Use of benchmark dose and meta-analysis to determine the most sensitive endpoint for risk assessment for dimethoate

Regulatory Toxicology and Pharmacology

Volumn 43, Issue 1, 2005, Pages 55-65

  Reiss, Richard ^a   Gaylor, David ^a  

^a Sciences International Inc   (United States)

Author keywords

Benchmark dose; Cholinesterase; Developmental effects; Dimethoate; Insecticide; Meta analysis

Indexed keywords

CHOLINESTERASE; DIMETHOATE;

ANIMAL EXPERIMENT; ARTICLE; CHOLINESTERASE INHIBITION; CONTROLLED STUDY; EXPOSURE; FEEDING; GESTATION PERIOD; INCIDENCE; INTERMETHOD COMPARISON; MORTALITY; NEUROTOXICITY; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; RAT; RISK ASSESSMENT; SENSITIVITY ANALYSIS; TOXICITY TESTING;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; BRAIN; CHOLINESTERASE INHIBITORS; DIET; DIMETHOATE; ENDPOINT DETERMINATION; FEMALE; INTUBATION, GASTROINTESTINAL; LITTER SIZE; MALE; META-ANALYSIS; MODELS, BIOLOGICAL; MORTALITY; NO-OBSERVED-ADVERSE-EFFECT LEVEL; RATS; REPRODUCTION; SEX FACTORS; TIME FACTORS;

ANIMALIA;

EID: 24644436407     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2005.06.012     Document Type: Article

References (22)

1. B.C. Allen, R.J. Kavlock, C.A. Kimmel, and E.M. Faustman Dose-response assessment for developmental toxicity: III. Statistical models Fundamental and Applied Toxicology 23 1994 496 509
2. Brooker, A., Stubbs, A., 1992. Dimethoate: dietary range finding study in mature male and female rate and their juvenile offspring. Report by Huntingdon Research Center, Ltd conducted under International GLP.
3. L.S. Gold, and E. Zeiger Handbook of Carcinogenic Potency and Genotoxicity Databases 1997 CRC Press Boca Raton, FL p. 559.
4. Kasper, U., Kaufmann, W., Deckardt, K., van Ravenzwaay, B., 2004. Dimethoate range-finding study in Wistar rats, administration via the diet over 4 weeks. Study conducted at BASF Aktiengesellchaft under international GLP.
5. R. Kodell, R. Howe, J. Chen, and D. Gaylor Mathematical modeling of reproductive and developmental toxic effects for quantitative risk assessment Risk Analysis 11 1991 583 590
6. L. Kupper, C. Portier, M. Hogan, and E. Yamamoto The impact of litter effects on dose-response modeling in teratology Biometrics 42 1986 85 98
7. Mellert, W., Hellwing, J., Gembardt, C., Deckardt, K. Van Ravenzwaay, B. 2003. Dimethoate two-generation reproduction toxicity study in Wistar rats - adminstration in the diet. Study conducted at BASF Aktiengesellchaft under international GLP.
8. B.E. Mileson, J.E. Chambers, and W.L. Chen Common mechanism of toxicity: a case study of organophosphorus pesticides Toxicological Sciences 41 1998 8 20
9. Myers, D.P., 2001a. Dimethoate developmental neurotoxicity study in the CD rat by oral gavage administration. Study conducted by Huntingdon Life Sciences, Ltd under international GLP.
10. Myers, D.P., 2001b. Dimethoate effects on cholinesterase in the CD rat (adult and juvenile) by oral gavage administration. Study conducted by Huntingdon Life Sciences, Ltd under international GLP.
11. Myers, D.P., 2001c. Dimethoate dose finding study in CD rats by oral gavage administration preliminary to developmental neurotoxicity study. Study conducted by Huntingdon Life Sciences, Ltd under international GLP.
12. Myers, D.P., 2004. Dimethoate cross fostering study in CD rats. Study conducted by Huntingdon Life Sciences, Ltd under international GLP.
13. OECD Test Guideline No. 416. Two Generation Reproduction Toxicity. Dated May 26, 1983. Paris, Organisation for Economic Cooperation and Development.
14. K. Rai, and J. Van Ryzin A dose-response model for teratological experiments involving quantal responses Biometrics 41 1985 1 9
15. J.N.K. Rao, and A.J. Scott A simple method for the analysis of clustered binary data Biometrics 48 1992 577 585
16. L.P. Sheets A consideration of age-dependent differences in susceptibility to organophosphorous and pyrethroid insecticides Neurotoxicology 1-2 2000 57 63
17. US EPA, 1996. Standard operating procedure for measuring cholinesterase inhibition in laboratory rats and dogs exposed to non-reversible cholinesterase inhibitors. Federal Register, April 26, 1996, vol. 61, p. 18593.
18. US EPA, 1998a. Health effects test guidelines OPPTS 870.6300 developmental neurotoxicity study. Report No. EPA-712-C-98-239.
19. US EPA, 1998b. Health effects test guidelines OPPTS 870.3800 reproduction and fertility effects. Report No. EPA-712-C-98-208.
20. US EPA, 2000a. Benchmark dose technical guidance document. EPA Report No. EPA/630/R-00/001.
21. US EPA, 2000b. Revised OP Cumulative Risk Assessment. Prepared by the Office of Pesticide Programs: 〈http://www.epa.gov/pesticides/cumulative/ rra-op/〉.
22. US EPA, 2001. Help Manual for Benchmark Dose Software. EPA Report No. EPA/600/R-00/014F.