Novel, potent, and selective quinoxaline-based 5-HT3 receptor ligands. 1. Further structure-activity relationships and pharmacological characterization

Journal of Medicinal Chemistry

Volumn 52, Issue 21, 2009, Pages 6946-6950

  Butini, Stefania ^a,b   Budriesi, Roberta ^c   Hamon, Michel ^d   Morelli, Elena ^a,e   Gemma, Sandra ^a,b   Brindisi, Margherita ^a,b   Borrelli, Giuseppe ^a,b   Novellino, Ettore ^a,e   Fiorini, Isabella ^a,b   Ioan, Pierfranco ^c   Chiarini, Alberto ^c   Cagnotto, Alfredo ^a,f   Mennini, Tiziana ^a,f   Fracasso, Claudia ^a,f   Caccia, Silvio ^a,f   Campiani, Giuseppe ^a,b  

^a European Research Centre for Drug Discovery and Development   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

^c UNIVERSITY OF BOLOGNA   (Italy)

^d INSERM   (France)

^e UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^f MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

PIPERAZINE; QUINOXALINE; SEROTONIN 3A RECEPTOR;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN HOMOGENATE; CHRONOTROPISM; CONTROLLED STUDY; IC 50; IN VITRO STUDY; NONHUMAN; PROTEIN BINDING; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STRUCTURE ACTIVITY RELATION; ULTRAVIOLET RADIATION;

ANIMALS; BLOOD-BRAIN BARRIER; DRUG PARTIAL AGONISM; GUINEA PIGS; HEART RATE; LIGANDS; MYOCARDIAL CONTRACTION; PYRROLES; QUINOXALINES; RATS; RECEPTORS, SEROTONIN, 5-HT3; REFLEX; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 71049159692     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm901126m     Document Type: Article

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