Mammalian Voltage-Gated Calcium Channels Are Potently Blocked by the Pyrethroid Insecticide Allethrin

Journal of Pharmacology and Experimental Therapeutics

Volumn 308, Issue 3, 2004, Pages 805-813

  Hildebrand, Michael E ^a   McRory, John E ^a,c   Snutch, Terrance P ^a   Stea, Anthony ^b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF THE FRASER VALLEY   (Canada)

^c UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALLETHRIN; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL P TYPE; CALCIUM CHANNEL Q TYPE; CALCIUM CHANNEL T TYPE; CALCIUM ION; INSECTICIDE; PYRETHROID; VOLTAGE GATED CALCIUM CHANNEL;

ARTICLE; CALCIUM TRANSPORT; CELL MEMBRANE TRANSPORT; CHANNEL GATING; HUMAN; HUMAN CELL; IC 50; INTOXICATION; PRIORITY JOURNAL; TRANSPORT KINETICS;

ALLETHRIN; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CALCIUM CHANNELS, T-TYPE; CELLS, CULTURED; HUMANS; INSECTICIDES; KINETICS; PYRETHRINS;

EID: 1342323398     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.058792     Document Type: Article

References (33)

1. Abou-Donia MB, Goldstein LB, Jones KH, Abdel-Rahman AA, Damodaran TV, Dechkovskaia AM, Bullman SL, Amir BE, and Khan WA (2001) Locomotor and sensorimotor performance deficit in rats following exposure to pyridostigmine bromide, DEET, and permethrin, alone and in combination. Toxicol Sci 60:305-314.
2. Ahlbom J, Fredriksson A, and Eriksson P (1994) Neonatal exposure to a type-I pyrethroid (bioallethrin) induces dose-response changes in brain muscarinic receptors and behaviour in neonatal and adult mice. Brain Res 645:318-324.
3. Catterall WA (2000) Structure and regulation of voltage-gated Ca2+ channels. Annu Rev Cell Dev Biol 16:521-555.
4. de la Cerda E, Navarro-Polanco RA, and Sanchez-Chapula JA (2002) Modulation of cardiac action potential and underlying ionic currents by the pyrethroid insecticide deltamethrin. Arch Med Res 33:448-454.
5. Dolmetsch RE, Pajvani U, Fife K, Spotts JM, and Greenberg ME (2001) Signaling to the nucleus by an L-type calcium channel-calmodulin complex through the MAP kinase pathway. Science (Wash DC) 294:333-339.
6. Forshaw PJ, Lister T, and Ray DE (2000) The role of voltage-gated chloride channels in type II pyrethroid insecticide poisoning. Toxicol Appl Pharmacol 163:1-8.
7. Ginsburg K and Narahashi T (1999) Time course and temperature dependence of allethrin modulation of sodium channels in rat dorsal root ganglion cells. Brain Res 847:38-49.
8. Hagiwara N, Irisawa H, and Kameyama M (1988) Contribution of two types of calcium currents to the pacemaker potentials of rabbit sino-atrial node cells. J Physiol (Lond) 395:233-253.
9. Hamill OP, Marty A, Neher E, Sakmann B, and Sigworth FJ (1981) Improved patch-clamp techniques for high-resolution current recordings from cells and cell-free membrane patches. Pflueg Arch 391:85-100.
10. Imamura L, Hasegawa H, Kurashina K, Hamanishi A, Tabuchi A, and Tsuda M (2000) Repression of activity-dependent c-fos and brain-derived neurotrophic factor mRNA expression by pyrethroid insecticides accompanying a decrease in Ca(2+) influx into neurons. J Pharmacol Exp Ther 295:1175-1182.
11. Imamura L, Hasegawa H, Kurashina K, Matsuno T, and Tsuda M (2002) Neonatal exposure of newborn mice to pyrethroid (permethrin) represses activity-dependent c-fos mRNA expression in cerebellum. Arch Toxicol 76:392-397.
12. Kakko I, Toimela T, and Tahti H (2003) The synaptosomal membrane bound ATPase as a target for the neurotoxic effects of pyrethroids, permethrin, and cypermethrin. Chemosphere 51:475-480.
13. Kumari B, Madan VF, Kumar R, and Kathpal TS (2002) Monitoring of seasonal vegetables for pesticide residues. Environ Monit Assess 74:263-270.
14. Martin RL, Pittendrigh B, Liu J, Reenan R, ffrench-Constant R, and Hanck DA (2000) Point mutations in domain III of a Drosophila neuronal Na channel confer resistance to allethrin. Insect Biochem Mol Biol 30:1051-1059.
15. McRory JE, Santi CM, Hamming KS, Mezeyova J, Sutton KG, Baillie DL, Stea A, and Snutch TP (2001) Molecular and functional characterization of a family of rat brain T-type calcium channels. J Biol Chem 276:3999-4011.
16. Motomura H and Narahashi T (2001) Interaction of tetramethrin and deltamethrin at the single sodium channel in rat hippocarnpal neurons. Neurotoxicology 22:329-339.
17. Perez-Reyes E (2003) Molecular physiology of low-voltage-activated t-type calcium channels. Physiol Rev 83:117-161.
18. Satoh H (1995) Role of T-type Ca2+ channel inhibitors in the pacemaker depolarization in rabbit sino-atrial nodal cells. Gen Pharmacol 26:581-587.
19. Schettgen T, Heudorf U, Drexler H, and Angerer J (2002) Pyrethroid exposure of the general population-is this due to diet. Toxicol Lett 134:141-145.
20. Smith TJ, Ingles PJ, and Soderlund DM (1998) Actions of the pyrethroid insecticides cismethrin and cypermethrin on house fly Vssc1 sodium channels expressed in Xenopus oocytes. Arch Insect Biochem Physiol 38:126-136.
21. Soderlund DM, Clark JM, Sheets LP, Mullin LS, Piccirillo VJ, Sargent D, Stevens JT, and Weiner ML (2002) Mechanisms of pyrethroid neurotoxicity: implications for cumulative risk assessment. Toxicology 171:3-59.
22. Soderlund DM and Lee SH (2001) Point mutations in homology domain II modify the sensitivity of rat Nav1.8 sodium channels to the pyrethroid insecticide cismethrin. Neurotoxicology 22:755-765.
23. Spencer CI, Yuill KH, Borg JJ, Hancox JC, and Kozlowski RZ (2001) Actions of pyrethroid insecticides on sodium currents, action potentials and contractile rhythm in isolated mammalian ventricular myocytes and perfused hearts. J Pharmacol Exp Ther 298:1067-1082.
24. Sutton KG, McRory JE, Guthrie H, Murphy TH, and Snutch TP (1999) P/ Q-type calcium channels mediate the activity-dependent feedback of syntaxin-1A. Nature (Lond) 401:800-804.
25. Tatebayashi H and Narahashi T (1994) Differential mechanism of action of the pyrethroid tetramethrin on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels. J Pharmacol Exp Ther 270:595-603.
26. Thier A (2001) Balancing the risks: vector control and pesticide use in response to emerging illness. J Urban Health 78:372-381.
27. Vais H, Atkinson S, Eldursi N, Devonshire AL, Williamson MS, and Usherwood PN (2000) A single amino acid change makes a rat neuronal sodium channel highly sensitive to pyrethroid insecticides. FEBS Lett 470:135-138.
28. Vais H, Atkinson S, Pluteanu F, Goodson SJ, Devonshire AL, Williamson MS, and Usherwood PN (2003) Mutations of the para sodium channel of Drosophila melanogaster identify putative binding sites for pyrethroids. Mol Pharmacol 64:914-922.
29. Vais H, Williamson MS, Devonshire AL, and Usherwood PN (2001) The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels. Pest Manag Sci 57:877-888.
30. Wang SY, Barile M, and Wang GK (2001) A phenylalanine residue at segment D3-S6 in Nav1.4 voltage-gated Na(+) channels is critical for pyrethroid action. Mol Pharmacol 60:620-628.
31. Wang SY and Wang GK (2003) Voltage-gated sodium channels as primary targets of diverse lipid-soluble neurotoxins. Cell Signal 15:151-159.
32. Zhao Y, Park Y, and Adams ME (2000) Functional and evolutionary consequences of pyrethroid resistance mutations in S6 transmembrane segments of a voltage-gated sodium channel. Biochem Biophys Res Commun 278:516-521.
33. Zlotkin E (1999) The insect voltage-gated sodium channel as target of insecticides. Annu Rev Entomol 44:429-455.