Stable Benzotriazole Esters as Mechanism-Based Inactivators of the Severe Acute Respiratory Syndrome 3CL Protease

Chemistry and Biology

Volumn 13, Issue 3, 2006, Pages 261-268

  Wu, Chung Yi ^a,b   King, Ke Yung ^a   Kuo, Chih Jung ^a,c   Fang, Jim Min ^a,d   Wu, Ying Ta ^a   Ho, Ming Yi ^a   Liao, Chung Lin ^a   Shie, Jiun Jie ^a   Liang, Po Huang ^a   Wong, Chi Huey ^a,b,d  

^a INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c ACADEMIA SINICA   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

CHEMBIO; HUMDISEASE; MICROBIO

Indexed keywords

3C LIKE PROTEASE, SARS CORONAVIRUS; 3C-LIKE PROTEASE, SARS CORONAVIRUS; BENZOTRIAZOLE; CYSTEINE; CYSTEINE PROTEINASE; ESTER; PROTEINASE; PROTEINASE INHIBITOR; TRIAZOLE DERIVATIVE; VIRUS PROTEIN;

ARTICLE; BINDING SITE; CHEMICAL MODEL; CHEMISTRY; DRUG ANTAGONISM; ENZYME SPECIFICITY; HUMAN; KINETICS; METABOLISM; MICROBIOLOGICAL EXAMINATION; SEVERE ACUTE RESPIRATORY SYNDROME;

BINDING SITES; CYSTEINE; CYSTEINE ENDOPEPTIDASES; ENDOPEPTIDASES; ESTERS; HUMANS; KINETICS; MICROBIAL SENSITIVITY TESTS; MODELS, CHEMICAL; PROTEASE INHIBITORS; SEVERE ACUTE RESPIRATORY SYNDROME; SUBSTRATE SPECIFICITY; TRIAZOLES; VIRAL PROTEINS;

CORONAVIRUS;

EID: 33646079601     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2005.12.008     Document Type: Article

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