"Gate-keeper" Residues and Active-Site Rearrangements in DNA Polymerase μ Help Discriminate Non-cognate Nucleotides

PLoS Computational Biology

Volumn 9, Issue 5, 2013, Pages

  Li, Yunlang ^a   Schlick, Tamar ^a  

^a NEW YORK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOINFORMATICS; DNA; MOLECULAR DYNAMICS;

ACTIVE SITE; BASE PAIRS; BINDING POCKETS; COGNATE NUCLEOTIDES; CONFORMATIONAL PATHWAYS; CORRELATED MOTIONS; DNA POLYMERASE; DYNAMICS SIMULATION; NUCLEOTIDE BINDING; STRUCTURE-FUNCTION RELATIONSHIP;

NUCLEOTIDES;

ADENOSINE TRIPHOSPHATE; ARGININE; ASPARTIC ACID; DEOXYCYTIDINE TRIPHOSPHATE; DEOXYGUANOSINE TRIPHOSPHATE; DNA POLYMERASE; DNA POLYMERASE MU; GLUTAMINE; GUANOSINE TRIPHOSPHATE; HISTIDINE; TRYPTOPHAN; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; KINETICS; MOLECULAR INTERACTION; STRUCTURE ACTIVITY RELATION;

EID: 84878501502     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1003074     Document Type: Article

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