SCOPUS 정보 검색 플랫폼

Volumn 21, Issue 7, 2013, Pages 2025-2036

Synthesis of new fluorinated, 2-substituted 5-pyrrolidinylsulfonyl isatin derivatives as caspase-3 and caspase-7 inhibitors: Nonradioactive counterparts of putative PET-compatible apoptosis imaging agents

(5) Limpachayaporn, Panupun a Schäfers, Michael a Schober, Otmar b Kopka, Klaus b Haufe, Günter a

a UNIVERSITY OF MÜNSTER (Germany)

b UNIVERSITY HOSPITAL MÜNSTER (Germany)

Author keywords

Apoptosis; Caspase inhibitor; Fluorinated pyrrolidine; Isatin sulfonamide; Molecular imaging; Positron Emission Tomography (PET); Radiotracer

Indexed keywords

2 SUBSTITUTED 5 PYRROLIDINYLSULFONYLISATIN DERIVATIVE; 5 [1 (2 ETHOXYMETHYLPYRROLIDINYL)SULFONYL]ISATIN; 5 [1 (2 METHOXYETHYLPYRROLIDINYL)SULFONYL]ISATIN; 5 [1 (2 METHOXYMETHYLPYRROLIDINYL)SULFONYL]ISATIN; 5 [1 (2 PHENOXYMETHYLPYRROLIDINYL)SULFONYL]ISATIN; 5 [1 [2 (2 FLUOROETHOXYMETHYL)PYRROLIDINYL]SULFONYL]ISATIN; 5 [1 [2 (2,2,2 TRIFLUOROETHOXYMETHYL)PYRROLIDINYL]SULFONYL]ISATIN; 5 [1 [2 (3 METHOXYPROPYL)PYRROLIDINYL]SULFONYL]ISATIN; CASPASE 3; CASPASE 3 INHIBITOR; CASPASE 6; CASPASE 7; CASPASE 7 INHIBITOR; CYSTEINE PROTEINASE INHIBITOR; INTERLEUKIN 1BETA CONVERTING ENZYME; ISATIN DERIVATIVE; N (4 FLUOROBUTYL) 5 [1 (2 ETHOXYMETHYLPYRROLIDINYL)SULFONYL]ISATIN; N (4 FLUOROBUTYL) 5 [1 (2 METHOXYETHYLPYRROLIDINYL)SULFONYL]ISATIN; N (4 FLUOROBUTYL) 5 [1 [2 (2 FLUOROETHOXYMETHYL)PYRROLIDINYL]SULFONYL]ISATIN; N (4 FLUOROBUTYL) 5 [1 [2 (2,2,2 TRIFLUOROETHOXYMETHYL)PYRROLIDINYL]SULFONYL]ISATIN; N (4 FLUOROBUTYL) 5 [1 [2 (3 METHOXYPROPYL)PYRROLIDINYL]SULFONYL]ISATIN; N BUTYL 5 [1 (2 ETHOXYMETHYLPYRROLIDINYL)SULFONYL]ISATIN; N BUTYL 5 [1 (2 METHOXYETHYLPYRROLIDINYL)SULFONYL]ISATIN; N BUTYL 5 [1 [2 (2 FLUOROETHOXYMETHYL)PYRROLIDINYL]SULFONYL]ISATIN; N BUTYL 5 [1 [2 (2,2,2 TRIFLUOROETHOXYMETHYL)PYRROLIDINYL]SULFONYL]ISATIN; N BUTYL 5 [1 [2 (3 METHOXYPROPYL)PYRROLIDINYL]SULFONYL]ISATIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BINDING AFFINITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; FLUORINATION; IC 50; IN VITRO STUDY; MOLECULAR IMAGING; POSITRON EMISSION TOMOGRAPHY;

APOPTOSIS; CASPASE 3; CASPASE 7; CASPASE INHIBITORS; HALOGENATION; HUMANS; ISATIN; POSITRON-EMISSION TOMOGRAPHY; PYRROLIDINES; SULFONAMIDES;

EID: 84875215747 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2013.01.011 Document Type: Article

Times cited : (26)

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