Pesticide exposure and neurodevelopmental outcomes: Review of the epidemiologic and animal studies

Journal of Toxicology and Environmental Health - Part B: Critical Reviews

Volumn 16, Issue 3-4, 2013, Pages 127-283

  Burns, Carol J ^a   McIntosh, Laura J ^b   Mink, Pamela J ^c   Jurek, Anne M ^c   Li, Abby A ^d  

^a DOW CHEMICAL COMPANY   (United States)

^b SafetyTox   (United States)

^c Allina Health   (United States)

^d EXPONENT INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARYLDIALKYLPHOSPHATASE; ORGANOCHLORINE INSECTICIDE; ORGANOPHOSPHATE INSECTICIDE; ORGANOPHOSPHATE PESTICIDE;

ARTICLE; BAYLEY SCALES OF INFANT DEVELOPMENT; BRAZELTON NEONATAL BEHAVIORAL ASSESSMENT SCALE; CHILD BEHAVIOR CHECKLIST; COGNITION; CONTINUOUS PERFORMANCE TEST; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; EPIDEMIOLOGY; FAGAN TEST OF INFANT INTELLIGENCE; GENOTYPE; HEAD CIRCUMFERENCE; HUMAN; MCCARTHY SCALES OF CHILDREN'S ABILITIES; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; NEPSY A DEVELOPMENTAL NEUROPSYCHOLOGICAL ASSESSMENT; NONHUMAN; OUTCOME ASSESSMENT; OUTCOMES RESEARCH; PERFORMANCE; PREGNANCY; SYSTEMATIC REVIEW; WECHSLER INTELLIGENCE SCALE;

ANIMALIA; MAMMALIA;

EID: 84879617224     PISSN: 10937404     EISSN: 15216950     Source Type: Journal    
DOI: 10.1080/10937404.2013.783383     Document Type: Article

References (389)

1. Abdel-Rahman, A., Dechkovskaia, A., Mehta-Simmons, H., Guan, X., Khan,W., and Abou-Donia, M. 2003. Increased expression of glial fibrillary acidic protein in cerebellum and hippocampus: Differential effects on neonatal brain regional acetylcholinesterase following maternal exposure to combined chlorpyrifos and nicotine. J. Toxicol. Environ. Health A 66: 2047-2066. (Pubitemid 37357671)
2. Abdel-Rahman, A., Dechkovskaia, A. M., Mehta-Simmons, H., Sutton, J. M., Guan, X., Khan, W. A., and Abou-Donia, M. B. 2004. Maternal exposure to nicotine and chlorpyrifos, alone and in combination, leads to persistently elevated expression of glial fibrillary acidic protein in the cerebellum of the offspring in late puberty. Arch. Toxicol. 78: 467-476. (Pubitemid 39222684)
3. Abou-Donia, M. B., Goldstein, L. B., Bullman, S., Tu, T., Khan, W. A., Dechkovskaia, A. M., and Abdel-Rahman, A. A. 2008. Imidacloprid induces neurobehavioral deficits and increases expression of glial fibrillary acidic protein in the motor cortex and hippocampus in offspring rats following in utero exposure. J. Toxicol. Environ. Health A 71: 119-130. (Pubitemid 350273972)
4. Abou-Donia, M. B., Khan, W. A., Dechkovskaia, A. M., Goldstein, L. B., Bullman, S. L., and Abdel-Rahman, A. 2006. In utero exposure to nicotine and chlorpyrifos alone, and in combination produces persistent sensorimotor deficits and Purkinje neuron loss in the cerebellum of adult offspring rats. Arch. Toxicol. 80: 620-631. (Pubitemid 44214529)
5. Achenbach, T., and Rescorla, L. 2000. Manual for the ASEBA preschool forms and profiles. Burlington, VT: University of Vermont, Research Center for Children, Youth, and Families.
6. Adams, J. 2010. Editor's note by editor-in-chief. Neurotoxicol. Teratol. 32: iii.
7. Agency for Toxic Substances and Disease Registry. 2002. Toxicological profile for DDT, DDE, and DDD. http://www.atsdr.cdc. gov/ToxProfiles/tp.asp?id= 81&tid=20
8. Agency for Toxic Substances and Disease Registry. 2003. Toxicological profile for pyrethrins and pyrethroids. http://www.atsdr. cdc.gov/ToxProfiles/ tp.asp?id=787&tid=153
9. Ahlbom, J., Fredriksson, A., and Eriksson, P. 1994. Neonatal exposure to a type-I pyrethroid (bioallethrin) induces doseresponse changes in brain muscarinic receptors and behaviour in neonatal and adult mice. Brain Res. 645: 318-324.
10. Al-Hachim, G. M., and Al-Baker, A. 1973. Effects of chlordane on conditioned avoidance response, brain seizure threshold and open-field performance of prenatally-treated mice. Br. J. Pharmacol. 49: 311-315.
11. Al-Hachim, G. M., and Fink, G. B. 1968a. Effect of DDT or parathion on openfield behavior of offspring from DDT-or parathion-treated mothers. Psychol. Rep. 22: 1193-1196.
12. Al-Hachim, G. M., and Fink, G. B. 1968b. Effect of DDT or parathion on the minimal electroshock seizure threshold of offspring from DDT or parathiontreated mothers. Psychopharmacologia 13: 408-412.
13. Al-Hachim, G. M., and Fink, G. B. 1968c. Effect of DDT or paration on condition avoidance response of offspring from DDT or paration treated mothers. Psychopharmacologia 12: 424-427.
14. Aldridge, J. E., Levin, E. D., Seidler, F. J., and Slotkin, T. A. 2005a. Developmental exposure of rats to chlorpyrifos leads to behavioral alterations in adulthood, involving serotonergic mechanisms and resembling animal models of depression. Environ. Health Perspect. 113: 527-531. (Pubitemid 40711339)
15. Aldridge, J. E., Meyer, A., Seidler, F. J., and Slotkin, T. A. 2005b. Alterations in central nervous system serotonergic and dopaminergic synaptic activity in adulthood after prenatal or neonatal chlorpyrifos exposure. Environ. Health Perspect. 113: 1027-1031. (Pubitemid 41149633)
16. Aldridge, J. E., Meyer, A., Seidler, F. J., and Slotkin, T. A. 2005c. Developmental exposure to terbutaline and chlorpyrifos: pharmacotherapy of preterm labor and an environmental neurotoxicant converge on serotonergic systems in neonatal rat brain regions. Toxicol. Appl. Pharmacol. 203: 132-144. (Pubitemid 40248369)
17. Aldridge, J. E., Seidler, F. J., Meyer, A., Thillai, I., and Slotkin, T. A. 2003. Serotonergic systems targeted by developmental exposure to chlorpyrifos: Effects during different critical periods. Environ. Health Perspect. 111: 1736-1743. (Pubitemid 37407933)
18. Aldridge, J. E., Seidler, F. J., and Slotkin, T. A. 2004. Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: Critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling. Environ. Health Perspect. 112: 148-155. (Pubitemid 38195822)
19. American Psychiatric Association. 2000. Diagnostic and statistical manual of mental disorders, 4th ed., text rev. Washington, DC: American Psychiatric Association.
20. Amira, M. S., Hamadi, F., Kamel, J., Khansa, C., Feriel, E., Fadhel, G. & Najiba, A. 2005. Impact of chlorpyrifos on cerebrum and cerebellum maturity in suckling rats. Toxicol Env Chem, 87: 551-558. (Pubitemid 43075186)
21. Arcury, T. A., Quandt, S. A., Barr, D. B., Hoppin, J. A., Mccauley, L., Grzywacz, J. G., and Robson, M. G. 2006. Farmworker exposure to pesticides: Methodologic issuesfor the collection of comparable data. Environ. Health Perspect. 114: 923-928. (Pubitemid 43871744)
22. Ashry, K. M., Abu-Qare, A. W., Saleem, F. R., Hussein, Y. A., Hamza, S. M., Kishk, A. M., and Abou-Donia, M. B. 2002. Inhibition and recovery of maternal and fetal cholinesterase enzymes following a single oral dose of chlorpyrifos in rats. Arch. Toxicol. 76: 30-39. (Pubitemid 34209102)
23. Astroff, A. B., Freshwater, K. J., and Eigenberg, D. A. 1998. Comparative organophosphateinduced effects observed in adult and neonatal Sprague-Dawley rats during the conduct of multigeneration toxicity studies. Reprod. Toxicol. 12: 619-645. (Pubitemid 29122164)
24. Astroff, A. B., and Young, A. D. 1998. The relationship between maternal and fetal effects following maternal organophosphate exposure during gestation in the rat. Toxicol. Ind. Health 14: 869-889. (Pubitemid 29030782)
25. Atterberry, T. T., Burnett, W. T., and Chambers, J. E. 1997. Age-related differences in parathion and chlorpyrifos toxicity in male rats: Target and nontarget esterase sensitivity and cytochrome P450-mediated metabolism. Toxicol. Appl. Pharmacol. 147: 411-418. (Pubitemid 28062758)
26. Axelstad, M., Boberg, J., Nellemann, C., Kiersgaard, M., Jacobsen, P. R., Christiansen, S., Hougaard, K. S., and Hass, U. 2011. Exposure to the widely used fungicide mancozeb causes thyroid hormone disruption in rat dams but no behavioral effects in the offspring. Toxicol. Sci. 120: 439-446.
27. Barlow, B. K., Richfield, E. K., Cory-Slechta, D. A., and Thiruchelvam, M. 2004. A fetal risk factor for Parkinson's disease. Dev. Neurosci. 26: 11-23. (Pubitemid 39451878)
28. Barr, D. B., Allen, R., Olsson, A. O., Bravo, R., Caltabiano, L. M., Montesano, A., Nguyen, J., Udunka, S., Walden, D., Walker, R. D., Weerasekera, G., Whitehead, R. D., Jr., Schober, S. E., and Needham, L. L. 2005. Concentrations of selective metabolites of rganophosphorus pesticides in the United States population. Environ. Res. 99: 314-326. (Pubitemid 41679345)
29. Barr, D. B., Ananth, C. V., Yan, X., Lashley, S., Smulian, J. C., Ledoux, T. A., Hore, P., and Robson, M. G. 2010. Pesticide concentrations in maternal and umbilical cord sera and their relation to birth outcomes in a population of pregnant women and newborns in New Jersey. Sci. Total Environ. 408: 790-795.
30. Barr, D. B., and Angerer, J. 2006. Potential uses of biomonitoring data: A case study using the organophosphorus pesticides chlorpyrifos and malathion. Environ. Health Perspect. 114: 1763-1769. (Pubitemid 44718284)
31. Barr, D. B., Bravo, R., Weerasekera, G., Caltabiano, L. M., Whitehead, R. D., Jr., Olsson, A. O., Caudill, S. P., Schober, S. E., Pirkle, J. L., Sampson, E. J., Jackson, R. J., and Needham, L. L. 2004. Concentrations of dialkyl phosphate metabolites of organophosphorus pesticides in the U.S. population. Environ. Health Perspect. 112: 186-200. (Pubitemid 38195827)
32. Bellinger, D. C. 2004. Assessing environmental neurotoxicant exposures and child neurobehavior: confounded by confounding? Epidemiology 15: 383-384. (Pubitemid 40416924)
33. Belloni, V., Dessi-Fulgheri, F., Zaccaroni, M., Di Consiglio, E., De Angelis, G., Testai, E., Santochirico, M., Alleva, E., and Santucci, D. 2011. Early exposure to low doses of atrazine affects behavior in juvenile and adult CD1 mice. Toxicology 279: 19-26.
34. Benasich, A. A., and Bejar, I. I. 1992. The Fagan test of inteligence: A critical review. J. Appl. Dev. Psychol. 13: 153-171.
35. Berge, G. N., Fonnum, F., and Brodal, P. 1987a. Neurotoxic effects of prenatal trichlorfon administration in pigs. Acta Vet. Scand. 28: 321-332.
36. Berge, G. N., Fonnum, F., Soli, N. E., and Sognen, E. 1987b. Neurotoxicological examination of the piglet brain after prenatal and postnatal exposure to trichlorfon. Acta Vet. Scand. 28: 313-320.
37. Berkowitz, G. S., Obel, J., Deych, E., Lapinski, R., Godbold, J., Liu, Z., Landrigan, P. J., and Wolff, M. S. 2003. Exposure to indoor pesticides during pregnancy in a multiethnic, urban cohort. Environ. Health Perspect. 111: 79-84.
38. Berkowitz, G. S., Wetmur, J. G., Birman-Deych, E., Obel, J., Lapinski, R. H., Godbold, J. H., Holzman, I. R., and Wolff, M. S. 2004. In utero pesticide exposure, maternal paraoxonase activity, and head circumference. Environ. Health Perspect. 112: 388-391. (Pubitemid 38351405)
39. Betancourt, A. M., and Carr, R. L. 2004. The effect of chlorpyrifos and chlorpyrifos-oxon on brain cholinesterase, muscarinic receptor binding, and neurotrophin levels in rats following early postnatal exposure. Toxicol. Sci. 77: 63-71. (Pubitemid 38128646)
40. Betancourt, A. M., Filipov, N. M., and Carr, R. L. 2007. Alteration of neurotrophins in the hippocampus and cerebral cortex of young rats exposed to chlorpyrifos and methyl parathion. Toxicol. Sci. 100: 445-455. (Pubitemid 350131371)
41. Billauer-Haimovitch, H., Slotkin, T. A., Dotan, S., Langford, R., Pinkas, A., and Yanai, J. 2009. Reversal of chlorpyrifos neurobehavioral teratogenicity in mice by nicotine administration and neural stem cell transplantation. Behav. Brain Res. 205: 499-504.
42. Bisenius, E. S., Veeramachaneni, D. N., Sammonds, G. E., and Tobet, S. 2006. Sex differences and the development of the rabbit brain: effects of vinclozolin. Biol. Reprod. 75: 469-476. (Pubitemid 44268081)
43. Bjorling-Poulsen, M., Andersen, H. R., and Grandjean, P. 2008. Potential developmental neurotoxicity of pesticides used in Europe. Environ. Health 7: 50-71.
44. Black, M. M., and Matula, K. 2000. Essentials of Bayley Scales of Infant Development-II Assessment. New York, NY: John Wiley and Sons.
45. Bortolozzi, A., Duffard, R., Antonelli, M., and Evangelista De Duffard, A. M. 2002. Increased sensitivity in dopamine D (2)-like brain receptors from 2, 4-dichlorophenoxyacetic acid (2, 4-D)-exposed and amphetamine-challenged rats. Ann. NY Acad. Sci. 965: 314-323. (Pubitemid 34721979)
46. Bortolozzi, A., Duffard, R., and De Duffard, A. M. 2003. Asymmetrical development of the monoamine systems in 2, 4-dichlorophenoxyacetic acid treated rats. Neurotoxicology 24: 149-157. (Pubitemid 36091168)
47. Bortolozzi, A. A., Duffard, R. O., and Evangelista De Duffard, A. M. 1999. Behavioral alterations induced in rats by a pre-and postnatal exposure to 2, 4-dichlorophenoxyacetic acid. Neurotoxicol. Teratol. 21: 451-465. (Pubitemid 29320100)
48. Bortolozzi, A. A., Evangelista De Duffard, A. M., Duffard, R. O., and Antonelli, M. C. 2004. Effects of 2, 4-dichlorophenoxyacetic acid exposure on dopamine D2-like receptors in rat brain. Neurotoxicol. Teratol. 26: 599-605. (Pubitemid 38760273)
49. Bouchard, M. F., Chevrier, J., Harley, K. G., Kogut, K., Vedar, M., Calderon, N., Trujillo, C., Johnson, C., Bradman, A., Barr, D. B., and Eskenazi, B. 2011. Prenatal exposure to organophosphate pesticides and IQ in 7-year old children. Environ. Health Perspect. 119: 1189-1195.
50. Bradberry, S. M., Cage, S. A., Proudfoot, A. T., and Vale, J. A. 2005. Poisoning due to pyrethroids. Toxicol. Rev. 24: 93-106. (Pubitemid 41455880)
51. Braquenier, J. B., Quertemont, E., Tirelli, E., and Plumier, J. C. 2010. Anxiety in adult female mice following perinatal exposure to chlorpyrifos. Neurotoxicol. Teratol. 32: 234-239.
52. Brazelton, T. B., and Nugent, J. K. 1995. Neonatal Behavioral Assessment Scale, 3rd ed. London, UK: Mac Keith Press.
53. Breckenridge, C. B., Holden, L., Sturgess, N., Weiner, M., Sheets, L., Sargent, D., Soderlund, D. M., Choi, J. S., Symington, S., Clark, J. M., Burr, S., and Ray, D. 2009. Evidence for a separate mechanism of toxicity for the type I and the type II pyrethroid insecticides. Neurotoxicology 30 (suppl. 1): S17-S31.
54. Bruckner, J. V. 2000. Differences in sensitivity of children and adults to chemical toxicity: The NAS panel report. Regul. Toxicol. Pharmacol. 31: 280-285. (Pubitemid 30640372)
55. Cabaleiro, T., Caride, A., Romero, A., and Lafuente, A. 2008. Effects of in utero and lactational exposure to endosulfan inprefrontal cortex of male rats. Toxicol. Lett. 176: 58-67. (Pubitemid 350251067)
56. Cantalamessa, F. 1993. Acute toxicity of two pyrethroids, permethrin, and cypermethrin in neonatal and adult rats. Arch. Toxicol. 67: 510-513. (Pubitemid 23261559)
57. Carr, R. L., Borazjani, A., and Ross, M. K. 2011. Effect of developmental chlorpyrifos exposure, on endocannabinoid metabolizing enzymes, in the brain of juvenile rats. Toxicol. Sci. 122: 112-120.
58. Carr, R. L., Chambers, H. W., Guarisco, J. A., Richardson, J. R., Tang, J., and Chambers, J. E. 2001. Effects of repeated oral postnatal exposure to chlorpyrifos on open-field behavior in juvenile rats. Toxicol. Sci. 59: 260-267. (Pubitemid 32149557)
59. Carr, R. L., and Nail, C. A. 2008. Effect of different administration paradigms on cholinesterase inhibition following repeated chlorpyrifos exposure in late preweanling rats. Toxicol. Sci. 106: 186-192.
60. Casida, J. E., and Quistad, G. B. 1998. Golden age of insecticide research: Past, present, or future? Annu. Rev. Entomol. 43: 1-16. (Pubitemid 28091226)
61. Cassidy, R. A., Vorhees, C. V., Minnema, D. J., and Hastings, L. 1994. The effects of chlordane exposure during pre-and postnatal periods at environmentally relevant levels on sex steroid-mediated behaviors and functions in the rat. Toxicol. Appl. Pharmacol. 126: 326-337. (Pubitemid 24203200)
62. Caudle, W. M., Richardson, J. R., Wang, M., and Miller, G. W. 2005. Perinatal heptachlor exposure increases expression of presynaptic dopaminergic markers in mouse striatum. Neurotoxicology 26: 721-728. (Pubitemid 41175904)
63. Centers for Disease Control and Prevention. 2005. Third national report on human exposure to environmental chemicals. Atlanta, GA: Center for Disease Control, Department of Health and Human Services.
64. Centers for Disease Control and Prevention. 2009. Fourth national report on human exposure to environmental chemicals. Atlanta, GA: Center for Disease Control, Department of Health and Human Services.
65. Chakraborti, T. K., Farrar, J. D., and Pope, C. N. 1993. Comparative neurochemical and neurobehavioral effects of repeated chlorpyrifos exposures in young and adult rats. Pharmacol. Biochem. Behav. 46: 219-224.
66. Chanda, S. M., and Pope, C. N. 1996. Neurochemical and neurobehavioral effects of repeated gestational exposure to chlorpyrifos in maternal and developing rats. Pharmacol. Biochem. Behav. 53: 771-776. (Pubitemid 26112943)
67. Chapin, R. E., Adams, J., Boekelheide, K., Gray, L. E., Jr., Hayward, S. W., Lees, P. S., Mcintyre, B. S., Portier, K. M., Schnorr, T. M., Selevan, S. G., Vandenbergh, J. G., and Woskie, S. R. 2008. NTP-CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A. Birth Defects Res. B Dev. Reprod. Toxicol. 83: 157-395. (Pubitemid 352002664)
68. Chen, T. H., Wang, Y. H., and Wu, Y. H. 2011a. Developmental exposures to ethanol or dimethylsulfoxide at low concentrations alter locomotor activity in larval zebrafish: implications for behavioral toxicity bioassays. Aquat Toxicol, 102: 162-166.
69. Chen, X. P., Wang, X., and Dong, J. Y. 2011b. Different reaction patterns of dopamine content to prenatal exposure to chlorpyrifos in different periods. J. Appl. Toxicol. 31: 355-359.
70. Chernoff, N., Kavlock, R.J., Rogers, E.H., Carver, B.D., Murray, S. 1979. Perinatal toxicity of maneb, ethylene thiourea, and ethylenebisisothiocyanate sulfide in rodents, J. Toxicol. Environ. Health 5: 821-834. (Pubitemid 10191771)
71. Clemens, G. R., Hartnagel, R. E., Bare, J. J., and Thyssen, J. H. 1990. Teratological, neurochemical, and postnatal neurobehavioral assessment of METASYSTOX-R, an organophosphate pesticide in the rat. Fundam. Appl. Toxicol. 14: 131-143. (Pubitemid 20097363)
72. Colbert, N. K., Pelletier, N. C., Cote, J. M., Concannon, J. B., Jurdak, N. A., Minott, S. B., and Markowski, V. P. 2005. Perinatal exposure to low levels of the environmental antiandrogen vinclozolin alters sexdifferentiated social play and sexual behaviors in the rat. Environ. Health Perspect. 113: 700-707. (Pubitemid 40862181)
73. Cole, T. B., Walter, B. J., Shih, D. M., Tward, A. D., Lusis, A. J., Timchalk, C., Richter, R. J., Costa, L. G., and Furlong, C. E. 2005. Toxicity of chlorpyrifos and chlorpyrifos oxon in a transgenic mouse model of the human paraoxonase (PON1) Q192R polymorphism. Pharmacogenet. Genomics 15: 589-598. (Pubitemid 41044245)
74. Cooper, J. R., Vodicnik, M. J., and Gordon, J. H. 1985. Effects of perinatal Kepone exposure on sexual differentiation of the rat brain. Neurotoxicology 6: 183-90. (Pubitemid 15122276)
75. Costa, L. G., Giordano, G., Guizzetti, M., and Vitalone, A. 2008. Neurotoxicity of pesticides: A brief review. Front. Biosc., 13: 1240-1249. (Pubitemid 351594708)
76. Costa, L.G., Giordano, G., Cole, T.B., Marsillach, J., and Furlong, C. E. 2012. Paraoxonase 1 (PON1) as a genetic determinant of susceptibility to organophosphate toxicity. Toxicology. http://dx.doi.org/10. 1016/i.tox.2012.07. 011
77. Crabbe, J. C., Gallaher, E. J., Cross, S. J., and Belknap, J. K. 1998. Genetic determinants of sensitivity to diazepam in inbred mice. Behav. Neurosci. 112: 668-677. (Pubitemid 28309157)
78. Crofton, K. M., Dean, K. F., Boncek, V. M., Rosen, M. B., Sheets, L. P., Chernoff, N., and Reiter, L. W. 1989. Prenatal or postnatal exposure to bis (tri-N-butyltin)oxide in the rat: Postnatal evaluation of teratology and behavior. Toxicol. Appl. Pharmacol. 97: 113-123. (Pubitemid 19054598)
79. Crofton, K. M., Howard, J. L., Moser, V. C., Gill, M. W., Reiter, L. W., Tilson, H. A., and Macphail, R. C. 1991. Interlaboratory comparison of motor activity experiments: Implications for neurotoxicological assessments. Neurotoxicol. Teratol. 13: 599-609.
80. Crofton, K. M., and Reiter, L. W. 1984. Effects of two pyrethroid insecticides on motor activity and the acoustic startle response in the rat. Toxicol. Appl. Pharmacol. 75: 318-328. (Pubitemid 14026443)
81. Crofton, K. M., and Reiter, L. W. 1987. Pyrethroid insecticides and the gammaaminobutyric acidA receptor complex: Motor activity and the acoustic startle response in the rat. J. Pharmacol. Exp. Ther. 243: 946-954. (Pubitemid 18017147)
82. Crowder, L. A., Lanzaro, G. C., and Whitson, R. S. 1980. Behavioral effects of methyl parathion and toxaphene exposure in rats. J. Environ. Sci. Health B 15: 365-378.
83. Curl, C. L., Fenske, R. A., Kissel, J. C., Shirai, J. H., Moate, T. F., Griffith, W., Coronado, G., and Thompson, B. 2002. Evaluation of take-home organophosphorus pesticide exposure among agricultural workers and their children. Environ. Health Perspect. 110: A787-A792. (Pubitemid 36024313)
84. Curwin, B. D., Hein, M. J., Sanderson, W. T., Striley, C., Heederik, D., Kromhout, H., Reynolds, S. J., and Alavanja, M. C. 2007. Urinary pesticide concentrations among children, mothers and fathers living in farm and non-farm households in Iowa. Ann. Occup. Hyg. 51: 53-65. (Pubitemid 46096396)
85. Da Silva, A. P., Meotti, F. C., Santos, A. R., and Farina, M. 2006. Lactational exposure to malathion inhibits brain acetylcholinesterase in mice. Neurotoxicology 27: 1101-1105. (Pubitemid 44838953)
86. Dam, K., Garcia, S. J., Seidler, F. J., and Slotkin, T. A. 1999. Neonatal chlorpyrifos exposure alters synaptic development and neuronal activity in cholinergic and catecholaminergic pathways. Brain Res. Dev. Brain Res. 116: 9-20. (Pubitemid 29359194)
87. Dam, K., Seidler, F. J., and Slotkin, T. A. 2000. Chlorpyrifos exposure during a critical neonatal period elicits gender-selective deficits in the development of coordination skills and locomotor activity. Brain Res. Dev. Brain Res. 121: 179-187. (Pubitemid 30392441)
88. Dambska, M., Iwanowski, L., and Kozlowski, P. 1979. The effect of transplacental intoxication with dichlorvos on the development of cerebral cortex in newborn rabbits. Neuropatol. Pol. 17: 571-576. (Pubitemid 10166201)
89. Dambska, M., and Maslinska, D. 1988. Morphological changes after acetylcholinesterase (AChE) inhibition by dichlorvos (DDVP) in young rabbit brain. J. Hirnforsch. 29: 569-571.
90. Darvill, T., Lonky, E., Reihman, J., Stewart, P., and Pagano, J. 2000. Prenatal exposure toPCBs and infant performance on the fagan test of infant intelligence. Neurotoxicology 21: 1029-1038. (Pubitemid 32172153)
91. De Castro, V. L., Chiorato, S. H., and Pinto, N. F. 2000a. Biological monitoring of embrio-fetal exposure to methamidophos or chlorothalonil on rat development. Vet. Hum. Toxicol. 42: 361-365.
92. De Castro, V. L., Chiorato, S. H., and Pinto, N. F. 2000b. Relevance of developmental testing of exposure to methamidophos during gestation to its toxicology evaluation. Toxicol. Lett. 118: 93-102. (Pubitemid 32008399)
93. De Castro, V. L., Destefani, C. R., Diniz, C., and Poli, P. 2007. Evaluation of neurodevelopmental effects on rats exposed prenatally to sulfentrazone. Neurotoxicology, 28: 1249-1259. (Pubitemid 350030930)
94. De Castro, V. L., Goes, K., and Chiorato, S. 2004. Developmental toxicity potential of paclobutrazol in the rat. Int. J. Environ. Health Res. 14: 371-380. (Pubitemid 39314394)
95. De Duffard, A. M., De Alderete, M. N., and Duffard, R. 1990. Changes in brain serotonin and 5-hydroxyindolacetic acid levels induced by 2, 4-dichlorophenoxyacetic butyl ester. Toxicology 64: 265-270.
96. Desesso, J. M. 2012. Comparative gestational milestones in vertebrate development. In Developmental and reproductive toxicology: A practical approach, 3rd ed., chap. 6. New York, NY: Informa.
97. Desesso, J. M., Scialli, A. R., and Holson, J. F. 1999. Apparent lability of neural tube closure in laboratory animals and humans. Am. J. Med. Genet. 87: 143-162. (Pubitemid 29530421)
98. Desesso, J. M., Watson, R. E., Keen, C. L., Hazelden, K. P., Haws, L. C., and Li, A. A. 2009. Analysis and integration of developmental neurotoxicity and ancillary data into risk assessment: A case study of dimethoate. J. Toxicol. Environ. Health A 72: 94-109.
99. Desi, I., and Nagymajtenyi, L. 1999. Electrophysiological biomarkers of an organophosphorous pesticide, dichlorvos. Toxicol. Lett. 107: 55-64. (Pubitemid 29276887)
100. Duffard, R., Garcia, G., Rosso, S., Bortolozzi, A., Madariaga, M., Di Paolo, O., and Evangelista De Duffard, A. M. 1996. Central nervous system myelin deficit in rats exposed to 2, 4-dichlorophenoxyacetic acid throughout lactation. Neurotoxicol. Teratol. 18: 691-696. (Pubitemid 26423033)
101. Dvergsten, C., and Meeker, R. B. 1994. Muscarinic cholinergic receptor regulation and acetylcholinesterase inhibition in response to insecticide exposure during development. Int J Devl Neurosci, 12: 63-75. (Pubitemid 24087124)
102. Eaton, D. L., Daroff, R. B., Autrup, H., Bridges, J., Buffler, P., Costa, L. G., Coyle, J., Mckhann, G., Mobley, W. C., Nadel, L., Neubert, D., Schulte-Hermann, R., and Spencer, P. S. 2008. Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment. Crit. Rev. Toxicol. 38(suppl. 2): 1-125.
103. Eells, J. B., and Brown, T. 2009. Repeated developmental exposure to chlorpyrifos and methyl parathion causes persistent alterations in nicotinic acetylcholine subunit mRNA expression with chlorpyrifos altering dopamine metabolite levels. Neurotoxicol. Teratol. 31: 98-103.
104. Ellis, W. G., Semple, J. L., Hoogenboom, E. R., Kavlock, R. J., and Zeman, F. J. 1987. Benomyl-induced craniocerebral anomalies in fetuses of adequately nourished and protein-deprived rats. Teratogen. Carcinogen. Mutagen. 7: 357-375. (Pubitemid 17131324)
105. Engel, S. M., Berkowitz, G. S., Barr, D. B., Teitelbaum, S. L., Siskind, J., Meisel, S. J., Wetmur, J. G., and Wolff, M. S. 2007. Prenatal organophosphate metabolite and organochlorine levels and performance on the Brazelton Neonatal Behavioral Assessment Scale in a multiethnic pregnancy cohort. Am. J. Epidemiol. 165: 1397-1404. (Pubitemid 47234308)
106. Engel, S. M.,Wetmur, J., Chen, J., Zhu, C., Barr, D. B., Canfield, R. L., and Wolff, M. S. 2011. Prenatal exposure to organophosphates, paraoxonase 1, and cognitive development in childhood. Environ. Health Perspect. 119: 1182-1188.
107. Eriksson, P. 1996. Developmental neurotoxicology in the neonate-Effects of pesticides and polychlorinated organic substances. Arch. Toxicol. Suppl. 18: 81-88.
108. Eriksson, P. 1997. Developmental neurotoxicity of environmental agents in the neonate. Neurotoxicology 18: 719-726. (Pubitemid 27430300)
109. Eriksson, P., Ahlbom, J., and Fredriksson, A. 1992. Exposure to DDT during a defined period in neonatal life induces permanent changes in brain muscarinic receptors and behaviour in adult mice. Brain Res. 582: 277-281.
110. Eriksson, P., Archer, T., and Fredriksson, A. 1990a. Altered behaviour in adult mice exposed to a single low dose of DDT and its fatty acid conjugate as neonates. Brain Res. 514: 141-142. (Pubitemid 20147598)
111. Eriksson, P., Falkeborn, Y., Nordberg, A., and Slanina, P. 1984. Effects of DDT on muscarine-and nicotine-like binding sites in CNS of immature and adult mice. Toxicol. Lett. 22: 329-334. (Pubitemid 14068793)
112. Eriksson, P., and Fredriksson, A. 1991. Neurotoxic effects of two different pyrethroids, bioallethrin and deltamethrin, on immature and adult mice: Changes in behavioral and muscarinic receptor variables. Toxicol. Appl. Pharmacol. 108: 78-85.
113. Eriksson, P., Johansson, U., Ahlbom, J., and Fredriksson, A. 1993. Neonatal exposure to DDT induces increased susceptibility to pyrethroid (bioallethrin) exposure at adult age-Changes in cholinergic muscarinic receptor and behavioural variables. Toxicology 77: 21-30.
114. Eriksson, P., Nilsson-Hakansson, L., Nordberg, A., Aspberg, A., and Fredriksson, A. 1990b. Neonatal exposure to DDT and its fatty acid conjugate: Effects on cholinergic and behavioural variables in the adult mouse. Neurotoxicology 11: 345-354. (Pubitemid 20246087)
115. Eriksson, P., and Nordberg, A. 1990. Effects of two pyrethroids, bioallethrin and deltamethrin, on subpopulations of muscarinic and nicotinic receptors in the neonatal mouse brain. Toxicol. Appl. Pharmacol. 102: 456-463. (Pubitemid 20096679)
116. Eriksson, P., and Talts, U. 2000. Neonatal exposure to neurotoxic pesticides increases adult susceptibility: A review of current findings. Neurotoxicology, 21: 37-47.
117. Eskenazi, B., Harley, K., Bradman, A.,Weltzien, E., Jewell, N. P., Barr, D. B., Furlong, C. E., and Holland, N. T. 2004. Association of in utero organophosphate pesticide exposure and fetal growth and length of gestation in an agricultural population. Environ. Health Perspect. 112: 1116-1124. (Pubitemid 39029169)
118. Eskenazi, B., Huen, K., Marks, A., Harley, K. G., Bradman, A., Barr, D. B., and Holland, N. 2010. PON1 and neurodevelopment in children from the CHAMACOS study exposed to organophosphate pesticides in utero. Environ. Health Perspect. 118: 1775-1781.
119. Eskenazi, B., Marks, A. R., Bradman, A., Fenster, L., Johnson, C., Barr, D. B., and Jewell, N. P. 2006. In utero exposure to dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloroethylene (DDE) and neurodevelopment among young Mexican American children. Pediatrics 118: 233-241. (Pubitemid 46071167)
120. Eskenazi, B., Marks, A. R., Bradman, A., Harley, K., Barr, D. B., Johnson, C., Morga, N., and Jewell, N. P. 2007. Organophosphate pesticide exposure and neurodevelopment in young Mexican-American children. Environ. Health Perspect. 115: 792-798. (Pubitemid 46785051)
121. Evangelista De Duffard, A. M., Brusco, A., Duffard, R., Garcia, G., and Pecci Saavedra, J. 1995. Changes in serotoninimmunoreactivity in the dorsal and median raphe nuclei of rats exposed to 2, 4-dichlorophenoxyacetic acid through lactation. Mol. Chem. Neuropathol. 26: 187-193.
122. Fagan, J. F. 2005. The Fagan Test of Infant Intelligence manual. Cleveland, OH: Case Western Reserve University.
123. Fagan, J. F., and Detterman, D. K. 1992. The Fagan test of infant intelligence: A technical summary. J. Appl. Dev. Psychol. 13: 173-193.
124. Farag, A. T., El Okazy, A. M., and El-Aswed, A. F. 2003. Developmental toxicity study of chlorpyrifos in rats. Reprod. Toxicol. 17: 203-208. (Pubitemid 36428314)
125. Faraone, S. V., Sergeant, J., Gillberg, C., and Biederman, J. 2003. The worldwideprevalence of ADHD: Is it an American condition? World Psychiatry 2: 104-113.
126. Fenske, R. A., Lu, C., Barr, D., and Needham, L. 2002. Children's exposure to chlorpyrifos and parathion in an agricultural community in central Washington State. Environ. Health Perspect. 110: 549-553. (Pubitemid 34546519)
127. Fenster, L., Eskenazi, B., Anderson, M., Bradman, A., Hubbard, A., and Barr, D. B. 2007. In utero exposure to DDT and performance on the Brazelton neonatal behavioral assessment scale. Neurotoxicology 28: 471-477. (Pubitemid 46844842)
128. Ferri, A., Bortolozzi, A., Duffard, R., and De Duffard, A. M. E. 2000. Monoamine levels in neonatal rats lactationally exposed to 2, 4-dichlorophenoxyacetic acid. Biogenic Amines 16: 73-100. (Pubitemid 32062981)
129. Flynn, K. M., Delclos, K. B., Newbold, R. R., and Ferguson, S. A. 2001. Behavioral responses of rats exposed to long-term dietary vinclozolin. J. Agric. Food Chem. 49: 1658-1665. (Pubitemid 32885008)
130. Flynn, K. M., Delclos, K. B., Newbold, R. R., and Ferguson, S. A. 2005. Long term dietary methoxychlor exposure in rats increases sodium solution consumption but has few effects on other sexually dimorphic behaviors. Food Chem. Toxicol. 43: 1345-1354. (Pubitemid 40884609)
131. Fraites, M. J., Narotsky, M. G., Best, D. S., Stoker, T. E., Davis, L. K., Goldman, J. M., Hotchkiss, M. G., Klinefelter, G. R., Kamel, A., Qian, Y., Podhorniak, L., and Cooper, R. L. 2011. Gestational atrazine exposure: Effects on male reproductive development and metabolite distribution in the dam, fetus, and neonate. Reprod. Toxicol. 32: 52-63.
132. Fredriksson, A., Fredriksson, M., and Eriksson, P. 1993. Neonatal exposure to paraquat or MPTP induces permanent changes in striatum dopamine and behavior in adult mice. Toxicol. Appl. Pharmacol. 122: 258-264. (Pubitemid 23314950)
133. Furlong, C. E., Cole, T. B., Jarvik, G. P., Pettan-Brewer, C., Geiss, G. K., Richter, R. J., Shih, D. M., Tward, A. D., Lusis, A. J., and Costa, L. G. 2005. Role of paraoxonase (PON1) status in pesticide sensitivity: Genetic and temporal determinants. Neurotoxicology 26: 651-659. (Pubitemid 41175899)
134. Furlong, C. E., Richter, R. J., Seidel, S. L., and Motulsky, A. G. 1988. Role of genetic polymorphism of human plasma paraoxonase/arylesterase in hydrolysis of the insecticide metabolites chlorpyrifos oxon and paraoxon. Am. J. Hum. Genet. 43: 230-238.
135. Garcia, G., Tagliaferro, P., Bortolozzi, A., Madariaga, M. J., Brusco, A., Evangelista De Duffard, A. M., Duffard, R., and Saavedra, J. P. 2001. Morphological study of 5-HT neurons and astroglial cells on brain of adult rats perinatal or chronically exposed to 2, 4-dichlorophenoxyacetic acid. Neurotoxicology 22: 733-741. (Pubitemid 34075631)
136. Garcia, G., Tagliaferro, P., Ferri, A., Evangelista De Duffard, A. M., Duffard, R., and Brusco, A. 2004. Study of tyrosine hydroxylase immunoreactive neurons in neonate rats lactationally exposed to 2, 4-dichlorophenoxyacetic acid. Neurotoxicology 25: 951-957. (Pubitemid 39335587)
137. Garcia, G. B., Konjuh, C., Duffard, R. O., and Evangelista De Duffard, A. M. 2006. Dopamine-beta-hydroxylase immunohistochemical study in the locus coeruleus of neonate rats exposed to 2, 4-dichlorophenoxyacetic acid through mother's milk. Drug Chem. Toxicol. 29: 435-442. (Pubitemid 44384741)
138. Garcia, S.J., Abu-Qare, A.W., Meeker-O'Connell, W.A., Borton, A.J., Abou-Donia, M.B. 2003. Methyl parathion: A review of health effects. J. Toxicol. Environ. Health B 6: 185-210. (Pubitemid 36232924)
139. Gerber, D. J., Sotnikova, T. D., Gainetdinov, R. R., Huang, S. Y., Caron, M. G., and Tonegawa, S. 2001. Hyperactivity, elevated dopaminergic transmission, and response to amphetamine in M1 muscarinic acetylcholine receptor-deficient mice. Proc. Natl. Acad. Sci. USA 98: 15312-15317. (Pubitemid 34014011)
140. Gioiosa, L., Fissore, E., Ghirardelli, G., Parmigiani, S., and Palanza, P. 2007. Developmental exposure to low-dose estrogenic endocrine disruptors alters sex differences in exploration and emotional responses in mice. Horm. Behav. 52: 307-316. (Pubitemid 47267910)
141. Gladen, B. C., and Rogan, W. J. 1991. Effects of perinatal polychlorinated biphenyls and dichlorodiphenyl dichloroethene on later development. J. Pediatr. 119: 58-63.
142. Gladen, B. C., Rogan, W. J., Hardy, P., Thullen, J., Tingelstad, J., and Tully, M. 1988. Development after exposure to polychlorinated biphenyls and dichlorodiphenyl dichloroethene transplacentally and through human milk. J. Pediatr. 113: 991-995. (Pubitemid 19014246)
143. Godin, S. J., Scollon, E. J., Hughes, M. F., Potter, P. M., Devito, M. J., and Ross, M. K. 2006. Species differences in the in vitro metabolism of deltamethrin and esfenvalerate: Differential oxidative and hydrolytic metabolism by humans and rats. Drug Metab. Dispos. 34: 1764-1771. (Pubitemid 44427480)
144. Gomeza, J., Zhang, L., Kostenis, E., Felder, C., Bymaster, F., Brodkin, J., Shannon, H., Xia, B., Deng, C., and Wess, J. 1999. Enhancement of D1 dopamine receptormediated locomotor stimulation in M (4) muscarinic acetylcholine receptor knockout mice. Proc. Natl. Acad. Sci. USA 96: 10483-10488. (Pubitemid 29422585)
145. Grandjean, P., and Landrigan, P. J. 2006. Developmental neurotoxicity of industrial chemicals. Lancet, 368: 2167-2178. (Pubitemid 44894541)
146. Gray, L. E., Jr. 1982. Neonatal chlordecone exposure alters behavioral sex differentiation in female hamsters. Neurotoxicology 3: 67-79. (Pubitemid 13169722)
147. Gray, L. E., Jr., Kavlock, R. J., Chernoff, N., Gray, J. A., and Mclamb, J. 1981. Perinatal toxicity of endrin in rodents. III. Alterations of behavioral ontogeny. Toxicology 21: 187-202.
148. Gray, L. E., Jr., Rogers, J. M., Kavlock, R. J., Ostby, J. S., Ferrell, J. M., and Gray, K. L. 1986. Prenatal exposure to the fungicide dinocap causes behavioral torticollis, ballooning and cleft palate in mice, but not rats or hamsters. Teratogen. Carcinogen. Mutagen. 6: 33-43. (Pubitemid 16153696)
149. Gray, L. E., Jr., Rogers, J. M., Ostby, J. S., Kavlock, R. J., and Ferrell, J. M. 1988. Prenatal dinocap exposure alters swimming behavior in mice due to complete otolith agenesis in the inner ear. Toxicol. Appl. Pharmacol. 92: 266-273. (Pubitemid 18079215)
150. Griffiths, R. 1996. The Griffiths Mental Development Scales. Oxon, England: The Test Agency Limited.
151. Guo-Ross, S. X., Chambers, J. E., Meek, E. C., and Carr, R. L. 2007. Altered muscarinic acetylcholine receptor subtype binding in neonatal rat brain following exposure to chlorpyrifos or methyl parathion. Toxicol. Sci. 100: 118-127. (Pubitemid 47617809)
152. Gupta, R. C., Rech, R. H., Lovell, K. L., Welsch, F., and Thornburg, J. E. 1985. Brain cholinergic, behavioral, and morphological development in rats exposed in utero to methylparathion. Toxicol. Appl. Pharmacol. 77: 405-413. (Pubitemid 15138492)
153. Gurtovenko, A. A., and Anwar, J. 2007. Modulating the structure and properties of cell membranes: The molecular mechanism of action of dimethyl sulfoxide. J. Phys. Chem. B 111: 10453-10460. (Pubitemid 47441849)
154. Hanslick, J. L., Lau, K., Noguchi, K. K., Olney, J. W., Zorumski, C. F., Mennerick, S., and Farber, N. B. 2009. Dimethyl sulfoxide (DMSO) produces widespread apoptosis in the developing central nervous system. Neurobiol. Dis. 34: 1-10.
155. Hass, U. 2006. The need for developmental neurotoxicity studies in risk assessment for developmental toxicity. Reprod. Toxicol. 22: 148-156. (Pubitemid 43994386)
156. Haviland, J. A., Butz, D. E., and Porter, W. P. 2010. Long-term sex selective hormonal and behavior alterations in mice exposed to low doses of chlorpyrifos In utero. Reprod. Toxicol. 29: 74-79.
157. Henderson, G. L., and Woolley, D. E. 1969. Studies on the relative insensitivity of the immature rat to the neurotoxic effects of 1, 1, 1-trichloro-2, 2-bis (p-chlorophenyl)ethane (DDT). J. Pharmacol. Exp. Ther. 170: 173-180.
158. Hildebrand, M. E., Mcrory, J. E., Snutch, T. P., and Stea, A. 2004. Mammalian voltage-gated calcium channels are potently blocked by the pyrethroid insecticide allethrin. J. Pharmacol. Exp. Ther. 308: 805-813. (Pubitemid 38263952)
159. Hill, A. B. 1965. The environment and disease: Association or causation? Proc. R. Soc. Med. 58: 295-300.
160. Hjelde, T., Mehl, A., Schanke, T. M., and Fonnum, F. 1998. Teratogenic effects of trichlorfon (Metrifonate) on the guinea-pig brain. Determination of the effective dose and the sensitive period. Neurochem. Int. 32: 469-477. (Pubitemid 28287200)
161. Holson, R. R., and Pearce, B. 1992. Principles and pitfalls in the analysis of prenatal treatment effects in multiparous species. Neurotoxicol. Teratol. 14: 221-228.
162. Holson, J. F., Nemec, M. D., Stump, D. G., Kaufman, L. E., Lindstrom, P., and Varsho, B. J. 2006. Significance, reliability, and interpretation of developmental and reproductive study findings. In Developmental and reproductive toxicology: A practical approach, 2nd ed., ed. D. Hood. Boca Raton, FL: CRC Press.
163. Holson, R. R., Freshwater, L., Maurissen, J. P., Moser, V. C., and Phang, W. 2008. Statistical issues and techniques appropriate for developmental neurotoxicity testing: A report from the ILSI Research Foundation/Risk Science Institute expert working group on neurodevelopmental endpoints. Neurotoxicol. Teratol. 30: 326-348.
164. Hong, J. S., and Ali, S. F. 1982. Chlordecone (Kepone) exposure in the neonate selectively alters brain and pituitary endorphin levels in prepuberal and adult rats. Neurotoxicology 3: 111-118.
165. Horton, M. K., Rundle, A., Camann, D. E., Boyd Barr, D., Rauh, V. A., and Whyatt, R. M. 2011. Impact of prenatal exposure to piperonyl butoxide and permethrin on 36-month neurodevelopment. Pediatrics 127: e699-e706.
166. Hotchkiss, A. K., Ostby, J. S., Vandenbergh, J. G., and Gray, L. E., Jr. 2003. An environmental antiandrogen, vinclozolin, alters the organization of play behavior. Physiol. Behav. 79: 151-156. (Pubitemid 36776666)
167. Icenogle, L. M., Christopher, N. C., Blackwelder, W. P., Caldwell, D. P., Qiao, D., Seidler, F. J., Slotkin, T. A., and Levin, E. D. 2004. Behavioral alterations in adolescent and adult rats caused by a brief subtoxic exposure to chlorpyrifos during neurulation. Neurotoxicol. Teratol. 26: 95-101. (Pubitemid 38299113)
168. Ivanovic, D. M., Leiva, B. P., Perez, H. T., Olivares, M. G., Diaz, N. S., Urrutia, M. S., Almagia, A. F., Toro, T. D., Miller, P. T., Bosch, E. O., and Larrain, C. G. 2004. Head size and intelligence, learning, nutritional status and brain development. Head, IQ, learning, nutrition and brain. Neuropsychologia 42: 1118-1131.
169. Jacobson, J. L., Jacobson, S. W., Padgett, R. J., Brummitt, G. A., and Billings, L. 1992. Effects of prenatal PCB exposure on cognitive processing efficiency and sustained attention. Dev. Psychol. 28: 297-306.
170. Jett, D. A., Navoa, R. V., Beckles, R. A., and Mclemore, G. L. 2001. Cognitive function and cholinergic neurochemistry in weanling rats exposed to chlorpyrifos. Toxicol. Appl. Pharmacol. 174: 89-98. (Pubitemid 32675511)
171. Jia, Z., and Misra, H. P. 2007. Developmental exposure to pesticides zineb and/or endosulfan renders the nigrostriatal dopamine system more susceptible to these environmental chemicals later in life. Neurotoxicology 28: 727-735. (Pubitemid 47064473)
172. Jinna, R. R., Uzodinma, J. E., and Desaiah, D. 1989. Age-related changes in rat brain ATPases during treatment with chlordecone. J. Toxicol. Environ. Health 27: 199-208. (Pubitemid 19191592)
173. Johansson, U., Fredriksson, A., and Eriksson, P. 1995. Bioallethrin causes permanent changes in behavioural and muscarinic acetylcholine receptor variables in adult mice exposed neonatally to DDT. Eur. J. Pharmacol. 293: 159-166.
174. Johnson, F. O., Chambers, J. E., Nail, C. A., Givaruangsawat, S., and Carr, R. L. 2009. Developmental chlorpyrifos and methyl parathion exposure alters radial-arm maze performance in juvenile and adult rats. Toxicol. Sci. 109: 132-142.
175. Johri, A., Yadav, S., Dhawan, A., and Parmar, D. 2007. Overexpression of cerebral and hepatic cytochrome P450s alters behavioral activity of rat offspring following prenatal exposure to lindane. Toxicol. Appl. Pharmacol. 225: 278-292. (Pubitemid 350176589)
176. Julvez, J., and Grandjean, P. 2009. Neurodevelopmental toxicity risks due to occupational exposure to industrialchemicals during pregnancy. Ind Health 47: 459-468.
177. Jusko, T. A., Koepsell, T. D., Baker, R. J., Greenfield, T. A., Willman, E. J., Charles, M. J., Teplin, S. W., Checkoway, H., and Hertz-Picciotto, I. 2006. Maternal DDT exposures in relation to fetal and 5-year growth. Epidemiology, 17: 692-700. (Pubitemid 44655606)
178. Kachroo, A., Irizarry, M. C., and Schwarzschild, M. A. 2010. Caffeine protects against combined paraquat and maneb-induced dopaminergic neuron degeneration. Exp. Neurol. 223: 657-661.
179. Kennepohl, E., and Munro, I. C. 2001. Phenoxy herbicides (2, 4-D). Tox. Stud. 2: 1623-1638.
180. Konjuh, C., Garcia, G., Lopez, L., De Duffard, A. M., Brusco, A., and Duffard, R. 2008. Neonatal hypomyelination by the herbicide 2, 4-dichlorophenoxyacetic acid. Chemical and ultrastructural studies in rats. Toxicol. Sci. 104: 332-340.
181. Krewski, D., Acosta, D., Jr., Andersen, M., Anderson, H., Bailar, J. C.3rd, Boekelheide, K., Brent, R., Charnley, G., Cheung, V. G., Green, S., Jr., Kelsey, K. T., Kerkvliet, N. I., Li, A. A., Mccray, L., Meyer, O., Patterson, R. D., Pennie, W., Scala, R. A., Solomon, G. M., Stephens, M., Yager, J., and Zeise, L. 2010. Toxicity testing in the 21st century: A vision and a strategy. J. Toxicol. Environ. Health B 13: 51-138.
182. Laessig, S. A., Auger, A. P., Mccarthy, M. M., and Silbergeld, E. K. 2007. Effects of prenatal chlordecone on sexually differentiated behavior in adult rats. Neurotoxicol. Teratol. 29: 255-263. (Pubitemid 46400370)
183. Lakshmana, M. K., and Raju, T. R. 1994. Endosulfan induces small but significant changes in the levels of noradrenaline, dopamine and serotonin in the developing rat brain and deficits in the operant learning performance. Toxicology 91: 139-150. (Pubitemid 24246858)
184. Lassiter, T. L., Barone, S., Jr., Moser, V. C., and Padilla, S. 1999. Gestational exposure to chlorpyrifos: Dose response profiles for cholinesterase and carboxylesterase activity. Toxicol. Sci. 52: 92-100.
185. Lassiter, T. L., Padilla, S., Mortensen, S. R., Chanda, S. M., Moser, V. C., and Barone, S., Jr. 1998. Gestational exposure to chlorpyrifos: Apparent protection of the fetus? Toxicol. Appl. Pharmacol. 152: 56-65. (Pubitemid 28498673)
186. Lawrence, L. J., and Casida, J. E. 1983. Stereospecific action of pyrethroid insecticides on the gamma-aminobutyric acid receptor-ionophore complex. Science 221: 1399-1401. (Pubitemid 13006127)
187. Levin, E. D., Addy, N., Baruah, A., Elias, A., Christopher, N. C., Seidler, F. J., and Slotkin, T. A. 2002. Prenatal chlorpyrifos exposure in rats causes persistent behavioral alterations. Neurotoxicol. Teratol. 24: 733-741. (Pubitemid 35375777)
188. Levin, E. D., Addy, N., Nakajima, A., Christopher, N. C., Seidler, F. J., and Slotkin, T. A. 2001. Persistent behavioral consequences of neonatal chlorpyrifos exposure in rats. Brain Res. Dev. Brain Res. 130: 83-89. (Pubitemid 32830975)
189. Levin, E. D., Timofeeva, O. A., Yang, L., Petro, A., Ryde, I. T., Wrench, N., Seidler, F. J., and Slotkin, T. A. 2010. Early postnatal parathion exposure in rats causes sexselective cognitive impairment and neurotransmitter defects which emerge in aging. Behav. Brain Res. 208: 319-327.
190. Li, A. A., Levine, T. E., Burns, C. J., and Kent Anger, W. 2012a. Integration of epidemiology and animal neurotoxicity data for risk assessment. Neurotoxicology 33: 823-832.
191. Li, A. A., Lowe, K. A., Mcintosh, L. J., and Mink, P. J. 2012b. Evaluation of epidemiology and animal data for risk assessment: chlorpyrifos developmental neurobehavioral outcomes. J. Toxicol. Environ. Health B 15: 109-184.
192. Liu, J., Olivier, K., and Pope, C. N. 1999. Comparative neurochemical effects of repeated methyl parathion or chlorpyrifos exposures in neonatal and adult rats. Toxicol. Appl. Pharmacol. 158: 186-196. (Pubitemid 29343441)
193. Llorens, J., Li, A. A., Ceccatelli, S., and Sunol, C. 2012. Strategies and tools for preventing neurotoxicity: To test, to predict and how to do it. Neurotoxicology 33: 796-804.
194. Lock, E. A., and Wilks, M. F. 2001. Paraquat. In Handbook of pesticide toxicology, 2nd ed., ed. R. I. Krieger. San Diego, CA: Academic Press.
195. Longnecker, M. P., Klebanoff, M. A., Zhou, H., and Brock, J. W. 2001. Association between maternal serum concentration of the DDT metabolite DDE and preterm and small-forgestational-age babies at birth. Lancet 358: 110-114. (Pubitemid 32709849)
196. Longnecker, M. P., Rogan, W. J., and Lucier, G. 1997. The human health effects of DDT (dichlorodiphenyltrichloroethane) and PCBS (polychlorinated biphenyls) and an overview of organochlorines in public health. Annu Rev Public Health 18: 211-244. (Pubitemid 27194070)
197. Lopez-Espinosa, M. J., Granada, A., Carreno, J., Salvatierra, M., Olea-Serrano, F., and Olea, N. 2007. Organochlorine pesticides in placentas from Southern Spain and some related factors. Placenta 28: 631-638. (Pubitemid 46863185)
198. Lovasi, G. S., Quinn, J. W., Rauh, V. A., Perera, F. P., Andrews, H. F., Garfinkel, R., Hoepner, L., Whyatt, R., and Rundle, A. 2011. Chlorpyrifos exposure and urban residential environment characteristics as determinants of early childhood neurodevelopment. Am. J. Public Health 101: 63-70.
199. Lowe, E. R., Poet, T. S., Rick, D. L., Marty, M. S., Mattsson, J. L., Timchalk, C., and Bartels, M. J. 2009. The effect of plasma lipids on the pharmacokinetics of chlorpyrifos and the impact on interpretation of blood biomonitoring data. Toxicol. Sci. 108: 258-272.
200. Mactutus, C. F., and Tilson, H. A. 1985. Evaluation of long-term consequences in behavioral and/or neural function following neonatal chlordecone exposure. Teratology 31: 177-186. (Pubitemid 15103543)
201. Mactutus, C. F., Unger, K. L., and Tilson, H. A. 1982. Neonatal chlordecone exposure impairs early learning and memory in the rat on a multiple measure passive avoidance task. Neurotoxicology 3: 27-44. (Pubitemid 13169719)
202. Mactutus, C. F., Unger, K. L., and Tilson, H. A. 1984. Evaluation of neonatal chlordecone neurotoxicity during early development: initial characterization. Neurobehav. Toxicol. Teratol. 6: 67-73. (Pubitemid 14138895)
203. Makris, S. L., Raffaele, K., Allen, S., Bowers, W. J., Hass, U., Alleva, E., Calamandrei, G., Sheets, L., Amcoff, P., Delrue, N., and Crofton, K. M. 2009. A retrospective performance assessment of the developmental neurotoxicity study in support of OECD test guideline 426. Environ. Health Perspect. 117: 17-25.
204. Mandel, J. S., Alexander, B. H., Baker, B. A., Acquavella, J. F., Chapman, P., and Honeycutt, R. 2005. Biomonitoring for farm families in the farm family exposure study. Scand. J. Work Environ. Health 31 (suppl. 1): 98-104; discussion 6-65. (Pubitemid 41309621)
205. Marks, A. R., Harley, K., Bradman, A., Kogut, K., Barr, D. B., Johnson, C., Calderon, N., and Eskenazi, B. 2010. Organophosphate pesticide exposure and attention in young Mexican-American children: the CHAMACOS study. Environ. Health Perspect. 118: 1768-1774.
206. Maslinska, D., Lewandowska, I., and Prokopczyk, J. 1981. Effect of prolonged acetylcholinesterase inhibition on postnatal brain development in rabbit.I.Level of serotonin in different brain regions. Acta Neuropathol. Suppl. 7: 52-55.
207. Maslinska, D., and Zalewska, Z. 1978. Effect of dichlorvos, administered to the pregnant rabbits, on the colinesterases activity in the progeny. Folia Histochem. Cytochem. (Krakow) 16: 335-341.
208. Mattsson, J. L., Maurissen, J. P., Nolan, R. J., and Brzak, K. A. 2000. Lack of differential sensitivity to cholinesterase inhibition in fetuses and neonates compared to dams treated perinatally with chlorpyrifos. Toxicol. Sci. 53: 438-446. (Pubitemid 30100161)
209. Maurissen, J. 2010. Practical considerations on the design, execution and analysis of developmental neurotoxicity studies to be published in Neurotoxicology and Teratology. Neurotoxicol. Teratol. 32: 121-123.
210. Maurissen, J. P., Hoberman, A. M., Garman, R. H., and Hanley, T. R., Jr. 2000. Lack of selective developmental neurotoxicity in rat pups from dams treated by gavage with chlorpyrifos. Toxicol. Sci. 57: 250-263.
211. McCarthy, D. 1972. Manual for the McCarthy Scales of Chilren's Abilities. New York, NY: Psychological Corporation.
212. McCauley, L. A., Lasarev, M. R., Higgins, G., Rothlein, J., Muniz, J., Ebbert, C., and Phillips, J. 2001. Work characteristics and pesticide exposures among migrant agricultural families: A community-based research approach. Environ. Health Perspect. 109: 533-538. (Pubitemid 32998813)
213. McDaniel, K. L., Padilla, S., Marshall, R. S., Phillips, P. M., Podhorniak, L., Qian, Y., and Moser, V. C. 2007. Comparison of acute neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in rat. Toxicol. Sci. 98: 552-560. (Pubitemid 47244823)
214. McKone, T. E., Castorina, R., Harnly, M. E., Kuwabara, Y., Eskenazi, B., and Bradman, A. 2007. Merging models and biomonitoring data to characterize sources and pathways of human exposure to organophosphorus pesticides in the Salinas Valley of California. Environ. Sci. Technol. 41: 3233-3240. (Pubitemid 46713385)
215. Meacham, C. A., Brodfuehrer, P. D., Watkins, J. A., and Shafer, T. J. 2008. Developmentallyregulated sodium channel subunits are differentially sensitive to alpha-cyano containing pyrethroids. Toxicol. Appl. Pharmacol. 231: 273-281.
216. Mehl, A., Schanke, T. M., Johnsen, B. A., and Fonnum, F. 1994. The effect of trichlorfon and other organophosphates on prenatal brain development in the guinea pig. Neurochem. Res. 19: 569-574. (Pubitemid 24139250)
217. Mehl, A., Schanke, T. M., Torvik, A., and Fonnum, F. 2007. The effect of trichlorfon and methylazoxymethanol on the development of guinea pig cerebellum. Toxicol. Appl. Pharmacol. 219: 128-135. (Pubitemid 46282870)
218. Mendola, P., Selevan, S. G., Gutter, S., and Rice, D. 2002. Environmental factors associated with a spectrum of neurodevelopmental deficits. MRDD Res. Rev. 8: 188-197. (Pubitemid 36378161)
219. Middaugh, L. D., Dow-Edwards, D., Li, A. A., Sandler, J. D., Seed, J., Sheets, L. P., Shuey, D. L., Slikker, W., Jr., Weisenburger, W. P., Wise, L. D., and Selwyn, M. R. 2003. Neurobehavioral assessment: A survey of use and value in safety assessment studies. Toxicol. Sci. 76: 250-261. (Pubitemid 38035418)
220. Mink, P. J., Kimmel, C. A., and Li, A. A. 2012. Potential effects of chlorpyrifos on fetal growth outcomes: implications for risk assessment. J. Toxicol. Environ. Health B 15: 281-316.
221. Miranda-Contreras, L., Davila-Ovalles, R., Benitez-Diaz, P., Pena-Contreras, Z., and Palacios-Pru, E. 2005. Effects of prenatal paraquat and mancozeb exposure on amino acid synaptic transmission in developing mouse cerebellar cortex. Brain Res. Dev. Brain Res. 160: 19-27. (Pubitemid 41512803)
222. Moniz, A. C., Bernardi, M. M., Souza-Spinosa, H. S., and Palermo-Neto, J. 1990. Effects of exposure to a pyrethroid insecticide during lactation on the behavior of infant and adult rats. Braz. J. Med. Biol. Res. 23: 45-48. (Pubitemid 20081610)
223. Moniz, A. C., Cruz-Casallas, P. E., Oliveira, C. A., Lucisano, A., Florio, J. C., Nicolau, A. A., Spinosa, H. S., and Bernardi, M. M. 1999. Perinatal fenvalerate exposure: behavioral and endocrinology changes in male rats. Neurotoxicol. Teratol. 21: 611-618. (Pubitemid 29415765)
224. Moniz, A. C., Cruz-Casallas, P. E., Salzgeber, S. A., Varoli, F. M., Spinosa, H. S., and Bernardi, M. M. 2005. Behavioral and endocrine changes induced by perinatal fenvalerate exposure in female rats. Neurotoxicol. Teratol. 27: 609-614. (Pubitemid 41112676)
225. Morales, E., Sunyer, J., Castro-Giner, F., Estivill, X., Julvez, J., Ribas-Fito, N., Torrent, M., Grimalt, J. O., and De Cid, R. 2008. Influence of glutathione S-transferase polymorphisms on cognitive functioning effects induced by P, p'-DDT among preschoolers. Environ. Health Perspect. 116: 1581-1585.
226. Moser, V. C. 2000. Dose-response and timecourse of neurobehavioral changes following oral chlorpyrifos in rats of different ages. Neurotoxicol. Teratol. 22: 713-723.
227. Moser, V. C., Chanda, S. M., Mortensen, S. R., and Padilla, S. 1998. Age-and gender-related differences in sensitivity to chlorpyrifos in the rat reflect developmental profiles of esterase activities. Toxicol. Sci. 46: 211-222. (Pubitemid 29069605)
228. Moser, V. C., Mcdaniel, K. L., Phillips, P. M., and Lowit, A. B. 2010. Time-course, doseresponse, and age comparative sensitivity of N-methyl carbamates in rats. Toxicol. Sci. 114: 113-123.
229. Moser, V. C., Shafer, T. J., Ward, T. R., Meacham, C. A., Harris, M. W., and Chapin, R. E. 2001. Neurotoxicological outcomes of perinatal heptachlor exposure in the rat. Toxicol. Sci. 60: 315-326. (Pubitemid 32273321)
230. Mundy, W. P., S. ; Shafer, T., Gilbert, M., Breier, J., Cowden, J., Crofton, K., Herr, D., Jensen, K., Raffaele, K., Radio, N., and Schumacher, K. 2009. Building a database of neurotoxicants: Evidence from human and animal studies. Poster presentad at Society of Toxicology Meeting, U.S. EPA.
231. Nagymajtenyi, L., Schulz, H., Papp, A., and Desi, I. 1998. Developmental neurotoxicological effects of lead and dimethoate in animal experiments. Neurotoxicology 19: 617-622. (Pubitemid 28402462)
232. Narahashi, T. 2000. Neuroreceptors and ion channels as the basis for drug action: Past, present, and future. J. Pharmacol. Exp. Ther. 294: 1-26. (Pubitemid 30434665)
233. Nasuti, C., Gabbianelli, R., Falcioni, M. L., Di Stefano, A., Sozio, P., and Cantalamessa, F. 2007. Dopaminergic system modulation, behavioral changes, and oxidative stress after neonatal administration of pyrethroids. Toxicology 229: 194-205. (Pubitemid 44937489)
234. National Academy of Sciences. 1988. Research on children and adolescents with mental, behavioral, and developmental disorders, Washington, DC: National Academy Press.
235. National Academy of Sciences. 2000. Scientific frontiers in developmental toxicity and risk assessment, Washington, DC: National Academy Press.
236. Nostrandt, A. C., Duncan, J. A., and Padilla, S. 1993. A modified spectrophotometric method appropriate for measuring cholinesterase activity in tissue from carbaryl-treated animals. Fundam. Appl. Toxicol. 21: 196-203. (Pubitemid 23242289)
237. O'rourke, M. K., Lizardi, P. S., Rogan, S. P., Freeman, N. C., Aguirre, A., and Saint, C. G. 2000. Pesticide exposure and creatinine variation among young children. J. Expos. Anal. Environ. Epidemiol. 10: 672-681. (Pubitemid 32038551)
238. Ogino, T., Hattori, J., Abiru, K., Nakano, K., Oka, E., and Ohtsuka, Y. 2005. Symptoms related to ADHD observed in patients with pervasive developmental disorder. Brain Dev. 27: 345-348. (Pubitemid 40991754)
239. Olson, K. L., Boush, G. M., and Matsumura, F. 1978. Behavioral effects of perinatal exposure of chlordimeform in rats. Bull. Environ. Contam. Toxicol. 20: 760-768. (Pubitemid 9137657)
240. Palanza, P., Morellini, F., Parmigiani, S., and Vom Saal, F. S. 2002. Ethological methods to study the effects of maternal exposure to estrogenic endocrine disrupters: A study with methoxychlor. Neurotoxicol. Teratol. 24: 55-69. (Pubitemid 34143249)
241. Palanza, P., Parmigiani, S., and Vom Saal, F. S. 2001. Effects of prenatal exposure to low doses of diethylstilbestrol, O, p'-DDT, and methoxychlor on postnatal growth and neurobehavioral development in male and female mice. Horm. Behav. 40: 252-265. (Pubitemid 32846360)
242. Palermo-Neto, J., Sakate, M., and Florio, J. C. 1997. Developmental and behavioral effects of postnatal amitraz exposure in rats. Braz. J. Med. Biol. Res. 30: 989-997. (Pubitemid 27377071)
243. Pan, I. J., Daniels, J. L., Goldman, B. D., Herring, A. H., Siega-Riz, A. M., and Rogan, W. J. 2009. Lactational exposure to polychlorinated biphenyls, dichlorodiphenyltrichloroethane, and dichlorodiphenyldichloroethylene and infant neurodevelopment: An analysis of the pregnancy, infection, and nutrition babies study. Environ. Health Perspect. 117: 488-494.
244. Pancetti, F., Olmos, C., Dagnino-Subiabre A., Rozas, C., Morales, B. 2007. Noncholinesterase effects induced by organophosphate pesticides and their relationship to cognitive processes: Implications for the action of acylpeptide hydrolase. J. Toxicol. Environ. Health B 10: 623-630. (Pubitemid 350211277)
245. Patro, N., Shrivastava, M., Tripathi, S., and Patro, I. K. 2009. S100beta upregulation: A possible mechanism of deltamethrin toxicity and motor coordination deficits. Neurotoxicol. Teratol. 31: 169-176.
246. Pauluhn, J., and Schmuck, G. 2003. Critical analysis of potential body temperature confounders on neurochemical endpoints caused by direct dosing and maternal separation in neonatal mice: A study of bioallethrin and deltamethrin interactionswith temperature on brain muscarinic receptors. J. Appl. Toxicol. 23: 9-18. (Pubitemid 36157712)
247. Pentyala, S. N., and Chetty, C. S. 1993. Comparative study on the changes in AChE and ATPase activities in neonate and adult rat brains under thiobencarb stress. J. Appl. Toxicol. 13: 39-42. (Pubitemid 23032660)
248. Perera, F. P., Rauh, V., Tsai, W. Y., Kinney, P., Camann, D., Barr, D., Bernert, T., Garfinkel, R., Tu, Y. H., Diaz, D., Dietrich, J., and Whyatt, R. M. 2003. Effects of transplacental exposure to environmental pollutants on birth outcomes in a multiethnic population. Environ. Health Perspect. 111: 201-205. (Pubitemid 36305318)
249. Poole, C. 2001. Low P-values or narrow confidence intervals: Which are more durable? Epidemiology 12: 291-294. (Pubitemid 32336389)
250. Pope, A. M., Heavner, J. E., Guarnieri, J. A., and Knobloch, C. P. 1986. Trichlorfon-induced congenital cerebellar hypoplasia in neonatal pigs. J. Am. Vet. Med. Assoc. 189: 781-783. (Pubitemid 17198221)
251. Pope, C. N. 1999. Organophosphorus pesticides: Do they all have the same mechanism of toxicity? J. Toxicol. Environ. Health B 2: 161-181. (Pubitemid 30054869)
252. Pope, C. N., and Chakraborti, T. K. 1992. Dose-related inhibition of brain and plasma cholinesterase in neonatal and adult rats following sublethal organophosphate exposures. Toxicology 73: 35-43.
253. Pope, C. N., Chakraborti, T. K., Chapman, M. L., Farrar, J. D., and Arthun, D. 1991. Comparison of in vivo cholinesterase inhibition in neonatal and adult rats by three organophosphorothioate insecticides. Toxicology 68: 51-61.
254. Prueitt, R. L., Goodman, J. E., Bailey, L. A., and Rhomberg, L. R. 2011. Hypothesisbased weight-of-evidence evaluation of the neurodevelopmental effects of chlorpyrifos. Crit. Rev. Toxicol. 41: 822-903.
255. Puertas, R., Lopez-Espinosa, M.-J., Cruz, F., Ramos, R., Freire, C., Perez-Garcia, M., Abril, A., Julvez, J., Salvatierra, M., Campoy, C., and Olea, N. 2010. Prenatal exposure to mirex impairs neurodevelopment at age of 4 years. Neurotoxicology 31: 154-160.
256. Purkerson-Parker, S., Mcdaniel, K. L., and Moser, V. C. 2001. Dopamine transporter binding in the rat striatum is increased by gestational, perinatal, and adolescent exposure to heptachlor. Toxicol. Sci. 64: 216-223. (Pubitemid 33130313)
257. Qiao, D., Seidler, F. J., Abreu-Villaca, Y., Tate, C. A., Cousins, M. M., and Slotkin, T. A. 2004. Chlorpyrifos exposure during neurulation: cholinergic synaptic dysfunction and cellular alterations in brain regions at adolescence and adulthood. Brain Res. Dev. Brain Res. 148: 43-52. (Pubitemid 38147803)
258. Qiao, D., Seidler, F. J., Padilla, S., and Slotkin, T. A. 2002. Developmental neurotoxicity of chlorpyrifos: What is the vulnerable period? Environ. Health Perspect. 110: 1097-1103. (Pubitemid 35363734)
259. Qiao, D., Seidler, F. J., Tate, C. A., Cousins, M. M., and Slotkin, T. A. 2003. Fetal chlorpyrifos exposure: Adverse effects on brain cell development and cholinergic biomarkers emerge postnatally and continue into adolescence and adulthood. Environ. Health Perspect. 111: 536-544. (Pubitemid 36546536)
260. Raffaele, K. C., Rowland, J., May, B., Makris, S. L., Schumacher, K., Scarano, L. J. 2010. The use of developmental neurotoxicity data in pesticide risk assessments. Neurotoxicol. Teratol. 32: 563-572.
261. Raines, K. W., Seidler, F. J., and Slotkin, T. A. 2001. Alterations in serotonin transporter expression in brain regions of rats exposed neonatally to chlorpyrifos. Brain Res. Dev. Brain Res. 130: 65-72. (Pubitemid 32830973)
262. Rauh, V., Arunajadai, S., Horton, M., Perera, F., Hoepner, L., Barr, D. B., and Whyatt, R. 2011. Seven-year neurodevelopmental scores and prenatal exposure to chlorpyrifos, a common agricultural pesticide. Environ. Health Perspect. 119: 1196-1201.
263. Rauh, V. A.,Garfinkel, R., Perera, F. P., Andrews, H. F., Hoepner, L., Barr, D. B., Whitehead, R., Tang, D., and Whyatt, R.W. 2006. Impact of prenatal chlorpyrifos exposure on neurodevelopment in the first 3 years of life among inner-city children. Pediatrics 118: e1845-e1859. (Pubitemid 46397562)
264. Ray, D. E., and Fry, J. R. 2006. A reassessment of the neurotoxicity of pyrethroid insecticides. Pharmacol. Ther. 111: 174-193. (Pubitemid 44226293)
265. Reeves, R., Thiruchelvam, M., Richfield, E. K., and Cory-Slechta, D. A. 2004. The effectof developmental exposure to the fungicide triadimefon on behavioral sensitization to triadimefon during adulthood. Toxicol. Appl. Pharmacol. 200: 54-63. (Pubitemid 39286674)
266. Reiss, R., and Gaylor, D. 2005. Use of benchmark dose and meta-analysis to determine the most sensitive endpoint for risk assessment for dimethoate. Regul. Toxicol. Pharmacol. 43: 55-65. (Pubitemid 41265873)
267. Rescorla, L. A. 2005. Assessment of young children using the Achenbach System of Empirically Based Assessment (ASEBA). Ment. Retard. Dev. Disabil. Res. Rev. 11: 226-237. (Pubitemid 41434682)
268. Rhodes, M. C., Seidler, F. J., Qiao, D., Tate, C. A., Cousins, M. M., and Slotkin, T. A. 2004. Does pharmacotherapy for preterm labor sensitize the developing brain to environmental neurotoxicants? Cellular and synaptic effects of sequential exposure to terbutaline and chlorpyrifos in neonatal rats. Toxicol. Appl. Pharmacol. 195: 203-217. (Pubitemid 38293152)
269. Ribas-Fito, N., Cardo, E., Sala, M., Eulalia De Muga, M., Mazon, C., Verdu, A., Kogevinas, M., Grimalt, J. O., and Sunyer, J. 2003. Breastfeeding, exposure to organochlorine compounds, and neurodevelopment in infants. Pediatrics, 111: e580-e585.
270. Ribas-Fito, N., Torrent, M., Carrizo, D., Julvez, J., Grimalt, J. O., and Sunyer, J. 2007. Exposure to hexachlorobenzene during pregnancy and children's social behavior at 4 years of age. Environ. Health Perspect. 115: 447-450. (Pubitemid 46554446)
271. Ribas-Fito, N., Torrent, M., Carrizo, D., Munoz-Ortiz, L., Julvez, J., Grimalt, J. O., and Sunyer, J. 2006. In utero exposure to background concentrations of DDT and cognitive functioning among preschoolers. Am. J. Epidemiol. 164: 955-962. (Pubitemid 44729836)
272. Ricceri, L., Venerosi, A., Capone, F., Cometa, M. F., Lorenzini, P., Fortuna, S., and Calamandrei, G. 2006. Developmental neurotoxicity of organophosphorous pesticides: fetal and neonatal exposure to chlorpyrifos alters sex-specific behaviors at adulthood in mice. Toxicol. Sci. 93: 105-113. (Pubitemid 44288254)
273. Rice, D., and Barone, S., Jr. 2000. Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. Environ. Health Perspect. 108 (suppl. 3): 511-533. (Pubitemid 30466179)
274. Rice, D. C. 2005. Assessing the effects of environmental toxicant exposure in developmental epidemiological studies: issues for risk assessment. Neurotoxicology 26: 483-489. (Pubitemid 41175886)
275. Richardson, J., and Chambers, J. 2003. Effects of gestational exposure to chlorpyrifos on postnatal central and peripheral cholinergic neurochemistry. J. Toxicol. Environ. Health A 66: 275-289. (Pubitemid 36184572)
276. Richardson, J. R., Caudle, W. M., Wang, M. Z., Dean, E. D., Pennell, K. D., and Miller, G. W. 2008. Developmental heptachlor exposure increases susceptibility of dopamine neurons to N-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) in a gender-specific manner. Neurotoxicology 29: 855-863.
277. Richardson, J. R., and Chambers, J. E. 2004. Neurochemical effects of repeated gestational exposure to chlorpyrifos in developing rats. Toxicol. Sci. 77: 83-90. (Pubitemid 38128648)
278. Richardson, J. R., and Chambers, J. E. 2005. Effects of repeated oral postnatal exposure to chlorpyrifos on cholinergic neurochemistry in developing rats. Toxicol. Sci. 84: 352-359. (Pubitemid 40542295)
279. Roberts, E. M., English, P. B., Grether, J. K., Windham, G. C., Somberg, L., and Wolff, C. 2007. Maternal residence near agricultural pesticide applications and autism spectrum disorders among children in the California Central Valley. Environ. Health Perspect. 115: 1482-1489. (Pubitemid 47618092)
280. Roegge, C. S., Timofeeva, O. A., Seidler, F. J., Slotkin, T. A., and Levin, E. D. 2008. Developmental diazinon neurotoxicity in rats: Later effects on emotional response. Brain. Res. Bull. 75: 166-172. (Pubitemid 350297656)
281. Rogan, W. J., and Gladen, B. C. 1991. PCBs, DDE, and child development at 18 and 24 months. Ann. Epidemiol. 1: 407-413.
282. Rogan, W. J., Gladen, B. C., Mckinney, J. D., Carreras, N., Hardy, P., Thullen, J., Tinglestad, J., and Tully, M. 1986. Neonatal effects of transplacental exposure to PCBs and DDE. J. Pediatr. 109: 335-341. (Pubitemid 16032535)
283. Rosecrans, J. A., Hong, J. S., Squibb, R. E., Johnson, J. H., Wilson, W. E., and Tilson, H. A. 1982. Effects of perinatal exposure to chlordecone (Kepone) on neuroendocrine and neurochemical responsiveness of rats to environmental challenges. Neurotoxicology 3: 131-142. (Pubitemid 13169728)
284. Rosecrans, J. A., Johnson, J. H., Tilson, H. A., and Hong, J. S. 1984. Hypothalamicpituitary adrenal (HPAA) axis function in adult Fischer-344 rats exposed during development to neurotoxic chemicals perinatally. Neurobehav. Toxicol. Teratol. 6: 281-288. (Pubitemid 15207059)
285. Ross, M. K., Borazjani, A., Edwards, C. C., and Potter, P. M. 2006. Hydrolytic metabolism of pyrethroids by human and other mammalian carboxylesterases. Biochem. Pharmacol. 71: 657-669. (Pubitemid 43121999)
286. Rosso, S. B., Garcia, G. B., Madariaga, M. J., Evangelista De Duffard, A. M., and Duffard, R. O. 2000. 2, 4-Dichlorophenoxyacetic acid in developing rats alters behaviour, myelination and regions brain gangliosides pattern. Neurotoxicology 21: 155-163.
287. Roy, T. S., Seidler, F. J., and Slotkin, T. A. 2004. Morphologic effects of subtoxic neonatal chlorpyrifos exposure in developing rat brain: Regionally selective alterations in neurons and glia. Brain Res. Dev. Brain Res. 148: 197-206. (Pubitemid 38177430)
288. Roy, T. S., Sharma, V., Seidler, F. J., and Slotkin, T. A. 2005. Quantitative morphological assessment reveals neuronal and glial deficits in hippocampus after a brief subtoxic exposure to chlorpyrifos in neonatal rats. Brain Res. Dev. Brain Res. 155: 71-80. (Pubitemid 40347309)
289. Sagiv, S. K., Nugent, J. K., Brazelton, T. B., Choi, A. L., Tolbert, P. E., Altshul, L. M., and Korrick, S. A. 2008. Prenatal organochlorine exposure and measures of behavior in infancy using the Neonatal Behavioral Assessment Scale (NBAS). Environ. Health Perspect. 116: 666-673. (Pubitemid 351864284)
290. Sagiv, S. K., Thurston, S. W., Bellinger, D. C., Tolbert, P. E., Altshul, L. M., and Korrick, S. A. 2010. Prenatal organochlorine exposure and behaviors associated with attention deficit hyperactivity disorder in school-aged children. Am. J. Epidemiol. 171: 593-601.
291. Sagiv, S. K., Tolbert, P. E., Altshul, L. M., and Korrick, S. A. 2007. Organochlorine exposures during pregnancy and infant size at birth. Epidemiology 18: 120-129. (Pubitemid 46005916)
292. Samuelsen, S. O., Bakketeig, L. S., Tretli, S., Johannesen, T. B., and Magnus, P. 2006. Head circumference at birth and risk of brain cancer in childhood: A population-based study. Lancet Oncol. 7: 39-42. (Pubitemid 43025391)
293. Sattler, J. M. 2001. Assessment of children: Cognitive applications. La Mesa, CA: Jerome M. Sattler, Publisher.
294. Sattler, J. M. 2008a. Wechser Preschool and Primary Scale of Intelligence-Third edition (WPPSI-III): Description. In Assessment of children: Cognitive foundations, 5th ed., ed. J. M. Sattler, 403-440. San Diego, CA: Jerome M. Sattler, Publisher.
295. Sattler, J. M. 2008b. Wechsler Intelligence Scale for Children-Fourth edition (WISCIV): Description. In Assessment of children: Cognitive foundations, 5th ed., ed. J. M. Sattler. San Diego, CA: Jerome M. Sattler, Publisher, 265-315.
296. Sattler, J. M., Weyandt, L., and Willis, J. O. 2006. Attention-deficit/ hyperactivity disorder. In Assessment of children: Behavioral, social, and clinical foundations, 5th ed., ed. J. M. Sattler and R. D. Hoge, 374-389. San Diego, CA: Jerome M. Sattler, Publisher.
297. Scollon, E. J., Starr, J. M., Godin, S. J., Devito, M. J., and Hughes, M. F. 2009. In vitro metabolism of pyrethroid pesticides by rat and human hepatic microsomes and cytochrome P450 isoforms. Drug Metab. Dispos. 37: 221-228.
298. Seth, P. K., Agrawal, A. K., and Bondy, S. C. 1981. Biochemical changes in the brain consequent to dietary exposure of developing and mature rats to chlordecone (Kepone). Toxicol. Appl. Pharmacol. 59: 262-267. (Pubitemid 11064652)
299. Shafer, T. J., and Crofton, K. M. 2011. Comments on: 'Perinatal toxicity of cyfluthrin in mice: Developmental and behavioral effects' by Soni and colleagues. Hum. Exp. Toxicol. 30: 1112-1113.
300. Shafer, T. J., and Meyer, D. A. 2004. Effects of pyrethroids on voltage-sensitive calcium channels: A critical evaluation of strengths, weaknesses, data needs, and relationship to assessment of cumulative neurotoxicity. Toxicol. Appl. Pharmacol. 196: 303-318. (Pubitemid 38469962)
301. Shafer, T. J., Meyer, D. A., and Crofton, K. M. 2005. Developmental neurotoxicity of pyrethroid insecticides: Critical review and future research needs. Environ. Health Perspect. 113: 123-136. (Pubitemid 40326320)
302. Sheets, L. P. 2000. A consideration of age-dependent differences in susceptibility to organophosphorus and pyrethroid insecticides. Neurotoxicology 21: 57-63.
303. Sheets, L. P., Doherty, J. D., Law, M. W., Reiter, L. W., and Crofton, K. M. 1994. Age-dependent differences in the susceptibility of rats to deltamethrin. Toxicol. Appl. Pharmacol. 126: 186-190. (Pubitemid 24168884)
304. Sierra, V., and Uphouse, L. 1986. Longterm consequences of neonatal exposure to chlordecone. Neurotoxicology 7: 609-621.
305. Slotkin, T. A. 2004. Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphates. Toxicol. Appl. Pharmacol. 198: 132-151. (Pubitemid 38960724)
306. Slotkin, T. A., Bodwell, B. E., Levin, E. D., and Seidler, F. J. 2008a. Neonatal exposure to low doses of diazinon: Long-term effects on neural cell development and acetylcholine systems. Environ. Health Perspect. 116: 340-348. (Pubitemid 351395602)
307. Slotkin, T. A., Cousins, M. M., Tate, C. A., and Seidler, F. J. 2001. Persistent cholinergic presynaptic deficits after neonatal chlorpyrifos exposure. Brain Res. 902: 229-243. (Pubitemid 32510872)
308. Slotkin, T. A., Lassiter, T. L., Ryde, I. T., Wrench, N., Levin, E. D. & Seidler, F. J. 2009a. Consumption of a high-fat diet in adulthood ameliorates the effects of neonatal parathion exposure on acetylcholine systems in rat brain regions. Environ Health Persp, 117: 916-922.
309. Slotkin, T. A., Levin, E. D., and Seidler, F. J. 2006a. Comparative developmental neurotoxicity of organophosphate insecticides: Effects on brain development are separable from systemic toxicity. Environ. Health Perspect. 114: 746-751.
310. Slotkin, T. A., Levin, E. D., and Seidler, F. J. 2009b. Developmental neurotoxicity of parathion: Progressive effects on serotonergic systems in adolescence and adulthood. Neurotoxicol. Teratol. 31: 11-17.
311. Slotkin, T. A., Oliver, C. A., and Seidler, F. J. 2005. Critical periods for the role of oxidative stress in the developmental neurotoxicity of chlorpyrifos and terbutaline, alone or in combination. Brain Res. Dev. Brain Res. 157: 172-180. (Pubitemid 40800417)
312. Slotkin, T. A., Ryde, I. T., Levin, E. D., and Seidler, F. J. 2008b. Developmental neurotoxicity of low dose diazinon exposure of neonatal rats: Effects on serotonin systems in adolescence and adulthood. Brain Res. Bull. 75: 640-647. (Pubitemid 351381825)
313. Slotkin, T. A., and Seidler, F. J. 2007. Prenatal chlorpyrifos exposure elicits presynaptic serotonergic and dopaminergic hyperactivity at adolescence: Critical periods for regional and sex-selective effects. Reprod. Toxicol. 23: 421-427. (Pubitemid 46602920)
314. Slotkin, T. A., and Seidler, F. J. 2008. Developmental neurotoxicants target neurodifferentiation into the serotonin phenotype: Chlorpyrifos, diazinon, dieldrin and divalent nickel. Toxicol. Appl. Pharmacol. 233: 211-219. (Pubitemid 50304205)
315. Slotkin, T. A., Southard, M. C., Adam, S. J., Cousins, M. M., and Seidler, F. J. 2004. Alpha7 nicotinic acetylcholine receptors targeted by cholinergic developmental neurotoxicants: Nicotine and chlorpyrifos. Brain Res. Bull. 64: 227-235. (Pubitemid 39349603)
316. Slotkin, T. A., Tate, C. A., Cousins, M. M., and Seidler, F. J. 2002. Functional alterations in CNS catecholamine systems in adolescence and adulthood after neonatal chlorpyrifos exposure. Brain Res. Dev. Brain Res. 133: 163-173. (Pubitemid 34212001)
317. Slotkin, T. A., Tate, C. A., Ryde, I. T., Levin, E. D., and Seidler, F. J. 2006b. Organophosphate insecticides target the serotonergic system in developing rat brainregions: Disparate effects of diazinon and parathion at doses spanning the threshold for cholinesterase inhibition. Environ. Health Perspect. 114: 1542-1546. (Pubitemid 44509652)
318. Smith, J. N., Campbell, J. A., Busby-Hjerpe, A. L., Lee, S., Poet, T. S., Barr, D. B., and Timchalk, C. 2009. Comparative chlorpyrifos pharmacokinetics via multiple routes of exposure and vehicles of administration in the adult rat. Toxicology 261: 47-58.
319. Sobotka, T. J., Brodie, R. E., and Cook, M. P. 1972. Behavioral and neuroendocrine effects in rats of postnatal exposure to low dietary levels of maneb. Dev. Psychobiol. 5: 137-148.
320. Soderlund, D. M., Clark, J. M., Sheets, L. P., Mullin, L. S., Piccirillo, V. J., Sargent, D., Stevens, J. T., and Weiner, M. L. 2002. Mechanisms of pyrethroid neurotoxicity: Implications for cumulative risk assessment. Toxicology 171: 3-59. (Pubitemid 34102445)
321. Song, X., Seidler, F. J., Saleh, J. L., Zhang, J., Padilla, S., and Slotkin, T. A. 1997. Cellular mechanisms for developmental toxicity of chlorpyrifos: Targeting the adenylyl cyclase signaling cascade. Toxicol. Appl. Pharmacol. 145: 158-174. (Pubitemid 27294780)
322. Spyker, J. M., and Avery, D.L. 1977. Neurobehavioral effects of prenatal exposure to the organophosphate diazinon in mice. J. Toxicol. Environ. Health 3: 989-1002. (Pubitemid 8271181)
323. Spurlock, F., and Lee, M. 2008. Synthetic pyrethroid use patterns, properties, and environmental effects. Washington, DC: American Chemical Society.
324. Squibb, R. E., and Tilson, H. A. 1982. Effects of gestational and perinatal exposure to chlordecone (Kepone) on the neurobehavioral development of Fischer-344 rats. Neurotoxicology 3: 17-26. (Pubitemid 13169718)
325. Srivastava, M. K., and Raizada, R. B. 1996. Development effect of technical dimethoate in rats: Maternal and fetal toxicity evaluation. Indian J Exp Biol, 34: 329-333. (Pubitemid 126500381)
326. Srivastava, M. K., and Raizada, R. B. 1999. Assessment of the no-observed-effect level (NOEL) of quinalphos in pregnant rats. Food Chem. Toxicol. 37: 649-653. (Pubitemid 29438565)
327. Srivastava, M. K., and Raizada, R. B. 2007. Lack of toxic effect of technical azadirachtin during postnatal development of rats. Food Chem. Toxicol. 45: 465-471. (Pubitemid 46176372)
328. Srivastava, M. K., Raizada, R. B., and Dikshith, T. S. 1992. Fetotoxic response of technical quinalphos in rats. Vet. Hum. Toxicol. 34: 131-133.
329. Stamper, C. R., Balduini, W., Murphy, S. D., & Costa, L. G. 1988. Behavioral and biochemical effects of postnatal parathion exposure in the rat. Neurotoxicol Teratol, 10: 261-266. (Pubitemid 19267562)
330. Stewart, P., Fitzgerald, S., Reihman, J., Gump, B., Lonky, E., Darvill, T., Pagano, J., and Hauser, P. 2003. Prenatal PCB exposure, the corpus callosum, and response inhibition. Environ. Health Perspect. 111: 1670-1677. (Pubitemid 37265981)
331. Stewart, P., Reihman, J., Gump, B., Lonky, E., Darvill, T., and Pagano, J. 2005. Response inhibition at 8 and 9 1/2 years of age in children prenatally exposed to PCBs. Neurotoxicol. Teratol. 27: 771-780. (Pubitemid 41642922)
332. Stewart, P., Reihman, J., Lonky, E., Darvill, T., and Pagano, J. 2000. Prenatal PCB exposure and neonatal behavioral assessment scale (NBAS) performance. Neurotoxicol. Teratol. 22: 21-29. (Pubitemid 30017974)
333. Stewart, P. W., Lonky, E., Reihman, J., Pagano, J., Gump, B. B., and Darvill, T. 2008. The relationship between prenatal PCB exposure and intelligence (IQ) in 9-year-old children. Environ. Health Perspect. 116: 1416-1422.
334. Strauss, E., Sherman, E. M. S., and Spreen, O. 2006. A compendium of neuropsychological tests: Administration, norms and commentary, 3rd ed. New York, NY: Oxford University Press.
335. Struve, M. F., Turner, K. J., and Dorman, D. C. 2007. Preliminary investigation of changes in the sexually dimorphic nucleus of the rat medial preoptic area following prenatal exposure to fenitrothion. J. Appl. Toxicol. 27: 631-636. (Pubitemid 350113429)
336. Sturtz, N., Deis, R. P., Jahn, G. A., Duffard, R., and Evangelista De Duffard, A. M. 2008. Effect of 2, 4-dichlorophenoxyacetic acid on rat maternal behavior. Toxicology 247: 73-79.
337. Sudakin, D. L., and Stone, D. L. 2011. Dialkyl phosphates as biomarkers of organophosphates: The current divide between epidemiology and clinicaltoxicology. Clin. Toxicol. (Phila.) 49: 771-781.
338. Sunyer, J., Basagana, X., Gonzalez, J. R., Julvez, J., Guerra, S., Bustamante, M., De Cid, R., Anto, J. M., and Torrent, M. 2010. Early life environment, neurodevelopment and the interrelation with atopy. Environ. Res. 110: 733-738.
339. Talts, U., Fredriksson, A., and Eriksson, P. 1998. Changes in behavior and muscarinic receptor density after neonatal and adult exposure to bioallethrin. Neurobiol. Aging 19: 545-552. (Pubitemid 29117121)
340. Tan, J., Loganath, A., Chong, Y. S., and Obbard, J. P. 2009. Exposure to persistent organic pollutants in utero and related maternal characteristics on birth outcomes: A multivariate data analysis approach. Chemosphere 74: 428-433.
341. Tanaka, H., Yan, S., Miura, N., and Shoyama, Y. 2003. Preparation of anti-2, 4-dichlorophenol and 2, 4-dichlorophenoxyacetic acid monoclonal antibodies. Cytotechnology 42: 101-107. (Pubitemid 38129282)
342. Tanaka, T. 1992. Effects of piperonyl butoxide on F1 generation mice. Toxicol. Lett. 60: 83-90.
343. Tanaka, T. 1995. Reproductive and neurobehavioral effects of imazalil administered to mice. Reprod. Toxicol. 9: 281-288.
344. Tanaka, T. 2001. Reproductive and neurobehavioural effects of thiabendazole administered to mice in the diet. Food Addit. Contam. 18: 375-383. (Pubitemid 32433290)
345. Tanaka, T. 2003. Reproductive and neurobehavioural effects of piperonyl butoxide administered to mice in the diet. Food Addit. Contam. 20: 207-214. (Pubitemid 36367389)
346. Tang, J., Carr, R. L., and Chambers, J. E. 1999. Changes in rat brain cholinesterase activity and muscarinic receptor density during and after repeated oral exposure to chlorpyrifos in early postnatal development. Toxicol. Sci. 51: 265-272. (Pubitemid 29496233)
347. Tang, J., Carr, R. L., and Chambers, J. E. 2003. The effects of repeated oral exposures to methyl parathion on rat brain cholinesterase and muscarinic receptors during postnatal development. Toxicol. Sci. 76: 400-406. (Pubitemid 38035433)
348. Thiruchelvam, M., Prokopenko, O., Cory-Slechta, D. A., Buckley, B., and Mirochnitchenko, O. 2005. Overexpression of superoxide dismutase or glutathione peroxidase protects against the paraquat + maneb-induced Parkinson disease phenotype. J. Biol. Chem. 280: 22530-22539. (Pubitemid 40827911)
349. Thiruchelvam, M., Richfield, E. K., Goodman, B. M., Baggs, R. B., and Cory-Slechta, D. A. 2002. Developmental exposure to the pesticides paraquat and maneb and the Parkinson's disease phenotype. Neurotoxicology 23: 621-633. (Pubitemid 36527682)
350. Thomas, K. W., Dosemeci, M., Hoppin, J. A., Sheldon, L. S., Croghan, C. W., Gordon, S. M., Jones, M. L., Reynolds, S. J., Raymer, J. H., Akland, G. G., Lynch, C. F., Knott, C. E., Sandler, D. P., Blair, A. E., and Alavanja, M. C. 2010. Urinary biomarker, dermal, and air measurement results for 2, 4-D and chlorpyrifos farm applicators in the Agricultural Health Study. J. Expos. Sci. Environ. Epidemiol. 20: 119-134.
351. Tilson, H. A., Squibb, R. E., and Burne, T. A. 1982. Neurobehavioral effects following a single dose of chlordecone (Kepone) administered neonatally to rats. Neurotoxicology 3: 45-57. (Pubitemid 13169720)
352. Timchalk, C., Nolan, R. J., Mendrala, A. L., Dittenber, D. A., Brzak, K. A., and Mattsson, J. L. 2002. A Physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model for the organophosphate insecticide chlorpyrifos in rats and humans. Toxicol. Sci. 66: 34-53. (Pubitemid 34202027)
353. Timofeeva, O. A., Roegge, C. S., Seidler, F. J., Slotkin, T. A., and Levin, E. D. 2008a. Persistent cognitive alterations in rats after early postnatal exposure to low doses of the organophosphate pesticide, diazinon. Neurotoxicol. Teratol. 30: 38-45.
354. Timofeeva, O. A., Sanders, D., Seemann, K., Yang, L., Hermanson, D., Regenbogen, S., Agoos, S., Kallepalli, A., Rastogi, A., Braddy, D., Wells, C., Perraut, C., Seidler, F. J., Slotkin, T. A., and Levin, E. D. 2008b. Persistent behavioral alterations in rats neonatally exposed to low doses of the organophosphate pesticide, parathion. Brain Res. Bull. 77: 404-411.
355. Torres-Sanchez, L., Rothenberg, S. J., Schnaas, L., Cebrian, M. E., Osorio, E., Del CarmenHernandez, M., Garcia-Hernandez, R. M., Del Rio-Garcia, C., Wolff, M. S., and Lopez-Carrillo, L. 2007. In utero P, p'-DDE exposure and infant neurodevelopment: A perinatal cohort in Mexico. Environ. Health Perspect. 115: 435-439. (Pubitemid 46554444)
356. Torres-Sanchez, L., Schnaas, L., Cebrian, M. E., Hernandez Mdel, C., Valencia, E. O., Garcia Hernandez, R. M., and Lopez-Carrillo, L. 2009. Prenatal dichlorodiphenyldichloroethylene (DDE) exposure and neurodevelopment: A follow-up from 12 to 30 months of age. Neurotoxicology 30: 1162-1165.
357. Tsuji, R., Kobayashi, K., Ikeda, M., Yoshioka, T., Yamada, T., Seki, T., Okuno, Y., Nakatsuka, I., Tsuruo, Y., and Kishioka, S. 2002. Lack of changes in brain muscarinic receptor and motor activity of mice after neonatal inhalation exposure to D-allethrin. J. Appl. Toxicol. 22: 423-429. (Pubitemid 35378860)
358. Turgeman, G., Pinkas, A., Slotkin, T. A., Tfilin, M., Langford, R., and Yanai, J. 2011. Reversal of chlorpyrifos neurobehavioral teratogenicity in mice by allographic transplantation of adult subventricular zone-derived neural stem cells. J. Neurosci. Res. 89: 1185-1193.
359. U.S. Environmental Protection Agency. 2005. Reregistration eligibility decision for 2, 4-D. Washington, DC: U.S. EPA, Office of Pesticide Programs.
360. U.S. Environmental Protection Agency. 2007. Revised N-methyl carbamate cumulative risk assessment. Washington, DC: U.S. EPA, Office of Pesticide Programs.
361. U.S. Environmental Protection Agency. 2010a. Draft framework for incorporating human epidemiologic, and incident data in health risk assessment. Washington, DC: U.S. EPA, Office of Pesticide Programs.
362. U.S. Environmental Protection Agency. 2010b. Pyrethroids: Evaluation of data from developmental neurotoxicity studies and consideration of comparative sensitivity. Washington, DC: U.S. EPA, Office of Prevention.
363. U.S. Environmental Protection Agency. 2011. Pyrethroid cumulative risk assessment. Washington, DC: U.S. EPA, Office of Prevention.
364. Uphouse, L., Mason, G., and Bondy, S. 1982. Comments concerning the use of dimethylsulfoxide as a solvent for studies of chlordecone neurotoxicity. Neurotoxicology 3: 149-154. (Pubitemid 13169730)
365. Venerosi, A., Calamandrei, G., and Ricceri, L. 2006. A social recognition test for female mice reveals behavioral effects of developmental chlorpyrifos exposure. Neurotoxicol. Teratol. 28: 466-471. (Pubitemid 44332875)
366. Venerosi, A., Ricceri, L., Rungi, A., Sanghez, V., and Calamandrei, G. 2010. Gestational exposure to the organophosphate chlorpyrifos alters social-emotional behaviour and impairs responsiveness to the serotonin transporter inhibitor fluvoxamine in mice. Psychopharmacology (Berlin) 208: 99-107.
367. Venerosi, A., Ricceri, L., Scattoni, M. L., and Calamandrei, G. 2009. Prenatal chlorpyrifos exposure alters motor behavior and ultrasonic vocalization in CD-1 mouse pups. Environ. Health 8: 12.
368. Vergieva, T. 1985. Behavioral teratology-Results achieved and perspectives of development. J. Hyg. Epidemiol. Microbiol. Immunol. 29: 121-127. (Pubitemid 15095626)
369. Veronesi, B., and Pope, C. 1990. The neurotoxicity of parathion-induced acetylcholinesterase inhibition in neonatal rats. Neurotoxicology, 11: 609-626.
370. Vijverberg, H. P., and Van Den Bercken, J. 1990. Neurotoxicological effects and the mode of action of pyrethroid insecticides. Crit. Rev. Toxicol. 21: 105-126.
371. Vinggaard, A. M., Christiansen, S., Laier, P., Poulsen, M. E., Breinholt, V., Jarfelt, K., Jacobsen, H., Dalgaard, M., Nellemann, C., and Hass, U. 2005. Perinatal exposure to the fungicide prochloraz feminizes the male rat offspring. Toxicol. Sci. 85: 886-897. (Pubitemid 40846863)
372. Vom Saal, F. S., Nagel, S. C., Palanza, P., Boechler, M., Parmigiani, S., and Welshons, W. V. 1995. Estrogenic pesticides: binding relative to estradiol in MCF-7 cells and effects of exposure during fetal life on subsequent territorial behaviour in male mice. Toxicol. Lett. 77: 343-350.
373. Watson, R. E., Desesso, J. M., Hurtt, M. E., and Cappon, G. D. 2006. Postnatal growth and morphological development of the brain: A species comparison. Birth Defects Res. B Dev. Reprod. Toxicol. 77: 471-484. (Pubitemid 44657371)
374. Weiner, M. L., Nemec, M., Sheets, L., Sargent, D., and Breckenridge, C. 2009. Comparative functional observational battery study of twelve commercial pyrethroid insecticides in male rats following acute oral exposure. Neurotoxicology 30(suppl. 1): S1-S16.
375. Weselek, M., Arbuckle, T.E., and Foster, W. 2007. Pesticide exposures and developmental outcomes: the epidemiological evidence. J. Toxicol. Environ. Health B 10: 41-80.
376. Whyatt, R. M., Camann, D., Perera, F. P., Rauh, V. A., Tang, D., Kinney, P. L., Garfinkel, R., Andrews, H., Hoepner, L., and Barr, D. B. 2005. Biomarkers in assessing residential insecticide exposures during pregnancy and effects on fetal growth. Toxicol. Appl. Pharmacol. 206: 246-254. (Pubitemid 40828245)
377. Whyatt, R. M., Rauh, V., Barr, D. B., Camann, D. E., Andrews, H. F., Garfinkel, R., Hoepner, L. A., Diaz, D., Dietrich, J., Reyes, A., Tang, D., Kinney, P. L., and Perera, F. P. 2004. Prenatal insecticide exposures and birth weight and length among an urban minority cohort. Environ. Health Perspect. 112: 1125-1132. (Pubitemid 39029170)
378. Wigle, D. T., Arbuckle, T. E., Walker, M., Wade, M. G., Liu, S., and Krewski, D. 2007. Environmental hazards: Evidence for effects on child health. J. Toxicol. Environ. Health B 10: 3-39.
379. Wigle, D. T., Arbuckle, T. E., Turner, M.C., Bérubé, A., Yang, Q., Liu, S., and Krewski, D. 2008. Epidemiologic evidence of relationships between reproductive and child health outcomes and environmental chemical contaminants. J. Toxicol. Environ. Health B 11: 373-517. (Pubitemid 352005804)
380. Williams, M. K., Rundle, A., Holmes, D., Reyes, M., Hoepner, L. A., Barr, D. B., Camann, D. E., Perera, F. P., and Whyatt, R. M. 2008. Changes in pest infestation levels, self-reported pesticide use, and permethrin exposure during pregnancy after the 2000-2001 U.S. Environmental Protection Agency restriction of organophosphates. Environ. Health Perspect. 116: 1681-1688.
381. Wise, L. D., Allen, H. L., Hoe, C. M., Verbeke, D. R., and Gerson, R. J. 1997. Developmental neurotoxicity evaluation of the avermectin pesticide, emamectin benzoate, in Sprague-Dawley rats. Neurotoxicol. Teratol. 19: 315-326. (Pubitemid 27326886)
382. Wolansky, M. J., and Harrill, J. A. 2008. Neurobehavioral toxicology of pyrethroid insecticides in adult animals: A critical review. Neurotoxicol. Teratol. 30: 55-78.
383. Wolansky, M. J., Mcdaniel, K. L., Moser, V. C., and Crofton, K. M. 2007. Influence of dosing volume on the neurotoxicity of bifenthrin. Neurotoxicol. Teratol. 29: 377-384. (Pubitemid 46779081)
384. Wolff, M. S., Engel, S., Berkowitz, G., Teitelbaum, S., Siskind, J., Barr, D. B., and Wetmur, J. 2007. Prenatal pesticide and PCB exposures and birth outcomes. Pediatr. Res. 61: 243-250. (Pubitemid 46146885)
385. Yang, D., Lauridsen, H., Buels, K., Chi, L. H., La Du, J., Bruun, D. A., Olson, J. R., Tanguay, R. L., and Lein, P. J. 2011. Chlorpyrifosoxon disrupts zebrafish axonal growth and motor behavior. Toxicol. Sci. 121: 146-159.
386. Young, J. G., Eskenazi, B., Gladstone, E. A., Bradman, A., Pedersen, L., Johnson, C., Barr, D. B., Furlong, C. E., and Holland, N. T. 2005. Association between in utero organophosphate pesticide exposure and abnormal reflexes in neonates. Neurotoxicology 26: 199-209. (Pubitemid 40248438)
387. Zalewska, Z., Rakowska, I., Matraszek, G., and Sitkiewicz, D. 1977. Effect of dichlorvos on some enzyme activities of the rat brain during postnatal development.I.Cholinesterases. Neuropatol. Pol. 15: 255-262. (Pubitemid 8139543)
388. Zeman, F. J., Hoogenboom, E. R., Kavlock, R. J., and Semple, J. L. 1986. Effects on the fetus of maternal benomyl exposure in the protein-deprived rat. J. Toxicol. Environ. Health 17: 405-417. (Pubitemid 16139585)
389. Zheng, Q., Olivier, K., Won, Y. K., and Pope, C. N. 2000. Comparative cholinergic neurotoxicity of oral chlorpyrifos exposures in preweanling and adult rats. Toxicol. Sci. 55: 124-132. (Pubitemid 30252443)6