HIV/Simian Immunodeficiency Virus (SIV) accessory virulence factor Vpx loads the host cell restriction factor SAMHD1 onto the E3 ubiquitin ligase complex CRL4 DCAF1

Journal of Biological Chemistry

Volumn 287, Issue 15, 2012, Pages 12550-12558

  Ahn, Jinwoo ^a   Hao, Caili ^b   Yan, Junpeng ^b   DeLucia, Maria ^a   Mehrens, Jennifer ^a   Wang, Chuanping ^b   Gronenborn, Angela M ^a   Skowronski, Jacek ^b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SEQUENCE; C TERMINUS; CATALYTIC DOMAINS; CRITICAL AMINO ACIDS; DOWN-REGULATION; HETEROLOGOUS PROTEINS; HOST CELLS; IMMUNODEFICIENCY VIRUS; MOLECULAR INTERFACES; MYELOID CELLS; POTENT INHIBITION; PROTEASOMAL DEGRADATION; UBIQUITIN LIGASES; UBIQUITINATION; VERTEBRATE SPECIES; VIRULENCE FACTORS;

AMINO ACIDS; DEGRADATION; PEPTIDES; VIRUSES;

DISEASES;

CELL PROTEIN; DDB1 CUL4 ASSOCIATED FACTOR 1; HYBRID PROTEIN; PEPTIDE; PROTEIN CRL4; PROTEIN VPX; STERILE ALPHA MOTIF DOMAIN AND HD DOMAIN CONTAINING PROTEIN 1; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; VIRUS PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; CONTROLLED STUDY; DOWN REGULATION; ENZYME SUBSTRATE COMPLEX; HOST CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SIMIAN IMMUNODEFICIENCY VIRUS; UBIQUITINATION; VERTEBRATE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CARRIER PROTEINS; CONSERVED SEQUENCE; DNA-BINDING PROTEINS; DOWN-REGULATION; HEK293 CELLS; HOST-PATHOGEN INTERACTIONS; HUMANS; MOLECULAR SEQUENCE DATA; MONOMERIC GTP-BINDING PROTEINS; MUTAGENESIS, SITE-DIRECTED; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; RECOMBINANT FUSION PROTEINS; SIMIAN IMMUNODEFICIENCY VIRUS; UBIQUITIN-PROTEIN LIGASES; VIRAL REGULATORY AND ACCESSORY PROTEINS;

HUMAN IMMUNODEFICIENCY VIRUS 2; PRIMATE LENTIVIRUS GROUP; SIMIAN IMMUNODEFICIENCY VIRUS; VERTEBRATA;

EID: 84859482628     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.340711     Document Type: Article

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