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Volumn 75, Issue 5, 2008, Pages 640-647

Developmental neurotoxicity of low dose diazinon exposure of neonatal rats: Effects on serotonin systems in adolescence and adulthood

Author keywords

Brain development; Diazinon; Organophosphate insecticides; Serotonin receptors; Serotonin transporter

Indexed keywords

CHLORPYRIFOS; DIMPYLATE; ORGANOPHOSPHATE INSECTICIDE; SEROTONIN RECEPTOR; SEROTONIN TRANSPORTER;

EID: 40749148130     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2007.10.008     Document Type: Article
Times cited : (77)

References (94)
  • 1
    • 19044372536 scopus 로고    scopus 로고
    • Developmental exposure of rats to chlorpyrifos leads to behavioral alterations in adulthood, involving serotonergic mechanisms and resembling animal models of depression
    • Aldridge J.E., Levin E.D., Seidler F.J., and Slotkin T.A. Developmental exposure of rats to chlorpyrifos leads to behavioral alterations in adulthood, involving serotonergic mechanisms and resembling animal models of depression. Environ. Health Perspect. 113 (2005) 527-531
    • (2005) Environ. Health Perspect. , vol.113 , pp. 527-531
    • Aldridge, J.E.1    Levin, E.D.2    Seidler, F.J.3    Slotkin, T.A.4
  • 2
    • 23844498721 scopus 로고    scopus 로고
    • Alterations in central nervous system serotonergic and dopaminergic synaptic activity in adulthood after prenatal or neonatal chlorpyrifos exposure
    • Aldridge J.E., Meyer A., Seidler F.J., and Slotkin T.A. Alterations in central nervous system serotonergic and dopaminergic synaptic activity in adulthood after prenatal or neonatal chlorpyrifos exposure. Environ. Health Perspect. 113 (2005) 1027-1031
    • (2005) Environ. Health Perspect. , vol.113 , pp. 1027-1031
    • Aldridge, J.E.1    Meyer, A.2    Seidler, F.J.3    Slotkin, T.A.4
  • 3
    • 13844275027 scopus 로고    scopus 로고
    • Developmental exposure to terbutaline and chlorpyrifos: pharmacotherapy of preterm labor and an environmental neurotoxicant converge on serotonergic systems in neonatal rat brain regions
    • Aldridge J.E., Meyer A., Seidler F.J., and Slotkin T.A. Developmental exposure to terbutaline and chlorpyrifos: pharmacotherapy of preterm labor and an environmental neurotoxicant converge on serotonergic systems in neonatal rat brain regions. Toxicol. Appl. Pharmacol. 203 (2005) 134-144
    • (2005) Toxicol. Appl. Pharmacol. , vol.203 , pp. 134-144
    • Aldridge, J.E.1    Meyer, A.2    Seidler, F.J.3    Slotkin, T.A.4
  • 4
    • 0242539881 scopus 로고    scopus 로고
    • Serotonergic systems targeted by developmental exposure to chlorpyrifos: effects during different critical periods
    • Aldridge J.E., Seidler F.J., Meyer A., Thillai I., and Slotkin T.A. Serotonergic systems targeted by developmental exposure to chlorpyrifos: effects during different critical periods. Environ. Health Perspect. 111 (2003) 1736-1743
    • (2003) Environ. Health Perspect. , vol.111 , pp. 1736-1743
    • Aldridge, J.E.1    Seidler, F.J.2    Meyer, A.3    Thillai, I.4    Slotkin, T.A.5
  • 5
    • 1042303694 scopus 로고    scopus 로고
    • Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling
    • Aldridge J.E., Seidler F.J., and Slotkin T.A. Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling. Environ. Health Perspect. 112 (2004) 148-155
    • (2004) Environ. Health Perspect. , vol.112 , pp. 148-155
    • Aldridge, J.E.1    Seidler, F.J.2    Slotkin, T.A.3
  • 7
    • 0035669353 scopus 로고    scopus 로고
    • Serotonin-1A receptors, serotonin transporter binding and serotonin transporter mRNA expression in the brainstem of depressed suicide victims
    • Arango V., Underwood M.D., Boldrini M., Tamir H., Kassir S.A., Hsiung S., Chen J.J., and Mann J.J. Serotonin-1A receptors, serotonin transporter binding and serotonin transporter mRNA expression in the brainstem of depressed suicide victims. Neuropsychopharmacology 25 (2001) 892-903
    • (2001) Neuropsychopharmacology , vol.25 , pp. 892-903
    • Arango, V.1    Underwood, M.D.2    Boldrini, M.3    Tamir, H.4    Kassir, S.A.5    Hsiung, S.6    Chen, J.J.7    Mann, J.J.8
  • 8
    • 0032970989 scopus 로고    scopus 로고
    • A review of central 5-HT receptors and their function
    • Barnes N.M., and Sharp T. A review of central 5-HT receptors and their function. Neuropharmacology 38 (1999) 1083-1152
    • (1999) Neuropharmacology , vol.38 , pp. 1083-1152
    • Barnes, N.M.1    Sharp, T.2
  • 9
    • 0034087725 scopus 로고    scopus 로고
    • Vulnerable processes of nervous system development: a review of markers and methods
    • Barone S., Das K.P., Lassiter T.L., and White L.D. Vulnerable processes of nervous system development: a review of markers and methods. Neurotoxicology 21 (2000) 15-36
    • (2000) Neurotoxicology , vol.21 , pp. 15-36
    • Barone, S.1    Das, K.P.2    Lassiter, T.L.3    White, L.D.4
  • 10
    • 33745775656 scopus 로고    scopus 로고
    • Effect of developmental exposure to chlorpyrifos on the expression of neurotrophin growth factors and cell-specific markers in neonatal rat brain
    • Betancourt A.M., Burgess S.C., and Carr R.L. Effect of developmental exposure to chlorpyrifos on the expression of neurotrophin growth factors and cell-specific markers in neonatal rat brain. Toxicol. Sci. 92 (2006) 500-506
    • (2006) Toxicol. Sci. , vol.92 , pp. 500-506
    • Betancourt, A.M.1    Burgess, S.C.2    Carr, R.L.3
  • 11
    • 1642463893 scopus 로고    scopus 로고
    • The effect of chlorpyrifos and chlorpyrifos-oxon on brain cholinesterase, muscarinic receptor binding, and neurotrophin levels in rats following early postnatal exposure
    • Betancourt A.M., and Carr R.L. The effect of chlorpyrifos and chlorpyrifos-oxon on brain cholinesterase, muscarinic receptor binding, and neurotrophin levels in rats following early postnatal exposure. Toxicol. Sci. 77 (2004) 63-71
    • (2004) Toxicol. Sci. , vol.77 , pp. 63-71
    • Betancourt, A.M.1    Carr, R.L.2
  • 12
    • 4243148518 scopus 로고    scopus 로고
    • Organophosphate toxicology: safety aspects of nonacetylcholinesterase secondary targets
    • Casida J.E., and Quistad G.B. Organophosphate toxicology: safety aspects of nonacetylcholinesterase secondary targets. Chem. Res. Toxicol. 17 (2004) 983-998
    • (2004) Chem. Res. Toxicol. , vol.17 , pp. 983-998
    • Casida, J.E.1    Quistad, G.B.2
  • 13
    • 0033383932 scopus 로고    scopus 로고
    • Determination of the reference dose for chlorpyrifos: proceedings of an expert panel
    • Clegg D.J., and van Gemert M. Determination of the reference dose for chlorpyrifos: proceedings of an expert panel. J. Toxicol. Environ. Health 2 (1999) 211-255
    • (1999) J. Toxicol. Environ. Health , vol.2 , pp. 211-255
    • Clegg, D.J.1    van Gemert, M.2
  • 14
    • 33644664469 scopus 로고    scopus 로고
    • Current issues in organophosphate toxicology
    • Costa L.G. Current issues in organophosphate toxicology. Clin. Chim. Acta 366 (2006) 1-13
    • (2006) Clin. Chim. Acta , vol.366 , pp. 1-13
    • Costa, L.G.1
  • 15
    • 0034733972 scopus 로고    scopus 로고
    • Chlorpyrifos exposure during a critical neonatal period elicits gender-selective deficits in the development of coordination skills and locomotor activity
    • Dam K., Seidler F.J., and Slotkin T.A. Chlorpyrifos exposure during a critical neonatal period elicits gender-selective deficits in the development of coordination skills and locomotor activity. Dev. Brain Res. 121 (2000) 179-187
    • (2000) Dev. Brain Res. , vol.121 , pp. 179-187
    • Dam, K.1    Seidler, F.J.2    Slotkin, T.A.3
  • 17
    • 0034667297 scopus 로고    scopus 로고
    • Imaging serotonergic neurotransmission in depression: hippocampal pathophysiology may mirror global brain alterations
    • Fujita M., Charney D.S., and Innis R.B. Imaging serotonergic neurotransmission in depression: hippocampal pathophysiology may mirror global brain alterations. Biol. Psychiatry 48 (2000) 801-812
    • (2000) Biol. Psychiatry , vol.48 , pp. 801-812
    • Fujita, M.1    Charney, D.S.2    Innis, R.B.3
  • 18
    • 0037186773 scopus 로고    scopus 로고
    • Chlorpyrifos targets developing glia: effects on glial fibrillary acidic protein
    • Garcia S.J., Seidler F.J., Qiao D., and Slotkin T.A. Chlorpyrifos targets developing glia: effects on glial fibrillary acidic protein. Dev. Brain Res. 133 (2002) 151-161
    • (2002) Dev. Brain Res. , vol.133 , pp. 151-161
    • Garcia, S.J.1    Seidler, F.J.2    Qiao, D.3    Slotkin, T.A.4
  • 19
    • 1942437974 scopus 로고    scopus 로고
    • Brain regional heterogeneity and toxicological mechanisms of organophosphates and carbamates
    • Gupta R.C. Brain regional heterogeneity and toxicological mechanisms of organophosphates and carbamates. Toxicol. Mech. Meth. 14 (2004) 103-143
    • (2004) Toxicol. Mech. Meth. , vol.14 , pp. 103-143
    • Gupta, R.C.1
  • 21
    • 0010749650 scopus 로고
    • Do serotonin and other neurotransmitters exert a trophic influence on the immature brain?
    • Hamon M., Bourgoin S., Chanez C., and De Vitry F. Do serotonin and other neurotransmitters exert a trophic influence on the immature brain?. Dev. Neurobiol. 12 (1989) 171-183
    • (1989) Dev. Neurobiol. , vol.12 , pp. 171-183
    • Hamon, M.1    Bourgoin, S.2    Chanez, C.3    De Vitry, F.4
  • 22
    • 0042519596 scopus 로고    scopus 로고
    • A morphogenetic role for acetylcholine in mouse cerebral neocortex
    • Hohmann C.F. A morphogenetic role for acetylcholine in mouse cerebral neocortex. Neurosci. Biobehav. Rev. 27 (2003) 351-363
    • (2003) Neurosci. Biobehav. Rev. , vol.27 , pp. 351-363
    • Hohmann, C.F.1
  • 23
    • 0032435521 scopus 로고    scopus 로고
    • Cholinergic regulation of cortical development and plasticity: new twists to an old story
    • Hohmann C.F., and Berger-Sweeney J. Cholinergic regulation of cortical development and plasticity: new twists to an old story. Perspect. Dev. Neurobiol. 5 (1998) 401-425
    • (1998) Perspect. Dev. Neurobiol. , vol.5 , pp. 401-425
    • Hohmann, C.F.1    Berger-Sweeney, J.2
  • 25
    • 33845970588 scopus 로고    scopus 로고
    • Nonenzymatic functions of acetylcholinesterase splice variants in the developmental neurotoxicity of organophosphates: chlorpyrifos, chlorpyrifos oxon and diazinon
    • Jameson R.R., Seidler F.J., and Slotkin T.A. Nonenzymatic functions of acetylcholinesterase splice variants in the developmental neurotoxicity of organophosphates: chlorpyrifos, chlorpyrifos oxon and diazinon. Environ. Health Perspect. 115 (2007) 65-70
    • (2007) Environ. Health Perspect. , vol.115 , pp. 65-70
    • Jameson, R.R.1    Seidler, F.J.2    Slotkin, T.A.3
  • 26
    • 2442623237 scopus 로고    scopus 로고
    • Chlorpyrifos-methyl shows anti-androgenic activity without estrogenic activity in rats
    • Kang H.G., Jeong S.H., Cho J.H., Kim D.G., Park J.M., and Cho M.H. Chlorpyrifos-methyl shows anti-androgenic activity without estrogenic activity in rats. Toxicology 199 (2004) 219-230
    • (2004) Toxicology , vol.199 , pp. 219-230
    • Kang, H.G.1    Jeong, S.H.2    Cho, J.H.3    Kim, D.G.4    Park, J.M.5    Cho, M.H.6
  • 27
    • 28344442026 scopus 로고    scopus 로고
    • Diisopropylfluorophosphate administration in the pre-weanling period induces long-term changes in anxiety behavior and passive avoidance in adult mice
    • Kofman O., and Ben-Bashat G. Diisopropylfluorophosphate administration in the pre-weanling period induces long-term changes in anxiety behavior and passive avoidance in adult mice. Psychopharmacology 183 (2006) 452-461
    • (2006) Psychopharmacology , vol.183 , pp. 452-461
    • Kofman, O.1    Ben-Bashat, G.2
  • 29
    • 0035717585 scopus 로고    scopus 로고
    • Pesticides and polychlorinated biphenyls (PCBs): an analysis of the evidence that they impair children's neurobehavioral development
    • Landrigan P.J. Pesticides and polychlorinated biphenyls (PCBs): an analysis of the evidence that they impair children's neurobehavioral development. Mol. Genet. Metab. 73 (2001) 11-17
    • (2001) Mol. Genet. Metab. , vol.73 , pp. 11-17
    • Landrigan, P.J.1
  • 31
    • 0032908629 scopus 로고    scopus 로고
    • Morphogenetic roles of acetylcholine
    • Lauder J.M., and Schambra U.B. Morphogenetic roles of acetylcholine. Environ. Health Perspect. 107 Suppl. 1 (1999) 65-69
    • (1999) Environ. Health Perspect. , vol.107 , Issue.SUPPL. 1 , pp. 65-69
    • Lauder, J.M.1    Schambra, U.B.2
  • 37
    • 0000587671 scopus 로고
    • The serotonin hypothesis of major depression
    • Bloom F.E., Kupfer D.J., Bunney B.S., Ciaranello R.D., Davis K.L., Koob G.F., Meltzer H.Y., Schuster C.R., Shader R.I., and Watson S.J. (Eds), Raven Press, New York
    • Maes M., and Meltzer H. The serotonin hypothesis of major depression. In: Bloom F.E., Kupfer D.J., Bunney B.S., Ciaranello R.D., Davis K.L., Koob G.F., Meltzer H.Y., Schuster C.R., Shader R.I., and Watson S.J. (Eds). Psychopharmacology: The Fourth Generation of Progress (1995), Raven Press, New York 933-944
    • (1995) Psychopharmacology: The Fourth Generation of Progress , pp. 933-944
    • Maes, M.1    Meltzer, H.2
  • 38
    • 0033920095 scopus 로고    scopus 로고
    • Disturbing behavior: neurotoxic effects in children
    • May M. Disturbing behavior: neurotoxic effects in children. Environ. Health Perspect. 108 (2000) A262-A267
    • (2000) Environ. Health Perspect. , vol.108
    • May, M.1
  • 39
    • 0028285978 scopus 로고
    • Molecular aspects of sexual differentiation of the rodent brain
    • McCarthy M.M. Molecular aspects of sexual differentiation of the rodent brain. Psychoneuroendocrinology 19 (1994) 415-427
    • (1994) Psychoneuroendocrinology , vol.19 , pp. 415-427
    • McCarthy, M.M.1
  • 40
    • 0036752591 scopus 로고    scopus 로고
    • Sex, stress and the hippocampus: allostasis, allostatic load and the aging process
    • McEwen B.S. Sex, stress and the hippocampus: allostasis, allostatic load and the aging process. Neurobiol. Aging 23 (2002) 921-939
    • (2002) Neurobiol. Aging , vol.23 , pp. 921-939
    • McEwen, B.S.1
  • 41
    • 0030875889 scopus 로고    scopus 로고
    • Characterization of the facilitative effects of perinatal choline supplementation on timing and temporal memory
    • Meck W.H., and Williams C.L. Characterization of the facilitative effects of perinatal choline supplementation on timing and temporal memory. Neuroreport 8 (1997) 2831-2835
    • (1997) Neuroreport , vol.8 , pp. 2831-2835
    • Meck, W.H.1    Williams, C.L.2
  • 42
    • 0033457359 scopus 로고    scopus 로고
    • Choline supplementation during prenatal development reduces proactive interference in spacial memory
    • Meck W.H., and Williams C.L. Choline supplementation during prenatal development reduces proactive interference in spacial memory. Dev. Brain Res. 118 (1999) 51-59
    • (1999) Dev. Brain Res. , vol.118 , pp. 51-59
    • Meck, W.H.1    Williams, C.L.2
  • 43
    • 33644875222 scopus 로고    scopus 로고
    • Exposure to nonpersistent insecticides and male reproductive hormones
    • Meeker J.D., Ryan L., Barr D.B., and Hauser R. Exposure to nonpersistent insecticides and male reproductive hormones. Epidemiology 17 (2006) 61-68
    • (2006) Epidemiology , vol.17 , pp. 61-68
    • Meeker, J.D.1    Ryan, L.2    Barr, D.B.3    Hauser, R.4
  • 44
    • 0033567850 scopus 로고    scopus 로고
    • Steroid-induced developmental plasticity in hypothalamic astrocytes: implications for synaptic patterning
    • Mong J.A., and McCarthy M.M. Steroid-induced developmental plasticity in hypothalamic astrocytes: implications for synaptic patterning. J. Neurobiol. 40 (1999) 602-619
    • (1999) J. Neurobiol. , vol.40 , pp. 602-619
    • Mong, J.A.1    McCarthy, M.M.2
  • 46
    • 0025917799 scopus 로고
    • 3H-paroxetine binding to the serotonin transporter is insensitive to changes in central serotonergic innervation in the rat
    • 3H-paroxetine binding to the serotonin transporter is insensitive to changes in central serotonergic innervation in the rat. Psychiatr. Res. 38 (1991) 97-104
    • (1991) Psychiatr. Res. , vol.38 , pp. 97-104
    • Moret, C.1    Briley, M.2
  • 47
    • 0026522462 scopus 로고
    • Serotonin enhances the β-adrenergic response in rat brain cortical slices
    • Morin D., Sapena R., Zini R., and Tillement J.P. Serotonin enhances the β-adrenergic response in rat brain cortical slices. Eur. J. Pharmacol. 225 (1992) 273-274
    • (1992) Eur. J. Pharmacol. , vol.225 , pp. 273-274
    • Morin, D.1    Sapena, R.2    Zini, R.3    Tillement, J.P.4
  • 48
    • 0031882555 scopus 로고    scopus 로고
    • Age- and gender-related differences in the time course of behavioral and biochemical effects produced by oral chlorpyrifos in rats
    • Moser V.C., and Padilla S. Age- and gender-related differences in the time course of behavioral and biochemical effects produced by oral chlorpyrifos in rats. Toxicol. Appl. Pharmacol. 149 (1998) 107-119
    • (1998) Toxicol. Appl. Pharmacol. , vol.149 , pp. 107-119
    • Moser, V.C.1    Padilla, S.2
  • 49
    • 0032091519 scopus 로고    scopus 로고
    • The neurobiology of depression
    • Nemeroff C.B. The neurobiology of depression. Sci. Am. 278 6 (1998) 42-49
    • (1998) Sci. Am. , vol.278 , Issue.6 , pp. 42-49
    • Nemeroff, C.B.1
  • 50
    • 0036288309 scopus 로고    scopus 로고
    • The neuropharmacology of serotonin and noradrenaline in depression
    • Nutt D.J. The neuropharmacology of serotonin and noradrenaline in depression. Int. Clin. Psychopharmacol. 17 (2002) S1-S12
    • (2002) Int. Clin. Psychopharmacol. , vol.17
    • Nutt, D.J.1
  • 54
    • 40749100234 scopus 로고    scopus 로고
    • Physicians for Social Responsibility, Pesticides and Children, Physicians for Social Responsibility, Washington DC, 1995.
    • Physicians for Social Responsibility, Pesticides and Children, Physicians for Social Responsibility, Washington DC, 1995.
  • 55
    • 0033369584 scopus 로고    scopus 로고
    • Organophosphorus pesticides: do they all have the same mechanism of toxicity?
    • Pope C.N. Organophosphorus pesticides: do they all have the same mechanism of toxicity?. J. Toxicol. Environ. Health 2 (1999) 161-181
    • (1999) J. Toxicol. Environ. Health , vol.2 , pp. 161-181
    • Pope, C.N.1
  • 56
    • 0036853032 scopus 로고    scopus 로고
    • Developmental neurotoxicity of chlorpyrifos: What is the vulnerable period?
    • Qiao D., Seidler F.J., Padilla S., and Slotkin T.A. Developmental neurotoxicity of chlorpyrifos: What is the vulnerable period?. Environ. Health Perspect. 110 (2002) 1097-1103
    • (2002) Environ. Health Perspect. , vol.110 , pp. 1097-1103
    • Qiao, D.1    Seidler, F.J.2    Padilla, S.3    Slotkin, T.A.4
  • 57
    • 0037732695 scopus 로고    scopus 로고
    • Fetal chlorpyrifos exposure: adverse effects on brain cell development and cholinergic biomarkers emerge postnatally and continue into adolescence and adulthood
    • Qiao D., Seidler F.J., Tate C.A., Cousins M.M., and Slotkin T.A. Fetal chlorpyrifos exposure: adverse effects on brain cell development and cholinergic biomarkers emerge postnatally and continue into adolescence and adulthood. Environ. Health Perspect. 111 (2003) 536-544
    • (2003) Environ. Health Perspect. , vol.111 , pp. 536-544
    • Qiao, D.1    Seidler, F.J.2    Tate, C.A.3    Cousins, M.M.4    Slotkin, T.A.5
  • 58
    • 0035940296 scopus 로고    scopus 로고
    • Alterations in serotonin transporter expression in brain regions of rats exposed neonatally to chlorpyrifos
    • Raines K.W., Seidler F.J., and Slotkin T.A. Alterations in serotonin transporter expression in brain regions of rats exposed neonatally to chlorpyrifos. Dev. Brain Res. 130 (2001) 65-72
    • (2001) Dev. Brain Res. , vol.130 , pp. 65-72
    • Raines, K.W.1    Seidler, F.J.2    Slotkin, T.A.3
  • 60
    • 33747888566 scopus 로고    scopus 로고
    • Developmental neurotoxicity of organophosphorous pesticides: fetal and neonatal exposure to chlorpyrifos alters sex-specific behaviors at adulthood in mice
    • Ricceri L., Venerosi A., Capone F., Cometa M.F., Lorenzini P., Fortuna S., and Calamendrei G. Developmental neurotoxicity of organophosphorous pesticides: fetal and neonatal exposure to chlorpyrifos alters sex-specific behaviors at adulthood in mice. Toxicol. Sci. 93 (2006) 105-113
    • (2006) Toxicol. Sci. , vol.93 , pp. 105-113
    • Ricceri, L.1    Venerosi, A.2    Capone, F.3    Cometa, M.F.4    Lorenzini, P.5    Fortuna, S.6    Calamendrei, G.7
  • 61
    • 0026725877 scopus 로고
    • Neurochemical alterations of serotonergic neuronal systems in depression
    • Risch C.S., and Nemeroff C.B. Neurochemical alterations of serotonergic neuronal systems in depression. J. Clin. Psychiatry 53 Suppl. 10 (1991) 3-6
    • (1991) J. Clin. Psychiatry , vol.53 , Issue.SUPPL. 10 , pp. 3-6
    • Risch, C.S.1    Nemeroff, C.B.2
  • 62
  • 65
    • 0032908419 scopus 로고    scopus 로고
    • Developmental cholinotoxicants: nicotine and chlorpyrifos
    • Slotkin T.A. Developmental cholinotoxicants: nicotine and chlorpyrifos. Environ. Health Perspect. 107 Suppl. 1 (1999) 71-80
    • (1999) Environ. Health Perspect. , vol.107 , Issue.SUPPL. 1 , pp. 71-80
    • Slotkin, T.A.1
  • 66
    • 0842342126 scopus 로고    scopus 로고
    • Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphates
    • Slotkin T.A. Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphates. Toxicol. Appl. Pharmacol. 198 (2004) 132-151
    • (2004) Toxicol. Appl. Pharmacol. , vol.198 , pp. 132-151
    • Slotkin, T.A.1
  • 67
    • 80855125087 scopus 로고    scopus 로고
    • Developmental neurotoxicity of organophosphates: a case study of chlorpyrifos
    • Gupta R.C. (Ed), Elsevier Academic Press, San Diego
    • Slotkin T.A. Developmental neurotoxicity of organophosphates: a case study of chlorpyrifos. In: Gupta R.C. (Ed). Toxicity of Organophosphate and Carbamate Pesticides (2005), Elsevier Academic Press, San Diego 293-314
    • (2005) Toxicity of Organophosphate and Carbamate Pesticides , pp. 293-314
    • Slotkin, T.A.1
  • 68
    • 0035370072 scopus 로고    scopus 로고
    • Persistent cholinergic presynaptic deficits after neonatal chlorpyrifos exposure
    • Slotkin T.A., Cousins M.M., Tate C.A., and Seidler F.J. Persistent cholinergic presynaptic deficits after neonatal chlorpyrifos exposure. Brain Res. 902 (2001) 229-243
    • (2001) Brain Res. , vol.902 , pp. 229-243
    • Slotkin, T.A.1    Cousins, M.M.2    Tate, C.A.3    Seidler, F.J.4
  • 69
    • 33646356457 scopus 로고    scopus 로고
    • Comparative developmental neurotoxicity of organophosphate insecticides: effects on brain development are separable from systemic toxicity
    • Slotkin T.A., Levin E.D., and Seidler F.J. Comparative developmental neurotoxicity of organophosphate insecticides: effects on brain development are separable from systemic toxicity. Environ. Health Perspect. 114 (2006) 746-751
    • (2006) Environ. Health Perspect. , vol.114 , pp. 746-751
    • Slotkin, T.A.1    Levin, E.D.2    Seidler, F.J.3
  • 70
    • 0031040838 scopus 로고    scopus 로고
    • Serotonin transporter expression in rat brain regions and blood platelets: aging and glucocorticoid effects
    • Slotkin T.A., McCook E.C., Ritchie J.C., Carroll B.J., and Seidler F.J. Serotonin transporter expression in rat brain regions and blood platelets: aging and glucocorticoid effects. Biol. Psychiatry 41 (1997) 172-183
    • (1997) Biol. Psychiatry , vol.41 , pp. 172-183
    • Slotkin, T.A.1    McCook, E.C.2    Ritchie, J.C.3    Carroll, B.J.4    Seidler, F.J.5
  • 71
    • 0032943702 scopus 로고    scopus 로고
    • Modeling geriatric depression in animals: biochemical and behavioral effects of olfactory bulbectomy in young versus aged rats
    • Slotkin T.A., Miller D.B., Fumagalli F., McCook E.C., Zhang J., Bissette G., and Seidler F.J. Modeling geriatric depression in animals: biochemical and behavioral effects of olfactory bulbectomy in young versus aged rats. J. Pharmacol. Exp. Ther. 289 (1999) 334-345
    • (1999) J. Pharmacol. Exp. Ther. , vol.289 , pp. 334-345
    • Slotkin, T.A.1    Miller, D.B.2    Fumagalli, F.3    McCook, E.C.4    Zhang, J.5    Bissette, G.6    Seidler, F.J.7
  • 72
    • 23644433656 scopus 로고    scopus 로고
    • The alterations in CNS serotonergic mechanisms caused by neonatal chlorpyrifos exposure are permanent
    • Slotkin T.A., and Seidler F.J. The alterations in CNS serotonergic mechanisms caused by neonatal chlorpyrifos exposure are permanent. Dev. Brain Res. 158 (2005) 115-119
    • (2005) Dev. Brain Res. , vol.158 , pp. 115-119
    • Slotkin, T.A.1    Seidler, F.J.2
  • 73
    • 34247154767 scopus 로고    scopus 로고
    • Comparative developmental neurotoxicity of organophosphates in vivo: transcriptional responses of pathways for brain cell development, cell signaling, cytotoxicity and neurotransmitter systems
    • Slotkin T.A., and Seidler F.J. Comparative developmental neurotoxicity of organophosphates in vivo: transcriptional responses of pathways for brain cell development, cell signaling, cytotoxicity and neurotransmitter systems. Brain Res. Bull. 72 (2007) 232-274
    • (2007) Brain Res. Bull. , vol.72 , pp. 232-274
    • Slotkin, T.A.1    Seidler, F.J.2
  • 74
    • 34249935494 scopus 로고    scopus 로고
    • Developmental exposure to terbutaline and chlorpyrifos, separately or sequentially, elicits presynaptic serotonergic hyperactivity in juvenile and adolescent rats
    • Slotkin T.A., and Seidler F.J. Developmental exposure to terbutaline and chlorpyrifos, separately or sequentially, elicits presynaptic serotonergic hyperactivity in juvenile and adolescent rats. Brain Res. Bull. 73 (2007) 301-309
    • (2007) Brain Res. Bull. , vol.73 , pp. 301-309
    • Slotkin, T.A.1    Seidler, F.J.2
  • 75
    • 34247116566 scopus 로고    scopus 로고
    • Prenatal chlorpyrifos exposure elicits presynaptic serotonergic and dopaminergic hyperactivity at adolescence: critical periods for regional and sex-selective effects
    • Slotkin T.A., and Seidler F.J. Prenatal chlorpyrifos exposure elicits presynaptic serotonergic and dopaminergic hyperactivity at adolescence: critical periods for regional and sex-selective effects. Reprod. Toxicol. 23 (2007) 421-427
    • (2007) Reprod. Toxicol. , vol.23 , pp. 421-427
    • Slotkin, T.A.1    Seidler, F.J.2
  • 76
    • 0034613402 scopus 로고    scopus 로고
    • Cellular determinants of reduced adaptability of the aging brain: neurotransmitter utilization and cell signaling responses after MDMA lesions
    • Slotkin T.A., Seidler F.J., and Ali S.F. Cellular determinants of reduced adaptability of the aging brain: neurotransmitter utilization and cell signaling responses after MDMA lesions. Brain Res. 879 (2000) 163-173
    • (2000) Brain Res. , vol.879 , pp. 163-173
    • Slotkin, T.A.1    Seidler, F.J.2    Ali, S.F.3
  • 77
    • 34250163568 scopus 로고    scopus 로고
    • Exposure to organophosphates reduces the expression of neurotrophic factors in neonatal rat brain regions: similarities and differences in the effects of chlorpyrifos and diazinon on the fibroblast growth factor superfamily
    • Slotkin T.A., Seidler F.J., and Fumagalli F. Exposure to organophosphates reduces the expression of neurotrophic factors in neonatal rat brain regions: similarities and differences in the effects of chlorpyrifos and diazinon on the fibroblast growth factor superfamily. Environ. Health Perspect. 115 (2007) 909-916
    • (2007) Environ. Health Perspect. , vol.115 , pp. 909-916
    • Slotkin, T.A.1    Seidler, F.J.2    Fumagalli, F.3
  • 78
    • 0037186808 scopus 로고    scopus 로고
    • Functional alterations in CNS catecholamine systems in adolescence and adulthood after neonatal chlorpyrifos exposure
    • Slotkin T.A., Tate C.A., Cousins M.M., and Seidler F.J. Functional alterations in CNS catecholamine systems in adolescence and adulthood after neonatal chlorpyrifos exposure. Dev. Brain Res. 133 (2002) 163-173
    • (2002) Dev. Brain Res. , vol.133 , pp. 163-173
    • Slotkin, T.A.1    Tate, C.A.2    Cousins, M.M.3    Seidler, F.J.4
  • 79
    • 33749428870 scopus 로고    scopus 로고
    • Organophosphate insecticides target the serotonergic system in developing rat brain regions: disparate effects of diazinon and parathion at doses spanning the threshold for cholinesterase inhibition
    • Slotkin T.A., Tate C.A., Ryde I.T., Levin E.D., and Seidler F.J. Organophosphate insecticides target the serotonergic system in developing rat brain regions: disparate effects of diazinon and parathion at doses spanning the threshold for cholinesterase inhibition. Environ. Health Perspect. 114 (2006) 1542-1546
    • (2006) Environ. Health Perspect. , vol.114 , pp. 1542-1546
    • Slotkin, T.A.1    Tate, C.A.2    Ryde, I.T.3    Levin, E.D.4    Seidler, F.J.5
  • 81
    • 0031194056 scopus 로고    scopus 로고
    • Cellular mechanisms for developmental toxicity of chlorpyrifos: targeting the adenylyl cyclase signaling cascade
    • Song X., Seidler F.J., Saleh J.L., Zhang J., Padilla S., and Slotkin T.A. Cellular mechanisms for developmental toxicity of chlorpyrifos: targeting the adenylyl cyclase signaling cascade. Toxicol. Appl. Pharmacol. 145 (1997) 158-174
    • (1997) Toxicol. Appl. Pharmacol. , vol.145 , pp. 158-174
    • Song, X.1    Seidler, F.J.2    Saleh, J.L.3    Zhang, J.4    Padilla, S.5    Slotkin, T.A.6
  • 82
    • 0032530289 scopus 로고    scopus 로고
    • Increase in serotonin-1A autoreceptors in the midbrain of suicide victims with major depression: postmortem evidence for decreased serotonin activity
    • Stockmeier C.A., Shapiro L.A., Dilley G.E., Kolli T.N., Friedman L., and Rajkowska G. Increase in serotonin-1A autoreceptors in the midbrain of suicide victims with major depression: postmortem evidence for decreased serotonin activity. J. Neurosci. 18 (1998) 7394-7401
    • (1998) J. Neurosci. , vol.18 , pp. 7394-7401
    • Stockmeier, C.A.1    Shapiro, L.A.2    Dilley, G.E.3    Kolli, T.N.4    Friedman, L.5    Rajkowska, G.6
  • 83
    • 33746216297 scopus 로고    scopus 로고
    • Mechanisms of neuroprotection by estrogen
    • Suzuki S., Brown C.M., and Wise P.M. Mechanisms of neuroprotection by estrogen. Endocrine 29 (2006) 209-215
    • (2006) Endocrine , vol.29 , pp. 209-215
    • Suzuki, S.1    Brown, C.M.2    Wise, P.M.3
  • 84
    • 40749113176 scopus 로고    scopus 로고
    • O.A. Timofeeva, C.S. Roegge, F.J. Seidler, T.A. Slotkin, E.D. Levin, Persistent cognitive alterations in rats after early postnatal exposure to low doses of the organophosphate pesticide, diazinon, Neurotoxicol. Teratol., in press.
    • O.A. Timofeeva, C.S. Roegge, F.J. Seidler, T.A. Slotkin, E.D. Levin, Persistent cognitive alterations in rats after early postnatal exposure to low doses of the organophosphate pesticide, diazinon, Neurotoxicol. Teratol., in press.
  • 85
    • 0034106868 scopus 로고    scopus 로고
    • Screening of selected pesticides for inhibition of CYP19 aromatase activity in vitro
    • Vinggaard A.M., Hnida C., Breinholt V., and Larsen J.C. Screening of selected pesticides for inhibition of CYP19 aromatase activity in vitro. Toxicol. in Vitro 14 (2000) 227-234
    • (2000) Toxicol. in Vitro , vol.14 , pp. 227-234
    • Vinggaard, A.M.1    Hnida, C.2    Breinholt, V.3    Larsen, J.C.4
  • 87
    • 0026357342 scopus 로고
    • Role of serotonin and other neurotransmitter receptors in brain development: basis for developmental pharmacology
    • Whitaker-Azmitia P.M. Role of serotonin and other neurotransmitter receptors in brain development: basis for developmental pharmacology. Pharmacol. Rev. 43 (1991) 553-561
    • (1991) Pharmacol. Rev. , vol.43 , pp. 553-561
    • Whitaker-Azmitia, P.M.1
  • 88
    • 0035891882 scopus 로고    scopus 로고
    • Serotonin and brain development: role in human developmental diseases.
    • Whitaker-Azmitia P.M. Serotonin and brain development: role in human developmental diseases. Brain Res. Bull. 56 (2001) 479-485
    • (2001) Brain Res. Bull. , vol.56 , pp. 479-485
    • Whitaker-Azmitia, P.M.1
  • 89
    • 0029123631 scopus 로고
    • Developmental neurotoxicity of chlorpyrifos: cellular mechanisms
    • Whitney K.D., Seidler F.J., and Slotkin T.A. Developmental neurotoxicity of chlorpyrifos: cellular mechanisms. Toxicol. Appl. Pharmacol. 134 (1995) 53-62
    • (1995) Toxicol. Appl. Pharmacol. , vol.134 , pp. 53-62
    • Whitney, K.D.1    Seidler, F.J.2    Slotkin, T.A.3
  • 90
    • 0035964772 scopus 로고    scopus 로고
    • Fetal and adolescent nicotine administration: effects on CNS serotonergic systems
    • Xu Z., Seidler F.J., Ali S.F., Slikker W., and Slotkin T.A. Fetal and adolescent nicotine administration: effects on CNS serotonergic systems. Brain Res. 914 (2001) 166-178
    • (2001) Brain Res. , vol.914 , pp. 166-178
    • Xu, Z.1    Seidler, F.J.2    Ali, S.F.3    Slikker, W.4    Slotkin, T.A.5
  • 91
    • 0037019858 scopus 로고    scopus 로고
    • Adolescent nicotine administration alters serotonin receptors and cell signaling mediated through adenylyl cyclase
    • Xu Z., Seidler F.J., Cousins M.M., Slikker W., and Slotkin T.A. Adolescent nicotine administration alters serotonin receptors and cell signaling mediated through adenylyl cyclase. Brain Res. 951 (2002) 280-292
    • (2002) Brain Res. , vol.951 , pp. 280-292
    • Xu, Z.1    Seidler, F.J.2    Cousins, M.M.3    Slikker, W.4    Slotkin, T.A.5
  • 92
    • 0036295541 scopus 로고    scopus 로고
    • Cell signaling as a target and underlying mechanism for neurobehavioral teratogenesis
    • Yanai J., Vatury O., and Slotkin T.A. Cell signaling as a target and underlying mechanism for neurobehavioral teratogenesis. Ann. N.Y. Acad. Sci. 965 (2002) 473-478
    • (2002) Ann. N.Y. Acad. Sci. , vol.965 , pp. 473-478
    • Yanai, J.1    Vatury, O.2    Slotkin, T.A.3
  • 93
    • 0032793007 scopus 로고    scopus 로고
    • Decrease in brain serotonin-2 receptor binding in patients with major depression following desipramine treatment: a positron emission tomography study with fluorine-18-labeled setoperone
    • Yatham L.N., Liddle P.F., Dennie J., Shiah I.S., Adam M.J., Lane C.J., Lam R.W., and Ruth T.J. Decrease in brain serotonin-2 receptor binding in patients with major depression following desipramine treatment: a positron emission tomography study with fluorine-18-labeled setoperone. Arch. Gen. Psychiatry 56 (1999) 705-711
    • (1999) Arch. Gen. Psychiatry , vol.56 , pp. 705-711
    • Yatham, L.N.1    Liddle, P.F.2    Dennie, J.3    Shiah, I.S.4    Adam, M.J.5    Lane, C.J.6    Lam, R.W.7    Ruth, T.J.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.