Design, synthesis and structure-activity relationship of novel quinoxalin-2-carboxamides as 5-HT3 receptor antagonists for the management of depression

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 22, 2010, Pages 6773-6776

  Mahesh, Radhakrishnan ^a   Devadoss, Thangaraj ^a   Pandey, Dilip Kumar ^a   Bhatt, Shvetank ^a   Yadav, Shushil Kumar ^a  

^a BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

Author keywords

5 HT 3 receptor antagonists; Anti depressants; Quinoxalin 2 carboxamides; Quinoxaline; Serotonin

Indexed keywords

1 (3 DIMETHYLAMINOPROPYL) 3 ETHYLCARBODIIMIDE HYDROCHLORIDE; 1 HYDROXYBENZOTRIAZOLE; 2 METHYLSEROTONIN; AMIDE; AMINE; CARBOXYLIC ACID; ONDANSETRON; PANCOPRIDE; QUINOXALIN 2 CARBOXAMIDE; QUINOXALIN 2 CARBOXYLIC ACID; SEROTONIN 3 ANTAGONIST; SEROTONIN 3 RECEPTOR; UNCLASSIFIED DRUG; ZACOPRIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DEPRESSION; DRUG ANTAGONISM; DRUG DESIGN; DRUG EFFICACY; DRUG SCREENING; DRUG SYNTHESIS; FORCED SWIMMING TEST; HETERONUCLEAR NUCLEAR MAGNETIC RESONANCE; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; ILEUM; LOCOMOTION; MOUSE; MYENTERIC PLEXUS; NONHUMAN; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION; TREATMENT RESPONSE;

AMIDES; ANIMALS; DEPRESSION; DRUG DESIGN; GUINEA PIGS; MICE; QUINOXALINES; RECEPTORS, SEROTONIN, 5-HT3; SEROTONIN ANTAGONISTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP;

CAVIA; MUS;

EID: 77958074837     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.08.128     Document Type: Article

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