HIV-specific T cell immunity across the entire HIV genome in Chinese men who have sex with men

Chinese Medical Journal

Volumn 119, Issue 23, 2006, Pages 1958-1965

  Zhang, Xiao Yan ^a   Huang, Xiang Gang ^a   Xu, Jian Qing ^a   Li, Shen Wei ^a   Jiang, Shu Lin ^a   Zhang, Xiao Xi ^a   Li, Dong Liang ^a   Ruan, Yu Hua ^a   Xing, Hui ^a   Shao, Yi Ming ^a  

^a CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

Author keywords

Cellular; Homosexuality; Human immunodeficiency virus; Immunity; Viral load

Indexed keywords

ANTIRETROVIRUS AGENT; GAG PROTEIN; NEF PROTEIN; POL PROTEIN; REV PROTEIN; TRANSACTIVATOR PROTEIN; VIF PROTEIN; VIRUS ANTIGEN; VIRUS ENVELOPE PROTEIN; VPR PROTEIN;

ADULT; ARTICLE; CELLULAR IMMUNITY; CHINA; CHINESE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IMMUNE RESPONSE; MALE HOMOSEXUAL; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; VIRUS GENOME; VIRUS LOAD; VIRUS STRAIN; HOMOSEXUALITY; IMMUNOLOGY; MALE;

ADULT; CHINA; GENOME, VIRAL; HIV-1; HOMOSEXUALITY; HUMANS; MALE; T-LYMPHOCYTES, CYTOTOXIC; VIRAL LOAD;

EID: 33847093055     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00029330-200612010-00004     Document Type: Article

References (20)

1. The Ministry of Health of the People's Republic of China, Joint United Nations Programme on HIV/AIDS and World Health Organization: 2005 update on the HIV/AIDS epidemic and response in China. (Accessed January 24, 2006 at http://www.chinaids.org.cn.)
2. Choi KH, Liu H, Guo Y, Han L, Mandel JS, Rutherford GW, et al. Emerging HIV-1 epidemic in China in men who have sex with men. Lancet 2003; 361: 2125-2126.
3. Jiang J, Cao N, Zhang J, Xia Q, Gong X, Xue H, et al. High prevalence of sexually transmitted diseases among men who have sex with men in Jiangsu Province, China. Sex Transm Dis 2006; 33: 118-123.
4. Zhang BC, Chu QS. HSM and HIV/AIDS in China. Cell Res 2005; 15: 858-864.
5. Horton H, Vogel T, O' Connor D, Picker L, Watkins DI. Analysis of the immune response and viral evolution during the acute phase of SIV infection. Vaccine 2002; 20: 1927-1932.
6. Leslie AJ, Pfafferott KJ, Chetty P, Draenert R, Addo MM, Feeney M, et al. HIV evolution: CTL escape mutation and reversion after transmission. Nat Med 2004; 10: 282-289.
7. McMichael AJ, Rowland-Jones SL. Cellular immune responses to HIV. Nature 2001; 410: 980-987.
8. Musey L, Hughes J, Schacker T, Shea T, Corey L, McElrath MJ. Cytotoxic-T cell responses, viral load, and disease progression in early human immunodeficiency virus type 1 infection. N Engl J Med 1997; 337: 1267-1274.
9. Ogg GS, Jin X, Bonhoeffer S, Dunbar PR, Nowak MA, Monard S, et al. Quantitation of HIV-1 specific cytotoxic T lymphocytes and plasma load of viral RNA. Science 1998; 279: 2103-2106.
10. Betts MR, Ambrozak DR, Douek DC, Bonhoeffer S, Brenchley JM, Casazza JP, et al. Analysis of total human immunodeficiency virus (HIV) specific CD4 (+) and CD8 (+) T cell responses: relationship to viral load in untreated HIV infection. J Virol 2001; 75: 11983-11991.
11. Addo MM, Yu XG, Rathod A, Cohen D, Eldridge RL, Strick D, et al. Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1) specific T cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J Virol 2003; 77: 2081-2092.
12. Sheth P, Shahabi K, Rebbapragada A, Kovacs C, Dimayuga R, Chakkalackal S, et al. HIV viral shedding in semen: lack of correlation with systemic virus specific CD8 responses. AIDS 2004; 18: 2202-2205.
13. Yu XG, Shang H, Addo MM, Eldridge RL, Phillips MN, Feeney ME, et al. Important contribution of p15 Gag specific responses to the total Gag specific CTL responses. AIDS 2002; 16: 321-328.
14. Gong X, Gui X, Zhang Y, Tien P. Screening for CD8 cytotoxic T lymphocytes specific for Gag of human immunodeficiency virus type 1 subtype B' Henan isolate from China and identification of novel epitopes restricted by the HLA-A2 and HLA-A11 alleles. J Gen Virol 2006; 87(Pt 1): 151-158.
15. Jiao Y, Xie J, Li T, Han Y, Qiu Z, Zuo L, Wang A. Correlation between Gag specific CD8 T cell responses, viral load, and CD4 count in HIV-1 infection is dependent on disease status. J Acquir Immune Defic Syndr 2006; 42: 263-268.
16. Brumme ZL, Harrigan PR. The impact of human genetic variation on HIV disease in the era of HAART. AIDS Rev 2006; 8: 78-87.
17. Stebbing J, Patterson S, Gotch F. New insights into the immunology and evolution of HIV. Cell Res 2003; 13: 1-7.
18. Yao J, Zhang FJ, He ZP, Zhao HX, Li XW, Feng X, et al. Subtype and sequence analysis of the C2-V3 region of env gene among HIV-1 infected homosexual men in Beijing. Chin J STD/AIDS Prev Cont 2002; 8: 131-133.
19. Zhang HW, Qiu ZF, Li TS. HIV-1 Nef specific cytotoxic T lymphocyte responses in long-term nonprogressors and AIDS patients. Natl J Med (Chin) 2004; 84: 1973-1976.
20. + T cell proliferation is coupled to perforin expression and is maintained in nonprogressors. Nat Immunol 2002; 3: 1061-1068.