Structure-Activity Relationships of Quinoxaline-Based 5-HT3A and 5-HT3AB Receptor-Selective Ligands

ChemMedChem

Volumn 8, Issue 6, 2013, Pages 946-955

  Thompson, Andrew J ^b   Verheij, Mark H P ^a   VanMuijlwijk Koezen, Jacqueline E ^a   Lummis, Sarah C R ^b   Leurs, Rob ^a   DeEsch, Iwan J P ^a  

^a AMSTERDAM INSTITUTE FOR MOLECULES   (Netherlands)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

5 HT3 receptors; Cys loops; Heteromers; Homomers; Quinoxalines; Serotonin; Subtypes

Indexed keywords

1 (3 CHLOROQUINOXALIN 2 YL) N METHYLPYRROLIDIN 3 AMINE; 2 (4 METHYL 1,4 DIAZEPAN 1 YL)QUINOXALINE; 2 (4 METHYLPIPERAZIN 1 YL)QUINOXALINE; 2 AMINO 3 (4 METHYLPIPERAZIN 1 YL)QUINOXALINE; 2 BROMO 3 (4 METHYLPIPERAZIN 1 YL)QUINOXALINE; 2 CHLORO 3 (4 METHYL 1,4 DIAZEPAN 1 YL)QUINOXALINE; 2 CHLORO 3 (4 METHYLPIPERAZIN 1 YL) QUINOXALINE; 2 ETHYL 3 (4 METHYLPIPERAZIN 1 YL)QUINOXALINE; 2,3 DIBROMOQUINOXALINE; 2,6,7 TRICHLORO 3 (4 METHYLPIPERAZIN 1 YL)QUINOXALINE; 3 (4 METHYLPIPERAZIN 1 YL) QUINOXALIN 2 OL; 3 (4 METHYLPIPERAZIN 1 YL)QUINOXALIN 2 AMINE; 3 ETHYL 3,4 DIHYDROQUINOXALIN 2(1 H) ONE; 3,6 DICHLORO 2 (4 METHYLPIPERAZIN 1 YL)QUINOXALINE; 6,7 DICHLORO 2 (4 METHYLPIPERAZIN 1 YL)QUINOXALINE; 6,7 DICHLORO 3,4 DIHYDROQUINOXALIN 2(1 H) ONE; [1 (3 CHLOROQUINOXALIN 2 YL)PYRROLIDIN 3 YL](METHYL) CARBAMATE; GRANISETRON; LIGAND; N METHYL 1 (QUINOXALIN 2 YL)PYRROLIDIN 3 AMINE; QUINOXALINE DERIVATIVE; RECEPTOR SUBTYPE; SEROTONIN 3A RECEPTOR SELECTIVE LIGAND; SEROTONIN 3AB RECEPTOR SELECTIVE LIGAND; TERT BUTYL METHYL[1 (QUINOXALIN 2 YL)PYRROLIDIN 3 YL]CARBAMATE; UNCLASSIFIED DRUG; VUF 10166;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; BINDING SITE; CRYSTAL STRUCTURE; DRUG SCREENING; DRUG SELECTIVITY; LIGAND BINDING; NUCLEOPHILICITY; PHARMACOPHORE; PRIORITY JOURNAL; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

BINDING SITES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; QUINOXALINES; RECEPTORS, SEROTONIN, 5-HT3; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84878366159     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201300032     Document Type: Article

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