Persistent cognitive alterations in rats after early postnatal exposure to low doses of the organophosphate pesticide, diazinon

Neurotoxicology and Teratology

Volumn 30, Issue 1, 2008, Pages 38-45

  Timofeeva, Olga A ^a   Roegge, Cindy S ^b   Seidler, Frederic J ^a   Slotkin, Theodore A ^a   Levin, Edward D ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b WIL RESEARCH LABORATORIES   (United States)

Author keywords

Cholinergic; Development; Diazinon; Non monotonic dose response; Organophosphate insecticides; Prepulse inhibition; Radial arm maze; Sex selective effects; Working Memory

Indexed keywords

ACETYLCHOLINESTERASE; DIMPYLATE; ORGANOPHOSPHATE PESTICIDE; SCOPOLAMINE;

ADULTHOOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLINESTERASE INHIBITION; COGNITIVE DEFECT; CONTROLLED STUDY; FEMALE; MALE; MAZE TEST; MEMORY DISORDER; NEWBORN; NONHUMAN; POSTNATAL DEVELOPMENT; PREPULSE INHIBITION; PRIORITY JOURNAL; RAT; SEX DIFFERENCE; STARTLE REFLEX;

ACOUSTIC STIMULATION; ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; BEHAVIOR, ANIMAL; CHOLINESTERASE INHIBITORS; COGNITION DISORDERS; DIAZINON; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; KETANSERIN; MALE; MAZE LEARNING; MOTOR ACTIVITY; NEURAL INHIBITION; PREGNANCY; REACTION TIME; SEROTONIN ANTAGONISTS;

RATTUS;

EID: 38349113169     PISSN: 08920362     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ntt.2007.10.002     Document Type: Article

References (35)

1. Abou-Donia M.B. Organophosphorus ester-induced chronic neurotoxicity. Archives of Environmental Health 58 (2003) 484-497
2. Aldridge J.E., Levin E.D., Seidler F.J., and Slotkin T.A. Developmental exposure to chlorpyrifos leads to behavioral alterations resembling animal models of depression and involving serotonergic mechanisms. Environmental Health Perspectives 113 (2005) 527-531
3. Aldridge J.E., Seidler F.J., and Slotkin T.A. Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling. Environmental Health Perspectives 112 (2004) 148-155
4. Barone S., Das K.P., Lassiter T.L., and White L.D. Vulnerable processes of nervous system development: a review of markers and methods. Neurotoxicology 21 (2000) 15-36
5. Betancourt A.M., Burgess S.C., and Carr R.L. Effect of developmental exposure to chlorpyrifos on the expression of neurotrophin growth factors and cell-specific markers in neonatal rat brain. Toxicological Sciences 92 (2006) 500-506
6. Byers D.M., Irwin L.N., Moss D.E., Sumaya I.C., and Hohmann C.F. Prenatal exposure to the acetylcholinesterase inhibitor methanesulfonyl fluoride alters forebrain morphology and gene expression. Developmental Brain Research 158 (2005) 13-22
7. Casida J.E., and Quistad G.B. Organophosphate toxicology: Safety aspects of nonacetylcholinesterase secondary targets. Chemical Research and Toxicology 17 (2004) 983-998
8. Funk K.A., Henderson J.D., Liu C.H., Higgins R.J., and Wilson B.W. Neuropathology of organophosphate-induced delayed neuropathy (OPIDN) in young chicks. Archives of Toxicology 68 (1994) 308-316
9. Icenogle L., Christopher N., Blackwelder W., Caldwell D., Qiao D., Seidler F., Slotkin T., and Levin E. Behavioral alterations in adolescent and adult rats after a brief subtoxic exposure to chlorpyrifos during neurulation. Neurotoxicology and Teratology 26 (2004) 95-101
10. Jameson R.R., Seidler F.J., and Slotkin T.A. Nonenzymatic functions of acetylcholinesterase splice variants in the developmental neurotoxicity of organophosphates: Chlorpyrifos, chlorpyrifos oxon and diazinon. Environmental Health Perspectives 115 (2007)
11. Lauder J.M., and Schambra U.B. Morphogenetic roles of acetylcholine. British Journal of Pharmacology 126 (1999) 1003-1008
12. Laviola G., Adriani W., Gaudino C., Marino R., and Keller F. Paradoxical effects of prenatal acetylcholinesterase blockade on neuro-behavioral development and drug-induced stereotypies in reeler mutant mice. Psychopharmacology 187 (2006) 331-44
13. Levin E., Crysthansis E., Yacisin K., and Linney E. Chlorpyrifos exposure of developing zebrafish: effects on survival and long-term effects on response latency and spatial discrimination. Neurotoxicology and Teratology 25 (2003) 51-57
14. Levin E.D., Addy N., Baruah A., Elias A., Christopher N.C., Seidler F.J., and Slotkin T.A. Prenatal chlorpyrifos exposure in rats causes persistent behavioral alterations. Neurotoxicology and Teratology 24 (2002) 733-741
15. Levin E.D., Addy N., Nakajima A., Christopher N.C., Seidler F.J., and Slotkin T.A. Persistent behavioral consequences of neonatal chlorpyrifos exposure in rats. Developmental Brain Research 130 (2001) 83-89
16. MacLusky N.J., and Naftolin F. Sexual differentiation of the central nervous system. Science 211 (1981) 1294-1302
17. McCarthy M.M. Molecular aspects of sexual differentiation of the rodent brain. Psychoneuroendocrinology 19 (1994) 415-427
18. Rice D., and Barone S. Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. Environmental Health Perspectives 108 Suppl 3 (2000) 511-533
19. Slotkin T.A. Developmental cholinotoxicants: nicotine and chlorpyrifos. Environmental Health Perspectives 107 Suppl. 1 (1999) 65-69
20. Slotkin T.A. Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, and organophosphates. Toxicology and Applied Pharmacology 198 (2004) 132-151
21. Slotkin T.A. Developmental neurotoxicity of organophosphates: a case study of chlorpyrifos. In: Gupta R.C. (Ed). Toxicity of Organophosphate and Carbamate Pesticide (2005), Elsevier Academic Press, San Diego 293-314
22. Slotkin T.A., Levin E.D., and Seidler F.J. Comparative developmental neurotoxicity of organophosphate insecticides: effects on brain development are separable from systemic toxicity. Environmental Health Perspectives 114 (2006) 746-751
23. Slotkin T.A., and Seidler F.J. Comparative developmental neurotoxicity of organophosphates in vivo: Transcriptional responses of pathways for brain cell development, cell signaling, cytotoxicity and neurotransmitter systems. Brain Research Bulletin 72 (2007) 232-274
24. Slotkin T.A., Seidler F.J., and Fumagalli F. Exposure to organophosphates reduces the expression of neurotrophic factors in neonatal rat brain regions: Similarities and differences in the effects of chlorpyrifos and diazinon on the fibroblast growth factor superfamily. Environmental Health Perspectives 115 (2007) 909-916
25. Slotkin T.A., Tate C.A., Ryde I.T., Levin E.D., and Seidler F.J. Organophosphate insecticides target the serotonergic system in developing rat brain regions: disparate effects of diazinon and parathion at doses spanning the threshold for cholinesterase inhibition. Environmental Health Perspectives 114 (2006) 1542-1546
26. Snedecor G.W., and Cochran W.G. Statistical Methods (1967), Iowa State University Press, Ames, Iowa
27. Song X., Seidler F.J., Saleh J.L., Zhang J., Padilla S., and Slotkin T.A. Cellular mechanisms for developmental toxicity of chlorpyrifos: targeting the adenylyl cyclase signaling cascade. Toxicology and Applied Pharmacology 145 (1997) 158-174
28. Spyker J.M., and Avery D.L. Neurobehavioral effects of prenatal exposure to the organophosphate diazinon in mice. Journal of Toxicology and Environmental Health 3 (1977) 989-1002
29. Swerdlow N., Geyer M., and Braff D. Neural circuit regulation of prepulse inhibition o startle in the rat: current knowledge and future challenges. Psychopharmacology 156 (2001) 194-215
30. Swerdlow N.R., Braff D.L., and Geyer M.A. Animal models of deficient sensorimotor gating: what we know, what we think we know, and what we hope to know soon. Behavioural Pharmacology 11 (2000) 185-204
31. Swerdlow N.R., Martinez Z.A., Hanlon F.M., Platten A., Farid M., Auerbach P., Braff D.L., and Geyer M.A. Toward understanding the biology of a complex phenotype: rat strain and substrain differences in the sensorimotor gating-disruptive effects of dopamine agonists. Journal of Neuroscience 20 (2000) 4325-4336
32. U.S. Environmental Protection Agency. Chlorpyrifos: End-Use Products Cancellation Order (2002)
33. Vaccari A., Brotman S., Cimino J., and Timiras P.S. Sex differentiation of neurotransmitter enzymes in central and peripheral nervous systems. Brain Research 132 (1977) 176-185
34. Weiss E.R., Maness P., and Lauder J.M. Why do neurotransmitters act like growth factors?. Perspectives in Developmental Neurobiology 5 (1998) 323-335
35. Whitney K.D., Seidler F.J., and Slotkin T.A. Developmental neurotoxicity of chlorpyrifos: Cellular mechanisms. Toxicology and Applied Pharmacology 134 (1995) 53-62