High frequency of regulatory T cells among HIV type 1-infected men who have sex with men correlates with disease progression

Chinese Medical Journal

Volumn 126, Issue 11, 2013, Pages 2054-2061

  Wang, Wan Hai ^a   Ming, Liang ^a   Wang, Ying ^c   Kan, Quan Cheng ^a   Zhang, Xiao Yan ^b,d  

^a THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c Shanghai Center for Disease Control and Prevention   (China)

^d Institute of Occupational Health and Poison Control   (China)

Author keywords

CTLA 4; FoxP3; HIV infected men who have sex with men; Regulatory T cells

Indexed keywords

ANTIRETROVIRUS AGENT; B7 ANTIGEN; CD28 ANTIGEN; CD45RA ANTIGEN; CD86 ANTIGEN; CHEMOKINE RECEPTOR CCR7; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 7 RECEPTOR; TRANSCRIPTION FACTOR FOXP3;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSS-SECTIONAL STUDY; DISEASE COURSE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; MAJOR CLINICAL STUDY; MALE; MEN WHO HAVE SEX WITH MEN; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; VIREMIA; VIRUS LOAD;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ADULT; CD4 LYMPHOCYTE COUNT; CROSS-SECTIONAL STUDIES; CTLA-4 ANTIGEN; DISEASE PROGRESSION; HIV-1; HOMOSEXUALITY, MALE; HUMANS; IMMUNOLOGIC MEMORY; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; RNA, VIRAL; T-LYMPHOCYTES, REGULATORY;

EID: 84878688048     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.20121253     Document Type: Article

References (46)

1. Rouse BT, Sarangi PP, Suvas S. Regulatory T cells in virus infections. Immunol Rev 2006; 212: 272-286.
2. Baecher-Allan C, Viglietta V, Hafler D. Human CD4+CD25+ regulatory T cells. Semin Immunol 2004; 16: 89-98.
3. Dittmer U, He H, Messer RJ, Schimmer S, Olbrich AR, Ohlen C, et al. Functional impairment of CD8+T cells by regulatory T cells during persistent retroviral infection. Immunity 2004; 20: 293-303.
4. Robertson S, Hasenkrug K. The role of virus-induced regulatory T cells in immunopathology. Springer Semin Immunopathol 2006; 28: 51-62.
5. Weiss L, Donkova-Petrini V, Caccavelli L, Balbo M, Carbonneil C, Levy Y. Human immunodeficiency virus driven expansion of CD4+CD25+ regulatory T cells, which suppress HIV-specific CD4 T-cell responses in HIV-infected patients. Blood 2004; 104: 3249-3256.
6. Sakaguchi S. Regulatory T cells: Key controllers of immunologic self-tolerance. Cell 2000; 101: 455-458.
7. Shevach EM. Regulatory T cells in autoimmmunity. Annu Rev Immunol 2000; 18: 423-449.
8. Sakaguchi S. Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 2004; 22: 531-562.
9. Aandahl EM, Michaëlsson J, Moretto WJ, Hecht FM, Nixon DF. Human CD4+CD25+ regulatory T cells control T-cell responses to HIV and cytomegalovirus antigens. J Virol 2004; 78: 2454-2459.
10. Kinter AL, Hennessey M, Bell A, Kern S, Lin Y, Daucher M, et al. CD25+CD4+ regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4+ and CD8+ HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status. J Exp Med 2004; 200: 331-343.
11. Tsunemi S, Iwasaki T, Imado T, Higasa S, Kakishita E, Shirasaka T, et al. Relationship of CD4+CD25+ regulatory T cells to immune status in HIV-infected patients. AIDS 2005; 19: 879-886.
12. Boettler T, Spangenberg HC, Neumann-Haefelin C, Panther E, Urbani S, Ferrari C, et al. T cells with a CD4+CD25+ regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection. J Virol 2005; 79: 7860-7867.
13. Boyer O, Saadoun D, Abriol J, Dodille M, Piette JC, Cacoub P, et al. CD4+CD25+ regulatory T-cell deficiency in patients with hepatitis C-mixed cryoglobulinemia vasculitis. Blood 2004; 103: 3428-3430.
14. Banham AH. Cell-surface IL-7 receptor expression facilitates the purification of FOXP3+ regulatory T cells. Trends Immunol 2006; 27: 541-544.
15. Eggena MP, Barugahare B, Jones N, Okello M, Mutalya S, Kityo C, et al. Depletion of regulatory T cells in HIV infection is associated with immune activation. J Immunol 2005; 174: 4407-4414.
16. Annacker O, Pimenta-Araujo R, Burlen-Defranoux O, Barbosa TC, Cumano A, Bandeira A. CD25+CD4+ T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10. J Immunol 2001; 166: 3008-3018.
17. Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, Zhu S, et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ Treg cells. J Exp Med 2006; 203: 1701-1711.
18. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299: 1057-1061.
19. Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003; 4: 330-336.
20. Fontenot JD, Rasmussen JP, Williams LM, Dooley JL, Farr AG, Rudensky AY. Regulatory T cell lineage specification by the forkhead transcription factor Foxp3. Immunity 2005; 22: 329-341.
21. Khattri R, Cox T, Yasayko SA, Ramsdell F. An essential role for Scurfin in CD4+CD25+T regulatory cells. Nat Immunol 2003; 4: 337-342.
22. Coffer PJ, Burgering BM. Forkhead-box transcription factors and their role in the immune system. Nat Rev Immunol 2004; 579: 191-198.
23. Sakaguchi S. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol 2005; 6: 345-352.
24. Wu Y, Borde M, Heissmeyer V, Feuerer M, Lapan AD, Stroud JC, et al. FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell 2006; 126: 375-387.
25. Zhang XY, Huang XG, Xu JQ, Li SW, Jiang SL, Zhang XX, et al. HIV-specific T cell immunity across the entire HIV genome in Chinese men who have sex with men. Chin Med J 2006; 119: 1958-1965.
26. Guidelines for the use of antiretroviral agents in HIV-1- infected adults and adolescents, Developed by the Panel on Clinical Practices for Treatment of HIV Infection convened by Department of Health and Human Services (DHHS). (Accessed at http://AIDSinfo:nih.gov)
27. Bi XQ, Suzuki Y, Gatanaga H, Oka S. High frequency and proliferation of CD4+FOXP3+ Treg in HIV-1-infected patients with low CD4 counts. Eur J Immunol 2009; 39: 301-309.
28. Sallusto F, Lenig D, Förster R, Lipp M, Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999; 401: 708-712.
29. Montes M, Lewis DE, Sanchez C, de Castilla DL, Graviss EA, Seas C, et al. Foxp3+ regulatory T cells in antiretroviral-naive HIV patients. AIDS 2006; 20: 1669-1671.
30. Cao W, Jamieson BD, Hultin LE, Hultin PM, Detels R. Regulatory T cell expansion and immune activation during untreated HIV type 1 infection are associated with disease progression. AIDS Res Hum Retroviruses 2009; 25: 183-191.
31. Nigam P, Velu V, Kannanganat S, Chennareddi L, Kwa S, Siddiqui M, et al. Expansion of FOXP3+ CD8T cells with suppressive potential in colorectal mucosa following a pathogenic simian immunodeficiency virus infection correlates with diminished antiviral T cell response and viral control. J Immunol 2010; 184: 1690-1701.
32. Cosmi L, Liotta F, Lazzeri E, Francalanci M, Angeli R, Mazzinghi B, et al. Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes. Blood 2003; 102: 4107-4114.
33. Siegmund K, Rückert B, Ouaked N, Bürgler S, Speiser A, Akdis CA, et al. Unique phenotype of human tonsillar and in vitro-induced FOXP3+CD8+ T cells. J Immunol 2009; 182: 2124-2130.
34. Wang L, Wang N. HIV/AIDS epidemic and the development of comprehensive surveillance system in China with challenges. Chin Med J 2010; 123: 3495-3500.
35. Oswald-Richter K, Grill SM, Shariat N, Leelawong M, Sundrud MS, Haas DW, et al. HIV infection of naturally occurring and genetically reprogrammed human regulatory T-cells. PLoS Biol 2004; 2: E198.
36. + regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 2003; 198: 1875-1886.
37. Nilsson J, Boasso A, Velilla PA, Zhang R, Vaccari M, Franchini G, et al. HIV-1-driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIV/ AIDS. Blood 2006; 108: 3808-3817.
38. Beyer M, Schultze JL. CD4+CD25highFOXP3+ regulatory T cells in peripheral blood are primarily of effector memory phenotype. J Clin Oncol 2007; 25: 2628-2630.
39. Friedline RH, Brown DS, Nguyen H, Kornfeld H, Lee J, Zhang Y, et al. CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance. J Exp Med 2009; 206: 421-434.
40. + regulatory cells that control intestinal inflammation. J Exp Med 2000; 192: 295-302.
41. Verhagen J, Sabatos CA, Wraith DC. The role of CTLA-4 in immune regulation. Immunol Lett 2008; 115: 73-74.
42. Read S, Greenwald R, Izcue A, Robinson N, Mandelbrot D, Francisco L, et al. Blockade of CTLA-4 on CD25+CD4+ regulatory T cells abrogates their function in vivo. J Immunol 2006; 177: 4376-4383.
43. Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T, Miyara M, Fehervari Z, et al. CTLA-4 control over Foxp3+ regulatory T cell function. Science 2008; 322: 271-275.
44. Chase AJ, Yang HC, Zhang H, Blankson JN, Siliciano RF. Preservation of FoxP3+ regulatory T cells in the peripheral blood of human immunodeficiency virus type 1-infected elite suppressors correlates with low CD4+ T-cell activation. J Virol 2008; 82: 8307-8315.
45. Xiao J, Qian KL, Cao QH, Qiu CL, Qiu C, Xue YL, et al. HLA-DR expression on regulatory T cells is closely associated with the global immune activation in HIV-1 infected subjects naïve to antiretroviral therapy. Chin Med J 2011; 124: 2340-2346.
46. Lim A, French MA, Price P. CD4+ and CD8+T cells expressing FoxP3 in HIV-infected patients are phenotypically distinct and influenced by disease severity and antiretroviral therapy. J Acquir Immune Defic Syndr 2009; 51: 248-257.