Design, synthesis, and biological characterization of a caspase 3/7 selective isatin labeled with 2-[18f]fluoroethylazide

Journal of Medicinal Chemistry

Volumn 51, Issue 24, 2008, Pages 8057-8067

  Smith, Graham ^a   Glaser, Matthias ^a   Perumal, Meg ^a   Nguyen, Quang De ^a   Shan, Bo ^a   Årstad, Erik ^a   Aboagye, Eric O ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 FLUOROBENZYL) 5 [2 (4 FLUOROPHENOXYMETHYL)PYRROLIDINE 1 SULFONYL]ISATIN; 1 [[1 (2 FLUOROETHYL) 1H [1,2,3] TRIAZOL 4 YL]METHYL] 5 (2 PHENOXYMETHYLPYRROLIDINE 1 SULFONYL)ISATIN; ALPHA TUBULIN; AROMATIC COMPOUND; AZIDE; CASPASE 3; CASPASE 7; CISPLATIN; FLUORINE 18; FLUORINE DERIVATIVE; ISATIN DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; TRACER; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG DESIGN; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG METABOLISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG STABILITY; DRUG SYNTHESIS; DRUG TUMOR LEVEL; DRUG UPTAKE; IN VIVO STUDY; ISOTOPE LABELING; LIPOPHILICITY; MALE; MOUSE; NONHUMAN; QUANTUM YIELD; RADIOCHEMISTRY; SINGLE DRUG DOSE;

ANIMALS; AZIDES; CASPASE 3; CASPASE 7; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; ENZYME ACTIVATION; ENZYME INHIBITORS; FLUORINE RADIOISOTOPES; HUMANS; ISATIN; MALE; MICE; NEOPLASM TRANSPLANTATION; NEOPLASMS; RADIOPHARMACEUTICALS;

EID: 58149090677     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm801107u     Document Type: Article

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