Effects of 2,4-dichlorophenoxyacetic acid exposure on dopamine D 2-like receptors in rat brain

Neurotoxicology and Teratology

Volumn 26, Issue 4, 2004, Pages 599-605

  Bortolozzi, Analía A ^a,c   Evangelista De Duffard, Ana María ^a   Duffard, Ricardo O ^a   Antonelli, Marta C ^b  

^a UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^c INST D INVESTIGACIONS B   (Spain)

Author keywords

2,4 D neurotoxicity; D2 receptor ontogeny

Indexed keywords

2,4 DICHLOROPHENOXYACETIC ACID; DOPAMINE 2 RECEPTOR; EMONAPRIDE; HERBICIDE; MEMBRANE RECEPTOR; TRITIUM;

ANIMAL EXPERIMENT; ARTICLE; BINDING ASSAY; BRAIN; CEREBELLUM; CLINICAL OBSERVATION; CONTROLLED STUDY; CORPUS STRIATUM; DIET; EXPOSURE; FEMALE; GESTATIONAL AGE; HIPPOCAMPUS; NEWBORN; NONHUMAN; ONTOGENY; PERINATAL PERIOD; PREFRONTAL CORTEX; PREGNANCY; PRIORITY JOURNAL; PUERPERIUM; RAT; RECEPTOR BINDING; RECEPTOR DENSITY; SEX DIFFERENCE; WEANING;

2,4-DICHLOROPHENOXYACETIC ACID; AGE FACTORS; ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; BRAIN; FEMALE; HERBICIDES; MALE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, DOPAMINE D2; SEX FACTORS;

ANIMALIA;

EID: 2942562204     PISSN: 08920362     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ntt.2004.04.001     Document Type: Article

References (39)

1. Andersen S.L., Rutstein M., Benzo J.M., Hostetter J.C., Teicher M.H. Sex differences in dopamine receptor overproduction and elimination. NeuroReport. 8:1997;1495-1498
2. Aspelin A. Pesticides Industry Sales and Usage: 1994 and 1995 Market Estimates. 1997;United States Environmental Protection Agency, Washington. Report No 733-R-97-002.
3. Baldessarini R.J., Tarazi F.I. Brain dopamine receptors: a primer on their current status, basic and clinical. Harv. Rev. Psychiatry. 3:1996;301-325
4. Borodinsky L.N., Pesce G., Pomata P., Fiszman M.L. Neurosteroid modulation of GABAA receptors in the developing rat brain cortex. Neurochem. Int. 31:1997;313-317
5. Bortolozzi A., Duffard R.O., Rubio M., Sturtz N., Evangelista de Duffard A.M. Regionally specific changes in central brain monoamine levels by 2, 4-dichlorophenoxyacetic acid in acute treated rats. Neurotoxicology. 19:1998;839-851
6. Bortolozzi A.A., Duffard R.O., Evangelista de Duffard A.M. Behavioral alterations induced in rats by a pre- and postnatal exposure to 2, 4-dichlorophenoxyacetic acid. Neurotoxicol. Teratol. 21:1999;451-465
7. Bortolozzi A., Evangelista de Duffard A.M., Duffard R., Antonelli M. Effects of 2, 4-dichlorophenoxyacetic acid exposure on dopamine D2-like receptors in rat brain. Society for Neuroscience. vol. 26:2000;1420. New Orleans, LA
8. Bortolozzi A., Evangelista de Duffard A.M., Dajas F., Duffard R., Silveira R. Intracerebral administration of 2, 4-diclorophenoxyacetic acid induces behavioral and neurochemical alterations in the rat brain. Neurotoxicology. 22:2001;221-232
9. Bortolozzi A., Duffard R., Antonelli M., Evangelista de Duffard A.M. Increased sensitivity in dopamine D(2)-like brain receptors from 2, 4-dichlorophenoxyacetic acid (2, 4-D)-exposed and amphetamine-challenged rats. Ann. N.Y. Acad. Sci. 965:2002;314-323
10. Bortolozzi A., Duffard R., de Evangelista Duffard A.M. Asymmetrical development of the monoamine systems in 2, 4-dichlorophenoxyacetic acid treated rats. Neurotoxicology. 24:2003;149-157
11. Brusco A., Saavedra J.P., Garcia G., Tagliaferro P., Evangelista de Duffard A.M., Duffard R. 2, 4-Dichlorophenoxyacetic acid through lactation induces astrogliosis in rat brain. Mol. Chem. Neuropathol. 30:1997;175-185
12. Campbell B.A., Marbry P.D. The role of catecholamines in behavioral arousal during ontogenesis. Psychopharmacology (Berlin). 31:1973;253-264
13. Duffard R.O., Mori de Moro G.B., Evangelista de Duffard A.M. Vulnerability of myelin development of the chick to the herbicide 2, 4-dichlorophenoxyacetic butyl ester. Neurochem. Res. 12:1987;1077-1080
14. Duffard R., Garcia G., Rosso S., Bortolozzi A., Madariaga M., Di Paolo O., Evangelista de Duffard A.M. Central nervous system myelin deficit in rats exposed to 2, 4-dichlorophenoxyacetic acid throughout lactation. Neurotoxicol. Teratol. 18:1996;691-696
15. Eriksson P., Ahlbom J., Fredriksson A. Exposure to DDT during a defined period in neonatal life induces permanent changes in brain muscarinic receptors and behaviour in adult mice. Brain Res. 582:1992;277-281
16. Evangelista de Duffard A.M., de Alderete M.N., Duffard R. Changes in brain serotonin and 5-hydroxyindolacetic acid levels induced by 2, 4-dichlorophenoxyacetic butyl ester. Toxicology. 64:1990;265-270
17. Evangelista de Duffard A.M., Orta C., Duffard R. Behavioral changes in rats fed a diet containing 2, 4-dichlorophenoxyacetic butyl ester. Neurotoxicology. 11:1990;563-572
18. Evangelista de Duffard A.M., Bortolozzi A., Duffard R.O. Altered behavioral responses in 2, 4-dichlorophenoxyacetic acid treated and amphetamine challenged rats. Neurotoxicology. 16:1995;479-488
19. Ferri A., Bortolozzi A., Duffard R., Evangelista de Duffard A.M. Monoamine levels in neonate rats lactationally exposed to 2, 4-dichlorophenoxyacetic acid. Biog. Amines. 16:2000;73-100
20. Ferri A., Duffard R., Sturtz N., Evangelista de Duffard A.M. Iron, zinc and copper levels in brain, serum and liver of neonates exposed to 2, 4-dichlorophenoxyacetic acid. Neurotoxicol. Teratol. 25:2003;607-613
21. Griffin R., Godfrey V., Kim Y., Burka L. Sex-dependent differences in the disposition of 2, 4-dichlorophenoxyacetic acid in Sprague-Dawley rats, B6C3F1 mice, and Syrian hamsters. Drug Metab. Dispos. 25:1997;1065-1071
22. Harris S.A., Solomon K.R. Exposure of homeowners, professional applicators and bystanders to 2, 4-dichlorophenoxyacetic acid (2, 4-D). Toxicologist. 11:1991
23. Harris S.A., Solomon K.R., Stephenson G.R. Exposure of homeowners and bystanders to 2, 4-dichlorophenoxyacetic acid (2, 4-D). J. Environ. Sci. Health. Part B, Pestic. Food Contam. Agric. Wastes. 27:1992;23-38
24. Holson R.R., Gazzara R.A., Ferguson S.A., Adams J. Behavioral effects of low-dose gestational day 11-13 retinoic acid exposure. Neurotoxicol. Teratol. 19:1997;355-362
25. Kohli J.D., Khanna R.N., Gupta B.N., Dhar M.M., Tandon J.S., Sircar K.P. Absorption and excretion of 2, 4-dichlorophenoxyacetic acid in man. Xenobiotica. 4:1974;97-100
26. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275
27. Mattsson J.L., Charles J.M., Yano B.L., Cunny H.C., Wilson R.D., Bus J.S. Single-dose and chronic dietary neurotoxicity screening studies on 2, 4-dichlorophenoxyacetic acid in rats. Fundam. Appl. Toxicol. 40:1997;111-119
28. Mori de Moro G., Duffard R., Evangelista de Duffard A.M. Neurotoxicity of 2, 4-dichlorophenoxyacetic butyl ester in chick embryos. Neurochem. Res. 18:1993;353-359
29. Oliveira G.H., Palermo-Neto J. Effects of 2, 4-dichlorophenoxyacetic acid (2, 4-D) on open-field behaviour and neurochemical parameters of rats. Pharmacol. Toxicol. 73:1993;79-85
30. Schulze G.E. Formulation and food deprivation affects 2, 4-D neurobehavioral toxicity in rats. Neurotoxicol. Teratol. 9:1987;363-367
31. Seeman P., Guan H.C., Van Tol H.H., Niznik H.B. Low density of dopamine D4 receptors in Parkinson's, schizophrenia, and control brain striata. Synapse. 14:1993;247-253
32. Short P., Colborn T. Pesticide use in the U.S. and policy implications: a focus on herbicides. Toxicol. Ind. Health. 15:1999;240-275
33. Squibb R.E., Tilson H.A., Mitchell C.L. Neurobehavioral assessment of 2, 4-dichlorophenoxyacetic acid (2, 4-D) in rats. Neurobehav. Toxicol. Teratol. 5:1983;331-335
34. Stevens J., Sumner D. Herbicides. 1991;1317-1332 Academic Press, New York
35. Tarazi F.I., Baldessarini R.J. Comparative postnatal development of dopamine D(1), D(2) and D(4) receptors in rat forebrain. Int. J. Dev. Neurosci. 18:2000;29-37
36. Taskar P.K., Das Y.T., Trout J.R., Chattopadhyay S.K., Brown H.D. Measurement of 2, 4-dichlorophenoxyacetic acid (2, 4-D) after occupational exposure. Bull. Environ. Contam. Toxicol. 29:1982;586-591
37. Teicher M.H., Andersen S.L., Hostetter J.C. Jr. Evidence for dopamine receptor pruning between adolescence and adulthood in striatum but not nucleus accumbens. Brain Res. Dev. Brain Res. 89:1995;167-172
38. Tyynela K., Elo H.A., Ylitalo P. Distribution of three common chlorophenoxyacetic acid herbicides into the rat brain. Arch. Toxicol. 64:1990;61-65
39. Viveros M.P., de Cabo C., Colado M.I., Martin M.I. Naltrexone administration during the preweanling period affects striatal and hypothalamic serotonergic systems, but not midbrain serotonergic or striatal dopaminergic systems in the adult rat. Neurosci. Lett. 201:1995;195-198