Divergent requirement for Gαs and cAMP in the differentiation and inflammatory profile of distinct mouse Th subsets

Journal of Clinical Investigation

Volumn 122, Issue 3, 2012, Pages 963-973

  Li, Xiangli ^a   Murray, Fiona ^a   Koide, Naoki ^a   Goldstone, Jonathan ^a   Dann, Sara M ^a,b   Chen, Jianzhong ^a   Bertin, Samuel ^a   Fu, Guo ^c   Weinstein, Lee S ^d   Chen, Min ^d   Corr, Maripat ^a   Eckmann, Lars ^a   Insel, Paul A ^a   Raz, Eyal ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; COLITIS; CONTROLLED STUDY; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; TH1 CELL; TH17 CELL; TH2 CELL;

ANIMALS; CALCIUM; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; INFLAMMATION; INTERFERON-GAMMA; INTERLEUKIN-17; MICE; MICE, INBRED C57BL; MODELS, BIOLOGICAL; PHENOTYPE; T-LYMPHOCYTES; TH17 CELLS;

EID: 84863271877     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI59097     Document Type: Article

References (37)

1. Weinstein LS, Liu J, Sakamoto A, Xie T, Chen M. Minireview: GNAS: normal and abnormal functions. Endocrinology. 2004;145(12):5459-5464. (Pubitemid 39564584)
2. Bender AT, Beavo JA. Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use. Pharmacol Rev. 2006;58(3):488-520. (Pubitemid 44394910)
3. Mosenden R, Taskén K. Cyclic AMP-mediated immune regulation - overview of mechanisms of action in T cells. Cell Signal. 2011;23(6):1009-1016.
4. Yao C, et al. Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion. Nat Med. 2009;15(6):633-640.
5. + T cells. Eur J Immunol. 2009;39(5):1301-1312.
6. Boniface K, et al. Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling. J Exp Med. 2009;206(3):535-548.
7. Datta SK, et al. Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax. Proc Natl Acad Sci U S A. 2010;107(23):10638-10643.
8. Chen M, et al. Increased glucose tolerance and reduced adiposity in the absence of fasting hypoglycemia in mice with liver-specific Gs alpha deficiency. J Clin Invest. 2005;115(11):3217-3227. (Pubitemid 41567586)
9. Darf ler FJ, Mahan LC, Koachman AM, Insel PA. Stimulation of forskolin of intact S49 lymphoma cells involves the nucleotide regulatory protein of adenylate cyclase. J Biol Chem. 1982;257(20):11901-11907.
10. Brand S. Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease. Gut. 2009;58(8):1152-1167.
11. Liu ZJ, Yadav PK, Su JL, Wang JS, Fei K. Potential role of Th17 cells in the pathogenesis of inflammatory bowel disease. World J Gastroenterol. 2009;15(46):5784-5788.
12. Ma J, McCarl CA, Khalil S, Lüthy K, Feske S. T-cell-specific deletion of STIM1 and STIM2 protects mice from EAE by impairing the effector functions of Th1 and Th17 cells. Eur J Immunol. 2010;40(11):3028-3042.
13. Ghoreschi K, et al. Generation of pathogenic T(H)17 cells in the absence of TGF-beta signalling. Nature. 2010;467(7318):967-971.
14. Zhou L, Littman DR. Transcriptional regulatory networks in Th17 cell differentiation. Curr Opin Immunol. 2009;21(2):146-152.
15. Ivanov II, et al. The orphan nuclear receptor ROR-gammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell. 2006;126(6):1121-1133. (Pubitemid 44380299)
16. Durant L, et al. Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis. Immunity. 2010;32(5):605-615.
17. Yang XO, et al. STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J Biol Chem. 2007;282(13):9358-9363. (Pubitemid 47104613)
18. + entry through ORAI1 is critical for T cell-mediated autoimmunity and allograft rejection. J Immunol. 2010;185(10):5845-5858.
19. Matza D, Flavell RA. Roles of Ca(v) channels and AHNAK1 in T cells: the beauty and the beast. Immunol Rev. 2009;231(1):257-264.
20. Kesten KS, Reuter NS, Swisher JD. Diltiazem: the latest calcium-channel blocker. Dimens Crit Care Nurs. 1984;3(3):154-160.
21. Conche C, Boulla G, Trautmann A, Randriamampita C. T cell adhesion primes antigen receptorinduced calcium responses through a transient rise in adenosine 3′,5′-cyclic monophosphate. Immunity. 2009;30(1):33-43.
22. + T cell lineage differentiation. Immunity. 2009;30(5):646-655.
23. Adams GB, et al. Haematopoietic stem cells depend on Galpha(s)-mediated signalling to engraft bone marrow. Nature. 2009;459(7243):103-107.
24. Weinstein LS. Gs alpha knockouts in mice and man. Rinsho Byori. 1999;47(5):425-429.
25. Matza D, et al. A scaffold protein, AHNAK1, is required for calcium signaling during T cell activation. Immunity. 2008;28(1):64-74.
26. Oh-hora M. Calcium signaling in the development and function of T-lineage cells. Immunol Rev. 2009;231(1):210-224.
27. Hell JW. Beta-adrenergic regulation of the L-type Ca2+ channel Ca(V)1.2 by PKA rekindles excitement. Sci Signal. 2010;3(141):pe33.
28. + channels. Evidence for direct regulation independent of phosphorylation by cAMP-dependent protein kinase or stimulation by a dihydropyridine agonist. J Biol Chem. 1988;263(20):9887-9895.
29. Mattera R, et al. Splice variants of the alpha subunit of the G protein Gs activate both adenylyl cyclase and calcium channels. Science. 1989;243(4892):804-807. (Pubitemid 19062636)
30. Nair BG, Parikh B, Milligan G, Patel TB. Gs alpha mediates epidermal growth factor-elicited stimulation of rat cardiac adenylate cyclase. J Biol Chem. 1990;265(34):21317-21322. (Pubitemid 120014155)
31. Poppleton H, Sun H, Fulgham D, Bertics P, Patel TB. Activation of Gsalpha by the epidermal growth factor receptor involves phosphorylation. J Biol Chem. 1996;271(12):6947-6951.
32. Sun H, et al. The juxtamembrane, cytosolic region of the epidermal growth factor receptor is involved in association with alpha-subunit of Gs. J Biol Chem. 1997;272(9):5413-5420. (Pubitemid 27102359)
33. Weber KS, Miller MJ, Allen PM. Th17 cells exhibit a distinct calcium profile from Th1 and Th2 cells and have Th1-like motility and NF-AT nuclear localization. J Immunol. 2008;180(3):1442-1450.
34. Zhou L, et al. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol. 2007;8(9):967-974. (Pubitemid 47300011)
35. Murray F, et al. Expression and activity of cAMP phosphodiesterase isoforms in pulmonary artery smooth muscle cells from patients with pulmonary hypertension: role for PDE1. Am J Physiol Lung Cell Mol Physiol. 2007;292(1):L294-L303. (Pubitemid 46103454)
36. Fu G, Gascoigne NR. Multiplexed labeling of samples with cell tracking dyes facilitates rapid and accurate internally controlled calcium flux measurement by flow cytometry. J Immunol Methods. 2009;350(1-2):194-199.
37. + T cells regulates TCR activation and experimental colitis in mice. J Clin Invest. 2010;120(2):570-581.