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Volumn 6, Issue 9, 2011, Pages

CD4 +FoxP3 + regulatory T cells from Gαi2 -/- mice are functionally active in vitro, but do not prevent colitis

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; INTERLEUKIN 4; INTERLEUKIN 6; TRANSCRIPTION FACTOR FOXP3; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; GNAI2 PROTEIN, MOUSE; HERMES ANTIGEN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; L SELECTIN;

EID: 80053062763     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0025073     Document Type: Article
Times cited : (7)

References (39)
  • 1
    • 0031066597 scopus 로고    scopus 로고
    • G(alpha)i2-deficient mice with colitis exhibit a local increase in memory CD4+ T cells and proinflammatory Th1-type cytokines
    • Hornquist CE, Lu X, Rogers-Fani PM, Rudolph U, Shappell S, et al. (1997) G(alpha)i2-deficient mice with colitis exhibit a local increase in memory CD4+ T cells and proinflammatory Th1-type cytokines. J Immunol 158: 1068-1077.
    • (1997) J Immunol , vol.158 , pp. 1068-1077
    • Hornquist, C.E.1    Lu, X.2    Rogers-Fani, P.M.3    Rudolph, U.4    Shappell, S.5
  • 2
    • 0036717877 scopus 로고    scopus 로고
    • Regression of Peyer's patches in G alpha i2 deficient mice prior to colitis is associated with reduced expression of Bcl-2 and increased apoptosis
    • Ohman L, Franzen L, Rudolph U, Birnbaumer L, Hornquist EH, (2002) Regression of Peyer's patches in G alpha i2 deficient mice prior to colitis is associated with reduced expression of Bcl-2 and increased apoptosis. Gut 51: 392-397.
    • (2002) Gut , vol.51 , pp. 392-397
    • Ohman, L.1    Franzen, L.2    Rudolph, U.3    Birnbaumer, L.4    Hornquist, E.H.5
  • 3
    • 0005220480 scopus 로고    scopus 로고
    • Immune activation in the intestinal mucosa before the onset of colitis in Galphai2-deficient mice
    • Ohman L, Franzen L, Rudolph U, Harriman GR, Hultgren Hornquist E, (2000) Immune activation in the intestinal mucosa before the onset of colitis in Galphai2-deficient mice. Scand J Immunol 52: 80-90.
    • (2000) Scand J Immunol , vol.52 , pp. 80-90
    • Ohman, L.1    Franzen, L.2    Rudolph, U.3    Harriman, G.R.4    Hultgren Hornquist, E.5
  • 4
    • 0037441998 scopus 로고    scopus 로고
    • B cell developmental requirement for the G alpha i2 gene
    • Dalwadi H, Wei B, Schrage M, Spicher K, Su TT, et al. (2003) B cell developmental requirement for the G alpha i2 gene. J Immunol 170: 1707-1715.
    • (2003) J Immunol , vol.170 , pp. 1707-1715
    • Dalwadi, H.1    Wei, B.2    Schrage, M.3    Spicher, K.4    Su, T.T.5
  • 5
    • 0032555295 scopus 로고    scopus 로고
    • Involvement of Galphai2 in the maintenance and biogenesis of epithelial cell tight junctions
    • Saha C, Nigam SK, Denker BM, (1998) Involvement of Galphai2 in the maintenance and biogenesis of epithelial cell tight junctions. J Biol Chem 273: 21629-21633.
    • (1998) J Biol Chem , vol.273 , pp. 21629-21633
    • Saha, C.1    Nigam, S.K.2    Denker, B.M.3
  • 6
    • 0034193331 scopus 로고    scopus 로고
    • Primary role for Gi protein signaling in the regulation of interleukin 12 production and the induction of T helper cell type 1 responses
    • He J, Gurunathan S, Iwasaki A, Ash-Shaheed B, Kelsall BL, (2000) Primary role for Gi protein signaling in the regulation of interleukin 12 production and the induction of T helper cell type 1 responses. J Exp Med 191: 1605-1610.
    • (2000) J Exp Med , vol.191 , pp. 1605-1610
    • He, J.1    Gurunathan, S.2    Iwasaki, A.3    Ash-Shaheed, B.4    Kelsall, B.L.5
  • 7
    • 34548598744 scopus 로고    scopus 로고
    • Aberrant T-cell ontogeny and defective thymocyte and colonic T-cell chemotactic migration in colitis-prone Galphai2-deficient mice
    • Elgbratt K, Bjursten M, Willen R, Bland PW, Hornquist EH, (2007) Aberrant T-cell ontogeny and defective thymocyte and colonic T-cell chemotactic migration in colitis-prone Galphai2-deficient mice. Immunology 122: 199-209.
    • (2007) Immunology , vol.122 , pp. 199-209
    • Elgbratt, K.1    Bjursten, M.2    Willen, R.3    Bland, P.W.4    Hornquist, E.H.5
  • 8
    • 0242636413 scopus 로고    scopus 로고
    • TCR-mediated hyper-responsiveness of autoimmune Galphai2(-/-) mice is an intrinsic naive CD4(+) T cell disorder selective for the Galphai2 subunit
    • Huang TT, Zong Y, Dalwadi H, Chung C, Miceli MC, et al. (2003) TCR-mediated hyper-responsiveness of autoimmune Galphai2(-/-) mice is an intrinsic naive CD4(+) T cell disorder selective for the Galphai2 subunit. Int Immunol 15: 1359-1367.
    • (2003) Int Immunol , vol.15 , pp. 1359-1367
    • Huang, T.T.1    Zong, Y.2    Dalwadi, H.3    Chung, C.4    Miceli, M.C.5
  • 9
    • 33644915004 scopus 로고    scopus 로고
    • Serum interleukin-1 receptor antagonist is an early indicator of colitis onset in Galphai2-deficient mice
    • Hultgren OH, Berglund M, Bjursten M, Hultgren Hornquist E, (2006) Serum interleukin-1 receptor antagonist is an early indicator of colitis onset in Galphai2-deficient mice. World J Gastroenterol 12: 621-624.
    • (2006) World J Gastroenterol , vol.12 , pp. 621-624
    • Hultgren, O.H.1    Berglund, M.2    Bjursten, M.3    Hultgren Hornquist, E.4
  • 11
    • 0034622276 scopus 로고    scopus 로고
    • Science, medicine, and the future: Tolerance and autoimmunity
    • Mackay IR, (2000) Science, medicine, and the future: Tolerance and autoimmunity. BMJ 321: 93-96.
    • (2000) BMJ , vol.321 , pp. 93-96
    • Mackay, I.R.1
  • 12
    • 0030704726 scopus 로고    scopus 로고
    • A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
    • Groux H, O'Garra A, Bigler M, Rouleau M, Antonenko S, et al. (1997) A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389: 737-742.
    • (1997) Nature , vol.389 , pp. 737-742
    • Groux, H.1    O'Garra, A.2    Bigler, M.3    Rouleau, M.4    Antonenko, S.5
  • 13
    • 0035186416 scopus 로고    scopus 로고
    • Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells
    • Weiner HL, (2001) Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells. Immunol Rev 182: 207-214.
    • (2001) Immunol Rev , vol.182 , pp. 207-214
    • Weiner, H.L.1
  • 16
    • 0037385314 scopus 로고    scopus 로고
    • An essential role for Scurfin in CD4+CD25+ T regulatory cells
    • Khattri R, Cox T, Yasayko SA, Ramsdell F, (2003) An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol 4: 337-342.
    • (2003) Nat Immunol , vol.4 , pp. 337-342
    • Khattri, R.1    Cox, T.2    Yasayko, S.A.3    Ramsdell, F.4
  • 17
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S, Nomura T, Sakaguchi S, (2003) Control of regulatory T cell development by the transcription factor Foxp3. Science 299: 1057-1061.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 18
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • Fontenot JD, Gavin MA, Rudensky AY, (2003) Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 4: 330-336.
    • (2003) Nat Immunol , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 19
    • 0038434099 scopus 로고    scopus 로고
    • Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis
    • Gambineri E, Torgerson TR, Ochs HD, (2003) Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis. Curr Opin Rheumatol 15: 430-435.
    • (2003) Curr Opin Rheumatol , vol.15 , pp. 430-435
    • Gambineri, E.1    Torgerson, T.R.2    Ochs, H.D.3
  • 20
    • 0035180067 scopus 로고    scopus 로고
    • Control of intestinal inflammation by regulatory T cells
    • Singh B, Read S, Asseman C, Malmstrom V, Mottet C, et al. (2001) Control of intestinal inflammation by regulatory T cells. Immunol Rev 182: 190-200.
    • (2001) Immunol Rev , vol.182 , pp. 190-200
    • Singh, B.1    Read, S.2    Asseman, C.3    Malmstrom, V.4    Mottet, C.5
  • 21
    • 65749103989 scopus 로고    scopus 로고
    • Regulatory lymphocytes and intestinal inflammation
    • Izcue A, Coombes JL, Powrie F, (2009) Regulatory lymphocytes and intestinal inflammation. Annu Rev Immunol 27: 313-338.
    • (2009) Annu Rev Immunol , vol.27 , pp. 313-338
    • Izcue, A.1    Coombes, J.L.2    Powrie, F.3
  • 22
    • 33745279455 scopus 로고    scopus 로고
    • Magnetic resonance imaging of experimental mouse colitis and association with inflammatory activity
    • Larsson AE, Melgar S, Rehnstrom E, Michaelsson E, Svensson L, et al. (2006) Magnetic resonance imaging of experimental mouse colitis and association with inflammatory activity. Inflamm Bowel Dis 12: 478-485.
    • (2006) Inflamm Bowel Dis , vol.12 , pp. 478-485
    • Larsson, A.E.1    Melgar, S.2    Rehnstrom, E.3    Michaelsson, E.4    Svensson, L.5
  • 23
    • 0037243827 scopus 로고    scopus 로고
    • CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms
    • Maloy KJ, Salaun L, Cahill R, Dougan G, Saunders NJ, et al. (2003) CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. J Exp Med 197: 111-119.
    • (2003) J Exp Med , vol.197 , pp. 111-119
    • Maloy, K.J.1    Salaun, L.2    Cahill, R.3    Dougan, G.4    Saunders, N.J.5
  • 24
    • 14944385390 scopus 로고    scopus 로고
    • Accelerated transition from the double-positive to single-positive thymocytes in G alpha i2-deficient mice
    • Zhang Y, Finegold MJ, Jin Y, Wu MX, (2005) Accelerated transition from the double-positive to single-positive thymocytes in G alpha i2-deficient mice. Int Immunol 17: 233-243.
    • (2005) Int Immunol , vol.17 , pp. 233-243
    • Zhang, Y.1    Finegold, M.J.2    Jin, Y.3    Wu, M.X.4
  • 25
    • 0027944111 scopus 로고
    • Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the alpha E beta 7 integrin
    • Cepek KL, Shaw SK, Parker CM, Russell GJ, Morrow JS, et al. (1994) Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the alpha E beta 7 integrin. Nature 372: 190-193.
    • (1994) Nature , vol.372 , pp. 190-193
    • Cepek, K.L.1    Shaw, S.K.2    Parker, C.M.3    Russell, G.J.4    Morrow, J.S.5
  • 26
    • 0028954002 scopus 로고
    • Recognition of E-cadherin on epithelial cells by the mucosal T cell integrin alpha M290 beta 7 (alpha E beta 7)
    • Karecla PI, Bowden SJ, Green SJ, Kilshaw PJ, (1995) Recognition of E-cadherin on epithelial cells by the mucosal T cell integrin alpha M290 beta 7 (alpha E beta 7). Eur J Immunol 25: 852-856.
    • (1995) Eur J Immunol , vol.25 , pp. 852-856
    • Karecla, P.I.1    Bowden, S.J.2    Green, S.J.3    Kilshaw, P.J.4
  • 27
    • 77956475716 scopus 로고    scopus 로고
    • Increased CD127 expression on activated FOXP3+CD4+ regulatory T cells
    • Simonetta F, Chiali A, Cordier C, Urrutia A, Girault I, et al. (2010) Increased CD127 expression on activated FOXP3+CD4+ regulatory T cells. Eur J Immunol 40: 2528-2538.
    • (2010) Eur J Immunol , vol.40 , pp. 2528-2538
    • Simonetta, F.1    Chiali, A.2    Cordier, C.3    Urrutia, A.4    Girault, I.5
  • 28
    • 2442637772 scopus 로고    scopus 로고
    • Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function
    • Thornton AM, Donovan EE, Piccirillo CA, Shevach EM, (2004) Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function. J Immunol 172: 6519-6523.
    • (2004) J Immunol , vol.172 , pp. 6519-6523
    • Thornton, A.M.1    Donovan, E.E.2    Piccirillo, C.A.3    Shevach, E.M.4
  • 30
    • 33744752786 scopus 로고    scopus 로고
    • Foxp3-expressing CD103+ regulatory T cells accumulate in dendritic cell aggregates of the colonic mucosa in murine transfer colitis
    • Leithauser F, Meinhardt-Krajina T, Fink K, Wotschke B, Moller P, et al. (2006) Foxp3-expressing CD103+ regulatory T cells accumulate in dendritic cell aggregates of the colonic mucosa in murine transfer colitis. Am J Pathol 168: 1898-1909.
    • (2006) Am J Pathol , vol.168 , pp. 1898-1909
    • Leithauser, F.1    Meinhardt-Krajina, T.2    Fink, K.3    Wotschke, B.4    Moller, P.5
  • 32
    • 20444434616 scopus 로고    scopus 로고
    • Peripheral and intestinal regulatory CD4+ CD25(high) T cells in inflammatory bowel disease
    • Maul J, Loddenkemper C, Mundt P, Berg E, Giese T, et al. (2005) Peripheral and intestinal regulatory CD4+ CD25(high) T cells in inflammatory bowel disease. Gastroenterology 128: 1868-1878.
    • (2005) Gastroenterology , vol.128 , pp. 1868-1878
    • Maul, J.1    Loddenkemper, C.2    Mundt, P.3    Berg, E.4    Giese, T.5
  • 33
    • 0036791004 scopus 로고    scopus 로고
    • Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells
    • Lehmann J, Huehn J, de la Rosa M, Maszyna F, Kretschmer U, et al. (2002) Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells. Proc Natl Acad Sci U S A 99: 13031-13036.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 13031-13036
    • Lehmann, J.1    Huehn, J.2    de la Rosa, M.3    Maszyna, F.4    Kretschmer, U.5
  • 34
    • 27144495833 scopus 로고    scopus 로고
    • How do CD4+CD25+ regulatory T cells control autoimmunity?
    • Bluestone JA, Tang Q, (2005) How do CD4+CD25+ regulatory T cells control autoimmunity? Curr Opin Immunol 17: 638-642.
    • (2005) Curr Opin Immunol , vol.17 , pp. 638-642
    • Bluestone, J.A.1    Tang, Q.2
  • 35
    • 70349241839 scopus 로고    scopus 로고
    • IL-6 signaling in psoriasis prevents immune suppression by regulatory T cells
    • Goodman WA, Levine AD, Massari JV, Sugiyama H, McCormick TS, et al. (2009) IL-6 signaling in psoriasis prevents immune suppression by regulatory T cells. J Immunol 183: 3170-3176.
    • (2009) J Immunol , vol.183 , pp. 3170-3176
    • Goodman, W.A.1    Levine, A.D.2    Massari, J.V.3    Sugiyama, H.4    McCormick, T.S.5
  • 36
    • 0037436119 scopus 로고    scopus 로고
    • Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
    • Pasare C, Medzhitov R, (2003) Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 299: 1033-1036.
    • (2003) Science , vol.299 , pp. 1033-1036
    • Pasare, C.1    Medzhitov, R.2
  • 37
    • 0034193039 scopus 로고    scopus 로고
    • IL-6 is required for the development of Th1 cell-mediated murine colitis
    • Yamamoto M, Yoshizaki K, Kishimoto T, Ito H, (2000) IL-6 is required for the development of Th1 cell-mediated murine colitis. J Immunol 164: 4878-4882.
    • (2000) J Immunol , vol.164 , pp. 4878-4882
    • Yamamoto, M.1    Yoshizaki, K.2    Kishimoto, T.3    Ito, H.4
  • 38
    • 0035910753 scopus 로고    scopus 로고
    • CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation
    • Suzuki A, Hanada T, Mitsuyama K, Yoshida T, Kamizono S, et al. (2001) CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation. J Exp Med 193: 471-481.
    • (2001) J Exp Med , vol.193 , pp. 471-481
    • Suzuki, A.1    Hanada, T.2    Mitsuyama, K.3    Yoshida, T.4    Kamizono, S.5
  • 39
    • 55549084247 scopus 로고    scopus 로고
    • Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells
    • Hill JA, Hall JA, Sun CM, Cai Q, Ghyselinck N, et al. (2008) Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells. Immunity 29: 758-770.
    • (2008) Immunity , vol.29 , pp. 758-770
    • Hill, J.A.1    Hall, J.A.2    Sun, C.M.3    Cai, Q.4    Ghyselinck, N.5


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