Genistein promotes cell death of ethanol-stressed HeLa cells through the continuation of apoptosis or secondary necrosis

Cancer Cell International

Volumn 13, Issue 1, 2013, Pages

  Xie, Xin ^a   Wang, Shan Shan ^a   Wong, Timothy Chung Sing ^a   Fung, Ming Chiu ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Apoptosis; Genistein; HeLa Cell; Necrosis; Stress Recovery

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; ALCOHOL; CASPASE 3; GENISTEIN; LACTATE DEHYDROGENASE; LIPOCORTIN 5; PHOSPHATIDYLSERINE; PROTEIN MCL 1; PROTEIN MDM2; X LINKED INHIBITOR OF APOPTOSIS;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL DEATH; CELL STRESS; CELL VIABILITY; CONCENTRATION RESPONSE; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; GENE TARGETING; HELA CELL; HUMAN; HUMAN CELL; IC 50; IMMUNOHISTOCHEMISTRY; MICROSCOPY; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

EID: 84879425476     PISSN: None     EISSN: 14752867     Source Type: Journal    
DOI: 10.1186/1475-2867-13-63     Document Type: Article

References (57)

1. Chabner BA, Roberts TG. Timeline: chemotherapy and the war on cancer. Nat Rev Cancer 2005, 5(1):65-72. 10.1038/nrc1529, 15630416.
2. Kasibhatla S, Tseng B. Why target apoptosis in cancer treatment?. Mol Cancer Ther 2003, 2(6):573-580.
3. Johnstone RW, Ruefli AA, Lowe SW. Apoptosis: a link between cancer genetics and chemotherapy. Cell 2002, 108(2):153-164. 10.1016/S0092-8674(02)00625-6, 11832206.
4. Dive C, Hickman JA. Drug-target interactions: only the first step in the commitment to a programmed cell death?. Br J Cancer 1991, 64(1):192-196. 10.1038/bjc.1991.269, 1977304, 1854622.
5. Schmitt CA, Lowe SW. Apoptosis and therapy. J Pathol 1999, 187(1):127-137. 10.1002/(SICI)1096-9896(199901)187:1<127::AID-PATH251>3.0.CO;2-T, 10341713.
6. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000, 100(1):57-70. 10.1016/S0092-8674(00)81683-9, 10647931.
7. Gerl R, Vaux DL. Apoptosis in the development and treatment of cancer. Carcinogenesis 2005, 26(2):263-270.
8. Lowe SW, Lin AW. Apoptosis in cancer. Carcinogenesis 2000, 21(3):485-495. 10.1093/carcin/21.3.485, 10688869.
9. Letai AG. Diagnosing and exploiting cancer's addiction to blocks in apoptosis. Nat Rev Cancer 2008, 8(2):121-132. 10.1038/nrc2297, 18202696.
10. Kurahashi N, Iwasaki M, Inoue M, Sasazuki S, Tsugane S. Plasma isoflavones and subsequent risk of prostate cancer in a nested case-control study: the Japan Public Health Center. J Clin Oncol 2008, 26(36):5923-5929. 10.1200/JCO.2008.16.8807, 19018085.
11. Shon YH, Park SD, Nam KS. Effective chemopreventive activity of genistein against human breast cancer cells. J Biochem Mol Biol 2006, 39(4):448-451. 10.5483/BMBRep.2006.39.4.448, 16889690.
12. Taylor CK, Levy RM, Elliott JC, Burnett BP. The effect of genistein aglycone on cancer and cancer risk: a review of in vitro, preclinical, and clinical studies. Nutr Rev 2009, 67(7):398-415. 10.1111/j.1753-4887.2009.00213.x, 19566600.
13. Li Y, Upadhyay S, Bhuiyan M, Sarkar FH. Induction of apoptosis in breast cancer cells MDA-MB-231 by genistein. Oncogene 1999, 18(20):3166-3172. 10.1038/sj.onc.1202650, 10340389.
14. Barnes S. Effect of genistein on in vitro and in vivo models of cancer. J Nutr 1995, 125(3 Suppl):777S-783S.
15. Hwang JT, Ha J, Park OJ. Combination of 5-fluorouracil and genistein induces apoptosis synergistically in chemo-resistant cancer cells through the modulation of AMPK and COX-2 signaling pathways. Biochem Biophys Res Commun 2005, 332(2):433-440. 10.1016/j.bbrc.2005.04.143, 15896711.
16. Shen J, Tai YC, Zhou J, Stephen Wong CH, Cheang PT, Fred Wong WS, Xie Z, Khan M, Han JH, Chen CS. Synergistic antileukemia effect of genistein and chemotherapy in mouse xenograft model and potential mechanism through MAPK signaling. Exp Hematol 2007, 35(1):75-83.
17. Kim SH, Kim SH, Kim YB, Jeon YT, Lee SC, Song YS. Genistein Inhibits Cell Growth by Modulating Various Mitogen-Activated Protein Kinases and AKT in Cervical Cancer Cells. Ann Ny Acad Sci 2009, 1171:495-500. 10.1111/j.1749-6632.2009.04899.x, 19723095.
18. Sasamura H, Takahashi A, Yuan J, Kitamura H, Masumori N, Miyao N, Itoh N, Tsukamoto T. Antiproliferative and antiangiogenic activities of genistein in human renal cell carcinoma. Urology 2004, 64(2):389-393. 10.1016/j.urology.2004.03.045, 15302513.
19. Sarkar FH. Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer. Cancer Res 2005, 65(19):9064-9072. 10.1158/0008-5472.CAN-05-1330, 16204081.
20. Suvarna B, Debashis S, Robert T, David LD, James DB. Gene Expression Changes Induced by Genistein in the Prostate Cancer Cell Line LNCaP. Open Prost Cancer J 2010, 3:86-98.
21. Li Y, Ahmed F, Ali S, Philip PA, Kucuk O, Sarkar FH. Inactivation of nuclear factor kappaB by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells. Cancer Res 2005, 65(15):6934-6942. 10.1158/0008-5472.CAN-04-4604, 16061678.
22. Banerjee S, Zhang Y, Ali S, Bhuiyan M, Wang Z, Chiao PJ, Philip PA, Abbruzzese J, Sarkar FH. Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer. Cancer Res 2005, 65(19):9064-9072. 10.1158/0008-5472.CAN-05-1330, 16204081.
23. Sarkar FH, Li YW. Using chemopreventive agents to enhance the efficacy of cancer therapy. Cancer Res 2006, 66(7):3347-3350. 10.1158/0008-5472.CAN-05-4526, 16585150.
24. Castaneda F, Rosin-Steiner S. Low concentration of ethanol induce apoptosis in HepG2 cells: role of various signal transduction pathways. Int J Med Sci 2006, 3(4):160-167. 1633825, 17088943.
25. Zhou Z, Sun X, Kang YJ. Ethanol-induced apoptosis in mouse liver: Fas- and cytochrome c-mediated caspase-3 activation pathway. Am J Pathol 2001, 159(1):329-338. 10.1016/S0002-9440(10)61699-9, 1850406, 11438480.
26. Asai K, Buurman WA, Reutelingsperger CP, Schutte B, Kaminishi M. Low concentrations of ethanol induce apoptosis in human intestinal cells. Scand J Gastroenterol 2003, 38(11):1154-1161. 10.1080/00365520310006252, 14686719.
27. Wu D, Cederbaum AI. Ethanol-induced apoptosis to stable HepG2 cell lines expressing human cytochrome P-4502E1. Alcohol Clin Exp Res 1999, 23(1):67-76. 10.1111/j.1530-0277.1999.tb04025.x, 10029205.
28. Taylor RC, Cullen SP, Martin SJ. Apoptosis: controlled demolition at the cellular level. Nat Rev Mol Cell Bio 2008, 9(3):231-241.
29. Kroemer G, Galluzzi L, Vandenabeele P, Abrams J, Alnemri ES, Baehrecke EH, Blagosklonny MV, El-Deiry WS, Golstein P, Green DR, et al. Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ 2009, 16(1):3-11. 10.1038/cdd.2008.150, 2744427, 18846107.
30. Galluzzi L, Vitale I, Abrams JM, Alnemri ES, Baehrecke EH, Blagosklonny MV, Dawson TM, Dawson VL, El-Deiry WS, Fulda S. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ 2012, 19(1):107-120. 10.1038/cdd.2011.96, 3252826, 21760595.
31. Hammill AK, Uhr JW, Scheuermann RH. Annexin V staining due to loss of membrane asymmetry can be reversible and precede commitment to apoptotic death. Exp Cell Res 1999, 251(1):16-21. 10.1006/excr.1999.4581, 10438567.
32. Geske FJ, Lieberman R, Strange R, Gerschenson LE. Early stages of p53-induced apoptosis are reversible. Cell Death Differ 2001, 8(2):182-191. 10.1038/sj.cdd.4400786, 11313720.
33. Wang K, Brems JJ, Gamelli RL, Ding J. Reversibility of caspase activation and its role during glycochenodeoxycholate-induced hepatocyte apoptosis. J Bio Chem 2005, 280(25):23490-23495.
34. Tang HL, Yuen KL, Tang HM, Fung MC. Reversibility of apoptosis in cancer cells. Br J Cancer 2009, 100(1):118-122. 10.1038/sj.bjc.6604802, 2634673, 19088725.
35. Green DR, Beere HM. Apoptosis. Mostly dead. Nature 2001, 412(6843):133-135. 10.1038/35084313, 11449252.
36. Vaux DL, Silke J. IAPs, RINGs and ubiquitylation. Nat Rev Mol Cell Biol 2005, 6(4):287-297.
37. Salvesen GS, Duckett CS. IAP proteins: blocking the road to death's door. Nat Rev Mol Cell Biol 2002, 3(6):401-410. 10.1038/nrm830, 12042762.
38. Vassilev LT, Vu BT, Graves B, Carvajal D, Podlaski F, Filipovic Z, Kong N, Kammlott U, Lukacs C, Klein C. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 2004, 303(5659):844-848. 10.1126/science.1092472, 14704432.
39. Moll UM, Petrenko O. The MDM2-p53 interaction. Mol Cancer Res 2003, 1(14):1001-1008.
40. Bonni A, Brunet A, West AE, Datta SR, Takasu MA, Greenberg ME. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science 1999, 286(5443):1358-1362. 10.1126/science.286.5443.1358, 10558990.
41. Du KY, Montminy M. CREB is a regulatory target for the protein kinase Akt/PKB. J Biol Chem 1998, 273(49):32377-32379. 10.1074/jbc.273.49.32377, 9829964.
42. Yan C, Lu D, Hai T, Boyd DD. Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination. EMBO J 2005, 24(13):2425-2435. 10.1038/sj.emboj.7600712, 1173153, 15933712.
43. Mashima T, Udagawa S, Tsuruo T. Involvement of transcriptional repressor ATF3 in acceleration of caspase protease activation during DNA damaging agent-induced apoptosis. J Cell Physiol 2001, 188(3):352-358. 10.1002/jcp.1130, 11473362.
44. Villunger A, Michalak EM, Coultas L, Mullauer F, Bock G, Ausserlechner MJ, Adams JM, Strasser A. p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science 2003, 302(5647):1036-1038. 10.1126/science.1090072, 14500851.
45. Beckerman R, Prives C. Transcriptional regulation by p53. Cold Spring Harb Perspect Biol 2010, 2(8):a000935. 10.1101/cshperspect.a000935, 2908772, 20679336.
46. Wang JM, Chao JR, Chen WH, Kuo ML, Yen JY, Yen HFY. The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-Kinase/Akt signaling pathway through a transcription factor complex containing CREB. Mol Cell Biol 1999, 19(9):6195-6206. 84561, 10454566.
47. Gong LJ, Li YW, Nedeljkovic-Kurepa A, Sarkar FH. Inactivation of NF-kappa B by genistein is mediated via Akt signaling pathway in breast cancer cells. Oncogene 2003, 22(30):4702-4709. 10.1038/sj.onc.1206583, 12879015.
48. Li Y, Sarkar FH. Inhibition of nuclear factor kappaB activation in PC3 cells by genistein is mediated via Akt signaling pathway. Clin Cancer Res 2002, 8(7):2369-2377.
49. Nelson EC, Evans CP, Mack PC, Devere-White RW, Lara PN. Inhibition of Akt pathways in the treatment of prostate cancer. Prostate Cancer Prostatic Dis 2007, 10(4):331-339. 10.1038/sj.pcan.4500974, 17471291.
50. Seol DW. Up-regulation of IAPs by PI-3K: a cell survival signal-mediated anti-apoptotic mechanism. Biochem Biophys Res Commun 2008, 377(2):508-511. 10.1016/j.bbrc.2008.10.021, 18929542.
51. Stehlik C, de Martin R, Kumabashiri I, Schmid JA, Binder BR, Lipp J. Nuclear factor (NF)-kappaB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor alpha-induced apoptosis. J Exp Med 1998, 188(1):211-216. 10.1084/jem.188.1.211, 2525542, 9653098.
52. Ogawara Y, Kishishita S, Obata T, Isazawa Y, Suzuki T, Tanaka K, Masuyama N, Gotoh Y. Akt enhances Mdm2-mediated ubiquitination and degradation of p53. J Biol Chem 2002, 277(24):21843-21850. 10.1074/jbc.M109745200, 11923280.
53. Mayo LD, Donner DB. A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus. Proc Natl Acad Sci USA 2001, 98(20):11598-11603. 10.1073/pnas.181181198, 58775, 11504915.
54. Li M, Zhang Z, Hill DL, Chen XB, Wang H, Zhang RW. Genistein, a dietary isoflavone, down-regulates the MDM2 oncogene at both transcriptional and posttranslational levels. Cancer Res 2005, 65(18):8200-8208. 10.1158/0008-5472.CAN-05-1302, 16166295.
55. Nakamura Y, Yogosawa S, Izutani Y, Watanabe H, Otsuji E, Sakai T. A combination of indol-3-carbinol and genistein synergistically induces apoptosis in human colon cancer HT-29 cells by inhibiting Akt phosphorylation and progression of autophagy. Mol Cancer 2009, 8:100. 10.1186/1476-4598-8-100, 2784428, 19909554.
56. Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell 2007, 129(7):1261-1274. 10.1016/j.cell.2007.06.009, 2756685, 17604717.
57. Testa JR, Tsichlis PN. AKT signaling in normal and malignant cells. Oncogene 2005, 24(50):7391-7393. 10.1038/sj.onc.1209100, 16288285.