Teratogenic effects of trichlorfon (Metrifonate) on the guinea-pig brain. Determination of the effective dose and the sensitive period

Neurochemistry International

Volumn 32, Issue 5-6, 1998, Pages 469-477

  Hjelde, T ^a   Mehl, A ^a,b   Schanke, T M ^a   Fonnum, Frode ^a,b  

^a UNIVERSITY OF OSLO   (Norway)

^b NORWEGIAN DEFENCE RESEARCH ESTABLISHMENT FFI   (Norway)

Author keywords

Brain development; Brain hypoplasia; Guinea pig; Metrifonate; Teratogen; Trichlorfon

Indexed keywords

ANTHELMINTIC AGENT; METRIFONATE; NEGUVON; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN; BRAIN CORTEX; BRAIN DEVELOPMENT; BRAIN WEIGHT; CEREBELLUM; DNA ALKYLATION; DOSE RESPONSE; FEMALE; FETUS; GESTATIONAL AGE; GUINEA PIG; HYPOPLASIA; HYPOTHALAMUS; MEDULLA OBLONGATA; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION; TERATOGENESIS;

ANIMALS; ANIMALS, NEWBORN; ANTHELMINTICS; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GESTATIONAL AGE; GUINEA PIGS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; TERATOGENS; TRICHLORFON;

ANIMALIA; CAVIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0032077175     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(97)00125-3     Document Type: Article

References (26)

1. Altman, J., 1972. Postnatal development of the cerebellar cortex in the rat. III. Maturation of the components of the granular layer. J. Comp. Neurol. 145, 465-514.
2. Balázs, R., Hack, N., Jörgensen, O.S., Cotman, C.W., 1989. N-methyl-D-aspartate promotes the survival of cerebellar granule cells: pharmacological characterization. Neurosci. Lett. 101, 241-246.
3. Berge, G.N., 1985. Toxic effects of the antiparasitic compounds fenchlorfos and trichlorfon during foetal development. PhD-thesis, University of Oslo, Norway.
4. Berge, G.N., Fonnum, F., Brodal, P., 1987. Neurotoxic effects of prenatal trichlorfon administration in pigs. Acta Vet. Scand. 28, 321-332.
5. Braun, R., Schöneich, J., Weissflog, L., Dedix, W., 1982. Activity of organophosphorous insecticides in bacterial tests for mutagenic and DNA repair - direct alkylation is metabolic activation and breakdown. Chem. Biol. Interactions. 39, 339-350.
6. Czeizel, A.E., Elek, C., Gundy, S., Metneki, J., Nemes, E., Reis, A., Sperling, K., Timar, L., Tusnady, G., Viragh, Z., 1993. Environmental trichlorfon and cluster of congenital abnormalities. Lancet 341, 539-542.
7. 7-alkylation in mice in vivo by metrifonate - discussion of possible genotoxic risk in mammals. Acta Pharmacol. Toxicol. 49, suppl V, 40-50.
8. Dobbing, J., Sands, J., 1970. Growth and development of the brain and spinal cord of the guinea-pig. Brain Res. 17, 115-123.
9. Dobbing, J., 1972. Vulnerable periods of brain development. In: CIBA Foundation Symposium Nutrition and the developing brain. Elsevier, Amsterdam, pp. 9-20.
10. ® während der Trächtigkeit. Schweiz Arch Tierheilkd. 123, 29-36.
11. ®-behandling av drektige purker. Congenital tremor and cerebellar hypopasia in piglets associated with trichlorfon-treatment of pregnant sows). Norsk Veterinærtidsskrift, 6, 385-387.
12. Hofer, W., 1981. Chemistry of metrifonate and dichlorvos. Acta Pharmacol. Toxicol. 49, Suppl V, 7-14.
13. Johnson, M.K., 1981. Delayed neurotoxicity - Do trichlorfon and/or dichlorvos cause delayed neuropathy in man or in test animals. Acta Pharm. Toxicol. 49, Suppl V, 87-98.
14. Johnson, P.S., Michaelis, E., 1992. Characterization of organophosphate interactivity at N-Methyl-D-aspartate receptors in brain synaptic membranes. Molec. Pharmacol. 41, 750-756.
15. ® vet. during pregnancy. Nord. Vet. Med. 30, 538-545.
16. Koelle, G.B., Friedenwald, J.S., 1949. A histochemical method for localizing cholinesterase activity. Proc. Soc. Exp. Biol. Med. 70, 617-622.
17. ®-treatment of pregnant sows cause cerebellar hypoplasia in piglets?. Svensk Veterinärtidning 29, 931-932.
18. Landis, D.M., Sidman, R.L., 1978. Electron microscopic analysis of postnatal histogenesis in the cerebellar cortex of staggerer mutant mice. J. Comp. Neurol. 179, 831-863.
19. Lewis, P.R., 1961. The effect of varying the conditions in the Koelle technique. Bibl. anat. 2, 11-20.
20. Lyle, J.G., Johnson, K.M., Edwards, M.J., Penny R.H., 1973. Effect of prenatal heat stress at mid-and late gestation on the learning of mature guinea-pigs. Dev. Psychobiol. 6, 483-494.
21. Mehl, A., Schanke, T.M., Johnsen, B.A., Fonnum, F., 1994. The effect of trichlorfon and other organophosphates on prenatal brain development in the guinea-pig. Neurochem. Res. 19, 569-574.
22. Metcalf, R.L., Fukuto, T.R., March, R.B., 1959. Toxic action of Dipterex and DDVP to the house fly. J. Econ. Entomol. 52 (1), 44-49.
23. Mishra, O.P., Delivoria-Papadopoulos, M., 1988. Anti-oxidant enzymes in fetal guinea-pig brain during development and the effect of maternal hypoxia. Dev. Brain Res. 42, 173-179.
24. Nordgren, I., Bergström, M., Holmstedt, B., Sandoz, M., 1978. Transformation and action of metrifonate. Arch. Toxicol. 41, 31-41.
25. Pope, A.M., Heavner, J.E., Guarnieri, J.A., Knobloch, C.P., 1986. Trichlorfon-induced congenital cerebellar hypoplasia in neonatal pigs. J. Am. Vet. Med. Assoc. 189 (7), 781-783.
26. Yamano, T., Morita, S., 1992. Hepatotoxicity of trichlorfon and dichlorvos in isolated rat hepatocytes. Toxicology, 76, 69-77.