In utero exposure to nicotine and chlorpyrifos alone, and in combination produces persistent sensorimotor deficits and Purkinje neuron loss in the cerebellum of adult offspring rats

Archives of Toxicology

Volumn 80, Issue 9, 2006, Pages 620-631

  Abou Donia, Mohamed B ^a   Khan, Wasiuddin A ^a   Dechkovskaia, Anjelika M ^a   Goldstein, Larry B ^a   Bullman, Sarah L ^a   Abdel Rahman, Ali ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Acetylcholinesterase; Adult; Behavioral; Cerebellum; Chlorpyrifos; Developmental; Glial fibrillary acidic protein; Maternal; Nicotine; Offspring; Purkinje cells

Indexed keywords

ACETYLCHOLINESTERASE; ALCOHOL; CHLORPYRIFOS; CHOLINESTERASE; GLIAL FIBRILLARY ACIDIC PROTEIN; NICOTINE; WATER;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN STEM; CELL LOSS; CEREBELLUM; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; ENZYME ACTIVITY; FEMALE; GRANULAR CELL; HISTOPATHOLOGY; MOTOR DYSFUNCTION; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; OSMOTIC PUMP; PRENATAL EXPOSURE; PRIORITY JOURNAL; PURKINJE CELL; RAT; SENSORIMOTOR DEFECT; SENSORY DYSFUNCTION;

ADMINISTRATION, TOPICAL; ANIMALS; BEHAVIOR, ANIMAL; CELL DEATH; CHLORPYRIFOS; CHOLINESTERASE INHIBITORS; CHOLINESTERASES; DRUG THERAPY, COMBINATION; FEMALE; INFUSION PUMPS, IMPLANTABLE; INJECTIONS, SUBCUTANEOUS; MALE; MATERNAL EXPOSURE; NICOTINE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PSYCHOMOTOR PERFORMANCE; PURKINJE CELLS; RATS;

ANIMALIA;

EID: 33747057459     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-006-0077-1     Document Type: Article

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