Facile nucleophilic fluorination reactions using tert-alcohols as a reaction medium: Significantly enhanced reactivity of alkali metal fluorides and improved selectivity

Journal of Organic Chemistry

Volumn 73, Issue 3, 2008, Pages 957-962

  Dong, Wook Kim ^a   Jeong, Hwan Jeong ^a   Seok, Tae Lim ^a   Sohn, Myung Hee ^a   Katzenellenbogen, John A ^b   Dae, Yoon Chi ^c  

^a Chonbuk National University Medical School   (South Korea)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^c Inha University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

APROTIC SOLVENTS; NUCLEOPHILIC FLUORINATION; RADIOPHARMACEUTICALS;

ALCOHOLS; CATALYST SELECTIVITY; FLUORINATION; HYDROGEN BONDS; OLEFINS; REACTION KINETICS;

NUCLEOPHILES;

1 (2 MESYLOXYETHYL)NAPHTHALENE; ALCOHOL; ALKALI METAL; ALKANE DERIVATIVE; ALKENE DERIVATIVE; ANILINE DERIVATIVE; ETHER DERIVATIVE; FLUORIDE; FLUORINE 18; N 5 BROMOPENTANOYL 3,4 DIMETHOXYANILINE; NAPHTHALENE DERIVATIVE; NUCLEOPHILE; OXYGEN; RADIOPHARMACEUTICAL AGENT; SOLVENT; SULFONIC ACID DERIVATIVE; TERT BUTYL ALCOHOL; UNCLASSIFIED DRUG;

ARTICLE; CATALYST; CHEMICAL REACTION; CHEMICAL STRUCTURE; CYCLIC ADDUCT; CYCLOADDITION; FLUORINATION; HYDROGEN BOND; ISOTOPE LABELING; NUCLEOPHILIC DISPLACEMENT REACTION; POSITRON EMISSION TOMOGRAPHY; REACTION TIME; SOLVATION;

ACETONITRILES; ALCOHOLS; FLUORIDES; FLUORINE; HYDROGEN BONDING; MESYLATES; METALS, ALKALI; MOLECULAR STRUCTURE; SOLVENTS;

EID: 38849134893     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo7021229     Document Type: Article

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