Gαq-containing G proteins regulate B cell selection and survival and are required to prevent B cell-dependent autoimmunity

Journal of Experimental Medicine

Volumn 207, Issue 8, 2010, Pages 1775-1789

  Misra, Ravi S ^a   Shi, Guixiu ^b   Moreno Garcia, Miguel E ^c   Thankappan, Anil ^d   Tighe, Michael ^d   Mousseau, Betty ^a   Kusser, Kim ^a   Becker Herman, Shirly ^c   Hudkins, Kelly L ^c   Dunn, Robert ^e   Kehry, Marilyn R ^e   Migone, Thi Sau ^f   Marshak Rothstein, Ann ^g   Simon, Melvin ^h   Randall, Troy D ^a   Alpers, Charles E ^c   Liggitt, Denny ^c   Rawlings, David J ^c   Lund, Frances E ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b SICHUAN UNIVERSITY   (China)

^c UNIVERSITY OF WASHINGTON   (United States)

^d TRUDEAU INSTITUTE   (United States)

^e BIOGEN   (United States)

^f Clinical Immunology   (United States)

^g UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^h UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B CELL ACTIVATING FACTOR RECEPTOR; B LYMPHOCYTE RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; PROTEIN KINASE B; ANTI-IGM; ANTIIDIOTYPIC ANTIBODY; ANTINUCLEAR ANTIBODY; AUTOANTIGEN; B CELL ACTIVATING FACTOR; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; IMMUNOGLOBULIN M ANTIBODY; LYMPHOCYTE ANTIGEN RECEPTOR; MONOCLONAL ANTIBODY; TNFSF13B PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CELL DEATH; CELL MATURATION; CELL SELECTION; CELL SURVIVAL; CONTROLLED STUDY; FEMALE; HOMEOSTASIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; ANEMIA; ANIMAL; ANTIGEN ANTIBODY COMPLEX; ARTHRITIS; AUTOIMMUNE DISEASE; BLOOD; C57BL MOUSE; CELL DIFFERENTIATION; CELL MOTION; CYTOLOGY; DRUG EFFECT; GENETICS; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; KIDNEY; LYMPHOCYTE ACTIVATION; METABOLISM; MORTALITY; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; RADIATION CHIMERA; SPLEEN; T LYMPHOCYTE; TRANSPLANTATION;

ANEMIA; ANIMALS; ANTIBODIES, ANTI-IDIOTYPIC; ANTIBODIES, ANTINUCLEAR; ANTIBODIES, MONOCLONAL; ANTIGEN-ANTIBODY COMPLEX; ARTHRITIS; AUTOANTIGENS; AUTOIMMUNE DISEASES; AUTOIMMUNITY; B-CELL ACTIVATING FACTOR; B-LYMPHOCYTE SUBSETS; B-LYMPHOCYTES; CELL DIFFERENTIATION; CELL MOVEMENT; CELL SURVIVAL; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HETEROTRIMERIC GTP-BINDING PROTEINS; HOMEOSTASIS; IMMUNE TOLERANCE; KIDNEY; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PROTO-ONCOGENE PROTEINS C-AKT; RADIATION CHIMERA; RECEPTORS, ANTIGEN, B-CELL; SPLEEN; T-LYMPHOCYTES;

EID: 77955353185     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20092735     Document Type: Article

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