Intracerebroventricular administration of ouabain, a Na/K-ATPase inhibitor, activates mTOR signal pathways and protein translation in the rat frontal cortex

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 45, Issue , 2013, Pages 73-82

  Kim, Se Hyun ^a   Yu, Hyun Sook ^a   Park, Hong Geun ^a   Ha, Kyooseob ^a,b   Kim, Yong Sik ^c   Shin, Soon Young ^d,e   Ahn, Yong Min ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Seoul National University Bundang Hospital   (South Korea)

^c Dongguk University Ilsan Hospital   (South Korea)

^d Konkuk University Hospital   (South Korea)

^e Konkuk University   (South Korea)

Author keywords

Bipolar disorder; Na pump; P70S6K; Protein synthesis; S6

Indexed keywords

3 HYDROXYLEUCINE; ENZYME; INITIATION FACTOR 4B; INITIATION FACTOR 4E BINDING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OUABAIN; PROTEIN KINASE B; PROTEIN S6; S6 KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CELL FREE SYSTEM; CINGULATE GYRUS; CONTROLLED STUDY; CYTOPLASM; DRUG EFFECT; DRUG PROTEIN BINDING; DRUG RESPONSE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; FRONTAL CORTEX; HYPERACTIVITY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MANIA; NERVE CELL MEMBRANE POTENTIAL; NONHUMAN; ORBITAL CORTEX; PREFRONTAL CORTEX; PROTEIN MODIFICATION; PROTEIN PROCESSING; PROTEIN SYNTHESIS; RAT; SIGNAL TRANSDUCTION; TRANSLATION INITIATION;

4′,6′-DIAMIDINO-2-PHENYLINDOLE; 4E-BP; ACSF; ANALYSIS OF VARIANCE; ANOVA; ARTIFICIAL CEREBROSPINAL FLUID; BDNF; BIPOLAR DISORDER; BRAIN-DERIVED NEUROTROPHIC FACTOR; DAPI; EGFR; EIF4B; EPIDERMAL GROWTH FACTOR RECEPTOR; ERK; EUKARYOTIC TRANSLATION INITIATION FACTOR 4B; EUKARYOTIC TRANSLATION INITIATION FACTOR 4E BINDING PROTEIN; EXTRACELLULAR SIGNAL REGULATED KINASE; ICV; INTRACEREBROVENTRICULAR; MAMMALIAN TARGET RAPAMYCIN; MAPK; MITOGEN-ACTIVATED PROTEIN KINASE; MTOR; N-METHYL-D-ASPARTATE; NA-PUMP; NA/K-ATPASE; NMDA; OD; OPTICAL DENSITY; P70 RIBOSOMAL S6 KINASE; P70S6K; PHOSPHOLIPASE C; PKC; PLC; PMS; POSTMITOCHONDRIAL SUPERNATANT; PROTEIN KINASE C; PROTEIN SYNTHESIS; S6; SMALL RIBOSOMAL PROTEIN 6; SODIUM AND POTASSIUM-ACTIVATED ADENOSINE TRIPHOSPHATASE;

ANIMALS; CARRIER PROTEINS; ENZYME INHIBITORS; EUKARYOTIC INITIATION FACTORS; FRONTAL LOBE; INJECTIONS, INTRAVENTRICULAR; MALE; MOTOR ACTIVITY; OUABAIN; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; RATS; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; RIBOSOME SUBUNITS, SMALL; SIGNAL TRANSDUCTION; SODIUM-POTASSIUM-EXCHANGING ATPASE; TOR SERINE-THREONINE KINASES;

EID: 84878491934     PISSN: 02785846     EISSN: 18784216     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2013.04.018     Document Type: Article

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