Influence of 4- or 5-substituents on the pyrrolidine ring of 5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin derivatives on their inhibitory activities towards caspases-3 and -7 Dedicated to Professor Dr. Ernst-Ulrich Würthwein on the occasion of his 65th birthday

European Journal of Medicinal Chemistry

Volumn 64, Issue , 2013, Pages 562-578

  Limpachayaporn, Panupun ^a   Riemann, Burkhard ^b   Kopka, Klaus ^b   Schober, Otmar ^b   Schäfers, Michael ^a   Haufe, Günter ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

Apoptosis; Caspases; Fluorinated pyrrolidine; Inhibitor; Isatin sulfonamide

Indexed keywords

5 [1 (2 METHOXYMETHYLPYRROLIDINYL)SULFONYL]ISATIN DERIVATIVE; 5 [1 (4 FLUORO 2 METHOXYMETHYLPYRROLIDINYL)SULFONYL]ISATIN; 5 [1 (4 METHOXY 2 METHOXYMETHYLPYRROLIDINYL)SULFONYL]ISATIN; 5 [1 (4 TRIFLUOROMETHYL 2 METHOXYMETHYLPYRROLIDINYL)SULFONYL]ISATIN; 5 [1 (4,4 DIFLUORO 2 METHOXYMETHYLPYRROLIDINYL)SULFONYL]ISATIN; CASPASE 3 INHIBITOR; CASPASE 7; CASPASE 7 INHIBITOR; CIS 5 [1 [2,5 BIS(METHOXYMETHYL)PYRROLIDINYL]SULFONYL]ISATIN; CIS N BENZYL 2,5 BIS(METHOXYMETHYL)PYRROLIDINE; CYSTEINE PROTEINASE INHIBITOR; N (4 FLUOROBUTYL) 5 [1 (4 METHOXY 2 METHOXYMETHYLPYRROLIDINYL)SULFONYL]ISATIN; N (4 FLUOROBUTYL) 5 [1 (4 TRIFLUOROMETHYL 2 METHOXYMETHYLPYRROLIDINYL)SULFONYL]ISATIN; N BUTYL 5 [1 (4 FLUORO 2 METHOXYMETHYLPYRROLIDINYL)SULFONYL]ISATIN; N BUTYL 5 [1 (4 METHOXY 2 METHOXYMETHYLPYRROLIDINYL)SULFONYL]ISATIN; N BUTYL 5 [1 (4 TRIFLUOROMETHYL 2 METHOXYMETHYLPYRROLIDINYL)SULFONYL]ISATIN; N BUTYL 5 [1 (4,4 DIFLUORO 2 METHOXYMETHYLPYRROLIDINYL)SULFONYL]ISATIN; N TERT BUTYLOXYCARBONYL 4 FLUORO 2 HYDROXYMETHYLPYRROLIDINE; N TERT BUTYLOXYCARBONYL 4 FLUORO 2 METHOXYMETHYLPYRROLIDINE; N TERT BUTYLOXYCARBONYL 4 HYDROXY 2 HYDROXYMETHYL PYRROLIDINE; N TERT BUTYLOXYCARBONYL 4 METHOXY 2 METHOXYMETHYL PYRROLIDINE; N TERT BUTYLOXYCARBONYL 4 METHOXY 2 METHOXYMETHYLPYRROLIDINE; N TERT BUTYLOXYCARBONYL 4 TRIFLUOROMETHYL 2 METHOXYMETHYLPYRROLIDINE; N TERT BUTYLOXYCARBONYL 4 TRIFLUOROMETHYL 2 METHOXYPYRROLIDINE; N TERT BUTYLOXYCARBONYL 4,4 DIFLUORO 2 HYDROXYMETHYL PYRROLIDINE; N TERT BUTYLOXYCARBONYL 4,4 DIFLUORO 2 METHOXYMETHYL PYRROLIDINE; PYRROLIDINE DERIVATIVE; TRACER; TRANS N BENZYL 2,5 BIS(METHOXYMETHYL)PYRROLIDINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

APOPTOSIS; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; ENZYME INHIBITION; FLUORINATION; IC 50; IN VIVO STUDY; MOLECULAR IMAGING; POSITRON EMISSION TOMOGRAPHY;

CASPASE 3; CASPASE 7; CASPASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; HUMANS; ISATIN; MOLECULAR STRUCTURE; PYRROLIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84877826940     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.04.011     Document Type: Article

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