Cocaine regulates protein kinase B and glycogen synthase kinase-3 activity in selective regions of rat brain

Journal of Neurochemistry

Volumn 107, Issue 2, 2008, Pages 570-577

  Perrine, Shane A ^a,b   Miller, Jonathon S ^b   Unterwald, Ellen M ^b  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Akt; Amygdala; Cocaine; Glycogen synthase kinase 3; Nucleus accumbens; Rat

Indexed keywords

COCAINE; GLYCOGEN SYNTHASE KINASE 3; PROTEIN KINASE B; THREONINE;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN REGION; BRAIN TISSUE; CAUDATE NUCLEUS; CONTROLLED STUDY; EMOTION; ENZYME ACTIVITY; HIPPOCAMPUS; MALE; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; WESTERN BLOTTING;

ANIMALS; BRAIN; COCAINE; DOPAMINE UPTAKE INHIBITORS; DRUG ADMINISTRATION SCHEDULE; GENE EXPRESSION REGULATION; GLYCOGEN SYNTHASE KINASE 3; MALE; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

RATTUS;

EID: 53149086276     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2008.05632.x     Document Type: Article

References (40)

1. Alimohamad H., Rajakumar N., Seah Y. H. Rushlow W. (2005) Antipsychotics alter the protein expression levels of beta-catenin and GSK-3 in the rat medial prefrontal cortex and striatum. Biol. Psychiatry 57, 533 542.
2. Baumann M. H., Raley T. J., Partilla J. S. Rothman R. B. (1993) Biosynthesis of dopamine and serotonin in the rat brain after repeated cocaine injections: a microdissection mapping study. Synapse 14, 40 50.
3. Beaulieu J. M., Sotnikova T. D., Yao W. D., Kockeritz L., Woodgett J. R., Gainetdinov R. R. Caron M. G. (2004) Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade. Proc. Natl Acad. Sci. USA 101, 5099 5104.
4. Beaulieu J. M., Sotnikova T. D., Gainetdinov R. R. Caron M. G. (2006) Paradoxical striatal cellular signaling responses to psychostimulants in hyperactive mice. J. Biol. Chem. 281, 32072 32080.
5. Beaulieu J. M., Gainetdinov R. R. Caron M. G. (2007a) The Akt-GSK-3 signaling cascade in the actions of dopamine. Trends Pharmacol. Sci. 28, 166 172.
6. Beaulieu J. M., Tirotta E., Sotnikova T. D., Masri B., Salahpour A., Gainetdinov R. R., Borrelli E. Caron M. G. (2007b) Regulation of Akt signaling by D2 and D3 dopamine receptors in vivo. J. Neurosci. 27, 881 885.
7. Beaulieu J. M., Zhang X., Rodriguiz R. M., Sotnikova T. D., Cools M. J., Wetsel W. C., Gainetdinov R. R. Caron M. G. (2008) Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency. Proc. Natl Acad. Sci. USA 105, 1333 1338.
8. Berke J. D. Hyman S. E. (2000) Addiction, dopamine, and the molecular mechanisms of memory. Neuron 25, 515 532.
9. Brami-Cherrier K., Valjent E., Garcia M., Pages C., Hipskind R. A. Caboche J. (2002) Dopamine induces a PI3-kinase-independent activation of Akt in striatal neurons: a new route to cAMP response element-binding protein phosphorylation. J. Neurosci. 22, 8911 8921.
10. Chen P. C., Lao C. L. Chen J. C. (2007) Dual alteration of limbic dopamine D1 receptor-mediated signalling and the Akt/GSK3 pathway in dopamine D3 receptor mutants during the development of methamphetamine sensitization. J. Neurochem. 100, 225 241.
11. Cunningham K. A., Paris J. M. Goeders N. E. (1992) Chronic cocaine enhances serotonin autoregulation and serotonin uptake binding. Synapse 11, 112 123.
12. Embi N., Rylatt D. B. Cohen P. (1980) Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase. Eur. J. Biochem. 107, 519 527.
13. Frame S. Cohen P. (2001) GSK3 takes centre stage more than 20 years after its discovery. Biochem. J. 359, 1 16.
14. Frame S., Cohen P. Biondi R. M. (2001) A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation. Mol. Cell 7, 1321 1327.
15. Gil M., Zhen X. Friedman E. (2003) Prenatal cocaine exposure alters glycogen synthase kinase-3beta (GSK3beta) pathway in select rabbit brain areas. Neurosci. Lett. 349, 143 146.
16. Gould T. D., Chen G. Manji H. K. (2004) In vivo evidence in the brain for lithium inhibition of glycogen synthase kinase-3. Neuropsychopharmacology 29, 32 38.
17. Ikeda M., Iwata N., Suzuki T. et al. (2006) Positive association of AKT1 haplotype to Japanese methamphetamine use disorder. Int. J. Neuropsychopharmacol. 9, 77 81.
18. Jones S. R., Gainetdinov R. R., Wightman R. M. Caron M. G. (1998) Mechanisms of amphetamine action revealed in mice lacking the dopamine transporter. J. Neurosci. 18, 1979 1986.
19. Kalia M. (2005) Neurobiological basis of depression: an update. Metabolism 54, 24 27.
20. Kalivas P. W. Volkow N. D. (2005) The neural basis of addiction: a pathology of motivation and choice. Am. J. Psychiatry 162, 1403 1413.
21. Leroy K. Brion J. P. (1999) Developmental expression and localization of glycogen synthase kinase-3beta in rat brain. J. Chem. Neuroanat. 16, 279 293.
22. Lowry O. H., Rosebrough N. J., Farr A. L. Randall R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265 275.
23. Ma K., Cheung S. M., Marshall A. J. Duronio V. (2008) PI(3,4,5)P3 and PI(3,4)P2 levels correlate with PKB/akt phosphorylation at Thr308 and Ser473, respectively; PI(3,4)P2 levels determine PKB activity. Cell. Signal. 20, 684 694.
24. Manning B. D. Cantley L. C. (2007) AKT/PKB signaling: navigating downstream. Cell 129, 1261 1274.
25. Mash D. C., Staley J. K., Izenwasser S., Basile M. Ruttenber A. J. (2000) Serotonin transporters upregulate with chronic cocaine use. J. Chem. Neuroanat. 20, 271 280.
26. McGinty J. F., Shi X. D., Schwendt M., Saylor A. Toda S. (2008) Regulation of psychostimulant-induced signaling and gene expression in the striatum. J. Neurochem. 104, 1440 1449.
27. Novikova S. I., He F., Bai J., Badan I., Lidow I. A. Lidow M. S. (2005) Cocaine-induced changes in the expression of apoptosis-related genes in the fetal mouse cerebral wall. Neurotoxicol. Teratol. 27, 3 14.
28. Paxinos G. Watson C. (2006) The Rat Brain in Stereotaxic Coordinates, pp. 1 161. Academic Press, London.
29. Perrine S. A., Sheikh I. S., Nwaneshiudu C. A., Schroeder J. A. Unterwald E. M. (2008) Withdrawal from chronic administration of cocaine decreases delta opioid receptor signaling and increases anxiety- and depression-like behaviors in the rat. Neuropharmacology 54, 355 364.
30. Prickaerts J., Moechars D., Cryns K., Lenaerts I., van Craenendonck H., Goris I., Daneels G., Bouwknecht J. A. Steckler T. (2006) Transgenic mice overexpressing glycogen synthase kinase 3beta: a putative model of hyperactivity and mania. J. Neurosci. 26, 9022 9029.
31. Ramsey A. J., Laakso A., Cyr M., Sotnikova T. D., Salahpour A., Medvedev I. O., Dykstra L. A., Gainetdinov R. R. Caron M. G. (2008) Genetic NMDA receptor deficiency disrupts acute and chronic effects of cocaine but not amphetamine. Neuropsychopharmacology, in press.
32. Rylatt D. B., Aitken A., Bilham T., Condon G. D., Embi N. Cohen P. (1980) Glycogen synthase from rabbit skeletal muscle. Amino acid sequence at the sites phosphorylated by glycogen synthase kinase-3, and extension of the N-terminal sequence containing the site phosphorylated by phosphorylase kinase. Eur. J. Biochem. 107, 529 537.
33. Shi X. McGinty J. F. (2007) Repeated amphetamine treatment increases phosphorylation of extracellular signal-regulated kinase, protein kinase B, and cyclase response element-binding protein in the rat striatum. J. Neurochem. 103, 706 713.
34. Song G., Ouyang G. Bao S. (2005) The activation of Akt/PKB signaling pathway and cell survival. J. Cell. Mol. Med. 9, 59 71.
35. Svenningsson P., Tzavara E. T., Carruthers R. et al. (2003) Diverse psychotomimetics act through a common signaling pathway. Science 302, 1412 1415.
36. Trimble M. R. (1988) The neurology of anxiety. Postgrad. Med. J. 64 (Suppl 2 22 26.
37. Unterwald E. M., Horne-King J. Kreek M. J. (1992) Chronic cocaine alters brain mu opioid receptors. Brain Res. 584, 314 318.
38. Unterwald E. M., Kreek M. J. Cuntapay M. (2001) The frequency of cocaine administration impacts cocaine-induced receptor alterations. Brain Res. 900, 103 109.
39. Wei Y., Williams J. M., Dipace C., Sung U., Javitch J. A., Galli A. Saunders C. (2007) Dopamine transporter activity mediates amphetamine-induced inhibition of Akt through a Ca2+/calmodulin-dependent kinase II-dependent mechanism. Mol. Pharmacol. 71, 835 842.
40. Woodgett J. R. (1990) Molecular cloning and expression of glycogen synthase kinase-3/factor A. EMBO J. 9, 2431 2438.