HIV-2 and SIVmac accessory virulence factor Vpx down-regulates SAMHD1 enzyme catalysis prior to proteasome-dependent degradation

Journal of Biological Chemistry

Volumn 288, Issue 26, 2013, Pages 19116-19126

  DeLucia, Maria ^a   Mehrens, Jennifer ^a   Wu, Ying ^a   Ahn, Jinwoo ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL MECHANISMS; MOLECULAR MECHANISM; NANOMOLAR AFFINITY; POLYUBIQUITINATION; REVERSE TRANSCRIPTION; SIMIAN IMMUNODEFICIENCY VIRUS; UBIQUITIN LIGASES; VIRULENCE FACTORS;

BIODEGRADATION; CATALYST ACTIVITY;

PROTEINS;

DDB1 AND CUL4 ASSOCIATED FACTOR 1; PROTEASOME; PROTEIN VPX; RECEPTOR; STERILE ALPHA MOTIF AND HD DOMAIN CONTAINING PROTEIN 1; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

ARTICLE; BINDING KINETICS; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CELL STRAIN HEK293; COMPLEX FORMATION; CONTROLLED STUDY; DOWN REGULATION; GEL PERMEATION CHROMATOGRAPHY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 2; IMMUNOBLOTTING; LIGHT SCATTERING; MOLECULAR CLONING; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CROSS LINKING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PURIFICATION; SIMIAN IMMUNODEFICIENCY VIRUS; SURFACE PLASMON RESONANCE; UBIQUITINATION; VIRUS STRAIN;

ENZYME TURNOVER; ENZYMES; HIV; RESTRICTION FACTORS; UBIQUITIN LIGASE; UBIQUITINATION; VIRULENCE FACTORS;

AMINO ACID SEQUENCE; ANIMALS; CATALYSIS; CROSS-LINKING REAGENTS; HEK293 CELLS; HIV-2; HUMANS; MACACA MULATTA; MOLECULAR SEQUENCE DATA; MONOMERIC GTP-BINDING PROTEINS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SIMIAN IMMUNODEFICIENCY VIRUS; SURFACE PLASMON RESONANCE; UBIQUITIN; VIRAL REGULATORY AND ACCESSORY PROTEINS; VIRULENCE FACTORS;

HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; PRIMATES; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 84879579348     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.469007     Document Type: Article

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