Effects of gestational exposure to chlorpyrifos on postnatal central and peripheral cholinergic neurochemistry

Journal of Toxicology and Environmental Health - Part A

Volumn 66, Issue 3, 2003, Pages 275-289

  Richardson, Jason R ^a   Chambers, Janice E ^a  

^a MISSISSIPPI STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORPYRIFOS; CHOLINE ACETYLTRANSFERASE; COCARBOXYLASE; ORGANOPHOSPHATE INSECTICIDE;

ANIMAL TISSUE; ARTICLE; CHOLINERGIC SYSTEM; CONCENTRATION RESPONSE; CONTROLLED STUDY; EMBRYOTOXICITY; ENZYME ACTIVITY; ENZYME INHIBITION; FETUS; LIVER TOXICITY; NEUROCHEMISTRY; NEUROTOXICITY; NEWBORN; NONHUMAN; POSTNATAL DEVELOPMENT; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; RAT; TERATOGENICITY;

ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; BRAIN; CHLORPYRIFOS; CHOLINESTERASE INHIBITORS; FEMALE; INSECTICIDES; LIVER; MATERNAL EXPOSURE; MATERNAL-FETAL EXCHANGE; PREGNANCY; RATS;

ANIMALIA; ZEA MAYS;

EID: 0037436039     PISSN: 15287394     EISSN: None     Source Type: Journal    
DOI: 10.1080/15287390306369     Document Type: Article

References (49)

1. Atterberry, T. T., Burnett, W. T., and Chambers, J. E. 1997. Age-related differences in parathion and chlorpyrifos in male rats: Target and nontarget esterase sensitivity and cytochrome P450-mediated metabolism. Toxicol. Appl. Pharmacol. 147:411-418.
2. Breslin, W. J.; Liberacki, A. B., Dittenber, D. A., and Quast, J. F. 1996. Evaluation of the developmental and reproductive toxicity of chlorpyrifos in the rat. Fundam. Appl. Toxicol. 29:119-130.
3. Brimijoin, S., and Koenigsberger, C. 1999. Cholinesterases in neural development: New findings and toxicological implications. Environ. Health Perspect. 107(S1):59-64.
4. Buznikov, G. A., Shmukler, Y. B., and Lauder, J. M. 1996. From oocyte to neuron: Do neurotransmitters function in the same way throughout development? Cell. Mol. Neurobiol. 16:537-559.
5. Carr, R. L., and Chambers, J. E. 1991. Acute effects of the organophosphate paraoxon on schedule controlled behavior and esterase activity in rats: Dose-response relationships. Pharmacol. Biochem. Behav. 40:929-936.
6. Carr, R. L., Chambers, H. W., Guarisco, J. A., Richardson, J. R., Tang, J., and Chambers, J. E. 2001. Effects of repeated oral postnatal exposure to chlorpyrifos on open-field behavior in juvenile rats. Toxicol. Sci. 59:260-267.
7. Chambers, H. W., and Chambers, J. E. 1989. An investigation of acetylcholinesterase inhibition and aging and choline acetyltransferase activity following a high level acute exposure to paraoxon. Pestic. Biochem. Physiol. 33:125-131.
8. Chambers, H. W., Brown, B., and Chambers, J. E. 1990. Noncatalytic detoxication of six organophosphorus compounds by rat liver homogenates. Pestic. Biochem. Physiol. 36:308-315.
9. Chambers, J. E., Wiygul, S. H., Harkness, J. E., and Chambers, H. W. 1988. Effects of acute paraoxon and atropine exposures on retention of shuttle avoidance behavior in rats. Neurosci. Res. Commun. 3:85-92.
10. Chanda, S. M., Harp, P., Liu, J., and Pope, C. N. 1995. Comparative developmental and maternal neurotoxicity following acute gestational exposure to chlorpyrifos in rats. J. Toxicol Environ. Health 44:189-202.
11. Chanda, S. M., and Pope, C. N. 1996. Neurochemical and neurobehavioral effects of repeated gestational exposure to chlorpyrifos in maternal and developing rats. Pharmacol. Biochem. Behav. 53:771-776.
12. Clegg, D. J., and van Gemert, M. 1999. Determination of the reference dose for chlorpyrifos: Proceedings of an expert panel. J. Toxicol. Environ. Health B 2:211-255.
13. Coyle, J. T., and Yamamura, H. I. 1976. Neurochemical aspects of the ontogenesis of cholinergic neurons in the rat brain. Brain Res. 118:429-440.
14. Dam, K., Garcia, S. J., Seidler, F. J., and Slotkin, T. A. 1999. Neonatal chlorpyrifos exposure alters synaptic development and neuronal activity in cholinergic and catecholaminergic pathways. Dev. Brain Res. 116:9-20.
15. Deacon, M. M., Murray, J. S., Pilny, M. K., Rao, K. S., Dittenber, D. A., Hanley, T. R., and John, J. A. 1980. Embryotoxicity and fetotoxicity or orally administered chlorpyrifos in mice. Toxicol. Appl. Pharmacol. 54:31-40.
16. Dobbing, J., and Sands, J. 1979. Comparative aspects of the brain growth spurt. Early Hum. Dev. 3:79-83.
17. Ecobichon, D. J. 1996. Toxic effects of pesticides. In Casarett and Doull's toxicology: The basic science of poisons, eds. M. O. Amdur, J. Doull, and C. D. Klaassen, pp. 643-683. New York: McGraw-Hill.
18. Ellman, G. L., Courtney, K. D., Andres, V., Jr., and Featherstone, R. M. 1961. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 7:88-95.
19. Fonnum, F. 1975. A rapid radiochemical method for the determination of choline acetyltransferase. J. Neurochem. 24:407-409.
20. Gaines, T. B. 1960. The acute toxicity of pesticides to rats. Toxicol. Appl. Pharmacol. 2:88-99.
21. Gupta, R. C., Rech, R. H., Lovell, K. L., Welsch, F., and Thornburg, J. E. 1985. Brain cholinergic, behavioral, and morphological development in rats exposed in utero to methylparathion. Toxicol. Appl. Pharmacol. 77:405-413.
22. Karanth, S., and Pope, C. N. 2000. Carboxylesterase and A-esterase activities during maturation and aging: Relationship to the toxicity of chlorpyrifos and parathion in rats. Toxicol. Sci. 58:282-289.
23. Kulkarni, A. P., and Hodgson, E. 1980. Metabolism of insecticides by mixed function oxidase systems. Pharmacol. Ther. 8:379-475.
24. Lassiter, T. L., Barone, S., Jr., Moser, V. C., and Padilla, S. 1999. Gestational exposure to chlorpyrifos: Dose response profiles for cholinesterase and carboxylesterase activity. Toxicol. Sci. 52:92-100.
25. Lassiter, T. L., Padilla, S., Mortensen, S. R., Chanda, S. M., Moser, V. C., and Barone, S., Jr. 1998. Gestational exposure to chlorpyrifos: Apparent protection of the fetus? Toxicol. Appl. Pharmacol. 152:56-65.
26. Lauder, J. M., and Schambra, U. B. 1999. Morphogenetic roles of acetylcholine. Environ. Health Perspect. 107(S1):65-69.
27. Layer, P. G., and Willbold, E. 1995. Novel functions of cholinesterases in development, physiology, and disease. Prog. Histochem. Cytochem. 29:1-93.
28. 3H]hemicholinium-3 binding in rat brain. Fundam. Appl. Toxicol. 34:84-90.
29. Liu, J., and Pope, C. N. 1998. Comparative presynaptic neurochemical changes in rat striatum following exposure to chlorpyrifos or parathion. J. Toxicol. Environ. Health 53:531-544.
30. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265-275.
31. Mattsson, J. L., Maurissen, J. P. J., Nolan, R. J., and Brzak, K. A. 2000. Lack of differential sensitivity to cholinesterase inhibition in fetuses and neonates compared to dams treated perinatally with chlorpyrifos. Toxicol. Sci. 53:438-446.
32. Maurissen, J. P., Hoberman, A. M., Garman, R. H., and Hanley, T. R., Jr. 2000. Lack of selective developmental neurotoxicity in rat pups from dams treated by gavage with chlorpyrifos. Toxicol. Sci. 57:250-263.
33. Michalek, H., Pintor, A., Fortuna, S., and Bisso, G. M. 1985. Effects of diisopropylfluorophosphate on brain cholinergic systems of rats at early developmental stages. Fundam. Appl. Toxicol. 5:S204-S212.
34. Mortensen, S. R., Brimijoin, S., Hooper, M. J., and Padilla, S. 1998. Comparison of the in vitro sensitivity of rat acetylcholinesterase to chlorpyrifos-oxon: What do tissue IC50 values represent? Toxicol. Appl. Pharmacol. 148:46-49.
35. Mortensen, S. R., Chanda, S. M., Hooper, M. J., and Padilla, S. 1996. Maturational differences in chlorpyrifosoxonase activity may contribute to age-related sensitivity to chlorpyrifos. J. Biochem. Toxicol. 11:279-287.
36. Moser, V. C., Chanda, S. M., Mortensen, S. R., and Padilla, S. 1998. Age and gender-related differences in sensitivity to chlorpyrifos in the rat reflect developmental profiles of esterase activities. Toxicol. Sci. 46:211-222.
37. Moser, V. C., and Padilla, S. 1998. Age- and gender-related differences in the time course of behavioral and biochemical effects produced by oral chlorpyrifos in rats. Toxicol. Appl. Pharmacol. 149:107-119.
38. Muscarella, D. E., Keown, J. F., and Bloon, S. E. 1984. Evaluation of the genotoxic and embryotoxic potential of chlorpyrifos and its metabolites in vivo and in vitro. Environ. Mutagen. 6:13-23.
39. Muto, M. A., Lobelle, F., Jr., Bidanset, J. H., and Wurpel, J. N. D. 1992. Embryotoxicity and neurotoxicity in rats associated with prenatal exposure to dursban. Vet. Hum. Toxicol. 34:49-50.
40. National Research Council. 1993. Pesticides in the diets of infants and children. Washington, DC: National Academy Press.
41. Pope, C. N., Chakraborti, T. K., Chapman, M. L., Farrar, J. D., and Arthun, D. 1991. Comparison of in vivo cholinesterase inhibition in neonatal and adult rats by three organophosphorothioate insecticides. Toxicology 68:51-61.
42. Richardson, J. R., Chambers, H. W., and Chambers, J. E. 2001. Analysis of the additivity of in vitro inhibition of cholinesterase by mixtures of chlorpyrifos-oxon and azinphos-methyl-oxon. Toxicol. Appl. Pharmacol. 172:128-139.
43. Russell, R. W., and Overstreet, D. H. 1987. Mechanisms underlying sensitivity to organophosphorus anticholinesterase compounds. Prog. Neurobiol. 28:97-129.
44. Simon, J. R., Atweh, S., and Kuhar, M. J. 1976. Sodium-dependent high affinity choline uptake: A regulatory step in the synthesis of acetylcholine. J. Neurochem. 26:909-922.
45. Slotkin, T. A., Cousins, M. M., Tate, C. A., and Seidler, F. J. 2001. Persistent cholinergic presynaptic deficits after neonatal chlorpyrifos exposure. Brain Res. 902:229-243.
46. Tang, J., Carr, R. L., and Chambers, J. E. 1999. Changes in rat brain cholinesterase activity and muscarinic receptor density during and after repeated oral exposure to chlorpyrifos in early postnatal development. Toxicol. Sci. 51:265-272.
47. Tilson, H. A. 1992. Study design considerations in developmental neurotoxicology. Neurotoxicol. Teratol. 14:199-203.
48. Wilson, B. W., Hooper, M. J., Hansen, M. E., and Nieberg, P. S. 1992. Reactivation of organophosphorus inhibited AChE with oximes. In Organophosphates: Chemistry, fate, and effects, eds. J. E. Chambers and P. E. Levi, pp. 108-137. San Diego, CA: Academic Press.
49. Zheng, Q., Olivier, K., Won, Y. K., and Pope, C. N. 2000. Comparative cholinergic neurotoxicity of oral chlorpyrifos exposures in preweanling and adult rats. Toxicol. Sci. 55:124-132.