A hydrogen bond in loop a is critical for the binding and function of the 5-HT3 receptor

Biochemistry

Volumn 47, Issue 24, 2008, Pages 6370-6377

  Price, Kerry L ^a   Bower, Kiowa S ^b   Thompson, Andrew J ^a   Lester, Henry A ^b   Dougherty, Dennis A ^b   Lummis, Sarah C R ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; BIOCHEMISTRY; HYDROGEN; HYDROGEN BONDS;

CYS LOOP RECEPTORS; HOMOLOGY MODELING; RADIOLIGAND BINDING; VOLTAGE-CLAMP ELECTROPHYSIOLOGY;

BINDING SITES;

AMINO ACID; GRANISETRON; RADIOLIGAND; SEROTONIN 3 RECEPTOR;

ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; ELECTROPHYSIOLOGY; HYDROGEN BOND; LIGAND BINDING; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; SEQUENCE HOMOLOGY; VOLTAGE CLAMP; WILD TYPE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ASPARAGINE; BINDING SITES; GLUTAMIC ACID; HYDROGEN BONDING; LIGANDS; MICE; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, SEROTONIN, 5-HT3;

EID: 45749098162     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi800222n     Document Type: Article

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