The enhanced antigen-specific production of cytokines induced by pertussis toxin is due to clonal expansion of T cells and not to altered effector functions of long-term memory cells

European Journal of Immunology

Volumn 30, Issue 8, 2000, Pages 2422-2431

  Gagliardi, Maria Cristina ^a   Sallusto, Federica ^b   Marinaro, Mariarosaria ^a   Langenkamp, Anja ^b   Lanzavecchia, Antonio ^b   De Magistris, Maria Teresa ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

Author keywords

Adjuvant; Clonal expansion; Cytokine; Immunomodulator; Th1 Th2

Indexed keywords

ANTIGEN; CD4 ANTIGEN; CYTOKINE; FREUND ADJUVANT; GAMMA INTERFERON; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 5; LYSOZYME; PERTUSSIS TOXIN; PROTEIN SUBUNIT;

ADOPTIVE TRANSFER; ANIMAL CELL; ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFECTOR CELL; IMMUNOMODULATION; LYMPHOCYTE CLONE; LYMPHOCYTE DIFFERENTIATION; MEMORY CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; TH1 CELL; TH2 CELL;

ANIMALS; ANTIGEN-PRESENTING CELLS; CELL DIFFERENTIATION; CYTOKINES; GLYCOSIDES; IMMUNOLOGIC MEMORY; INTERFERON TYPE II; INTERLEUKIN-5; MICE; MICE, INBRED BALB C; MICE, SCID; PERTUSSIS TOXIN; T-LYMPHOCYTES; TRITERPENES; VIRULENCE FACTORS, BORDETELLA;

EID: 0033838435     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(2000)30:8<2422::AID-IMMU2422>3.0.CO;2-H     Document Type: Article

References (52)

1. Current status of immunological adjuvants
2. Approaching the asymptote? Evolution and revolution in immunology
3. A new analysis of allogeneic interactions
4. The instructive role of innate immunity in the acquired immune response
5. Induction of TH1 and TH2 immunity in neonatal mice
6. Adjuvant-guided type-1 and type-2 immunity: Infectious/noninfectious dichotomy defines the class of response
7. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity
8. Bacterial ADP-ribosylating toxins: Form, function, and recombinant vaccine development
9. The mechanism of cholera toxin adjuvanticity
10. Structure and mucosal adjuvanticity of cholera and Escherichia coli heat-labile enterotoxins
11. Mechanisms of pertussis toxin-induced myelomonocytic cell adhesion: Role of Mac-1(CD11b/CD18) and urokinase receptor (CD87)
12. Pertussis toxin interferes with superantigen-induced deletion of peripheral T cells without affecting T cell activation in vivo. Inhibition of deletion and associated programmed cell death depends on ADP-ribosyltransferase activity
13. Native, but not genetically inactivated, pertussis toxin protects mice against experimental allergic encephalomyelitis
14. The mitogenic effect of the lymphocytosis promoting factor from Bordetella pertussis on human lymphocytes
15. Biological activities of crystalline pertussigen from Bordetella pertussis
16. Enhancement of the intensity, persistence, and passive transfer of delayed-type hypersensitivity lesions by pertussigen in mice
17. Pertussigen enhances antigen-driven interferon-gamma production by sensitized lymphoid cells
18. Enhancement of interleukin-4 production by pertussis toxin
19. Regulation of DTH and IgE responses by IL-4 and IFN-gamma in immunized mice given pertussis toxin
20. Pertussis toxin potentiates Th1 and Th2 responses to coinjected antigen: Adjuvant action is associated with enhanced regulatory cytokine production and expression of the costimulatory molecules B7-1, B7-2 and CD28
21. A new look at T cells
22. IL-2 secretion is pertussis toxin sensitive in a T lymphocyte hybridoma
23. The effects of pertussis toxin and cholera toxin on mitogen-induced interleukin-2 production: Evidence for G protein involvement in signal transduction
24. Single-cytokine-producing CD4 memory cells predominate in type 1 and type 2 immunity
25. Pertussis toxin-induced mitogenesis in human T lymphocytes
26. Pertussis toxin prevents the induction of peripheral T cell anergy and enhances the T cell response to an encephalitogenic peptide of myelin basic protein
27. Analysis of adjuvant function by direct visualization of antigen presentation in vivo: Endotoxin promotes accumulation of antigen-bearing dendritic cells in the T cell areas of lymphoid tissue
28. Interleukin-12 is produced by macrophages in response to live or killed Bordetella pertussis and enhances the efficacy of an acellular pertussis vaccine by promoting induction of Th1 cells
29. Development of Th1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages
30. Interleukin-1 favours the in vitro development of type 2 T helper (Th2) human T cell clones
31. + T cells
32. Pertussis toxin inhibits migration of B and T lymphocytes into splenic white pulp cords
33. Interfferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production
34. CD69-induced monocyte apoptosis involves multiple nonredundant signaling pathways
35. Characterization of the signal transduction pathway activated in human monocytes and dendritic cells by MPIF-1, a specific ligand for CC chemokine receptor 1
36. Detection of G proteins in purified bovine brain myelin
37. D2 dopamine receptors stimulate mitogenesis through pertussis toxin-sensitive G proteins and Ras-involved ERK and SAP/ JNK pathways in rat C6-D2L glioma cells
38. Mechanisms of C5a and C3a complement fragment induced [Ca2+]i signaling in mouse microglia
39. The central cannabinoid receptor (CB1) mediates inhibition of nitric oxide production by rat microglial cells
40. In vitro and in vivo induction of nitric oxide by murine macro phages stimulated with Bordetella pertussis
41. CD40 engagement stimulates IL-12 p70 production by human microglial cells: Basis for Th1 polarization in the CNS
42. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation
43. CD40 activation boosts T cell immunity in vivo by enhancing T cell clonal expansion and delaying peripheral T cell deletion
44. The mucosal adjuvanticity of cholera toxin involves enhancement of co-stimulatory activity by selective up-regulation of B7.2 expression
45. Adjuvanticity of the cholera toxin A1-based gene fusion protein, CTA1- DD, is critically dependent on the ADP-ribosyltransferase and Ig- binding activity
46. Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4
47. Cholera toxin suppresses interleukin (IL)-12 production and IL-12 receptor beta1 and beta2 chain expression
48. Identification of a 43-kilodalton human T lymphocyte membrane protein as a receptor for pertussis toxin
49. Pertussis toxin triggers rapid second messenger production in human T lymphocytes
50. Pertussis toxin effects on T lymphocytes are mediated through CD3 and not by pertussis toxin catalyzed modification of a G protein
51. Pertussis toxin-sensitive G-proteins are not involved in activation of T-lymphocytes
52. Lipopolysaccharide interferes with the induction of peripheral T cell death