Persistent cholinergic presynaptic deficits after neonatal chlorpyrifos exposure

Brain Research

Volumn 902, Issue 2, 2001, Pages 229-243

  Slotkin, T A ^a   Cousins, M M ^a   Tate, C A ^a   Seidler, F J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Acetylcholine; Chlorpyrifos; Choline acetyltransferase activity; Choline transporter; Developmental neurotoxicology; Hemicholinium 3

Indexed keywords

CHLORPYRIFOS; CHOLINE ACETYLTRANSFERASE; HEMICHOLINIUM 3;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR DISORDER; BRAIN CORTEX; BRAIN STEM; CHOLINERGIC SYNAPSE; CONTROLLED STUDY; CORPUS STRIATUM; DOSE TIME EFFECT RELATION; ENZYME ACTIVITY; HIPPOCAMPUS; MESENCEPHALON; NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; RAT; SEX DIFFERENCE; TISSUE DISTRIBUTION;

ACETYLCHOLINE; AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; BIOLOGICAL MARKERS; BRAIN; BRAIN STEM; CARRIER PROTEINS; CEREBRAL CORTEX; CHLORPYRIFOS; CHOLINE O-ACETYLTRANSFERASE; CHOLINERGIC FIBERS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL EXPOSURE; HEMICHOLINIUM 3; HIPPOCAMPUS; INSECTICIDES; MESENCEPHALON; NEOSTRIATUM; NERVE TISSUE PROTEINS; PLASMA MEMBRANE NEUROTRANSMITTER TRANSPORT PROTEINS; PRESYNAPTIC TERMINALS; RATS; RATS, SPRAGUE-DAWLEY; SEX FACTORS; SYMPORTERS; TRITIUM;

EID: 0035370072     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(01)02387-3     Document Type: Article

References (63)

1. Migration and distribution of two populations of hippocampal granule cell precursors during the perinatal and postnatal periods
2. Comparative ontogenic profile of cholinergic markers, including nicotinic and muscarinic receptors, in the rat brain
3. Vulnerable processes of nervous system development: A review of markers and methods
4. 3H]Thymidine-radiographic studies of neurogenesis in the rat olfactory bulb
5. Neurons in the rat dentate gyrus granular layer substantially increase during juvenile and adult live
6. Chlorpyrifos interferes with cell development in rat brain regions
7. Comparative neurochemical and neurobehavioral effects of repeated chlorpyrifos exposures in young and adult rats
8. Neurochemical and neurobehavioral effects of repeated gestational exposure to chlorpyrifos in maternal and developing rats
9. Determination of acetylcholine dynamics
10. Developmental neurotoxicity of chlorpyrifos in vivo and in vitro: Effects on nuclear transcription factor involved in cell replication and differentiation
11. Neonatal chlorpyrifos exposure alters synaptic development and neuronal activity in cholinergic and catecholaminergic pathways
12. Developmental neurotoxicity of chlorpyrifos: Delayed targeting of DNA synthesis after repeated administration
13. Chlorpyrifos releases norepinephrine from adult and neonatal rat brain synaptosomes
14. Chlorpyrifos exposure during a critical neonatal period elicits gender-selective deficits in the development of coordination skills and locomotor activity
15. Exposures from indoor spraying of chlorpyrifos pose greater health risks to children than currently estimated
16. Potential exposure and health risks of infants following indoor residential pesticide applications
17. Accumulation of chlorpyrifos on residential surfaces and toys accessible to children
18. High-affinity choline transport regulation by drug administration during postnatal development
19. Morphometric study of human cerebral cortex development
20. Early biochemical detection of delayed neurotoxicity resulting from developmental exposure to chlorpyrifos
21. High affinity choline transport and acetylCoA production in brain and their roles in the regulation of acetylcholine synthesis
22. Chlorpyrifos, parathion, and their oxons bind to and desensitize a nicotinic acetylcholine receptor: Relevance to their toxicities
23. Postmortem changes in high affinity choline uptake
24. Pesticides and inner-city children: Exposures, risks, and prevention
25. Gestational exposure to chlorpyrifos: Apparent protection of the fetus?
26. Nutritional influences on adrenal chromaffin cell development: Comparison with central neurons
27. Long-term behavioral effects of neonatal chlorpyrifos exposure
28. Organophosphorus neuropathy target esterase inhibitors selectively block outgrowth of neurite-like and cell processes in cultured cells
29. 1996 Annual report of the American association of poison control centers toxic exposure surveillance system
30. Comparative neurochemical effects of repeated methyl parathion or chlorpyrifos exposures in neonatal and adult rats
31. 3H]hemicholinium-3 binding in rat brain
32. Comparative presynaptic neurochemical changes in rat striatum following exposure to chlorpyrifos or parathion
33. Protein measurement with the Folin phenol reagent
34. Rate of synaptic replacement in denervated rat hippocampus declines precipitously from the juvenile period to adulthood
35. Age- and gender-related differences in sensitivity to chlorpyrifos in the rat reflect developmental profiles of esterase activities
36. Age- and gender-related differences in the time course of behavioral and biochemical effects produced by oral chlorpyrifos in rats
37. High-affinity transport of choline in neuronal tissue
38. Ion channels as targets for insecticides
39. Effects of prenatal nicotine exposure on development of central and peripheral cholinergic neurotransmitter systems. Evidence for cholinergic trophic influences in developing brain
40. Organophosphorus pesticides: Do they all have the same mechanism of toxicity?
41. Dose-related inhibition of brain and plasma cholinesterase in neonatal and adult rats following sublethal organophosphate exposures
42. Comparison of in vivo cholinesterase inhibition in neonatal and adult rats by three organophosphorothioate insecticides
43. Critical periods of vulnerability for the developing nervous system: Evidence from humans and animal models
44. Structural-functional relationships in experimentally induced brain damage
45. Developing brain as a target of toxicity
46. Chlorpyrifos elicits mitotic abnormalities and apoptosis in neuroepithelium of cultured rat embryos
47. Modulation of NMDA receptor function: Implications for vertebrate neural development
48. Development of high affinity choline uptake and associated acetylcholine synthesis in the rat fascia dentata
49. Sodium-dependent high affinity choline uptake: A regulatory step in the synthesis of acetylcholine
50. Developmental cholinotoxicants: Nicotine and chlorpyrifos
51. Regulatory changes in presynaptic cholinergic function assessed in rapid autopsy material from patients with Alzheimer disease: Implications for etiology and therapy
52. Cellular mechanisms for developmental toxicity of chlorpyrifos: Targeting the adenylyl cyclase signaling cascade
53. Modeling the developmental neurotoxicity of chlorpyrifos in vitro: Macromolecule synthesis in PC12 cells
54. Adolescent nicotine exposure causes persistent upregulation of nicotinic cholinergic receptors in rat brain regions
55. An animal model of adolescent nicotine exposure: Effects on gene expression and macromolecular constituents in rat brain regions
56. 3H]hemicholinium-3 in the rat brain: A potentially selective marker for presynaptic cholinergic sites
57. Developmental neurotoxicity of chlorpyrifos: Cellular mechanisms
58. Differential development of cholinergic nerve terminal markers in rat brain regions: Implications for nerve terminal density, impulse activity and specific gene expression
59. 3H]hemicholinium-3 binding
60. Comparative cholinergic neurotoxicity of oral chlorpyrifos exposures in preweanling and adult rats