Novel and highly potent 5-HT3 receptor agonists based on a pyrroloquinoxaline structure

Journal of Medicinal Chemistry

Volumn 40, Issue 22, 1997, Pages 3670-3678

  Campiani, Giuseppe ^a   Cappelli, Andrea ^a   Nacci, Vito ^a   Anzini, Maurizio ^a   Vomero, Salvatore ^a   Hamon, Michel ^b   Cagnotto, Alfredo ^c   Fracasso, Claudia ^c   Uboldi, Chiara ^c   Caccia, Silvio ^c   Console, Silvana ^c   Mennini, Tiziana ^c  

^a UNIVERSITY OF SIENA   (Italy)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^c MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 METHYL 1 PIPERAZINYL) 7 TRIFLUOROMETHYLPYRROLO[1,2 A]QUINOXALINE; 5 METHYLSEROTONIN; 7 FLUORO 4 (PIPERAZIN 1 YL)PYRROLO[1,2 A]QUINOXALINE; GRANISETRON; MESULERGINE; METHYSERGIDE; ONDANSETRON; QUINOXALINE DERIVATIVE; QUINZAPINE; SEROTONIN 3 AGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; CHOLINERGIC NERVE; DEGENERATIVE DISEASE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MENTAL DISEASE; NONHUMAN; RAT;

ANIMALS; BLOOD-BRAIN BARRIER; CELL LINE; CEREBRAL CORTEX; HYBRID CELLS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; QUINOXALINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT3; REFLEX; SEROTONIN AGONISTS; SPECTROPHOTOMETRY, INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 9844234810     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970376w     Document Type: Article

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