Colon cancer-associated DNA polymerase β variant induces genomic instability and cellular transformation

Journal of Biological Chemistry

Volumn 287, Issue 28, 2012, Pages 23840-23849

  Nemec, Antonia A ^a   Donigan, Katherine A ^a   Murphy, Drew L ^a   Jaegers, Joachim ^b   Sweasy, Joann B ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WADSWORTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTATES; BASE EXCISION REPAIRS; BINDING AFFINITIES; BINDING POCKETS; BIOCHEMICAL ANALYSIS; CATALYTIC RATES; CELLULAR TRANSFORMATION; CHEMOTHERAPEUTIC AGENTS; CHROMOSOMAL ABERRATION; CLOSE PROXIMITY; COLORECTAL CANCER; DNA POLYMERASE; GENOMIC INSTABILITY; GENOMIC SEQUENCE; HUMAN TUMORS; NON-POLAR; RAPIDLY ADVANCING TECHNOLOGY; TEMPLATE STRAND;

AMINO ACIDS; BINDING ENERGY; DISEASES; DNA; TUMORS;

GENES;

ASPARTIC ACID; DNA; DNA DIRECTED DNA POLYMERASE BETA; GLYCINE;

ARTICLE; BINDING AFFINITY; CARCINOGENESIS; CATALYSIS; CELL TRANSFORMATION; CHEMICAL ANALYSIS; CHROMOSOME ABERRATION; COLON CANCER; DNA STRAND; EXCISION REPAIR; GENE EXPRESSION; GENE MUTATION; GENE SEQUENCE; GENETIC VARIABILITY; GENOMIC INSTABILITY; HUMAN; PHENOTYPE; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; BASE SEQUENCE; BIOCATALYSIS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; CHROMOSOME ABERRATIONS; COLONIC NEOPLASMS; DNA; DNA POLYMERASE BETA; DNA REPAIR; EMBRYO, MAMMALIAN; FIBROBLASTS; GENOMIC INSTABILITY; HEK293 CELLS; HUMANS; KINETICS; MICE; MICE, KNOCKOUT; MODELS, MOLECULAR; MUTATION; PROTEIN BINDING;

EID: 84863614548     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.362111     Document Type: Article

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