Spatial orientation of the antagonist granisetron in the ligand-binding site of the 5-HT3 receptor

Molecular Pharmacology

Volumn 68, Issue 2, 2005, Pages 365-371

  Yan, Dong ^a   White, Michael M ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ARGININE; BEMESETRON; BINDING PROTEIN; DOCKING PROTEIN; FRESH WATER; GRANISETRON; INDAZOLE DERIVATIVE; ION CHANNEL; ONDANSETRON; SEROTONIN 3 RECEPTOR; TROPANE DERIVATIVE; TRYPTOPHAN;

ANALYTIC METHOD; ARTICLE; CHANNEL GATING; CHEMICAL STRUCTURE; CONTROLLED STUDY; DNA TEMPLATE; DRUG CONFORMATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; EXPERIMENTAL MODEL; GENETIC ALGORITHM; LIGAND BINDING; LYMNAEA; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SIMULATION; SNAIL; STRUCTURE ANALYSIS; THEORETICAL MODEL;

ANIMALS; BINDING SITES; CELL LINE; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; GRANISETRON; HUMANS; LIGANDS; MICE; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, SEROTONIN, 5-HT3;

EID: 23044435706     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.105.011957     Document Type: Article

References (40)

1. 3 receptor using site directed mutagenesis: Importance of Glutamate 106. Neuropharmacology 36:637-647.
2. 3A/3B receptors. Neuropharmacology 41:282-284.
3. Brejc K, van Dijk WJ, Klaassen RV, Schuurmans M, van Der Oost J, Smit AB, and Sixma TK (2001) Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors. Nature (Lond) 411:269-276.
4. Carter P, Winter G, Wilkinson A, and Fersht A (1984) The use of double mutants to detect structural changes in the active site of tyrosyl-tRNA synthetase (Bacillus stearothermophilus). Cell 38:835-840.
5. Celie P, van Rossum-Fikkert S, van Dijk W, Brejc K, Smit A, and Sixma T (2004) Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures. Neuron 41:907-914.
6. 50) of an enzymatic reaction. Biochem Pharmacol 22:3099-3108.
7. Colquhoun D (1998) Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and the effects of mutating receptors. Br J Pharmacol 125:924-947.
8. Connolly C and Wafford K (2004) The cys-loop superfamily of ligand-gated ion channels; The impact of receptor structure on function. Biochem Soc Trans 32:529-534.
9. A receptor structure relieved by AChBP. Trends Biochem Sci 27:280-287.
10. Davies P, Pistis M, Hanna M, Peters J, Lambert J, Hales T, and Kirkness E (1999) The 5HT3B subunit is a major determinant of serotonin receptor function. Nature (Lond) 397:359-363.
11. 3B receptor subunit. J Biol Chem 274:30799-30810.
12. Gasteiger J and Marsili M (1980) Iterative partial equalization of orbital electronegativity- A rapid access to atomic charges. Tetrahedron 36:3219-3228.
13. + channel pore through mutant cycles with a peptide inhibitor. Science (Wash DC) 268:307-310.
14. 3A receptor subunits. Mol Pharmacol 55:1037-1043.
15. 3 receptor A subunit. Eur J Pharmacol 245:187-192.
16. Hussy N, Lukas W, and Jones K (1994) Functional properties of a cloned 5-hydroxytryptamine ionotropic receptor subunit: comparison with native mouse receptors. J Physiol (Lond) 481:311-323.
17. Karlin A (2002) Emerging structure of the nicotinic acetylcholine receptor. Nat Rev Neurosci 3:102-114.
18. Ku H (1966) Notes on the use of propagation of error formulas. J Res Nat Bur Standards C Eng Instrum 70:263-273.
19. Laskowski R, MacArthur M, Moss D, and Thorton J (1993) PROCHECK: a program to check the stereochemical quality of protein structures. J Appl Crystallogr 26:283-291.
20. 2+-binding sites. Proc Natl Acad Sci USA 99:3210-3215.
21. Lester H, Dibas M, Dahan D, Leite J, and Dougherty D (2004) Cys-loop receptors: new twists and turns. Trends Neurosci 27:329-336.
22. Maksay G, Bukadi Z, and Simonyi M (2003) Binding interactions of antagonists with 5-hydroxytryptamine3A receptor models. J Recept Signal Transduct Res 23:255-270.
23. Malany S, Osaka H, Sine S, and Taylor P (2000) Orientation of α-neurotoxin at the subunit interfaces of the nicotinic acetylcholine receptor. Biochemistry 39:15388-15398.
24. Morris G, Goodsell DS, Halliday RS, Huey R, Hart W, Belew R, and Olson A (1998) Automated docking using Lamarckian genetic algorithm and an empirical free energy binding free energy function. J Comp Chem 19:1639-1662.
25. Pettersen E, Goddard T, Huang C, Couch G, Greenblatt D, Meng E, and Ferrin T (2004) UCSF Chimera: a visualization system for exploratory research and analysis. J Comput Chem 25:1605-1612.
26. 3 receptor. J Biol Chem 279:23294-23301.
27. Reeves D and Lummis S (2002) The molecular basis of the structure and function of the 5-HT3 receptor: a model ligand-gated ion channel. Mol Membr Biol 19:11-26.
28. 3 receptor agonist-binding residues using homology modeling. Biophys J 84:2338-2344.
29. Sali A and Blundell T (1993) Comparative protein modeling by satisfaction of spatial restraints. J Mol Biol 234:779-815.
30. 3 receptor: the role of glutamate residues 97,224, and 235. J Biol Chem 278:22709-22716.
31. Sippl M (1993) Recognition of errors in three-dimensional structures of proteins. Proteins 17:355-362.
32. Smit A, Syed N, Schaap D, van Minnen J, Klumperman J, Kits KS, Lodder H, van der Schors R, van Elk R, Sorgedrager B, et al. (2001) A glia-derived acetylcholine-binding protein that modulates synaptic transmission. Nature (Lond) 411:261-268.
33. 3 receptor ligand binding domain. J Biol Chem 275:5620-5625.
34. 3 receptors in the CNS:3B or not 3B? Trends Pharmacol Sci 24:157-160.
35. 3ASR binding site. BMC Biochem 3:15.
36. Wigler M, Sweet R, Sim G, Wold B, Pellicer A, Lacy E, Maniatis T, Silverstein S, and Axel R (1979) Transformation of mammalian cells with genes from procaryotes and eucaryotes. Cell 16:777-785.
37. Willcockson I, Hong A, Whisenant R, Edwards J, Wang H, Sarkar H, and Pedersen S (2002) Orientation of d-tubocurarine in the muscle nicotinic acetylcholine receptor-binding site. J Biol Chem 277:42249-42258.
38. 3 receptor. J Biol Chem 274:5537-5541.
39. 3 receptors. Neuropharmacology 43:367-373.
40. 3 receptor channels in dissociated rat superior cervical ganglion neurons. J Physiol (Lond) 448:237-256.