulay G, Spicher K et al (1997) Inactivation of the G alpha i2 and G alpha o genes by homologous recombination. Receptors Channels 5:187-192 (Pubitemid 28242956)
38. Jin Y, Wu MX (2008) Requirement of Galphai in thymic homing and early T cell development. Mol Immunol 45:3401-3410
39. Jin T, Xu X, Hereld D (2008a) Chemotaxis, chemokine receptors and human disease. Cytokine 44:1-8
40. Jin YZ, Thompson BD, Zhou ZY et al (2008b) Reciprocal function of Gαi2 and Gαi3 in graft-versus-host disease. Eur J Immunol 38:1988-1998
41. Kabashima K, Murata T, Tanaka H et al (2003) Thromboxane A2 modulates interaction of dendritic cells and T cells and regulates acquired immunity. Nat Immunol 4:694-701 (Pubitemid 36874447)
42. Khan KJ, Ullman TA, Ford AC et al (2011) Antibiotic therapy in inflammatory bowel disease: a systematic review and meta-analysis. Am J Gastroenterol 106:661-673
43. Koelle MR (2006) Heterotrimeric G protein signaling: getting inside the cell. Cell 126:25-27
44. Kunkel EJ, Butcher EC (2002) Chemokines and the tissue-specific migration of lymphocytes. Immunity 16:1-4 (Pubitemid 34143211)
45. Li Z, Jiang H, Xie W et al (2000) Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction. Science 287:1046-1049 (Pubitemid 30094361)
46. Li X, Murray F, Koide N et al (2012) Divergent requirement for Galphas and cAMP in the differentiation and inflammatory profile of distinct mouse Th subsets. J Clin Invest 122:963-973
47. Meyer-Bahlburg A, Andrews SF, Yu KO et al (2008) Characterization of a late transitional B cell population highly sensitive to BAFF-mediated homeostatic proliferation. J Exp Med 205:155-168 (Pubitemid 351185723)
48. Misra RS, Shi G, Moreno-Garcia ME et al (2010) G alpha q-containing G proteins regulate B cell selection and survival and are required to prevent B cell-dependent autoimmunity. J Exp Med 207:1775-1789
49. Molon B, Gri G, Bettella M et al (2005) T cell costimulation by chemokine receptors. Nat Immunol 6:465-471 (Pubitemid 41716759)
50. Moser B, Wolf M, Walz A et al (2004) Chemokines: multiple levels of leukocyte migration control. Trends Immunol 25:75-84 (Pubitemid 38167488)
51. Murakami N, Yokomizo T, Okuno T et al (2004) G2A is a proton-sensing G-protein-coupled receptor antagonized by lysophosphatidylcholine. J Biol Chem 279:42484-42491 (Pubitemid 39372132)
52. Neish AS (2009) Microbes in gastrointestinal health and disease. Gastroenterology 136:6-80
53. Neptune ER, Iiri T, Bourne HR (1999) Galphai is not required for chemotaxis mediated by Gi-coupled receptors. J Biol Chem 274:2824-2828 (Pubitemid 29075365)
54. Ngai J, Methi T, Andressen KW et al (2008) The heterotrimeric G-protein alpha-subunit Galphaq regulates TCR-mediated immune responses through an Lck-dependent pathway. Eur J Immunol 38:3208-3218
55. Ngai J, Inngjerdingen M, Berge T et al (2009) Interplay between the heterotrimeric G-protein subunits Galphaq and Galphai2 sets the threshold for chemotaxis and TCR activation. BMC Immunol 10:27
56. Offermanns S, Mancino V, Revel JP et al (1997) Vascular system defects and impaired cell chemokinesis as a result of Galpha13 deficiency. Science 275:533-536 (Pubitemid 27051909)
57. Ohman L, Franzen L, Rudolph U et al (2002) Regression of Peyer's patches in G alpha i2 deficient mice prior to colitis is associated with reduced expression of Bcl-2 and increased apoptosis. Gut 51:392-397
58. Ohman L, Astrom RG, Hultgren Hornquist E (2005) Impaired B cell responses to orally administered antigens in lamina propria but not Peyer's patches of Galphai2-deficient mice prior to colitis. Immunology 115:271-278 (Pubitemid 40733414)
59. Oliveira-Dos-Santos AJ, Matsumoto G, Snow BE et al (2000) Regulation of T cell activation, anxiety, and male aggression by RGS2. Proc Natl Acad Sci USA 97:12272-12277
60. Padigel UM, Stein L, Redding K et al (2007) Signaling through Galphai2 protein is required for recruitment of neutrophils for antibody-mediated elimination of larval Strongyloides stercoralis in mice. J Leuk Biol 81:1120-1126 (Pubitemid 46495661)
61. Pena JA, Thompson-Snipes L, Calkins PR et al (2009) Alterations in myeloid dendritic cell innate immune responses in the Galphai2-deficient mouse model of colitis. Inflamm Bowel Dis 15:248-260
62. Radu CG, Yang LV, Riedinger M et al (2004) T cell chemotaxis to lysophosphatidylcholine through the G2A receptor. Proc Natl Acad Sci USA 101:245-250 (Pubitemid 38084235)
63. Rieken S, Sassmann A, Herroeder S et al (2006) G12/G13 family G proteins regulate marginal zone B cell maturation, migration, and polarization. J Immunol 177:2985-2993 (Pubitemid 44277814)
64. Rudolph U, Finegold MJ, Rich SS et al (1995) Ulcerative colitis and adenocarcinoma of the colon in G alpha i2-deficient mice. Nat Genet 10:143-150
65. Ryan M, McCarthy L, Rappuoli R et al (1998) Pertussis toxin potentiates Th1 and Th2 responses to co-injected antigen: adjuvant action is associated with enhanced regulatory cytokine production and expression of the co-stimulatory molecules B7-1, B7-2 and CD28. Int Immunol 10:651-662 (Pubitemid 28221466)
66. Saha C, Nigam SK, Denker BM (1998) Involvement of Galphai2 in the maintenance and biogenesis of epithelial cell tight junctions. J Biol Chem 273:21629-21633 (Pubitemid 28405334)
67. Shi G, Partida-Sánchez S, Misra RS et al (2007) Identification of an alternative Gαq-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes. J Exp Med 204:2705-2718 (Pubitemid 350044793)
68. Shive CL, Hofstetter H, Arredondo L et al (2000) The enhanced antigen-specific production of cytokines induced by pertussis toxin is due to clonal expansion of T cells and not to altered effector functions of long-term memory cells. Eur J Immunol 30:2422-2431
69. Soede RD, Zeelenberg IS, Wijnands YM et al (2001) Stromal cell-derived factor-1-induced LFA-1 activation during in vivo migration of T cell hybridoma cells requires Gq/11, RhoA, and myosin, as well as Gi and Cdc42. J Immunol 166:4293-4301 (Pubitemid 32233709)
70. Spangrude GJ, Sacchi F, Hill HR et al (1985) Inhibition of lymphocyte and neutrophil chemotaxis by pertussis toxin. J Immunol 135:4135-4143 (Pubitemid 16250403)
71. Strasser A, Bouillet P (2003) The control of apoptosis in lymphocyte selection. Immunol Rev 193:82-92 (Pubitemid 36688042)
72. Targan SR, Karp LC (2005) Defects in mucosal immunity leading to ulcerative colitis. Immunol Rev 206:296-305 (Pubitemid 41105177)
73. Taurog JD, Richardson JA, Croft JT et al (1994) The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats. J Exp Med 180:2359-2364 (Pubitemid 24351619)
74. Thien M, Phan TG, Gardam S et al (2004) Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches. Immunity 20:785-798 (Pubitemid 38757447)
75. Thompson BD, Jin Y, Wu KH et al (2007) Inhibition of G alpha i2 activation by G alpha i3 in CXCR3-mediated signaling. J Biol Chem 282:9547-9555 (Pubitemid 47104623)
76. von Boehmer H, Melchers F (2010) Checkpoints in lymphocyte development and autoimmune disease. Nat Immunol 11:14-20
77. Wang Y, Li Y, He Y et al (2011) Expression of G protein alphaq Subunit is decreased in lymphocytes from rheumatoid arthritis patients and is correlated with disease activity. Scand J Immunol. doi: 10.1111/j.1365-3083.2011.02635.x
78. Warnock RA, Askari S, Butcher EC et al (1998) Molecular mechanisms of lymphocyte homing to peripheral lymph nodes. J Exp Med 187:205-216 (Pubitemid 28060436)
79. Wettschureck N, Offermanns S (2005) Mammalian G proteins and their cell type specific functions. Physiol Rev 85:1159-1204 (Pubitemid 41362268)
80. Wiege K, Le DD, Syed SN et al (2012) Defective macrophage migration in Galphai2- but not Galphai3-deficient mice. J Immunol 189:980-987
81. Xu G, Shi Y (2007) Apoptosis signaling pathways and lymphocyte homeostasis. Cell Res 17:759-771 (Pubitemid 47411431)
82. Yanamadala V, Negoro H, Denker BM (2009) Heterotrimeric G proteins and apoptosis: intersecting signaling pathways leading to context dependent phenotypes. Curr Mol Med 9:527-545
83. Yang M, Sang H, Rahman A et al (2001) G alpha 16 couples chemoattractant receptors to NF-kappa B activation. J Immunol 166:6885-6892 (Pubitemid 32467235)
84. Zarbock A, Deem TL, Burcin TL et al (2007) Galphai2 is required for chemokine-induced neutrophil arrest. Blood 110:3773-3779 (Pubitemid 350159648)
85. Zhang Y, Finegold MJ, Jin Y et al (2005) Accelerated transition from the double-positive to single-positive thymocytes in G alpha i2-deficient mice. Int Immunol 17:233-243 (Pubitemid 40372646)
86. Zhou J, Stanners J, Kabouridis P et al (1998) Inhibition of TCR/CD3-mediated signaling by a mutant of the hematopoietically expressed G16 GTP-binding protein. Eur J Immunol 28:1645-1655 (Pubitemid 28221169)
87. Zlotnik A, Burkhardt AM, Homey B (2011) Homeostatic chemokine receptors and organ-specific metastasis. Nat Rev Immunol 11:597-606