Pharmacophore based synthesis of 3-chloroquinoxaline-2-carboxamides as serotonin3 (5-HT3) receptor antagonist

Biological and Pharmaceutical Bulletin

Volumn 27, Issue 9, 2004, Pages 1403-1405

  Mahesh, Radhakrishnan ^a   Perumal, Ramachandran Venkatesha ^a   Pandi, Pandi Vijaya ^a  

^a BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

Author keywords

Mannich base; Quinoxalinecarboxamide; Serotonin3 (5 HT 3) receptor antagonist

Indexed keywords

3 CHLORO 2 QUINOXALOYLCHLORIDE; 3 CHLOROQUINOXALINE 2 CARBOXAMIDE DERIVATIVE; 4 AMINOPHENOL; MANNICH BASE; ONDANSETRON; QUINOXALINE DERIVATIVE; SEROTONIN 3 AGONIST; SEROTONIN 3 ANTAGONIST; UNCLASSIFIED DRUG; 2 METHYL 5 HT; 2-METHYL-5-HT; DRUG DERIVATIVE; SEROTONIN; SEROTONIN 3 RECEPTOR; SEROTONIN ANTAGONIST;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; GUINEA PIG; ILEUM; MALE; MICROWAVE RADIATION; MYENTERIC PLEXUS; NONHUMAN; PHARMACOPHORE; POLYMERIZATION; ANIMAL; CHEMICAL STRUCTURE; DRUG ANTAGONISM; DRUG EFFECT; IN VITRO STUDY; MUSCLE CONTRACTION; SMOOTH MUSCLE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; GUINEA PIGS; ILEUM; MALE; MOLECULAR STRUCTURE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; MYENTERIC PLEXUS; QUINOXALINES; RECEPTORS, SEROTONIN, 5-HT3; SEROTONIN; SEROTONIN ANTAGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 16644369517     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.27.1403     Document Type: Article

References (16)

1. Coates A., Abraham S., Kaye S. B., Eur. J. Cancer Clin. Oncol., 19, 203-208 (1983).
2. Craig J. B., Powell B. L., Am. J. Med. Sci., 293, 34-44 (1987).
3. Cubeddu L. X., Seminar Oncol., 19, 2 (1992).
4. Ohtaka H., Fujita T., "Progress in Drug Research," Vol. 41, Chap. 4, ed. by Jucker E., Birkhauser Verlag Basel, Switzerland, 1993, p. 338.
5. Barnes J. M., Barnes N. M., Cooper S. J., Neurosci. Biobehav. Rev., 16, 107-113 (1993).
6. Hibert M. F., Hoffmann R., Miller R. C., Carr A. A., J. Med. Chem., 33, 1594-1600 (1990).
7. Krishnan V. S. H., Chowdary K. S., Dubey P. K., Vijaya S., Indian J. Chem., 40B, 565-573 (2001).
8. Mahesh R., Venkatesha Perumal R., Indian J. Chem., 43B, 1012-1014 (2004).
9. Blackburn T. P., Cox B., Guildford A. J., Le Count D. J., Middlemiss D. M., Pearce R. J., Thornbee C. W., J. Med. Chem., 30, 2252-2259 (1987).
10. Butler A., Elswood C. J., Burridge J., Ireland S. J., Bunce K. T., Kilpatrick G. J., Tyers M. B., Br. J. Pharmacol., 101, 591-598 (1990).
11. Paton W. D. M., Zar A. M., J. Physiol. (London), 194, 13-33 (1968).
12. MacKay D., J. Pharm. Pharmacol., 30, 312-313 (1978).
13. Kamm O., Mathur A. O., "Organic Syntheses," Vol. I, ed. by Blatt A. H., John Wiley & Sons, Inc., New York, 1941, pp. 392-394.
14. Burckhalter J. H., Tendick F. H., Jones E. M., Jones P. A., Holcomb W. F., Rawlins A. L., J. Med. Chem., 70, 1363-1373 (1948).
15. Stout D. M., Matier W. L., Yang C. B., Reynolds R. D., Brown B. S., J. Med. Chem., 26, 808-813 (1983).
16. King F. D., Sanger G. J., Drugs Future, 14, 875-888 (1989).