Synthesis, 18F-radiolabeling, and in vivo biodistribution studies of N-fluorohydroxybutyl isatin sulfonamides using positron emission tomography

Journal of Medicinal Chemistry

Volumn 56, Issue 11, 2013, Pages 4509-4520

  Limpachayaporn, Panupun ^a   Wagner, Stefan ^b   Kopka, Klaus ^b   Hermann, Sven ^a   Schäfers, Michael ^a   Haufe, Günter ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3 INHIBITOR; CASPASE 7; FLUORIDE; FLUORINE 18; ISATIN DERIVATIVE; N [(3 (F 18 ) FLUORO 4 HYDROXYBUTYL) 5 (1 2 (METHOXYMETHYL)PYRROLIDINYL)SULFONYL] ISATIN; N [4 (F 18) FLUORO 3 HYDROXYBUTYL] ISATIN; SULFONAMIDE; UNCLASSIFIED DRUG; CASPASE 3; CASPASE INHIBITOR; DRUG DERIVATIVE; FLUORINE; ISATIN; N (3 FLUORO 4 HYDROXYBUTYL) 5 (1 (2 (METHOXYMETHYL)PYRROLIDINYL)SULFONYL)ISATIN; N (4 FLUORO 3 HYDROXYBUTYL) 5 (1 (2 (METHOXYMETHYL)PYRROLIDINYL)SULFONYL)ISATIN; N-(3-FLUORO-4-HYDROXYBUTYL)-5-(1-(2-(METHOXYMETHYL)PYRROLIDINYL)SULFONYL)ISATIN; N-(4-FLUORO-3-HYDROXYBUTYL)-5-(1-(2-(METHOXYMETHYL)PYRROLIDINYL)SULFONYL)ISATIN; RADIOPHARMACEUTICAL AGENT;

ARTICLE; BINDING AFFINITY; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RADIOCHEMISTRY; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER ASSISTED EMISSION TOMOGRAPHY; HUMAN; MOUSE; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TISSUE DISTRIBUTION;

ANIMALS; CASPASE 3; CASPASE 7; CASPASE INHIBITORS; FLUORINE RADIOISOTOPES; HUMANS; ISATIN; MICE; MODELS, MOLECULAR; POSITRON-EMISSION TOMOGRAPHY AND COMPUTED TOMOGRAPHY; RADIOPHARMACEUTICALS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; TISSUE DISTRIBUTION;

EID: 84879044088     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400257a     Document Type: Article

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