Novel potent 5-HT3 receptor ligands based on the pyrrolidone structure: Synthesis, biological evaluation, and computational rationalization of the ligand-receptor interaction modalities

Bioorganic and Medicinal Chemistry

Volumn 10, Issue 3, 2002, Pages 779-801

  Cappelli, Andrea ^a   Anzini, Maurizio ^b   Vomero, Salvatore ^a   Mennuni, Laura ^c   Makovec, Francesco ^c   Doucet, Edith ^d   Hamon, Michel ^d   Menziani, M Cristina ^e   De Benedetti, Pier G ^e   Giorgi, Gianluca ^a   Ghelardini, Carla ^f   Collina, Simona ^g  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^c Rotta Research Laboratorium   (Italy)

^d PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^e UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^f UNIVERSITY OF FLORENCE   (Italy)

^g UNIVERSITY OF PAVIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 (1 AZABICYCLO[2.2.2]OCT 3 YL) 1,2 DIHYDRO 3H BENZ[E]ISOINDOL 3 ONE; 2 (1 AZABICYCLO[2.2.2]OCT 3 YL) 2,3 DIHYDRO 1H BENZ[E]ISOINDOL 1 ONE; 2 (8 METHYL 8 AZABICYCLO[3.2.1]OCT 3 YL) 1,2 DIHYDRO 3H BENZ[E]ISOINDOL 3 ONE; 2 (8 METHYL 8 AZABICYCLO[3.2.1]OCT 3 YL) 2,3 DIHYDRO 1H BENZ[E]ISOINDOL 1 ONE; 2 (8 METHYL 8 AZABICYCLO[3.2.1]OCT 3 YL) 2,3 DIHYDRO 1H BENZ[E]QUINOLIN 1 ONE; 2 (8 METHYL 8 AZABICYCLO[3.2.1]OCT 3 YL) 2,3 DIHYDRO 1H BENZ[F]ISOINDOL 1 ONE; 2 (8 METHYL 8 AZABICYCLO[3.2.1]OCT 3 YL) 2,3 DIHYDRO 1H ISOINDOL 1 ONE; 2 (8 METHYL 8 AZABICYCLO[3.2.1]OCT 3 YL) 2,3 DIHYDRO 1H PYRROLO[3,4 B]QUINOLIN 1 ONE; 2 (8 METHYL 8 AZABICYCLO[3.2.1]OCT 3 YL) 2,3 DIHYDRO 4 ETHOXY 1H PYRROLO[3,4 C]QUINOLIN 1 ONE; 2 (8 METHYL 8 AZABICYCLO[3.2.1]OCT 3 YL) 2,3 DIHYDRO 4 METHOXY 1H PYRROLO[3,4 C]QUINOLIN 1 ONE; 2 (8 METHYL 8 AZABICYCLO[3.2.1]OCT 3 YL) 2,3 DIHYDRO 4 PROPYLOXY 1H PYRROLO[3,4 C]QUINOLIN 1 ONE; 2 (8 METHYL 8 AZABICYCLO[3.2.1]OCT 3 YL) 2,3,3A,4,5,9B HEXAHYDRO 1H PYRROLO[3,4 C]QUINOLIN 1 ONE; 2 (8 METHYL 8 AZABICYCLO[3.2.1]OCT 3 YL) 2,3,4,5 TETRAHYDRO 5 PROPYL 1H PYRROLO[3,4 C]QUINOLIN 1,4 DIONE; 2 (8 METHYL 8 AZABICYCLO[3.2.1]OCT 3 YL) 4 CHLORO 2,3 DIHYDRO 1H PYRROLO[3,4 C]QUINOLIN 1 ONE; 2 (8 METHYL 8 AZABICYCLO[3.2.1]OCT 3 YL) 9 CHLORO 2,3 DIHYDRO 1H PYRROLO[3,4 B]QUINOLIN 1 ONE; GRANISETRON; LIGAND; PYRROLIDINE DERIVATIVE; QUINUCLIDINE DERIVATIVE; SCOPOLAMINE; SEROTONIN 3 AGONIST; SEROTONIN 3 ANTAGONIST; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR; TROPANE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; 2 PYRROLIDONE DERIVATIVE; GUANIDINE; SEROTONIN 3 RECEPTOR; SEROTONIN RECEPTOR AFFECTING AGENT;

AMNESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BIOASSAY; BIOLOGY; BRAIN MEMBRANE; CALCULATION; CARBON NUCLEAR MAGNETIC RESONANCE; CELL STRAIN; CHEMICAL INTERACTION; COGNITIVE DEFECT; CONTROLLED STUDY; CRYSTAL STRUCTURE; DEFENSE MECHANISM; DRUG ACTIVITY; DRUG BINDING; DRUG INHIBITION; DRUG SCREENING; DRUG SYNTHESIS; EVALUATION; IN VITRO STUDY; MALE; METHODOLOGY; NONHUMAN; PROTEIN TRANSPORT; PROTON NUCLEAR MAGNETIC RESONANCE; QUALITATIVE ANALYSIS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; THEORETICAL STUDY; THIN LAYER CHROMATOGRAPHY; X RAY CRYSTALLOGRAPHY; ANIMAL; BINDING COMPETITION; BINDING SITE; BRADYCARDIA; CELL CULTURE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DOSE RESPONSE; METABOLISM; MOUSE; SYNTHESIS;

AMNESIA; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; BRADYCARDIA; DOSE-RESPONSE RELATIONSHIP, DRUG; GUANIDINE; LIGANDS; MICE; PYRROLIDINONES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT3; SEROTONIN AGENTS; TUMOR CELLS, CULTURED;

EID: 18244384253     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(01)00332-7     Document Type: Article

References (55)